LOCUS       NM_023785               1098 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus pro-platelet basic protein (Ppbp), mRNA.
ACCESSION   NM_023785
VERSION     NM_023785.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1098)
  AUTHORS   Zheng,C., Wang,J., Zhou,Y., Duan,Y., Zheng,R., Xie,Y., Wei,X.,
            Wu,J., Shen,H., Ye,M., Kong,B., Liu,Y., Xu,P., Zhang,Q. and
            Liang,T.
  TITLE     IFNalpha-induced BST2+ tumor-associated macrophages facilitate
            immunosuppression and tumor growth in pancreatic cancer by
            ERK-CXCL7 signaling
  JOURNAL   Cell Rep 43 (4), 114088 (2024)
   PUBMED   38602878
  REMARK    GeneRIF: IFNalpha-induced BST2[+] tumor-associated macrophages
            facilitate immunosuppression and tumor growth in pancreatic cancer
            by ERK-CXCL7 signaling.
REFERENCE   2  (bases 1 to 1098)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1098)
  AUTHORS   Liu,Z., Wang,Y., Ding,Y., Wang,H., Zhang,J. and Wang,H.
  TITLE     CXCL7 aggravates the pathological manifestations of neuromyelitis
            optica spectrum disorder by enhancing the inflammatory infiltration
            of neutrophils, macrophages and microglia
  JOURNAL   Clin Immunol 245, 109139 (2022)
   PUBMED   36184052
  REMARK    GeneRIF: CXCL7 aggravates the pathological manifestations of
            neuromyelitis optica spectrum disorder by enhancing the
            inflammatory infiltration of neutrophils, macrophages and
            microglia.
REFERENCE   4  (bases 1 to 1098)
  AUTHORS   Zhang,F., Jiang,N., Gao,Y., Fan,Z., Li,Q., Ke,G., Li,B., Wu,Q.,
            Xu,R. and Liu,S.
  TITLE     PPBP as a marker of diabetic nephropathy podocyte injury via
            Bioinformatics Analysis
  JOURNAL   Biochem Biophys Res Commun 577, 165-172 (2021)
   PUBMED   34555684
  REMARK    GeneRIF: PPBP as a marker of diabetic nephropathy podocyte injury
            via Bioinformatics Analysis.
REFERENCE   5  (bases 1 to 1098)
  AUTHORS   Yan,J., Zhao,Q., Wang,J., Tian,X., Wang,J., Xia,X., Ott,M., Rao,G.,
            Heimberger,A.B. and Li,S.
  TITLE     FGL2-wired macrophages secrete CXCL7 to regulate the stem-like
            functionality of glioma cells
  JOURNAL   Cancer Lett 506, 83-94 (2021)
   PUBMED   33676940
  REMARK    GeneRIF: FGL2-wired macrophages secrete CXCL7 to regulate the
            stem-like functionality of glioma cells.
REFERENCE   6  (bases 1 to 1098)
  AUTHORS   Brunskill,E.W., Aronow,B.J., Georgas,K., Rumballe,B.,
            Valerius,M.T., Aronow,J., Kaimal,V., Jegga,A.G., Yu,J.,
            Grimmond,S., McMahon,A.P., Patterson,L.T., Little,M.H. and
            Potter,S.S.
  TITLE     Atlas of gene expression in the developing kidney at microanatomic
            resolution
  JOURNAL   Dev Cell 15 (5), 781-791 (2008)
   PUBMED   19000842
  REMARK    Erratum:[Dev Cell. 2009 Mar;16(3):482. Yu, Jing [added]]
REFERENCE   7  (bases 1 to 1098)
  AUTHORS   Smith,J.B., Wadleigh,D.J., Xia,Y.R., Mar,R.A., Herschman,H.R. and
            Lusis,A.J.
  TITLE     Cloning and genomic localization of the murine LPS-induced CXC
            chemokine (LIX) gene, Scyb5
  JOURNAL   Immunogenetics 54 (8), 599-603 (2002)
   PUBMED   12439624
REFERENCE   8  (bases 1 to 1098)
  CONSRTM   IUIS/WHO Subcommittee on Chemokine Nomenclature
  TITLE     Chemokine/chemokine receptor nomenclature
  JOURNAL   J Immunol Methods 262 (1-2), 1-3 (2002)
   PUBMED   12080938
REFERENCE   9  (bases 1 to 1098)
  AUTHORS   Oda,M., Haruta,H., Nagao,M. and Nagata,Y.
  TITLE     Isolation and characterization of mouse homolog of the neutrophil
            activating peptide-2
  JOURNAL   Biochem Biophys Res Commun 290 (2), 865-868 (2002)
   PUBMED   11785982
REFERENCE   10 (bases 1 to 1098)
  AUTHORS   Zhang,C., Thornton,M.A., Kowalska,M.A., Sachis,B.S., Feldman,M.,
            Poncz,M., McKenzie,S.E. and Reilly,M.P.
  TITLE     Localization of distal regulatory domains in the
            megakaryocyte-specific platelet basic protein/platelet factor 4
            gene locus
  JOURNAL   Blood 98 (3), 610-617 (2001)
   PUBMED   11468158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010273.1 and BQ030657.1.
            
            On Feb 26, 2016 this sequence version replaced NM_023785.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF219112.1, AK010273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1080              AK010273.1         2-1081
            1081-1098           BQ030657.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     gene            1..1098
                     /gene="Ppbp"
                     /gene_synonym="2400003M24Rik; b-TG1; beta-TG; CTAP3;
                     CTAPIII; Cxcl7; LA-PF4; LDGF; MDGF; NAP-2; NAP-2-L1;
                     Scyb7; TGB; TGB1; THBGB1"
                     /note="pro-platelet basic protein"
                     /db_xref="GeneID:57349"
                     /db_xref="MGI:MGI:1888712"
     exon            1..206
                     /gene="Ppbp"
                     /gene_synonym="2400003M24Rik; b-TG1; beta-TG; CTAP3;
                     CTAPIII; Cxcl7; LA-PF4; LDGF; MDGF; NAP-2; NAP-2-L1;
                     Scyb7; TGB; TGB1; THBGB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..427
                     /gene="Ppbp"
                     /gene_synonym="2400003M24Rik; b-TG1; beta-TG; CTAP3;
                     CTAPIII; Cxcl7; LA-PF4; LDGF; MDGF; NAP-2; NAP-2-L1;
                     Scyb7; TGB; TGB1; THBGB1"
                     /note="chemokine (C-X-C motif) ligand 7; platelet basic
                     protein"
                     /codon_start=1
                     /product="platelet basic protein precursor"
                     /protein_id="NP_076274.1"
                     /db_xref="CCDS:CCDS19415.1"
                     /db_xref="GeneID:57349"
                     /db_xref="MGI:MGI:1888712"
                     /translation="MGFRLRPTSSCTRACPLHNLQILLLLGLILVALAPLTAGKSDGM
                     DPYIELRCRCTNTISGIPFNSISLVNVYRPGVHCADVEVIATLKNGQKTCLDPNAPGV
                     KRIVMKILEGY"
     exon            207..336
                     /gene="Ppbp"
                     /gene_synonym="2400003M24Rik; b-TG1; beta-TG; CTAP3;
                     CTAPIII; Cxcl7; LA-PF4; LDGF; MDGF; NAP-2; NAP-2-L1;
                     Scyb7; TGB; TGB1; THBGB1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..1083
                     /gene="Ppbp"
                     /gene_synonym="2400003M24Rik; b-TG1; beta-TG; CTAP3;
                     CTAPIII; Cxcl7; LA-PF4; LDGF; MDGF; NAP-2; NAP-2-L1;
                     Scyb7; TGB; TGB1; THBGB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1063..1068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppbp"
                     /gene_synonym="2400003M24Rik; b-TG1; beta-TG; CTAP3;
                     CTAPIII; Cxcl7; LA-PF4; LDGF; MDGF; NAP-2; NAP-2-L1;
                     Scyb7; TGB; TGB1; THBGB1"
                     /note="hexamer: AATAAA"
     polyA_site      1083
                     /gene="Ppbp"
                     /gene_synonym="2400003M24Rik; b-TG1; beta-TG; CTAP3;
                     CTAPIII; Cxcl7; LA-PF4; LDGF; MDGF; NAP-2; NAP-2-L1;
                     Scyb7; TGB; TGB1; THBGB1"
                     /note="major polyA site"
ORIGIN      
        1 aacatagcag cagtgttctg ggcagctcag cctcacgttg ttccctcctg gctctgggga
       61 cagttctagc tcactgctct tcattatggg cttcagactc agacctacat cgtcctgcac
      121 cagggcctgc ccacttcata acctccagat cttgctgctg ctgggcctga tccttgttgc
      181 gctggctccc cttacagctg gaaaatctga tggcatggac ccatatatcg aactgcgctg
      241 cagatgtacg aataccatct ctggaatccc attcaattct atctcccttg tgaatgtgta
      301 caggccagga gttcactgtg ctgatgtgga agtgatagcc acactgaaga atggacaaaa
      361 aacgtgcctg gacccaaatg cccctggcgt caagagaatc gtcatgaaaa tcttggaagg
      421 ttactgacca gctgcttcat ctgtgccaaa ccattttcct gctcaggaag ggttgagggt
      481 ttgaaatctg gacttggtag aattattttt ccactttgaa attgggatgt tctctcgttc
      541 tgtctcagaa atcacactgt attctgagaa ggcatgataa agaatgtcac aacaaacaaa
      601 caaacaatga tgaagacggg caagccaagt tgcaacctgc aatttatggt ctatttctgc
      661 agttcttggc taagcattct gacatgtcct gcatttctct atttgagctt ttcttttcaa
      721 atgtactatg tcaagttttc attctgtgtt tttaataatt atttctttta gttttgagat
      781 tataattaca tcccttcccc tttcattttt ctccctctga acccttctat atacccatcc
      841 ttgctctctt caaatccatg gctgcttttt tttcccattg agcattgtta tatacatata
      901 taatgataaa tttcgtagtg gtcaattgca acggaaatcg cctggagtca agcagttttc
      961 gctctggtca tgaccatgtt tttccaatgt cttatcccta gaatgtcttg tttccaagca
     1021 acctctgcaa cattttacat atgtttactt gaaactgaac acaataaaat catagaaagt
     1081 aaaaaaaaaa aaaaaaaa
//
