LOCUS       NM_011146               1787 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus peroxisome proliferator activated receptor gamma
            (Pparg), transcript variant 2, mRNA.
ACCESSION   NM_011146
VERSION     NM_011146.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1787)
  AUTHORS   McClure,J.J., McIlroy,G.D., Symons,R.A., Clark,S.M., Cunningham,I.,
            Han,W., Kania,K., Colella,F., Rochford,J.J., De Bari,C. and
            Roelofs,A.J.
  TITLE     Disentangling the detrimental effects of local from systemic
            adipose tissue dysfunction on articular cartilage in the knee
  JOURNAL   Osteoarthritis Cartilage 32 (12), 1552-1565 (2024)
   PUBMED   39103079
REFERENCE   2  (bases 1 to 1787)
  AUTHORS   Xie,X., Gao,M., Zhao,W., Li,C., Zhang,W., Yang,J., Zhang,Y.,
            Chen,E., Guo,Y., Guo,Z., Zhang,M., Ngowi,E.E., Wang,H., Wang,X.,
            Zhu,Y., Wang,Y., Li,X., Yao,H., Yan,L., Fang,F., Li,M., Qiao,A. and
            Liu,X.
  TITLE     LncRNA Snhg3 aggravates hepatic steatosis via PPARgamma signaling
  JOURNAL   Elife 13, 96988 (2024)
   PUBMED   39436790
  REMARK    GeneRIF: LncRNA Snhg3 aggravates hepatic steatosis via PPARgamma
            signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1787)
  AUTHORS   Cohen,E.D., Roethlin,K., Yee,M., Woeller,C.F., Brookes,P.S.,
            Porter,G.A. Jr. and O'Reilly,M.A.
  TITLE     PPARgamma drives mitochondrial stress signaling and the loss of
            atrial cardiomyocytes in newborn mice exposed to hyperoxia
  JOURNAL   Redox Biol 76, 103351 (2024)
   PUBMED   39276392
  REMARK    GeneRIF: PPARgamma drives mitochondrial stress signaling and the
            loss of atrial cardiomyocytes in newborn mice exposed to hyperoxia.
REFERENCE   4  (bases 1 to 1787)
  AUTHORS   Yi,Zhang., Feng,R., Li,H., Wu,W., Ma,W., Chen,X., Chen,J. and
            Liang,C.
  TITLE     CXCR4 influences PUFA desaturation and oxidative stress injury in
            experimental prostatitis mice by activating Fads2 via PPARgamma
  JOURNAL   Free Radic Biol Med 223, 237-249 (2024)
   PUBMED   39094710
  REMARK    GeneRIF: CXCR4 influences PUFA desaturation and oxidative stress
            injury in experimental prostatitis mice by activating Fads2 via
            PPARgamma.
REFERENCE   5  (bases 1 to 1787)
  AUTHORS   Zuo,S., Wang,Y., Bao,H., Zhang,Z., Yang,N., Jia,M., Zhang,Q.,
            Jian,A., Ji,R., Zhang,L., Lu,Y., Huang,Y. and Shen,P.
  TITLE     Lipid synthesis, triggered by PPARgamma T166 dephosphorylation,
            sustains reparative function of macrophages during tissue repair
  JOURNAL   Nat Commun 15 (1), 7269 (2024)
   PUBMED   39179603
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1787)
  AUTHORS   Hu,E., Tontonoz,P. and Spiegelman,B.M.
  TITLE     Transdifferentiation of myoblasts by the adipogenic transcription
            factors PPAR gamma and C/EBP alpha
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9856-9860 (1995)
   PUBMED   7568232
REFERENCE   7  (bases 1 to 1787)
  AUTHORS   Jones,P.S., Savory,R., Barratt,P., Bell,A.R., Gray,T.J.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Bell,D.R.
  TITLE     Chromosomal localisation, inducibility, tissue-specific expression
            and strain differences in three murine
            peroxisome-proliferator-activated-receptor genes
  JOURNAL   Eur J Biochem 233 (1), 219-226 (1995)
   PUBMED   7588749
REFERENCE   8  (bases 1 to 1787)
  AUTHORS   Wu,Z., Xie,Y., Bucher,N.L. and Farmer,S.R.
  TITLE     Conditional ectopic expression of C/EBP beta in NIH-3T3 cells
            induces PPAR gamma and stimulates adipogenesis
  JOURNAL   Genes Dev 9 (19), 2350-2363 (1995)
   PUBMED   7557387
REFERENCE   9  (bases 1 to 1787)
  AUTHORS   Zhu,Y., Qi,C., Korenberg,J.R., Chen,X.N., Noya,D., Rao,M.S. and
            Reddy,J.K.
  TITLE     Structural organization of mouse peroxisome proliferator-activated
            receptor gamma (mPPAR gamma) gene: alternative promoter use and
            different splicing yield two mPPAR gamma isoforms
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7921-7925 (1995)
   PUBMED   7644514
REFERENCE   10 (bases 1 to 1787)
  AUTHORS   Zhu,Y., Alvares,K., Huang,Q., Rao,M.S. and Reddy,J.K.
  TITLE     Cloning of a new member of the peroxisome proliferator-activated
            receptor gene family from mouse liver
  JOURNAL   J Biol Chem 268 (36), 26817-26820 (1993)
   PUBMED   8262913
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171970.3 and AC153828.8.
            
            On Aug 2, 2022 this sequence version replaced NM_011146.3.
            
            Summary: This gene encodes a nuclear receptor protein belonging to
            the peroxisome proliferator-activated receptor (Ppar) family. The
            encoded protein is a ligand-activated transcription factor that is
            involved in the regulation of adipocyte differentiation and glucose
            homeostasis. The encoded protein forms a heterodimer with retinoid
            X receptors and binds to DNA motifs termed 'peroxisome proliferator
            response elements' to either activate or inhibit gene expression.
            Mice lacking the encoded protein die at an embryonic stage due to
            severe defects in placental vascularization. When the embryos
            lacking this gene are supplemented with healthy placentas, the
            mutants survive to term, but succumb to lipodystrophy and multiple
            hemorrhages. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Apr
            2015].
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021798.1, AY243585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC171970.3         161915-162061
            148-375             AC171970.3         179709-179936
            376-545             AC171970.3         181361-181530
            546-684             AC171970.3         190813-190951
            685-884             AC153828.8         83810-84009
            885-1335            AC153828.8         93585-94035
            1336-1787           AC153828.8         110672-111123
FEATURES             Location/Qualifiers
     source          1..1787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.41 cM"
     gene            1..1787
                     /gene="Pparg"
                     /gene_synonym="Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma;
                     PPARgamma2"
                     /note="peroxisome proliferator activated receptor gamma"
                     /db_xref="GeneID:19016"
                     /db_xref="MGI:MGI:97747"
     exon            1..147
                     /gene="Pparg"
                     /gene_synonym="Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma;
                     PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            148..375
                     /gene="Pparg"
                     /gene_synonym="Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma;
                     PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            376..545
                     /gene="Pparg"
                     /gene_synonym="Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma;
                     PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..684
                     /gene="Pparg"
                     /gene_synonym="Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma;
                     PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..884
                     /gene="Pparg"
                     /gene_synonym="Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma;
                     PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1335
                     /gene="Pparg"
                     /gene_synonym="Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma;
                     PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1787
                     /gene="Pparg"
                     /gene_synonym="Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma;
                     PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1764..1769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pparg"
                     /gene_synonym="Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma;
                     PPARgamma2"
                     /note="hexamer: ATTAAA"
     polyA_site      1787
                     /gene="Pparg"
                     /gene_synonym="Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma;
                     PPARgamma2"
                     /note="major polyA site"
ORIGIN      
        1 aatcttttgc aagacataga caaaacacca gtgtgaatta cagcaaatct ctgttttatg
       61 ctgttatggg tgaaactctg ggagattctc ctgttgaccc agagcatggt gccttcgctg
      121 atgcactgcc tatgagcact tcacaagaaa ttaccatggt tgacacagag atgccattct
      181 ggcccaccaa cttcggaatc agctctgtgg acctctccgt gatggaagac cactcgcatt
      241 cctttgacat caagcccttt accacagttg atttctccag catttctgct ccacactatg
      301 aagacattcc attcacaaga gctgacccaa tggttgctga ttacaaatat gacctgaagc
      361 tccaagaata ccaaagtgcg atcaaagtag aacctgcatc tccaccttat tattctgaaa
      421 agacccagct ctacaacagg cctcatgaag aaccttctaa ctccctcatg gccattgagt
      481 gccgagtctg tggggataaa gcatcaggct tccactatgg agttcatgct tgtgaaggat
      541 gcaagggttt tttccgaaga accatccgat tgaagcttat ttatgatagg tgtgatctta
      601 actgccggat ccacaaaaaa agtagaaata aatgtcagta ctgtcggttt cagaagtgcc
      661 ttgctgtggg gatgtctcac aatgccatca ggtttgggcg gatgccacag gccgagaagg
      721 agaagctgtt ggcggagatc tccagtgata tcgaccagct gaacccagag tctgctgatc
      781 tgcgagccct ggcaaagcat ttgtatgact catacataaa gtccttcccg ctgaccaaag
      841 ccaaggcgag ggcgatcttg acaggaaaga caacggacaa atcaccattt gtcatctacg
      901 acatgaattc cttaatgatg ggagaagata aaatcaagtt caaacatatc acccccctgc
      961 aggagcagag caaagaggtg gccatccgaa tttttcaagg gtgccagttt cgatccgtag
     1021 aagccgtgca agagatcaca gagtatgcca aaaatatccc tggtttcatt aaccttgatt
     1081 tgaatgacca agtgactctg ctcaagtatg gtgtccatga gatcatctac acgatgctgg
     1141 cctccctgat gaataaagat ggagtcctca tctcagaggg ccaaggattc atgaccaggg
     1201 agttcctcaa aagcctgcgg aagccctttg gtgactttat ggagcctaag tttgagtttg
     1261 ctgtgaagtt caatgcactg gaattagatg acagtgactt ggctatattt atagctgtca
     1321 ttattctcag tggagaccgc ccaggcttgc tgaacgtgaa gcccatcgag gacatccaag
     1381 acaacctgct gcaggccctg gaactgcagc tcaagctgaa tcacccagag tcctctcagc
     1441 tgttcgccaa ggtgctccag aagatgacag acctcaggca gatcgtcaca gagcacgtgc
     1501 agctactgca tgtgatcaag aagacagaga cagacatgag ccttcacccc ctgctccagg
     1561 agatctacaa ggacttgtat tagcaggaaa gtcccacccg ctgacaacgt gttccttcta
     1621 ttgattgcac tattattttg agggaaaaaa atctgacacc taagaaattt actgtgaaaa
     1681 agcatttaaa aacaaaaagt tttagaacat gatctatttt atgcatattg tttataaaga
     1741 tacatttaca atttactttt aatattaaaa attaccacat tataaaa
//
