LOCUS       NM_001304965            4971 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus POU domain, class 6, transcription factor 1 (Pou6f1),
            transcript variant 1, mRNA.
ACCESSION   NM_001304965 XM_006520610
VERSION     NM_001304965.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4971)
  AUTHORS   Wu,D. and Dean,J.
  TITLE     RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse
            pre-implantation cell differentiation
  JOURNAL   Cell Rep 42 (2), 112047 (2023)
   PUBMED   36724075
  REMARK    GeneRIF: RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote
            mouse pre-implantation cell differentiation.
REFERENCE   2  (bases 1 to 4971)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4971)
  AUTHORS   McClard,C.K., Kochukov,M.Y., Herman,I., Liu,Z., Eblimit,A.,
            Moayedi,Y., Ortiz-Guzman,J., Colchado,D., Pekarek,B.,
            Panneerselvam,S., Mardon,G. and Arenkiel,B.R.
  TITLE     POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult
            Brain
  JOURNAL   J Neurosci 38 (6), 1443-1461 (2018)
   PUBMED   29305536
  REMARK    GeneRIF: POU6f1 is necessary for proper dendrite specification and
            patterning, as well as synapse development and function in
            adult-born neurons
REFERENCE   4  (bases 1 to 4971)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 4971)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4971)
  AUTHORS   Molinari,S., Relaix,F., Lemonnier,M., Kirschbaum,B., Schafer,B. and
            Buckingham,M.
  TITLE     A novel complex regulates cardiac actin gene expression through
            interaction of Emb, a class VI POU domain protein, MEF2D, and the
            histone transacetylase p300
  JOURNAL   Mol Cell Biol 24 (7), 2944-2957 (2004)
   PUBMED   15024082
  REMARK    GeneRIF: These results demonstrate the importance of the
            Emb-MEF2D-histone transacetylase p300 complex in the
            transcriptional regulation of the cardiac actin gene and suggest a
            potential role in chromatin remodeling associated with muscle gene
            activation.
REFERENCE   7  (bases 1 to 4971)
  AUTHORS   Vadasz,C., Saito,M., Balla,A., Kiraly,I., Vadasz,C. 2nd,
            Gyetvai,B., Mikics,E., Pierson,D., Brown,D. and Nelson,J.C.
  TITLE     Mapping of quantitative trait loci for ethanol preference in
            quasi-congenic strains
  JOURNAL   Alcohol 20 (2), 161-171 (2000)
   PUBMED   10719795
REFERENCE   8  (bases 1 to 4971)
  AUTHORS   Bulleit,R.F., Cui,H., Wang,J. and Lin,X.
  TITLE     NMDA receptor activation in differentiating cerebellar cell
            cultures regulates the expression of a new POU gene, Cns-1
  JOURNAL   J Neurosci 14 (3 Pt 2), 1584-1595 (1994)
   PUBMED   7907365
REFERENCE   9  (bases 1 to 4971)
  AUTHORS   Xia,Y.R., Andersen,B., Mehrabian,M., Diep,A.T., Warden,C.H.,
            Mohandas,T., McEvilly,R.J., Rosenfeld,M.G. and Lusis,A.J.
  TITLE     Chromosomal organization of mammalian POU domain factors
  JOURNAL   Genomics 18 (1), 126-130 (1993)
   PUBMED   8276396
REFERENCE   10 (bases 1 to 4971)
  AUTHORS   Okamoto,K., Wakamiya,M., Noji,S., Koyama,E., Taniguchi,S.,
            Takemura,R., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Muramatsu,M. et al.
  TITLE     A novel class of murine POU gene predominantly expressed in central
            nervous system
  JOURNAL   J Biol Chem 268 (10), 7449-7457 (1993)
   PUBMED   8463278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123724.9.
            
            On Apr 9, 2022 this sequence version replaced NM_001304965.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085139.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC123724.9         58454-58693         c
            241-333             AC123724.9         52664-52756         c
            334-526             AC123724.9         50532-50724         c
            527-643             AC123724.9         46480-46596         c
            644-772             AC123724.9         45335-45463         c
            773-1026            AC123724.9         44566-44819         c
            1027-1155           AC123724.9         42722-42850         c
            1156-1359           AC123724.9         41919-42122         c
            1360-1501           AC123724.9         39501-39642         c
            1502-1670           AC123724.9         38567-38735         c
            1671-4971           AC123724.9         34009-37309         c
FEATURES             Location/Qualifiers
     source          1..4971
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.35 cM"
     gene            1..4971
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /note="POU domain, class 6, transcription factor 1"
                     /db_xref="GeneID:19009"
                     /db_xref="MGI:MGI:102935"
     exon            1..240
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /inference="alignment:Splign:2.1.0"
     exon            241..333
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..2016
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription regulatory protein MCP-1; octamer-binding
                     transcription factor EMB"
                     /codon_start=1
                     /product="POU domain, class 6, transcription factor 1
                     isoform 1"
                     /protein_id="NP_001291894.1"
                     /db_xref="CCDS:CCDS79411.1"
                     /db_xref="GeneID:19009"
                     /db_xref="MGI:MGI:102935"
                     /translation="MDPGAGSDSSLTVNEQVIVMSGHETIRVLEVGVDAQLPAEEESK
                     GLESVAAGGSQSGGPVEASGPAEAGSCDPDHSAEATVAARSPSESCPSDCHLQPSPEP
                     ASGITDPDAAGCTSCPPGQVAGQQGLAVWTIPTATVAALPGLTAASPTGGTFKPPLAG
                     LQAAAVLNTALPTPVQAAPPIQASSPAQPRPPAQPQPLFQTQPLLQTTPAILPQPTAA
                     TVAAPTPKTVDATPQITVQPAGFAFSPGIISAASLGGQTQILGSLTTAPVITNTIPSM
                     PGISSQILTNAQGQVIGALPWVVNSASVATPAPAQSLQVQAVTPQLLLNAQGQVIATL
                     ASSPLPQPVAVRKPNTPESPAKSEVQPIQPTQAVPQPAVILTSPTPALKPSAATPIPI
                     TCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTAT
                     EGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAELRNQEGQQNLMEFVGGEPSK
                     KRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN
                     TSKLNVFQIP"
     exon            334..526
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /inference="alignment:Splign:2.1.0"
     exon            527..643
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /inference="alignment:Splign:2.1.0"
     exon            644..772
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1026
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1155
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1359
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1501
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1670
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..4971
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4946..4951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /note="hexamer: AATAAA"
     polyA_site      4971
                     /gene="Pou6f1"
                     /gene_synonym="2310038G18Rik; cns-1; Emb"
                     /note="major polyA site"
ORIGIN      
        1 gtcccggccc gtgcgtggcc cgcaacccac cgccgctccg ctctgccagc cccggcgggg
       61 ggctcagggg gcggcgggtc ccgagtggct ccgggccgag cgagccgggc cgagccgctc
      121 cggcttcttt gtctgcgggc ggccgccccg gccgcggccc cctggcccgg gctgggggat
      181 gagtgtctag ccggtggccg ctgggcagcc ggggagcggg aggctgggct tcgggctccg
      241 aatgcactag gtgtgggctg gcgcctacca caccctgcag tgagcatgga tcccggagct
      301 ggatcggact catctctgac tgtcaatgag caggtcattg tgatgtcagg ccacgagacc
      361 atccgagtat tggaggtggg agtggatgcc cagcttccag ccgaggagga gagcaaagga
      421 ctggagagtg tggcagctgg tggctcccag agtggaggcc ctgttgaagc cagtggacct
      481 gctgaagctg ggtcatgtga ccccgaccat tctgcagagg caactgtcgc tgcccggagt
      541 ccctccgagt cctgccccag cgattgccac cttcaaccaa gccccgagcc agcctcaggc
      601 atcacagacc ctgacgccgc tggctgtaca agctgccccc caggtcaagt ggctgggcag
      661 caggggctgg ccgtgtggac aatccctaca gcaactgtgg ctgccctccc aggactgacc
      721 gcggcctctc ccacgggggg aactttcaag ccacctttag ctggtctcca agcagctgcc
      781 gtgctgaaca ccgctctccc gacacctgta caagctgccc caccaatcca ggcctcctcg
      841 cccgcccagc cccggccacc agctcagccc cagccactgt tccagaccca gccgctgcta
      901 cagaccacgc ctgccatcct cccacaaccc accgctgcca ccgttgctgc ccccacaccc
      961 aagacagtgg acgccacccc gcagatcact gtccagcctg caggcttcgc atttagccca
     1021 gggatcatca gtgcagcctc cctcggggga cagacgcaga tcctgggctc cctcactaca
     1081 gctccagtta ttaccaacac cattcccagc atgcccggga tcagcagtca gatcctcacg
     1141 aatgctcagg gacaggttat tggagcactt ccgtgggtag tgaactcagc tagcgtggcc
     1201 acaccagcac cggcacagag cctgcaggtc caagccgtga ctccccagct cttgttgaat
     1261 gcccagggcc aggtgatcgc aaccctagcc agcagccccc tgcctcagcc tgtggctgtc
     1321 aggaagccaa acacaccgga gtcccctgct aagagtgagg tgcagcctat ccagccgaca
     1381 caagccgtgc cccagcctgc agtaatcctc accagcccaa cgccagcgct caagccgtca
     1441 gctgcaactc ccatcccaat cacctgctca gagaccccaa ccgtcagtca gttggtatca
     1501 aagccgcaca ccccaagtct ggatgaggac gggatcaact tagaagagat ccgggagttt
     1561 gctaagaatt ttaagatccg gcggctctcc ctgggtctga cacagaccca ggtgggccag
     1621 gctttgacgg cgacagaagg gccggcctac agccaatcag ccatctgcag gtttgagaaa
     1681 ttggacatca cacccaagag cgcccagaag ctgaagccgg ttttggaaaa gtggttgatg
     1741 gaggcagagc tccgcaacca ggaaggccag cagaacctga tggagttcgt gggcggcgag
     1801 ccctccaaga aacgcaagcg gcgcacttcc ttcacaccgc aggccataga ggctctcaat
     1861 gcctactttg agaaaaaccc cctgcccacc ggccaggaga tcacggagat cgccaaggag
     1921 ctcaactacg accgggaggt ggtgagggtc tggttctgta atcgacgcca gacactgaag
     1981 aacaccagca agctgaacgt ctttcagatc ccgtagggct cagtgtcagc gtgtgccggc
     2041 gcactgtact cttccctcag caaccagccg aagtcactgc ggtgactgta ctgtgtgcag
     2101 ctgcgtttgc cctaggtcgt gagcctccac ctgtgcatgc gtgtcaatgc ctgcctcttc
     2161 tgcccacata tgtcacaccc tggggaggcc tgaggggctg catgagagcc ttaggctctg
     2221 gctgggcatg tggaaggagg gggtttgtgg agtcatagaa aagcactttg ctaaggtggt
     2281 ttctgaaggg cgagttccgg ttgggaacca gaaaggctct gtctttgggg cagggctgta
     2341 gcaacttttg gggacaactg tgtagtagct cttggttttg gtggcaccct ttgctcttcc
     2401 cttcgctcct ctgtggttgt gcccatgtga caactgcagc ctcacactgc ctccctaact
     2461 ctgtctatgg gcacactgaa ccccttaaag gacagaggcg atagaatcca gagaagcatg
     2521 gtgtgctgct cagactcact ggctgccttg atcttgaggg cagaaggttc ccaaagtgaa
     2581 gctgaggggt cggatgccca aggtcaggag ctgcgaggtc tctccccagg tcctgctggt
     2641 ggtgggtttg tgctcactcg aaatgttttc tcccgcaaac caagttggaa ggaagcaaga
     2701 gtaaactctc tcaccctgga gagtcttagg tctgtggcag gcctggagtt tataaagtaa
     2761 atgaggacat ccacccagac ttatctaagt ttccagctgt cttccaacac aagagcatgc
     2821 tagagtttgg gaaattttcc tctgcccact tacacagaca gcagcatggg gcacggattc
     2881 cgactgactt tcccccctct cgtgccctta cccatctcag tgcaggactg agatgtcttc
     2941 aaaggagcca attgaaccaa aagccagaca tggaggagct ggcgtgggag gaagacagta
     3001 tctaaaggga tgatggtccg gggaggtctc ttgttgaggc tgacttaact ctagttttgt
     3061 ttgtaattaa gtcttggaga tctccagaga cgtcactttg tccagttgta gaccagatct
     3121 gtctttgagc aaccctcccc tccacccccc gtcctcatcc ctctggggtg ctcctctgag
     3181 ccaacagtgc ccaggtcagg actttccctg ggtaggtgat ggcaatccgg gacctggcat
     3241 cacacccaag ccactaagcc agactttgca gccacagaga ggctggcaga cttttcactt
     3301 cagtgcattg gctggggaat gtggctcagc gggagagagc ttggcatgta taaggctcca
     3361 gagtcagatt gtagcaccaa ggggaaacac tttgctttca agaagtcagg aaagagctaa
     3421 gacgttctct tggatgaccc ctttacaagc tgtgggcatc aactgtctcg atacttttgg
     3481 ggttggtttg ttggcttttg ttttgttttg tttgtgatag gatcacactg tagcccaggc
     3541 taacctcaga cttggaattg aaggcgacct gatcctcctg tctcccccca cctcccaagc
     3601 actgggtctg cagtcgcgtg ccactgtgcc gctgtgcctg gctcttctcc actccacagc
     3661 cttactgagc ttgctctctg gatgatgttg acatcacgtg atctaccctg aagcaatgac
     3721 tctcaaacat ggacatgatg cagagacacc agggctcagc tttctctctc gtaccctgtt
     3781 ccctttcctg gtcctcttgg gtcctgcagt actggtgtgg agggacctcc tagtagctct
     3841 gacaatgaga ggagggcagt tgtgtgctga tcacacacac acacacacac cacaagtctg
     3901 tcaggtataa ggagacaagt aggttgcttt cctgatcctg cctcccaaga aagaataatt
     3961 cccagagcga ttctaggtca tgtgattatc atcctgcttc tgtgagatgg aagtcaggag
     4021 gggtcctgta agagagcttt cagtagggat gcttagagcc ctgaagctta tcaagatgat
     4081 gcacctgaga aaactatatg cagatctgca gcttttcttg ctcaaagcct gcactcagga
     4141 ggtactacac agtcagccat gctgtggtca gccatgctgt ggtcagccat gctgtggaca
     4201 tgggagagga tgccatgcag tctatgcatg acaggcgggg ataatcatgg cccactaaat
     4261 taagccgacc actcgttctc accccgtcct ttgtccaaat ctgtcttctc aaggctggcc
     4321 tagagtgaac cattttctcc tgtgttggaa agatatattg gtctttcaga acagtaccat
     4381 gtttacaggc tggacttctc aaggaaggga ttcaagagta taaagtgtac ccaaagtggg
     4441 gttcgctttg gcctttggac tctgctcccc agcctgggcc actgatctac agtctttgtt
     4501 attttgggga gcattagact ctaaaaaagt tttaatagca gttttatcat gaaagcacct
     4561 tctcggacgt aaacccgcgc tcgatggctt tttttgccct ggaaagggga gaatgggagg
     4621 aagtagttca actgtgtggt tggtttgttt taagtgatgg gaaaccaaga cactctgtgg
     4681 ccctgctgaa tcagctgcgc ccttcgaccc tgcactaact atggcacttc acccaagcaa
     4741 agtgaaccgt gaacacacgt gagtttggaa tgagaacacc tgatgtgttt gtgttcttga
     4801 aaagccagtc accttcctat tcccaggacg cctttcctgc ctggtgggcc aaatcccgaa
     4861 gtcccaacat tctcctggca cggcaagggg ccactgccca ctgctagctg gggaggagga
     4921 agggggagta ttgccgtagc gtgtgaataa acagtatttt tttctttcgt a
//
