LOCUS       NM_026438               1292 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus pyrophosphatase (inorganic) 1 (Ppa1), mRNA.
ACCESSION   NM_026438
VERSION     NM_026438.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1292)
  AUTHORS   Wu,Y., Sun,Y., Song,Y., Wang,J., Han,Y., Yang,N., Lin,H., Yin,Y.
            and Han,X.
  TITLE     PPA1 promotes adipogenesis by regulating the stability of C/EBPs
  JOURNAL   Cell Death Differ 31 (8), 1044-1056 (2024)
   PUBMED   38762596
  REMARK    GeneRIF: PPA1 promotes adipogenesis by regulating the stability of
            C/EBPs.
REFERENCE   2  (bases 1 to 1292)
  AUTHORS   Sun,Y., Yao,J., Lu,C., Yang,N., Han,X., Lin,H. and Yin,Y.
  TITLE     Cold-inducible PPA1 is critical for the adipocyte browning in mice
  JOURNAL   Biochem Biophys Res Commun 677, 45-53 (2023)
   PUBMED   37549601
  REMARK    GeneRIF: Cold-inducible PPA1 is critical for the adipocyte browning
            in mice.
REFERENCE   3  (bases 1 to 1292)
  AUTHORS   Yin,Y., Wu,Y., Zhang,X., Zhu,Y., Sun,Y., Yu,J., Gong,Y., Sun,P.,
            Lin,H. and Han,X.
  TITLE     PPA1 Regulates Systemic Insulin Sensitivity by Maintaining
            Adipocyte Mitochondria Function as a Novel PPARgamma Target Gene
  JOURNAL   Diabetes 70 (6), 1278-1291 (2021)
   PUBMED   33722839
  REMARK    GeneRIF: PPA1 Regulates Systemic Insulin Sensitivity by Maintaining
            Adipocyte Mitochondria Function as a Novel PPARgamma Target Gene.
REFERENCE   4  (bases 1 to 1292)
  AUTHORS   Tan,Z., Niu,B., Tsang,K.Y., Melhado,I.G., Ohba,S., He,X., Huang,Y.,
            Wang,C., McMahon,A.P., Jauch,R., Chan,D., Zhang,M.Q. and
            Cheah,K.S.E.
  TITLE     Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic
            transcriptional network coordinate chondrocyte differentiation
            transitions
  JOURNAL   PLoS Genet 14 (4), e1007346 (2018)
   PUBMED   29659575
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1292)
  AUTHORS   Tezuka,Y., Okada,M., Tada,Y., Yamauchi,J., Nishigori,H. and
            Sanbe,A.
  TITLE     Regulation of neurite growth by inorganic pyrophosphatase 1 via JNK
            dephosphorylation
  JOURNAL   PLoS One 8 (4), e61649 (2013)
   PUBMED   23626709
  REMARK    GeneRIF: PPA1 may play a role in neuronal differentiation via JNK
            dephosphorylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1292)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   7  (bases 1 to 1292)
  AUTHORS   Naylor,S.L., Gray,P.W. and Lalley,P.A.
  TITLE     Mouse immune interferon (IFN-gamma) gene is on chromosome 10
  JOURNAL   Somat Cell Mol Genet 10 (5), 531-534 (1984)
   PUBMED   6433489
REFERENCE   8  (bases 1 to 1292)
  AUTHORS   O'Brien,S.J. and Nash,W.G.
  TITLE     Genetic mapping in mammals: chromosome map of domestic cat
  JOURNAL   Science 216 (4543), 257-265 (1982)
   PUBMED   7063884
REFERENCE   9  (bases 1 to 1292)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   10 (bases 1 to 1292)
  AUTHORS   Lalley,P.A., Francke,U. and Minna,J.D.
  TITLE     Assignment of the genes coding for pyrophosphatase and hexokinase-1
            to mouse chromosome 10: implications for comparative gene mapping
            in man and mouse
  JOURNAL   Cytogenet Cell Genet 22 (1-6), 570-572 (1978)
   PUBMED   752542
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124421.4.
            
            On Apr 29, 2007 this sequence version replaced NM_026438.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008575.1, AK088397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC124421.4         48795-48965         c
            172-230             AC124421.4         45968-46026         c
            231-284             AC124421.4         38084-38137         c
            285-404             AC124421.4         36555-36674         c
            405-491             AC124421.4         33810-33896         c
            492-618             AC124421.4         32120-32246         c
            619-746             AC124421.4         30548-30675         c
            747-832             AC124421.4         29916-30001         c
            833-902             AC124421.4         27099-27168         c
            903-945             AC124421.4         25153-25195         c
            946-1292            AC124421.4         23421-23767         c
FEATURES             Location/Qualifiers
     source          1..1292
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.25 cM"
     gene            1..1292
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /note="pyrophosphatase (inorganic) 1"
                     /db_xref="GeneID:67895"
                     /db_xref="MGI:MGI:97831"
     exon            1..171
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..977
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /EC_number="3.6.1.1"
                     /note="PPase; pyrophosphate phospho-hydrolase"
                     /codon_start=1
                     /product="inorganic pyrophosphatase"
                     /protein_id="NP_080714.2"
                     /db_xref="CCDS:CCDS23882.1"
                     /db_xref="GeneID:67895"
                     /db_xref="MGI:MGI:97831"
                     /translation="MSGFSSEERAAPFTLEYRVFLKNEKGQYISPFHDVPIYADKDVF
                     HMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWE
                     DPGHSDKHTGCCGDNDPIDVCEIGSKVCARGEIIRVKVLGILAMIDEGETDWKVIAIN
                     VDDPDAANYKDISDVERLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKNKDFAVD
                     IIKSTHDYWKALVTKKTDGKGISCMNTTVSESPFKCDPDAAKAIVDALPPPCESACSL
                     PTDVDKWFHQQKN"
     exon            172..230
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            231..284
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            285..404
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            405..491
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            492..618
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            619..746
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            747..832
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            833..902
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            903..945
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1292
                     /gene="Ppa1"
                     /gene_synonym="2010317E03Rik; Pyp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcgtggt acgcaggcgc gggctttctc ctccgtacag cggctccggg tctgggctgt
       61 gtggttgtgt ggctgtgcag cggcggcggc ggtgcatctc cgacaccatg agcggcttca
      121 gcagcgagga gcgcgccgcg cccttcaccc tcgagtaccg cgtcttcctc aaaaatgaga
      181 aagggcagta catttctcca tttcatgatg ttccaattta tgcagacaag gatgtgttcc
      241 acatggtggt tgaggttcca cgctggtcca acgccaaaat ggagattgct acaaaggacc
      301 ctttaaaccc aatcaagcaa gatgtgaaaa aggggaagct ccgctatgtg gcgaatctgt
      361 tcccttataa agggtatatt tggaactacg gcgccatccc tcagacatgg gaagacccag
      421 gacacagtga caagcacact ggctgctgtg gtgacaacga cccaatcgat gtttgtgaaa
      481 tcggaagcaa ggtgtgtgcc agaggtgaga taatcagggt gaaggtcctg ggcatactgg
      541 ccatgatcga tgagggcgag accgactgga aggtcattgc cattaatgtg gacgatccgg
      601 acgcagccaa ttataaagat atttctgatg tcgaacggct aaaacccggc tatttagaag
      661 ctactgttga ttggtttaga aggtataagg ttcctgatgg aaaaccagaa aatgagtttg
      721 cattcaatgc agaatttaaa aacaaggact ttgcagttga cattattaaa agcacccacg
      781 attattggaa agcattagtg actaagaaaa cagatgggaa aggaatcagt tgcatgaaca
      841 ccacggtgtc ggagagcccc ttcaagtgcg atcctgatgc tgccaaagcc attgtggatg
      901 ctttgccacc accatgtgaa tctgcctgct cactgccgac agatgtggat aaatggttcc
      961 atcagcagaa aaactgaaga gcttcctctg gaacacgagc tgttacggcc gcatcctgtt
     1021 cacctggaag cattagatgc aaaagatttt ccaagctcta aatttctgta gctcaccgaa
     1081 tgaagtagac tctgctgtga ctggtccact agttcagaac tggttcagaa ggttagccat
     1141 ctagacacct cacatctcaa ccaagacagc ttttattaaa ccttagctct caaagccgtg
     1201 gggacatgga agtcatttgt gcatggatgt gcagtgtgga cacctattgg atgtacatgt
     1261 ttactgtgtt aggaaataaa attattttac tg
//
