LOCUS       NM_011145               3231 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus peroxisome proliferator activator receptor delta
            (Ppard), transcript variant 1, mRNA.
ACCESSION   NM_011145 XM_990965
VERSION     NM_011145.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3231)
  AUTHORS   Cen,B., Wei,J., Wang,D. and DuBois,R.N.
  TITLE     Peroxisome Proliferator-Activated Receptor delta Suppresses the
            Cytotoxicity of CD8+ T Cells by Inhibiting RelA DNA-Binding
            Activity
  JOURNAL   Cancer Res Commun 4 (10), 2673-2684 (2024)
   PUBMED   39292167
  REMARK    GeneRIF: Peroxisome Proliferator-Activated Receptor delta
            Suppresses the Cytotoxicity of CD8+ T Cells by Inhibiting RelA
            DNA-Binding Activity.
REFERENCE   2  (bases 1 to 3231)
  AUTHORS   Park,S., Cha,H.N., Shin,M.G., Park,S., Kim,Y., Kim,M.S., Shin,K.H.,
            Thoudam,T., Lee,E.J., Wolfe,R.R., Dan,J., Koh,J.H., Kim,I.Y.,
            Choi,I., Lee,I.K., Sung,H.K. and Park,S.Y.
  TITLE     Inhibitory Regulation of FOXO1 in PPARdelta Expression Drives
            Mitochondrial Dysfunction and Insulin Resistance
  JOURNAL   Diabetes 73 (7), 1084-1098 (2024)
   PUBMED   38656552
  REMARK    GeneRIF: Inhibitory Regulation of FOXO1 in PPARdelta Expression
            Drives Mitochondrial Dysfunction and Insulin Resistance.
REFERENCE   3  (bases 1 to 3231)
  AUTHORS   Ke,Q., Xiao,Y., Liu,D., Shi,C., Shen,R., Qin,S., Jiang,L., Yang,J.
            and Zhou,Y.
  TITLE     PPARalpha/delta dual agonist H11 alleviates diabetic kidney injury
            by improving the metabolic disorders of tubular epithelial cells
  JOURNAL   Biochem Pharmacol 222, 116076 (2024)
   PUBMED   38387308
  REMARK    GeneRIF: PPARalpha/delta dual agonist H11 alleviates diabetic
            kidney injury by improving the metabolic disorders of tubular
            epithelial cells.
REFERENCE   4  (bases 1 to 3231)
  AUTHORS   Mazzarella,L., Falvo,P., Adinolfi,M., Tini,G., Gatti,E.,
            Piccioni,R., Bonetti,E., Gavilan,E., Valli,D., Gruszka,A.,
            Bodini,M., Gallo,B., Orecchioni,S., de Michele,G., Migliaccio,E.,
            Duso,B.A., Roerink,S., Stratton,M., Bertolini,F., Alcalay,M.,
            Dellino,G.I. and Pelicci,P.G.
  TITLE     High-Fat Diet Promotes Acute Promyelocytic Leukemia through
            PPARdelta-Enhanced Self-renewal of Preleukemic Progenitors
  JOURNAL   Cancer Prev Res (Phila) 17 (2), 59-75 (2024)
   PUBMED   37956420
  REMARK    GeneRIF: High-Fat Diet Promotes Acute Promyelocytic Leukemia
            through PPARdelta-Enhanced Self-renewal of Preleukemic Progenitors.
REFERENCE   5  (bases 1 to 3231)
  AUTHORS   Wang,Y.T., Wang,F.F., Li,H., Xu,J.Y., Lu,X.L. and Wang,Y.
  TITLE     Deletion of the PPARdelta gene exacerbates high-fat diet-induced
            nonalcoholic fatty liver disease in mice through the gut-liver axis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (10), 121-128 (2023)
   PUBMED   37953575
  REMARK    GeneRIF: Deletion of the PPARdelta gene exacerbates high-fat
            diet-induced nonalcoholic fatty liver disease in mice through the
            gut-liver axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3231)
  AUTHORS   Cohen,R.D., Welch,C., Xia,Y., Lusis,A.J. and Reue,K.
  TITLE     Localization of mouse peroxisome proliferator-activated receptor
            delta (Ppard) on chromosome 17 near colipase (Clps)
  JOURNAL   Mamm Genome 7 (7), 557-558 (1996)
   PUBMED   8672143
REFERENCE   7  (bases 1 to 3231)
  AUTHORS   Jones,P.S., Savory,R., Barratt,P., Bell,A.R., Gray,T.J.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Bell,D.R.
  TITLE     Chromosomal localisation, inducibility, tissue-specific expression
            and strain differences in three murine
            peroxisome-proliferator-activated-receptor genes
  JOURNAL   Eur J Biochem 233 (1), 219-226 (1995)
   PUBMED   7588749
REFERENCE   8  (bases 1 to 3231)
  AUTHORS   Amri,E.Z., Bonino,F., Ailhaud,G., Abumrad,N.A. and Grimaldi,P.A.
  TITLE     Cloning of a protein that mediates transcriptional effects of fatty
            acids in preadipocytes. Homology to peroxisome
            proliferator-activated receptors
  JOURNAL   J Biol Chem 270 (5), 2367-2371 (1995)
   PUBMED   7836471
REFERENCE   9  (bases 1 to 3231)
  AUTHORS   Kliewer,S.A., Forman,B.M., Blumberg,B., Ong,E.S., Borgmeyer,U.,
            Mangelsdorf,D.J., Umesono,K. and Evans,R.M.
  TITLE     Differential expression and activation of a family of murine
            peroxisome proliferator-activated receptors
  JOURNAL   Proc Natl Acad Sci U S A 91 (15), 7355-7359 (1994)
   PUBMED   8041794
REFERENCE   10 (bases 1 to 3231)
  AUTHORS   Chen,F., Law,S.W. and O'Malley,B.W.
  TITLE     Identification of two mPPAR related receptors and evidence for the
            existence of five subfamily members
  JOURNAL   Biochem Biophys Res Commun 196 (2), 671-677 (1993)
   PUBMED   8240342
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126937.3 and CT025652.7.
            
            On Aug 26, 2022 this sequence version replaced NM_011145.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070398.1, SRR13948564.1152777.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC126937.3         140216-140339
            125-208             AC126937.3         144487-144570
            209-415             CT025652.7         76575-76781         c
            416-570             CT025652.7         67547-67701         c
            571-709             CT025652.7         65818-65956         c
            710-912             CT025652.7         64563-64765         c
            913-1363            CT025652.7         64008-64458         c
            1364-3231           CT025652.7         61573-63440         c
FEATURES             Location/Qualifiers
     source          1..3231
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.64 cM"
     gene            1..3231
                     /gene="Ppard"
                     /gene_synonym="Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta;
                     Pparb; Pparb/d; PPARdelta; PPAR[b]"
                     /note="peroxisome proliferator activator receptor delta"
                     /db_xref="GeneID:19015"
                     /db_xref="MGI:MGI:101884"
     exon            1..124
                     /gene="Ppard"
                     /gene_synonym="Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta;
                     Pparb; Pparb/d; PPARdelta; PPAR[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            125..208
                     /gene="Ppard"
                     /gene_synonym="Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta;
                     Pparb; Pparb/d; PPARdelta; PPAR[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            209..415
                     /gene="Ppard"
                     /gene_synonym="Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta;
                     Pparb; Pparb/d; PPARdelta; PPAR[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            416..570
                     /gene="Ppard"
                     /gene_synonym="Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta;
                     Pparb; Pparb/d; PPARdelta; PPAR[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            571..709
                     /gene="Ppard"
                     /gene_synonym="Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta;
                     Pparb; Pparb/d; PPARdelta; PPAR[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            710..912
                     /gene="Ppard"
                     /gene_synonym="Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta;
                     Pparb; Pparb/d; PPARdelta; PPAR[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1363
                     /gene="Ppard"
                     /gene_synonym="Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta;
                     Pparb; Pparb/d; PPARdelta; PPAR[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..3231
                     /gene="Ppard"
                     /gene_synonym="Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta;
                     Pparb; Pparb/d; PPARdelta; PPAR[b]"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3206..3211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppard"
                     /gene_synonym="Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta;
                     Pparb; Pparb/d; PPARdelta; PPAR[b]"
                     /note="hexamer: AATAAA"
     polyA_site      3231
                     /gene="Ppard"
                     /gene_synonym="Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta;
                     Pparb; Pparb/d; PPARdelta; PPAR[b]"
                     /note="major polyA site"
ORIGIN      
        1 gggagcgtgt gacgccgcag gccgcggcgg acctggggat taatgggaaa agttttggca
       61 ggagctgggg gattctgcgg agcctgcggg acggcggcag cggcgcgaga ggcggccggg
      121 acagtgctgt gcagcggtgt gggtatgcgc atgggactca ctcagaggct cctgctcact
      181 gacagatgaa gacaaaccca cggtaaaggc agtccatctg cgctcagacc cagatggtgg
      241 cagagctatg accaggcctg caggcgccac gccaagtggg ggtcagtcat ggaacagcca
      301 caggaggaga cccctgaggc ccgggaagag gagaaagagg aagtggccat gggtgacgga
      361 gccccggagc tcaatggggg accagaacac acgcttcctt ccagcagctg tgcagacctc
      421 tcccagaatt cctccccttc ctccctgctg gaccagctgc agatgggctg tgatggggcc
      481 tcaggcggca gcctcaacat ggaatgtcgg gtgtgcgggg acaaggcctc gggcttccac
      541 tacggggtcc acgcgtgcga ggggtgcaag ggcttcttcc gccggacaat ccgcatgaag
      601 ctcgagtatg agaagtgcga tcggatctgc aagatccaga agaagaaccg caacaagtgt
      661 cagtactgcc gcttccagaa gtgcctggca ctcggcatgt cgcacaacgc tatccgcttt
      721 ggacggatgc cggaggccga gaagaggaag ctggtggcgg ggctgactgc cagcgagggg
      781 tgccagcaca acccccagct ggccgacctg aaggccttct ctaagcacat ctacaacgcc
      841 tacctgaaaa acttcaacat gaccaaaaag aaggcccgga gcatcctcac cggcaagtcc
      901 agccacaacg caccctttgt catccacgac atcgagacac tgtggcaggc agagaagggc
      961 ctggtgtgga aacagctggt gaacgggctg ccgccctaca acgagatcag tgtgcacgtg
     1021 ttctaccgct gccagtccac cacagtggag acagtccgag agctcaccga gttcgccaag
     1081 aacatcccca acttcagcag cctcttcctc aatgaccagg tgaccctcct caagtatggc
     1141 gtgcacgagg ccatctttgc catgctggcc tccatcgtca acaaagacgg gctgctggtg
     1201 gccaacggca gtggcttcgt cacccacgag ttcttgcgaa gtctccgcaa gcccttcagt
     1261 gacatcattg agcccaagtt cgagtttgct gtcaagttca atgcgctgga gctcgatgac
     1321 agtgacctgg cgctcttcat cgcggccatc attctgtgtg gagaccggcc aggcctcatg
     1381 aatgtgcccc aggtagaagc catccaggac accattctgc gggctctaga attccatctg
     1441 caggtcaacc accctgacag ccagtacctc ttccccaagc tgctgcagaa gatggcagac
     1501 ctgcggcagc tggtcactga gcatgcccag atgatgcagt ggctaaagaa gacggagagt
     1561 gagaccttgc tgcaccccct gctccaggaa atctacaagg acatgtacta aggccgcagc
     1621 ccaggcctcc cctcaggctc tgctgggccc agccacggac tgttcagagg accagccaca
     1681 ggcactggca gtcaagcagc tagagcctac tcacaacact ccagacacgt ggcccagact
     1741 cttcccccaa cacccccacc cccaccaacc cccccattcc cccaaccccc ctcccccacc
     1801 ccgctctccc catggcccgt ttcctgtttc tcctcagcac ctcctgttct tgctgtctcc
     1861 ctagcgccct tgctcccccc ctttgccttc cttctctagc atccccctcc tcccagtcct
     1921 cacatttgtc tgattcacag cagacagccc gttggtacgc tcaccagcag cctaaaagca
     1981 gtggggcctg tgctggccca gtcctgcctc tcctctctat ccccttcaaa gacatgagcc
     2041 atccaaagaa acactacgct ctctctgggc ccagctttcc aagaagcctg gcctggacca
     2101 actgccatcc cagcttgtgg tcaccaccac agggttcctc ctccagagag caagtgggca
     2161 gggagcctgg gccgggagcc atattcccag gctgtctcag ccctaggcac accactctct
     2221 gacacttcct ttcttctcgc cggcgtccta ggtcattgtc acagatgacc cttgtgctgc
     2281 ctaggagatg acccctccag atgtcccctc cagatgcggt ccaacggccc cactgaaggg
     2341 aagggggtag aggcaggccg gaaggagcag cggcacactt aggtcccagg gtcagaagct
     2401 agacagcgag tgggcaggcc ctccatcagc acccctcctc taccctgtag cagcatccag
     2461 actggcagat cccagtacca ggaactggac catagctgtt ctttcttctc ctgggagatg
     2521 ctggcacacc tgcccccccc ccccccttgc agctgccccg gtgtagccat gacactggct
     2581 cacctctcgg tcaccacaga gtccctccca ttccctcccc aaggccactg gggtacagct
     2641 atggccctgt tcttaggact ggtgatctgt gagcaggcag ggatatccta ccaggtcacc
     2701 cctgccagct cacaggcaga gttgctaggg ttcctctgac cctgtcctct ctcccactca
     2761 cttgtaccag tagctctgtg gccttctctt cttttgcctg gctggtcacc tgctcccatc
     2821 tgctgcttca agtggcttga aacttgctgg gtgctcccat actcagcccc agcccggcag
     2881 atcctgcctc taggcccata ggtgatcagc ccaggctcgg ctcctgccaa cacagaatgc
     2941 tgccagattc cccgctagca cactccctgc ccctcacctc tactgatcag gtcttggggt
     3001 gttccttgtg gggcccaccc aggctgagaa tggagctaca tcacccgccc tgcccccacc
     3061 tgcccagccc cgcccaggtc tggtgctgag gatgcagctc ctctcagggt ctgaagtctc
     3121 caaatctgaa atgtatattt ttgctaggag ccccagcttc ccgtgttttt aatataaata
     3181 gtgtatacag actgacggaa ctttaaataa atgggaatta cgtatttaag a
//
