LOCUS       NM_001402987            6868 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus peroxisome proliferative activated receptor, gamma,
            coactivator 1 alpha (Ppargc1a), transcript variant 4, mRNA.
ACCESSION   NM_001402987 XM_006503774
VERSION     NM_001402987.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6868)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6868)
  AUTHORS   Xu,Q., Liu,H., Ding Shiwen Fan,X., Lv,W., Jiang,Y., Liang,Y., Xu,H.
            and Dai,J.
  TITLE     PGC-1alpha regulates endoplasmic reticulum stress in IPF-derived
            fibroblasts
  JOURNAL   Int Immunopharmacol 138, 112514 (2024)
   PUBMED   38943974
  REMARK    GeneRIF: PGC-1alpha regulates endoplasmic reticulum stress in
            IPF-derived fibroblasts.
REFERENCE   3  (bases 1 to 6868)
  AUTHORS   Ma,H., Jia,H., Zou,W., Ji,F., Wang,W., Zhao,J., Yuan,C. and Jiao,J.
  TITLE     Gasdermin D Mediated Mitochondrial Metabolism Orchestrate
            Neurogenesis Through LDHA During Embryonic Development
  JOURNAL   Adv Sci (Weinh) 11 (35), e2402285 (2024)
   PUBMED   39033542
REFERENCE   4  (bases 1 to 6868)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   5  (bases 1 to 6868)
  AUTHORS   Yan,Y.S., Mo,J.Y., Huang,Y.T., Zhu,H., Wu,H.Y., Lin,Z.L., Liu,R.,
            Liu,X.Q., Lv,P.P., Feng,C., Sheng,J.Z., Jin,M. and Huang,H.F.
  TITLE     Intrauterine hyperglycaemia during late gestation caused
            mitochondrial dysfunction in skeletal muscle of male offspring
            through CREB/PGC1A signaling
  JOURNAL   Nutr Diabetes 14 (1), 56 (2024)
   PUBMED   39043630
  REMARK    GeneRIF: Intrauterine hyperglycaemia during late gestation caused
            mitochondrial dysfunction in skeletal muscle of male offspring
            through CREB/PGC1A signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6868)
  AUTHORS   Kakuma,T., Wang,Z.W., Pan,W., Unger,R.H. and Zhou,Y.T.
  TITLE     Role of leptin in peroxisome proliferator-activated receptor gamma
            coactivator-1 expression
  JOURNAL   Endocrinology 141 (12), 4576-4582 (2000)
   PUBMED   11108270
REFERENCE   7  (bases 1 to 6868)
  AUTHORS   Lehman,J.J., Barger,P.M., Kovacs,A., Saffitz,J.E., Medeiros,D.M.
            and Kelly,D.P.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator-1
            promotes cardiac mitochondrial biogenesis
  JOURNAL   J Clin Invest 106 (7), 847-856 (2000)
   PUBMED   11018072
REFERENCE   8  (bases 1 to 6868)
  AUTHORS   Esterbauer,H., Oberkofler,H., Krempler,F. and Patsch,W.
  TITLE     Human peroxisome proliferator activated receptor gamma coactivator
            1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal
            localization, and tissue expression
  JOURNAL   Genomics 62 (1), 98-102 (1999)
   PUBMED   10585775
REFERENCE   9  (bases 1 to 6868)
  AUTHORS   Boss,O., Bachman,E., Vidal-Puig,A., Zhang,C.Y., Peroni,O. and
            Lowell,B.B.
  TITLE     Role of the beta(3)-adrenergic receptor and/or a putative
            beta(4)-adrenergic receptor on the expression of uncoupling
            proteins and peroxisome proliferator-activated receptor-gamma
            coactivator-1
  JOURNAL   Biochem Biophys Res Commun 261 (3), 870-876 (1999)
   PUBMED   10441518
REFERENCE   10 (bases 1 to 6868)
  AUTHORS   Puigserver,P., Wu,Z., Park,C.W., Graves,R., Wright,M. and
            Spiegelman,B.M.
  TITLE     A cold-inducible coactivator of nuclear receptors linked to
            adaptive thermogenesis
  JOURNAL   Cell 92 (6), 829-839 (1998)
   PUBMED   9529258
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC111037.8 and AC116763.11.
            
            On Mar 24, 2022 this sequence version replaced XM_006503774.5.
            
            Summary: This gene encodes a transcriptional coactivator that
            induces and coordinates gene expression regulating mitochondrial
            biogenesis, respiration, hepatic gluconeogenesis, thermogenic
            program in brown fat and muscle fiber-type switching. Mice lacking
            the encoded protein exhibit reduced thermogenic capacity,
            hyperactivity and resistance to diet-induced obesity. Mice lacking
            the encoded protein specifically in the heart exhibit peripartum
            cardiomyopathy. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.159649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               AC111037.8         136412-137002       c
            592-771             AC116763.11        21634-21813
            772-966             AC116763.11        72097-72291
            967-1092            AC116763.11        74530-74655
            1093-1297           AC116763.11        75520-75724
            1298-1343           AC116763.11        80080-80125
            1344-1417           AC116763.11        80235-80308
            1418-2333           AC116763.11        95914-96829
            2334-2438           AC116763.11        97342-97446
            2439-2559           AC116763.11        97607-97727
            2560-2681           AC116763.11        106998-107119
            2682-2833           AC116763.11        107468-107619
            2834-6868           AC116763.11        112042-116076
FEATURES             Location/Qualifiers
     source          1..6868
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 27.02 cM"
     gene            1..6868
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /note="peroxisome proliferative activated receptor, gamma,
                     coactivator 1 alpha"
                     /db_xref="GeneID:19017"
                     /db_xref="MGI:MGI:1342774"
     exon            1..591
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..2937
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /note="isoform b is encoded by transcript variant 4;
                     peroxisome proliferator-activated receptor gamma
                     coactivator 1-alpha; PPAR-gamma coactivator 1-alpha"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator 1-alpha isoform b"
                     /protein_id="NP_001389916.1"
                     /db_xref="GeneID:19017"
                     /db_xref="MGI:MGI:1342774"
                     /translation="MAGCGLSEDTFLSSFFYNYGSSWETPSNQCAALVGEDQPLCPDL
                     PELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAV
                     LTETLDSLPVDEDGLPSFDALTDGAVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLL
                     APANTQLSYNECSGLSTQNHAANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRP
                     CSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTP
                     ESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKT
                     VVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKSSGLSRGHEERKTKRPSLRL
                     FGDHDYCQSLNSKTDILINISQELQDSRQLDFKDASCDWQGHICSSTDSGQCYLRETL
                     EASKQVSPCSTRKQLQDQEIRAELNKHFGHPCQAVFDDKSDKTSELRDGDFSNEQFSK
                     LPVFINSGLAMDGLFDDSEDESDKLSYPWDGTQPYSLFDVSPSCSSFNSPCRDSVSPP
                     KSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRT
                     HRNSPLYVRSRSRSPYSRRPRYDSYEAYEHERLKRDEYRKEHEKRESERAKQRERQKQ
                     KAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDA
                     FAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDTNSDDFDPASTKSKYDSLDFD
                     SLLKEAQRSLRR"
     exon            592..771
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..966
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1092
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1297
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1343
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1417
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..2333
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2438
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2559
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2681
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2833
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..6868
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5710..5715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /note="hexamer: AATAAA"
     polyA_site      5733
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /note="major polyA site"
     regulatory      6840..6845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /note="hexamer: AATAAA"
     polyA_site      6868
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /note="major polyA site"
ORIGIN      
        1 agcctcgcgc gcacacgccc gcccgcctgc tctgcctctg cgccctgcat cccggctcgc
       61 tcgttctctc gccctctcgc ctcccctgcg gtctctcgct ctgcgcgcac acaccgcaca
      121 cacgcacacg cacacacacg cgcgcataca cgcagccggc acaggcggcg gcggcggcgg
      181 ctgccggagt caggacgaac ctctctaggt accgtcttga gaaggcggca gcagcggcgg
      241 cggcggcggc ggcggcagcg gcggcggcga tagcggcggc ggcggcggcg gcggcagccc
      301 gagcatccct gctcagccgg agagggagca tcgccgagag ttcccgtccc ctcggccatt
      361 cccttccccc ccctcctttt ctttatttgc gagagaattt cagctgcctt attggtttcg
      421 tttgatttgg aaacattttt ggttgctttg tgtgtgtgtg tgtcctgttt ttttttcttt
      481 cctcgtttta tttgcatcca gagcatggcg ggctgcgggc tgtcggaaga caccttcctc
      541 tcctccttct tttacaacta cggctcctcc tgggaaaccc cttccaacca gtgtgctgct
      601 ctggttggtg aggaccagcc tctttgccca gatcttcctg aacttgacct ttctgaactt
      661 gatgtgaatg acttggatac agacagcttt ctgggtggat tgaagtggtg tagcgaccaa
      721 tcggaaatca tatccaacca gtacaacaat gagcctgcga acatatttga gaagatagat
      781 gaagagaatg aggcaaactt gctagcggtt ctcacagaga cactggacag tctccccgtg
      841 gatgaagacg gattgccctc atttgatgca ctgacagatg gagccgtgac cactgacaac
      901 gaggccagtc cttcctccat gcctgacggc acccctcccc ctcaggaggc agaagagccg
      961 tctctactta agaagctctt actggcacca gccaacactc agctcagcta caatgaatgc
     1021 agcggtctta gcactcagaa ccatgcagca aaccacaccc acaggatcag aacaaaccct
     1081 gccattgtta agaccgagaa ttcatggagc aataaagcga agagcatttg tcaacagcaa
     1141 aagccacaaa gacgtccctg ctcagagctt ctcaagtatc tgaccacaaa cgatgaccct
     1201 cctcacacca aacccacaga aaacaggaac agcagcagag acaaatgtgc ttcgaaaaag
     1261 aagtcccata cacaaccgca gtcgcaacat gctcaagcca aaccaacaac tttatctctt
     1321 cctctgaccc cagagtcacc aaatgacccc aagggttccc catttgagaa caagactatt
     1381 gagcgaacct taagtgtgga actctctgga actgcaggcc taactcctcc cacaactcct
     1441 cctcataaag ccaaccaaga taaccctttc aaggcttcgc caaagctgaa gccctcttgc
     1501 aagaccgtgg tgccaccgcc aaccaagagg gcccggtaca gtgagtgttc tggtacccaa
     1561 ggcagccact ccaccaagaa agggcccgag caatctgagt tgtacgcaca actcagcaag
     1621 tcctcagggc tcagccgagg acacgaggaa aggaagacta aacggcccag tctccggctg
     1681 tttggtgacc atgactactg tcagtcactc aattccaaaa cggatatact cattaacata
     1741 tcacaggagc tccaagactc tagacaacta gacttcaaag atgcctcctg tgactggcag
     1801 gggcacatct gttcttccac agattcaggc cagtgctacc tgagagagac tttggaggcc
     1861 agcaagcagg tctctccttg cagcaccaga aaacagctcc aagaccagga aatccgagcg
     1921 gagctgaaca agcacttcgg tcatccctgt caagctgtgt ttgacgacaa atcagacaag
     1981 accagtgaac taagggatgg cgacttcagt aatgaacaat tctccaaact acctgtgttt
     2041 ataaattcag gactagccat ggatggccta tttgatgaca gtgaagatga aagtgataaa
     2101 ctgagctacc cttgggatgg cacgcagccc tattcattgt tcgatgtgtc gccttcttgc
     2161 tcttccttta actctccgtg tcgagactca gtgtcaccac cgaaatcctt attttctcaa
     2221 agaccccaaa ggatgcgctc tcgttcaaga tccttttctc gacacaggtc gtgttcccga
     2281 tcaccatatt ccaggtcaag atcaaggtcc ccaggcagta gatcctcttc aagatcctgt
     2341 tactactatg aatcaagcca ctacagacac cgcacacacc gcaattctcc cttgtatgtg
     2401 agatcacgtt caaggtcacc ctacagccgt aggcccaggt acgacagcta tgaagcctat
     2461 gagcacgaaa ggctcaagag ggatgaatac cgcaaagagc acgagaagcg ggagtctgaa
     2521 agggccaaac agagagagag gcagaagcag aaagcaattg aagagcgccg tgtgatttac
     2581 gttggtaaaa tcagacctga cacaacgcgg acagaattga gagaccgctt tgaagttttt
     2641 ggtgaaattg aggaatgcac cgtaaatctg cgggatgatg gagacagcta tggtttcatc
     2701 acctaccgtt acacctgtga cgctttcgct gctcttgaga atggatatac tttacgcagg
     2761 tcgaacgaaa ctgacttcga gctgtacttt tgtggacgga agcaattttt caagtctaac
     2821 tatgcagacc tagataccaa ctcagacgat tttgaccctg cttccaccaa gagcaagtat
     2881 gactctctgg attttgatag tttactgaag gaagctcaga gaagcttgcg caggtaacgt
     2941 gttcccaggc tgaggaatga cagagagatg gtcaatacct catgggacag cgtgtccttt
     3001 cccaagactc ttgcaagtca tacttaggaa tttctcctac tttacactct ctgtacaaaa
     3061 ataaaacaaa acaaaacaac aataacaaca acaacaacaa caataacaac aacaaccata
     3121 ccagaacaag aacaacggtt tacatgaaca cagctgctga agaggcaaga gacagaatga
     3181 taatccagta agcacacgtt tattcacggg tgtcagcttt gctttccctg gaggctcttg
     3241 gtgacagtgt gtgtgcgtgt gtgtgtgtgg gtgtgcgtgt gtgtatgtgt gtgtgtgtac
     3301 ttgtttggaa agtacatatg tacacatgtg aggacttggg ggcacctgaa cagaacgaac
     3361 aagggcgacc ccttcaaatg gcagcatttc catgaagaca cacttaaaac ctacaacttc
     3421 aaaatgttcg tattctatac aaaaggaaaa taaataaata taaattaaaa ggaaagaaaa
     3481 ctcacaaacc accctaaaat gacactgctg atgcctgttg tcagcctccg gtaccgtctt
     3541 ttcagaaagt gcaaaaccca gaaagtgcaa aaccaacctg cagcaagctc tctctctctc
     3601 ttaatgtaat cattacgtga caatcccgaa gacactacag gttccataga actcatatcc
     3661 acctctctct ctctctctct ctctctctct ctctctctct ctctcctctc tcctctctcc
     3721 tctctccctc ccttctttgc cattgaatct gggtgggaga ggatactgca ggcaccagat
     3781 gctaaacttt cctaacattt tgaagtttct gtagtttgtc ctttgtcctg acacctatgt
     3841 atatgttcaa aatgttgatc ttccactgca gattttgaaa agccttgtta ttggtcaagc
     3901 ggggagtgtg ttcagtggct ccttctgagg agcagacgcg gtgttacatg agtactgaga
     3961 gttgagtaga actctctgga tgtgttcaga tagtgtaatt gctacattct ctgatgtagt
     4021 taagtattta cagatgttaa atggagtatt tttattttat gtacatactc tacaactatg
     4081 ttcttttttg ttacagctat gcactgtaaa tgcagccttc ttttcaaaac tgctaaattt
     4141 ttcttaatca agaatattca aatgtaatta tgaggtgaaa caattattgt acactaacat
     4201 atttagaagc taaacttact gcttatatat atttgattgt aaaaaaaaaa aaaaacaaaa
     4261 ccaacaaaac aaaagacagt gtgtgtgtgt gtgtccgttg agtgcaagtc caacaaaatg
     4321 gcgcttcacg cacatccatc ccttcttagg tgagcttcaa tctaagcatc ttgtcaacaa
     4381 caacaaaaat cctaggcccc tcaaggtatt aaccacttct gcaatatttt tccacatttt
     4441 cttgttgctt gtttttcttt gaagttttat acactggatt tgttagggga atgaaatttt
     4501 ctcatctaaa atttttctag acaatatcat gattttatgt aaagtctctc aatggggaac
     4561 cattaagaaa tgtttttatt ttctctatca acagtagatt tgaaactaga ggtcaaaaaa
     4621 aatcttttta aaatgctgtt ttgttttaat ttttgtgatt ttaatttgat acaaaatgct
     4681 gaggtaataa ttacagtatg atttttacaa tagtcaatgt gtgtctgaag actatctttg
     4741 aagccagtat ctctttccct tggcagagta tgatgatggt atttaatctg tattttttac
     4801 agttatacat cctgtaaaat actgatattt cattcctttg tttactaaag agacatattt
     4861 atcagttgca gatagcctat ttattataaa ttaagagatg atgaaaataa taaggtcagt
     4921 ggagactttc tacccagggt gcatggcagt tgtcaggctg gagtgtacct tcttcgtttg
     4981 ggaaactcag ctctcgcaga agcagtgttc catctttcac tagcatggcc tctgatacga
     5041 ccatggtgtt gttcttggtg acattgcttc tgctaaattt aatattaata ataataaatg
     5101 tcagaaaaaa aaccctccat tttgagcatc aggatttcat ctgagtatgg agtcgctgcc
     5161 atgggagtca ctaaactttg gagtatgtat ttcatttcca aattgagatg catttactgt
     5221 ttggctgaca tgaattttct ggaagatatg atagacctac tacttaaccg tttttgtttg
     5281 tttttttttc tttgttgttg ttgttttgtt ttttgttttt ttgtttttct ctctcaccca
     5341 acactatctt acaaaatggg tttcaccccc aggccaatgc agctaatttt gacagctgca
     5401 ttcatttatc accagcatat tgtgttctga gtgaatccac tgtctgtcct gtcgaatgct
     5461 tgctcaagtg tttggcttat tatttctaag tagatagaaa gcaataaata actatgaaat
     5521 aaaaaagaat tgtgttcaca ggttctgcgt tacaacagta acacatcttt aatccgccta
     5581 attcttgttc tgtaggataa atgcaggtat tttaactctt tgtgaacgcc aaactaaagt
     5641 ttacagtctt tctttctgaa ttttgagtat cttctgttgt agaataataa taaaaagact
     5701 attaagagca ataaattatt tttaagaaat caatatttag taaatcctgt tatgtgttta
     5761 aggaccagat gcgttctcta ttttgccttt aaatttttgt gatccaactt taaaaacata
     5821 cgttgtcttg tttgccctgg atcatggaca tgactaaaat tttgtggttt cttttcttac
     5881 ttatcaaaag acaacactac agatttcatg ttgaggattc attgagctct caccctctgg
     5941 cctgacaaat cttgttacca tgaagatagt tttcctccgt ggacttcaaa ttgcatctaa
     6001 aattagtgaa gcttgtgtat cttatgcaga cactgtgggt agcccatcaa aatataagct
     6061 gtaagctttg ttcctttcat tttttttttt ttacttcttt tgggagagaa tatttccaac
     6121 aaacacatgc accccaccaa caggggaggc aaatttcagc atagatctat aagactttca
     6181 gatgaccatg ggccattgcc ttcatgctgt ggtaagtact acatctacaa ttttggtacc
     6241 cgaactggtg ctttagaaat gcggggtttt tattaaaaaa aaaaaaaaga aatgtagcag
     6301 aataattctt ttagtgcagc aactcagttt ttgtaaagga ctctgagaac acttgggctg
     6361 tgaacattca aagcagcaga gagggaacct ggcactattg gggtaaagtg tttgggtcag
     6421 ttgaaaaaaa ggaaaccttt tcatgccttt agatgtgagc taacagtagg taatgatcat
     6481 gtgtcccttt ttgatggctg tacgaagaac ttcaatcact gtagtctaag atctgatcta
     6541 tagatgacct agaatagcca tgtaatataa tgtgatgatt ctaaatttgt acctatgtga
     6601 cagacatttt caataatgtg aaaactgcag atttgatgga gctactttaa gatttgtagg
     6661 tgaaagtgtg ctactgttgg ttgaactatg ctgaagaggg aaagtgagtg attagtttga
     6721 gcccttgctg gctcttttcc acctgccaat tctacatgta ttgttgtggt tttattcatt
     6781 gtatgaaaat tcctgtgatt tttttttaaa tgtgcagtac acatcagcct cactgagcta
     6841 ataaagggaa aagaatgttt caaatcta
//
