LOCUS       NM_175006               2402 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus POU domain, class 6, transcription factor 2 (Pou6f2),
            mRNA.
ACCESSION   NM_175006
VERSION     NM_175006.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2402)
  AUTHORS   Chapman,P.D., Kulkarni,A.S., Trevisan,A.J., Han,K., Hinton,J.M.,
            Deltuvaite,P., Fenno,L.E., Ramakrishnan,C., Patton,M.H.,
            Schwarz,L.A., Zakharenko,S.S., Deisseroth,K. and Bikoff,J.B.
  TITLE     A brain-wide map of descending inputs onto spinal V1 interneurons
  JOURNAL   Neuron 113 (4), 524-538 (2025)
   PUBMED   39719703
REFERENCE   2  (bases 1 to 2402)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2402)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2402)
  AUTHORS   Lin,F., Li,Y., Wang,J., Jardines,S., King,R., Chrenek,M.A.,
            Wiggs,J.L., Boatright,J.H. and Geisert,E.E.
  TITLE     POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels
            specific populations of retinal ganglion cells
  JOURNAL   Sci Rep 14 (1), 10096 (2024)
   PUBMED   38698014
  REMARK    GeneRIF: POU6F2, a risk factor for glaucoma, myopia and dyslexia,
            labels specific populations of retinal ganglion cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2402)
  AUTHORS   Deska-Gauthier,D., Borowska-Fielding,J., Jones,C., Zhang,H.,
            MacKay,C.S., Michail,R., Bennett,L.A., Bikoff,J.B. and Zhang,Y.
  TITLE     Embryonic temporal-spatial delineation of excitatory spinal V3
            interneuron diversity
  JOURNAL   Cell Rep 43 (1), 113635 (2024)
   PUBMED   38160393
REFERENCE   6  (bases 1 to 2402)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 2402)
  AUTHORS   Yang,Z., Ding,K., Pan,L., Deng,M. and Gan,L.
  TITLE     Math5 determines the competence state of retinal ganglion cell
            progenitors
  JOURNAL   Dev Biol 264 (1), 240-254 (2003)
   PUBMED   14623245
REFERENCE   8  (bases 1 to 2402)
  AUTHORS   Perotti,D., Testi,M.A., Mondini,P., Pilotti,S., Green,E.D.,
            Pession,A., Sozzi,G., Pierotti,M.A., Fossati-Bellani,F. and
            Radice,P.
  TITLE     Refinement within single yeast artificial chromosome clones of a
            minimal region commonly deleted on the short arm of chromosome 7 in
            Wilms tumours
  JOURNAL   Genes Chromosomes Cancer 31 (1), 42-47 (2001)
   PUBMED   11284034
REFERENCE   9  (bases 1 to 2402)
  AUTHORS   Xiang,M.
  TITLE     Requirement for Brn-3b in early differentiation of postmitotic
            retinal ganglion cell precursors
  JOURNAL   Dev Biol 197 (2), 155-169 (1998)
   PUBMED   9630743
REFERENCE   10 (bases 1 to 2402)
  AUTHORS   Zhou,H., Yoshioka,T. and Nathans,J.
  TITLE     Retina-derived POU-domain factor-1: a complex POU-domain gene
            implicated in the development of retinal ganglion and amacrine
            cells
  JOURNAL   J Neurosci 16 (7), 2261-2274 (1996)
   PUBMED   8601806
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            LXEJ02011613.1, AC154628.2, AC154356.2 and AC154207.3.
            
            On Jul 30, 2020 this sequence version replaced NM_175006.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083772.1, BC138151.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               LXEJ02011613.1     909868-910157       c
            291-382             AC154628.2         41540-41631         c
            383-611             AC154628.2         38019-38247         c
            612-1009            AC154356.2         126945-127342
            1010-1150           AC154207.3         59310-59450
            1151-1357           AC154207.3         79741-79947
            1358-1526           AC154207.3         92145-92313
            1527-1695           AC154207.3         102672-102840
            1696-2402           AC154207.3         106197-106903
FEATURES             Location/Qualifiers
     source          1..2402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 6.05 cM"
     gene            1..2402
                     /gene="Pou6f2"
                     /gene_synonym="D130006K24Rik; RPF-1"
                     /note="POU domain, class 6, transcription factor 2"
                     /db_xref="GeneID:218030"
                     /db_xref="MGI:MGI:2443631"
     exon            1..290
                     /gene="Pou6f2"
                     /gene_synonym="D130006K24Rik; RPF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2200
                     /gene="Pou6f2"
                     /gene_synonym="D130006K24Rik; RPF-1"
                     /note="retina-derived POU-domain factor-1"
                     /codon_start=1
                     /product="POU domain, class 6, transcription factor 2"
                     /protein_id="NP_778171.2"
                     /db_xref="GeneID:218030"
                     /db_xref="MGI:MGI:2443631"
                     /translation="MIAGQVSKPLLSVRSEMNAELRGEDKAATSDSELNEPLLAPAES
                     NDSEDTPSKLFGARGNTVLPDPGTPDQHQACQTHPTFPVGPQPLLTAQQLASAVAGVM
                     PGGPPALNQPILIPFNMAGQLGGQQGLVLTLPTANLTNIQGLVAAAAAGGIMTLPLQN
                     LQATSSLNSQLQQLQQLQLQQQQQQQQQQQQQQQQQQQPPPPPTSQHPQPASQAPPQS
                     QPTPPHQPPPASQQLPAPPAQLQQATQPQQHQPHSHPQNQTQNQPSPTQQSSSPPQKP
                     SPSPGHSLPSPLTPPNPLQLVNNPLASQAAAAAAAMGSIASSQAFGNALSSLQGVTGQ
                     LVTNAQGQIIGTIPLMPNPGPSSQAASGTQGLQVQPITPQLLTNAQGQIIATVIGNQI
                     LPVINTQGITLSPIKPGQQLHQSSQTSVGQAGTQGNLLHLAHGQAATSHSPVRQASSS
                     SSSSSSSSALSVGQLVSNPQTAAGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQA
                     LSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSLTAKLNPGLLYPARFEKLDI
                     TPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNA
                     HFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLKQHEPTSAAPLEP
                     LADSPEENC"
     exon            291..382
                     /gene="Pou6f2"
                     /gene_synonym="D130006K24Rik; RPF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..611
                     /gene="Pou6f2"
                     /gene_synonym="D130006K24Rik; RPF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..1009
                     /gene="Pou6f2"
                     /gene_synonym="D130006K24Rik; RPF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1150
                     /gene="Pou6f2"
                     /gene_synonym="D130006K24Rik; RPF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1357
                     /gene="Pou6f2"
                     /gene_synonym="D130006K24Rik; RPF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1526
                     /gene="Pou6f2"
                     /gene_synonym="D130006K24Rik; RPF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1695
                     /gene="Pou6f2"
                     /gene_synonym="D130006K24Rik; RPF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..2402
                     /gene="Pou6f2"
                     /gene_synonym="D130006K24Rik; RPF-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagataaga gagaggagag agggagagtg tgtgtgcaag agagagggag agggagagag
       61 gacacgctct ctaaagctgc cactttttcc tccccttcgc tctttccccc catcctagga
      121 tccaatgata gctggacaag tcagtaagcc cttgctgtca gtgcggagtg aaatgaatgc
      181 ggagttgaga ggtgaggaca aggctgctac ttcagacagc gagctgaatg agcccctgct
      241 tgcgcccgcg gaatcaaatg acagcgagga cactcccagc aagctcttcg gggccagagg
      301 aaacacagtc ttgccagatc caggaactcc tgaccagcac caggcctgtc agacccatcc
      361 cacctttcca gttgggccac agcctcttct gacggcacag cagttagcct ctgctgtggc
      421 cggggtgatg ccgggaggcc ccccagccct caatcagcca atcctcatcc ccttcaacat
      481 ggcgggacag ctaggtggtc agcaaggcct ggtcctcaca ctgcccaccg cgaatctcac
      541 aaacatccaa gggctggtag cagcagctgc agctggaggc attatgactc tgccattgca
      601 aaatctacaa gctacctcat ccctgaactc ccagctgcaa cagctccagc aactccagct
      661 gcaacagcaa caacagcagc agcagcaaca acagcaacaa caacagcagc aacaacaacc
      721 acctcctcca ccaaccagcc agcacccaca gccagcctca caggcacccc cacagtccca
      781 gcccacaccg cctcaccagc caccacctgc ctcacagcag ttgccggctc ccccagctca
      841 gctgcagcag gctactcagc ctcaacagca tcaacctcac tcccaccccc agaaccagac
      901 ccagaaccag ccatctccaa cccagcagag ctcaagcccc cctcagaaac ccagcccatc
      961 tcccggacat agccttccgt caccgctcac accgcctaac cctctacagc tggttaataa
     1021 tcctctagca agccaggccg ccgctgctgc agcagccatg ggctccatag caagttcaca
     1081 ggcctttggc aatgccctct ccagccttca gggggtcaca ggtcaactag ttactaatgc
     1141 acaaggacag attattggga ccattccact gatgcctaac ccagggccat cgagtcaagc
     1201 agcaagtggc actcagggcc ttcaagtaca gcctatcaca ccccagctcc taaccaatgc
     1261 ccagggccaa atcattgcca ccgtcatcgg aaaccagatc ttgcctgtga tcaacaccca
     1321 gggtatcacc ctgtccccca tcaagccagg ccagcagctt caccaatctt cccagacatc
     1381 agtgggtcaa gcaggcaccc aaggcaacct tctgcacctg gctcatggcc aagctgccac
     1441 ctctcacagt cccgtgcgac aggcttcctc ctcctcctct tcatcctcct cttcttcagc
     1501 tttgagcgtg ggccagttag tcagcaatcc tcaaacagca gcgggtgagg tggacggggt
     1561 taatctggaa gagatccgag aatttgccaa agcttttaaa atccgacgcc tgtcccttgg
     1621 cctgacacag actcaggtgg gacaagccct cagtgccaca gagggccccg catacagcca
     1681 gtcggccatc tgcagacaca ccatcctgag aagccacttt ttcctaccac aggaagccca
     1741 agagaacact atagctagca gtctgacagc caaactgaac cctggccttt tgtatcctgc
     1801 caggtttgaa aagctggaca tcacccctaa aagtgcccag aagatcaagc cggtgcttga
     1861 gcggtggatg gctgaggctg aggcccgcca tcgagcaggt atgcagaatc tcacggaatt
     1921 tattgggagt gagccatcca aaaagcgcaa gcggcgcacc tccttcacgc cccaggccct
     1981 tgagatcctc aatgcccact ttgagaagaa cacacacccc tcagggcagg aaatgaccga
     2041 gattgctgag aagctaaact acgaccggga agtagttaga gtttggttct gcaataagag
     2101 acaagctcta aagaacacaa tcaaacgctt aaagcaacac gagcccacct cggcggcccc
     2161 cctggagccc ttagcagatt ctccagaaga aaactgttag acacacccat tcatggtcgg
     2221 aaggaagcat cacagaaact gagcactacc ctgaatctcc acaaaaaaag aaaggaagga
     2281 aagaagaaag aagaaagaat ttaaagactt gccccagtca tcatctccct tgtatgtaaa
     2341 agactaaaaa acaaaaaact accaaatggg cagaatggtt tatacgtgtc cgttggtttt
     2401 cc
//
