LOCUS       NM_133249              10328 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus peroxisome proliferative activated receptor, gamma,
            coactivator 1 beta (Ppargc1b), transcript variant 1, mRNA.
ACCESSION   NM_133249
VERSION     NM_133249.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10328)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10328)
  AUTHORS   Yan,M., Su,L., Wu,K., Mei,Y., Liu,Z., Chen,Y., Zeng,W., Xiao,Y.,
            Zhang,J., Cai,G. and Bai,Y.
  TITLE     USP7 promotes cardiometabolic disorders and mitochondrial
            homeostasis dysfunction in diabetic mice via stabilizing PGC1beta
  JOURNAL   Pharmacol Res 205, 107235 (2024)
   PUBMED   38815879
  REMARK    GeneRIF: USP7 promotes cardiometabolic disorders and mitochondrial
            homeostasis dysfunction in diabetic mice via stabilizing PGC1beta.
REFERENCE   3  (bases 1 to 10328)
  AUTHORS   Zhang,Z., Meng,Y., Lin,T., Zhang,Z., Tao,Z., Yin,H., Yang,F. and
            Zhou,X.
  TITLE     Dancr-BRG1 regulates Nfatc1 transcription and Pgc1beta-dependent
            metabolic shifts in osteoclastogenesis
  JOURNAL   Proc Natl Acad Sci U S A 121 (5), e2313656121 (2024)
   PUBMED   38252822
  REMARK    GeneRIF: Dancr-BRG1 regulates Nfatc1 transcription and
            Pgc1beta-dependent metabolic shifts in osteoclastogenesis.
REFERENCE   4  (bases 1 to 10328)
  AUTHORS   Abe,Y., Kofman,E.R., Ouyang,Z., Cruz-Becerra,G., Spann,N.J.,
            Seidman,J.S., Troutman,T.D., Stender,J.D., Taylor,H., Fan,W.,
            Link,V.M., Shen,Z., Sakai,J., Downes,M., Evans,R.M., Kadonaga,J.T.,
            Rosenfeld,M.G. and Glass,C.K.
  TITLE     A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator
            complex formation for inflammatory gene activation
  JOURNAL   Proc Natl Acad Sci U S A 121 (2), e2316104121 (2024)
   PUBMED   38165941
REFERENCE   5  (bases 1 to 10328)
  AUTHORS   Abe,Y., Kofman,E.R., Almeida,M., Ouyang,Z., Ponte,F., Mueller,J.R.,
            Cruz-Becerra,G., Sakai,M., Prohaska,T.A., Spann,N.J.,
            Resende-Coelho,A., Seidman,J.S., Stender,J.D., Taylor,H., Fan,W.,
            Link,V.M., Cobo,I., Schlachetzki,J.C.M., Hamakubo,T., Jepsen,K.,
            Sakai,J., Downes,M., Evans,R.M., Yeo,G.W., Kadonaga,J.T.,
            Manolagas,S.C., Rosenfeld,M.G. and Glass,C.K.
  TITLE     RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1beta- and
            RNA-dependent co-activator of osteoclast gene expression
  JOURNAL   Mol Cell 83 (19), 3421-3437 (2023)
   PUBMED   37751740
REFERENCE   6  (bases 1 to 10328)
  AUTHORS   Kamei,Y., Ohizumi,H., Fujitani,Y., Nemoto,T., Tanaka,T.,
            Takahashi,N., Kawada,T., Miyoshi,M., Ezaki,O. and Kakizuka,A.
  TITLE     PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand,
            whose expression induces a high-energy expenditure and antagonizes
            obesity
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12378-12383 (2003)
   PUBMED   14530391
  REMARK    GeneRIF: PGC-1beta/ERRL1 can function as a protein ligand of ERR,
            and that its level contributes to the control of energy balance in
            vivo
REFERENCE   7  (bases 1 to 10328)
  AUTHORS   St-Pierre,J., Lin,J., Krauss,S., Tarr,P.T., Yang,R., Newgard,C.B.
            and Spiegelman,B.M.
  TITLE     Bioenergetic analysis of peroxisome proliferator-activated receptor
            gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in
            muscle cells
  JOURNAL   J Biol Chem 278 (29), 26597-26603 (2003)
   PUBMED   12734177
  REMARK    GeneRIF: profoundly alter mitochondrial metabolism (PGC-1alpha)
REFERENCE   8  (bases 1 to 10328)
  AUTHORS   Meirhaeghe,A., Crowley,V., Lenaghan,C., Lelliott,C., Green,K.,
            Stewart,A., Hart,K., Schinner,S., Sethi,J.K., Yeo,G., Brand,M.D.,
            Cortright,R.N., O'Rahilly,S., Montague,C. and Vidal-Puig,A.J.
  TITLE     Characterization of the human, mouse and rat PGC1 beta
            (peroxisome-proliferator-activated receptor-gamma co-activator 1
            beta) gene in vitro and in vivo
  JOURNAL   Biochem J 373 (Pt 1), 155-165 (2003)
   PUBMED   12678921
REFERENCE   9  (bases 1 to 10328)
  AUTHORS   Hentschke,M., Susens,U. and Borgmeyer,U.
  TITLE     PGC-1 and PERC, coactivators of the estrogen receptor-related
            receptor gamma
  JOURNAL   Biochem Biophys Res Commun 299 (5), 872-879 (2002)
   PUBMED   12470660
REFERENCE   10 (bases 1 to 10328)
  AUTHORS   Lin,J., Puigserver,P., Donovan,J., Tarr,P. and Spiegelman,B.M.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator 1beta
            (PGC-1beta), a novel PGC-1-related transcription coactivator
            associated with host cell factor
  JOURNAL   J Biol Chem 277 (3), 1645-1648 (2002)
   PUBMED   11733490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116595.4 and AC121903.2.
            
            On Jul 20, 2018 this sequence version replaced NM_133249.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF453324.1, BC150699.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC116595.4         46197-46319
            124-297             AC121903.2         33623-33796
            298-510             AC121903.2         40982-41194
            511-627             AC121903.2         44661-44777
            628-1729            AC121903.2         45423-46524
            1730-1766           AC121903.2         47249-47285
            1767-1828           AC121903.2         47837-47898
            1829-2636           AC121903.2         48917-49724
            2637-2712           AC121903.2         52148-52223
            2713-2834           AC121903.2         54191-54312
            2835-2989           AC121903.2         57191-57345
            2990-10328          AC121903.2         58148-65486
FEATURES             Location/Qualifiers
     source          1..10328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.41 cM"
     gene            1..10328
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /note="peroxisome proliferative activated receptor, gamma,
                     coactivator 1 beta"
                     /db_xref="GeneID:170826"
                     /db_xref="MGI:MGI:2444934"
     exon            1..123
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..3090
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisome proliferator-activated receptor gamma
                     coactivator 1-beta; PPAR gamma coactivator-1beta protein;
                     ERR ligand 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator 1-beta isoform 1"
                     /protein_id="NP_573512.1"
                     /db_xref="CCDS:CCDS29284.1"
                     /db_xref="GeneID:170826"
                     /db_xref="MGI:MGI:2444934"
                     /translation="MAGNDCGALLDEELSSFFLNYLSDTQGGDSGEEQLCADLPELDL
                     SQLDASDFDSATCFGELQWCPETSETEPSQYSPDDSELFQIDSENEALLAALTKTLDD
                     IPEDDVGLAAFPELDEGDTPSCTPASPAPLSAPPSPTLERLLSPASDVDELSLLQKLL
                     LATSSPTASSDALKDGATWSQTSLSSRSQRPCVKVDGTQDKKTPTLRAQSRPCTELHK
                     HLTSVLPCPRVKACSPTPHPSPRLLSKEEEEEVGEDCPSPWPTPASPQDSLAQDTASP
                     DSAQPPEEDVRAMVQLIRYMHTYCLPQRKLPQRAPEPIPQACSSLSRQVQPRSRHPPK
                     AFWTEFSILRELLAQDILCDVSKPYRLAIPVYASLTPQSRPRPPKDSQASPAHSAMAE
                     EVRITASPKSTGPRPSLRPLRLEVKRDVNKPTRQKREEDEEEEEEEEEEEEEKEEEEE
                     EWGRKRPGRGLPWTKLGRKMDSSVCPVRRSRRLNPELGPWLTFTDEPLGALPSMCLDT
                     ETHNLEEDLGSLTDSSQGRQLPQGSQIPALESPCESGCGDTDEDPSCPQPTSRDSSRC
                     LMLALSQSDSLGKKSFEESLTVELCGTAGLTPPTTPPYKPMEEDPFKPDTKLSPGQDT
                     APSLPSPEALPLTATPGASHKLPKRHPERSELLSHLQHATTQPVSQAGQKRPFSCSFG
                     DHDYCQVLRPEAALQRKVLRSWEPIGVHLEDLAQQGAPLPTETKAPRREANQNCDPTH
                     KDSMQLRDHEIRASLTKHFGLLETALEGEDLASCKSPEYDTVFEDSSSSSGESSFLLE
                     EEEEEEEGGEEDDEGEDSGVSPPCSDHCPYQSPPSKASRQLCSRSRSSSGSSSCSSWS
                     PATRKNFRRESRGPCSDGTPSVRHARKRREKAIGEGRVVYIRNLSSDMSSRELKKRFE
                     VFGEIVECQVLTRSKRGQKHGFITFRCSEHAALSVRNGATLRKRNEPSFHLSYGGLRH
                     FRWPRYTDYDPTSEESLPSSGKSKYEAMDFDSLLKEAQQSLH"
     exon            124..297
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            298..510
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            511..627
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            628..1729
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1766
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1828
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2636
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2712
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2834
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2989
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..10328
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10309..10314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /note="hexamer: ATTAAA"
     polyA_site      10328
                     /gene="Ppargc1b"
                     /gene_synonym="4631412G21Rik; Perc; PGC-1beta;
                     PGC-1beta/ERRL1; PPARGC-1-beta"
                     /note="major polyA site"
ORIGIN      
        1 gggctcggcg ctgactccgc cgcacgctgc agccgcggct ggaagatggc ggggaacgac
       61 tgcggcgcgc tgctggatga agagctctcg tccttcttcc tcaactatct ctctgacacg
      121 cagggtgggg actctggaga ggaacagctg tgtgctgact tgccagagct tgacctctcc
      181 cagctggacg ccagtgactt tgactcagcc acgtgctttg gggagctgca gtggtgcccg
      241 gagacctcag agacagagcc cagccagtac agccccgatg actccgagct cttccagatt
      301 gacagtgaga atgaagctct cttggctgcg cttacgaaga ccctggatga catccccgaa
      361 gacgatgtgg ggctggctgc cttcccagaa ctggatgaag gcgacacacc atcctgcacc
      421 ccagcctcac ctgccccctt atctgcaccc cccagcccca ccctggagag gcttctgtcc
      481 ccagcgtctg acgtggacga gctttcactg ctacagaagc tcctcctggc cacatcctcc
      541 ccaacagcaa gctctgacgc tctgaaggac ggggccacct ggtcccagac cagcctcagt
      601 tccagaagtc agcggccttg tgtcaaggtg gatggcaccc aggataagaa gacccccaca
      661 ctgcgggctc agagccggcc ttgtacggaa ctgcataagc acctcacttc ggtgctgccc
      721 tgtcccagag tgaaagcctg ctccccaact ccgcacccga gccctcggct cctctccaaa
      781 gaggaggagg aggaggtggg ggaggattgc ccaagccctt ggccgactcc agcctcgccc
      841 caagactccc tagcacagga cacggccagc cccgacagtg cccagcctcc cgaggaggat
      901 gtgagggcca tggtacagct cattcgctac atgcatacct actgcctgcc tcagaggaag
      961 ctgccccaac gggccccaga gccaatcccc caggcctgca gcagcctctc caggcaggtt
     1021 caaccccgat cccggcatcc ccccaaagcc ttctggactg agttctctat cctaagggaa
     1081 cttctggccc aagatatcct ctgtgatgtt agcaagccct accgcctggc catacctgtc
     1141 tatgcttccc tcacacctca gtccaggccc aggcccccca aggacagtca ggcctcccct
     1201 gcccactctg ccatggcaga agaggtgaga atcactgctt cccccaagag caccgggcct
     1261 agacccagcc tgcgtcctct gaggctggag gtgaaacggg atgttaacaa gcctacaagg
     1321 caaaagcggg aggaagatga ggaggaggag gaggaagaag aagaagagga agaagaaaaa
     1381 gaagaggaag aagaggagtg gggcaggaag agaccaggtc gtggcctgcc atggaccaaa
     1441 ctagggagga agatggacag ctccgtgtgc cccgtgcggc gctccaggag actgaatcca
     1501 gagctgggtc cctggctgac attcactgat gagcccttag gtgctctgcc ctcgatgtgc
     1561 ctggatacag agacccacaa cctggaggaa gacctgggca gcctcacaga cagtagtcaa
     1621 ggccggcagc tcccccaggg atcccagatc cccgccctgg aaagcccctg tgagagtggg
     1681 tgcggagaca cagatgaaga tccaagctgc ccacagccca cttccagaga ctcctccagg
     1741 tgcctcatgc tggccttgtc acaaagcgac tctcttggca agaagagctt tgaggagtcc
     1801 ctgacggtgg agctttgcgg cacggcagga ctcacgccac ccaccacacc tccatacaag
     1861 ccaatggagg aggacccctt caagccagac accaagctca gcccaggcca agacacagct
     1921 cccagccttc cctcccccga ggctcttccg ctcacagcca ccccaggagc ttcccacaag
     1981 ctgcccaaga ggcacccaga gcgaagcgag ctcctgtccc atttgcagca tgccacaacc
     2041 caaccagtct cacaggctgg ccagaagcgc cccttctcct gctcctttgg agaccacgac
     2101 tactgccagg tgctcaggcc agaggctgcc ctgcagagga aggtgctgcg gtcctgggag
     2161 ccaatcgggg tccaccttga agacttggcc cagcagggtg cccctctgcc aacggaaaca
     2221 aaggccccta ggagggaggc aaaccagaac tgtgacccta cccacaagga cagcatgcag
     2281 ctaagagacc atgagatccg tgccagtctc acaaagcact ttgggctgct ggagactgct
     2341 ctggaaggtg aagacctggc gtcctgtaaa agcccggagt atgacaccgt atttgaggac
     2401 agcagcagca gcagtggcga gagtagcttc ctgcttgagg aggaggagga agaggaggag
     2461 ggaggggaag aggacgatga aggagaggac tcaggggtca gccctccctg ctctgatcac
     2521 tgcccctacc agagcccacc cagtaaggcc agtcggcagc tctgctcccg aagccgctcc
     2581 agttccggct cctcgtcctg cagctcctgg tcaccagcca cccggaagaa cttcagacgt
     2641 gagagcagag ggccctgttc agatggaacc ccaagcgtcc ggcatgccag gaagcggcgg
     2701 gaaaaggcca tcggtgaagg ccgtgtggta tacattcgaa atctctccag tgacatgagc
     2761 tctcgggaac taaagaagcg ctttgaggtg ttcggtgaga ttgtagagtg ccaggtgctg
     2821 acgagaagta aaagaggcca gaagcacggt tttatcacct tccggtgttc agagcacgct
     2881 gccctgtccg tgaggaacgg cgccaccctg agaaagcgca atgagccctc cttccacctg
     2941 agctatggag ggctccggca cttccgttgg cccagataca ctgactatga tcccacatct
     3001 gaggagtccc ttccctcatc tgggaaaagc aagtacgaag ccatggattt tgacagctta
     3061 ctgaaagagg cccagcagag cctgcattga tatcagcctt aaccttcgag gaatacctca
     3121 atacctcaga caaggccctt ccaatatgtt tacgttttca aagaaaagag tatatgagaa
     3181 ggagagcgag cgagcgagcg agcgagcgag tgagcgtgag agatcacaca ggagagagaa
     3241 agacttgaat ctgctgtcgt ttcctttaaa aaaaaaaaaa cgaaaaacaa aaacaaatca
     3301 atgtttacat tgaacaaagc tgcttccgtc cgtctgtccg tccgtccgtc cgtccgtgag
     3361 tttccatgct gttgatgttc cactgccacg ttagcgtcgt cctcgcttcc agcggatcgt
     3421 cctgggtgcg cctccaagtg ctgtcagtcg tcctctgccc ctcccacccg actgacttcc
     3481 ttctgttaga cttgagctgt gttcacataa catcttctgt ctgtagagtg tgatgatgac
     3541 attgttactt gtgaatagaa tcaggagtta gaaactcatt tttaattgaa gaaaaaaaaa
     3601 gtatatcctt aaaaagaaaa aaaaaaaaac aaatgtattt atggctctga ttactgtgcc
     3661 tgggattaac gtactgcttc cttgattgtt taactatgca ctgtcacgag gtgtttgcta
     3721 ctgagctgcg ctgctgcttc cctggtccat gtagtcctgg agatactggg tggcttctaa
     3781 gtccccagga aagaggggct tgccgtcaca ggtgtgaaga agagagaggt gtctagggat
     3841 cttctaccaa gtcctggtgt cttttgagtg agttccactc gagctgtaac gagaatccct
     3901 tccccctgtc tacccacact tggagggcac ctgtttttag tgctcagaac cttgagtgcc
     3961 tgtagggaag gtggggtaag ctatgttaga cccattccac ggggaaagag gatatagtgc
     4021 cctgagaggt gaactgtgaa atgtgctgcc caaggtctca cggcagagca gtgagccacc
     4081 tctagcctcc tgactgctgg ccccagcctg cggcagtagt tagcctaaag atgcaaaagt
     4141 cagagactgg aggagtggaa ttagctaaat tgagcaatag gctagaagcc taatagctca
     4201 cttgagaatt gggccaccag ttgactcacc agcattaagg caaattcaag tttcagcaca
     4261 gactcaggtg tccctgagct tcgatcctcg gtgtcctgcg acttatcctg cctgtggata
     4321 cccctcaagg ttctgagatc cctgcaagcg gtgcacagac ttcacctagg ggctgtcctt
     4381 tgcgggcagg gagggcaact agcagcccat tccgatatcc tacagtgtcc ctgcctgccc
     4441 ctcctctgta aagttagagt tgccgagtga ggggttgtac aggttggggg tgtggacaag
     4501 gcactcccaa ggagcattca cagtgagctc ctcttgaccc cgttcttgac tactgtcaaa
     4561 gccatatcca gtgtgacatt ctctgggtcc ccaggggccc ttctcgaggg agagccggct
     4621 ctatgggcag agtatcagct ctaatgcttc atatagatca gttcctcctt ggtcttgtga
     4681 cattttctct ctttctcccc ctctccatcc attcattcat tgttctgcca aataagaaag
     4741 tttgattaat cagctgctaa tgacaggctt attcctttga taattggtgg ttaatttttt
     4801 tttttaagat tatcaagtac ctcagtagag aaagtgagcc atgatcttgt gcttggtgtt
     4861 gggaaaagtc ttcacctata gataaggagg ctggctctag cagaaatagg ggaacagaga
     4921 atctgtgtgt gagatagatc ccttggcctc cctaaacccc aggttccctt tctgtgaaat
     4981 ggactgagga gcaaattaga cagcaagaag tcttagcagc tactcaggca gtacatagtc
     5041 acgcctcccc ccaccccccc cccatacaca cacacatcct tgggatgcaa acatagttaa
     5101 ttgatcataa acactaattt ttttgagcct ggtcgtgctc ttagaataca cagtgctcta
     5161 ggcaggcatt attaattggt cggtgtttta actgatttga catcctgttc taatctttgg
     5221 aagactatca ttgtagagcc atatgctggc tggtttttat gctggccgtt cctgtcataa
     5281 cctgatccat gaaaaagaaa aaaatgcccc tgaagccatt actcagtaga agactcccaa
     5341 actattacaa aacaaagggg tgtggaaagg gaagggcgca gtagaacacg gaatcagaac
     5401 tggagaagac gtgacttctg aggatagatc caaaagggga cttttcacag tacagaccta
     5461 atcgttctga attcctttat tcatttattc gttgcctggc atatggtagg cacatggaag
     5521 atgggtgtgg actgggatgg ttcttcagtt gtatctacta aaaccggggc tctaaccaca
     5581 gaggaaagcc agtgatcgct gaaatcaccc aaagggaaag ggaccagaca taatctggag
     5641 agccatttga actctgaccc caccaagacc ttcttttgtg actttatgag tctcttcttc
     5701 ttgggacctc caatgtagga gttgtccaag gaaccatggg ctcttatctt accatctgct
     5761 tccgcagcta cactgaagcc agatgctggg tctggagtaa aagatcaaat tcttaataaa
     5821 cactaagtct ttctctctcc cagccagggt tacctggagc tgaccagtca gttcactctc
     5881 tggcactcaa agtcactcag atgttgttct tgagcagaac agagccctga gccctaccgg
     5941 aacttcctgg tgggaactga tgcccaccaa gactctctag tattctccac ttaccctctc
     6001 ataaaaatgg actaccagct ctgcagataa cccctcctcc ccctctctgg aagagccatt
     6061 cggtgctgca tataatttac caaggagact gtcaggcccc ttcgagacca ggaatccatc
     6121 ttggtctctt tcccatcaaa tcaaggagta acccagaggg agcagccgcc atgggcaacc
     6181 ttctcgttgt agctgtcgtg atgtgtctca atgatgttta cgtgtgattg ccatagcttc
     6241 ctatagactg ttgacagccg cccagggagg gcagttctcc gtgtcatatc tctgctgtgc
     6301 tggtattttc tagaaatgtc tgatccaatc actaagagga attcttccgt ctccttcctc
     6361 agtcactaca aggctgaatc agagtcctct ctctctcagg ggactctgtt acggaaggaa
     6421 aatgcatcaa ataggtaaat atgactgaat gggatacagc caaggtcccc actccccatc
     6481 ccccgacatc acttgtggcc ccagctagaa aaatgctttg agtcagaaag tacccatcct
     6541 atgcctgtgt gtctctgttg atcttttaga atctggtgaa cagcaaggtt ccaggggtgg
     6601 tgggaggact gctttgagcc agccacaaag acttagtcct caagtcctaa tatggcaaga
     6661 catacagtaa gatgtccctt gtgacctcaa gccctgcagg tcagcatctg ggggaaaatg
     6721 tgatatgcct gccctggctg ctgtactcgt ggtaaatgga gagaaagtgc agctctctcc
     6781 agggtctgtc ccagcctttc gctgaccctg ctgctgcaga ggcaagggca cctctctgtg
     6841 aactggagtc acccttagag ggtgtgttga tgtgattcac tgaggtcaaa agtatttttc
     6901 ttaatgtttg atcctgagtg gctgtgatca tcttgagaaa gccatattcc agtgtcacgt
     6961 gtgacaatgg aaagggattg ggtgtgtgat aataaataga atgaacctgt tggtgtcatt
     7021 agccaaagaa aagggattcc ttcacctttg tcgccggggt agaaggaaac tgactactct
     7081 ttatgtgcaa tatatgttga cactgccctc caattccctg agagttttgt acacagatga
     7141 gctccaggac tgtttggagt gtctggggat acagggtgag ggcagggaga gcctgggaga
     7201 gaaacttcca agcatagaga tagccttggc ctctagaaca gatgggagtg tggggcaggg
     7261 tgcccctgac tctagctgtg gaataccggg acacccggaa agcagttagg cagacccttt
     7321 gcactaatga tgaaagcact ttgagaaatc tgacacttca gccttgtccc acactctcct
     7381 ctggtaaatt ctgtgtatcc tttatctggg tgaggtgctg tcctaaaggc taggttagag
     7441 gagaaggaag ggggctgggt gagaaagaaa gcagaggcgt cattcaaggt gagcctgcag
     7501 atagtcagtc ctggcctggt ttctttctta gaagctcagg aaacagaagg atcggtttac
     7561 atcttggtgc ccacttttat aaaaactgaa gaacagccta gccaattgca atgctttgtg
     7621 gagcaatctt ccctttatgt ttcttattta cggtgtgacc ttaggcccct gttccttgag
     7681 cgaatgaggc tgtccgatga taacatgata acagagccag gggagcccag agttctactt
     7741 actctctggc tagaccgggg tgtgtgtatg ggggaagggc actcccttca aggtcatcaa
     7801 cctccaatag gatgagatcc acacagtcct ggctgaggtg ccttctatga agaggctagc
     7861 tccccaggac agatccaagc catagtctat tgtgggatgg taaagaatta accctcatgc
     7921 ctcgttgaca acctccagtc tccagttagc cttgtcatcg tccccaccga acagctttta
     7981 atctgaatgt tgtgaccact tggccgtctc ttgcttgctt gcagataata ctagcaatac
     8041 acttgttttc tccaaatcgc tcaacttaag acagttttca cacattgctt tcaaatgatt
     8101 ataagacaca tggggccaca ggaggcatgg atcacactgc atatgtttag ggcaactttt
     8161 atttttattt tattttattt tattttattt tattttattt tattttattt tatttttgaa
     8221 tctttaaagg tatagcagca gtgaccaagc ctttgggatt tggggagaca aatttttcac
     8281 aaagccattt catcagaatg ccttgattat tggaaggagt aggaatccat atgcccaaat
     8341 caaggggctt gcaacatatg gtttctaggc gatcggtctc tacaacagct cctctgaaag
     8401 gtattcacgt ggctacaacc cctcgtgcca tatttttatt tcatcaaagg attctccaag
     8461 gaagccttaa agagcctcct ttctcccttc gctggtcttg ggtagtgtcc ttgtggagga
     8521 gcttggtcag cactttgcct catcaatgtg tggtcaccaa cctagtggcc aaagactggt
     8581 gtccaccaga caccaagagg gaaggcaaaa taagttcctt tggtcagcca tcaagtcggc
     8641 caacattaac ttggcagtga gatgcagcaa ctcgagtggg ttgtcctacg tgttccgcac
     8701 caactcagaa aatcgtcagc tgcttagcag cttatgcagt ccaggaaatg cactacttat
     8761 cctgtggaag aggggatggg gttgaaccca gcacccacat gtcccgaggg gtttactgta
     8821 actgcaatac tggcagtcta gctgccaacc ttgttaagtg aacctcttct aggtggccca
     8881 catggtacct tggggacaag tgaagttatg aatgaggatt gggggagaag ggggccctgg
     8941 ccatgacctt tgatattgtc cactgaatag ccaaacaggt ttgtttgttt gtttgtttgt
     9001 taattttttt ttgtattttg tatttttgaa tcttgtccaa tgtttttgtg ttaggaataa
     9061 taagtcataa actattccca ccttggtttc tgaaggggtg ttctgattcc agttgaaaca
     9121 ggttggaagt ctcaagggag catggtctga ggagtccatg ggacaggcag tggagcccgt
     9181 ggggttccca gtggttgctg ggaaagataa ccatccggaa gtccaactct gtgcaagtga
     9241 ttccagaggt tcgcagctgc ctccttgtcc cctacatcct ttaagcactg gcctaaagca
     9301 cacgcttttg ttagaagcag ctgctgaggt tgaaaccaag actacccagc tccctaaacc
     9361 ctaaatttca agagatgctg tctgtagcta gccttaatgg attggcaagg tggtttcttt
     9421 gctcccttcc aacagttcca actcttggac tcaaaaccct tttctcttag tgtgaccata
     9481 cagcctagag aattttgagc aatagggaag ccagggcttt ccttggctct acgacagggt
     9541 caaaccaggg aatggctaaa ctttagagat ttggtcatac ccaggatact actgtagggg
     9601 gcattatgta ttacggagct caacaaggta actgtaacct ggggtgcgtg tgagtgtaag
     9661 gctgtgcatg cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttac
     9721 attgatgcat ttcttgagaa aggtgcaaga atttcaccta tacagaggga cacatctgct
     9781 ttattattta taatagaagc taaattttaa ttttttaaag gacactgcta atgattgaaa
     9841 aatcgagttt ttagttttgc tatttttttt aattggtaga agatttttat atattttttt
     9901 ccatttcgtt gggttgtgtc cttatttata taaatactat atccataaga ggcgaggaag
     9961 aagaacttct ttgctcttaa ttattgtggt tgtcattgtc cctattttgt ttccggcgtg
    10021 atttatccgt cttaccttct aaatgagcaa ccgttttcct gtatttgtac attgtcagat
    10081 tctatagttt cgtagataat ttaaccaaaa ttgctctatg tattattatt ctgtgagtat
    10141 aaagttctat tttaacggtc tgtaaatact tcagaactgg cttcttttct cagctcccac
    10201 tggggagcta ttgtttacat cacaaaaaac tgtagaatct ctatgctcat gtactgtaaa
    10261 tagtgacgtg atctgcttat aaataaaacg aacaaataca ctatggaaat taaaaaatac
    10321 cacccaca
//
