LOCUS       NM_013633               1353 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus POU domain, class 5, transcription factor 1 (Pou5f1),
            transcript variant 1, mRNA.
ACCESSION   NM_013633
VERSION     NM_013633.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1353)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   2  (bases 1 to 1353)
  AUTHORS   Levy,E.W., Leite,I., Joyce,B.W., Shvartsman,S.Y. and Posfai,E.
  TITLE     A tug-of-war between germ cell motility and intercellular bridges
            controls germline cyst formation in mice
  JOURNAL   Curr Biol 34 (24), 5728-5738 (2024)
   PUBMED   39566500
REFERENCE   3  (bases 1 to 1353)
  AUTHORS   Iyer,D.P., Khoei,H.H., van der Weijden,V.A., Kagawa,H.,
            Pradhan,S.J., Novatchkova,M., McCarthy,A., Rayon,T., Simon,C.S.,
            Dunkel,I., Wamaitha,S.E., Elder,K., Snell,P., Christie,L.,
            Schulz,E.G., Niakan,K.K., Rivron,N. and Bulut-Karslioglu,A.
  TITLE     mTOR activity paces human blastocyst stage developmental
            progression
  JOURNAL   Cell 187 (23), 6566-6583 (2024)
   PUBMED   39332412
REFERENCE   4  (bases 1 to 1353)
  AUTHORS   Festuccia,N., Vandormael-Pournin,S., Chervova,A., Geiselmann,A.,
            Langa-Vives,F., Coux,R.X., Gonzalez,I., Collet,G.G.,
            Cohen-Tannoudji,M. and Navarro,P.
  TITLE     Nr5a2 is dispensable for zygotic genome activation but essential
            for morula development
  JOURNAL   Science 386 (6717), eadg7325 (2024)
   PUBMED   39361745
REFERENCE   5  (bases 1 to 1353)
  AUTHORS   Dias Mirandela,M., Zoch,A., Leismann,J., Webb,S., Berrens,R.V.,
            Valsakumar,D., Kabayama,Y., Auchynnikava,T., Schito,M.,
            Chowdhury,T., MacLeod,D., Xiang,X., Zou,J., Rappsilber,J.,
            Allshire,R.C., Voigt,P., Cook,A.G., Barau,J. and O'Carroll,D.
  TITLE     Two-factor authentication underpins the precision of the piRNA
            pathway
  JOURNAL   Nature 634 (8035), 979-985 (2024)
   PUBMED   39294378
REFERENCE   6  (bases 1 to 1353)
  AUTHORS   Takeda,J., Seino,S. and Bell,G.I.
  TITLE     Human Oct3 gene family: cDNA sequences, alternative splicing, gene
            organization, chromosomal location, and expression at low levels in
            adult tissues
  JOURNAL   Nucleic Acids Res 20 (17), 4613-4620 (1992)
   PUBMED   1408763
REFERENCE   7  (bases 1 to 1353)
  AUTHORS   Yeom,Y.I., Ha,H.S., Balling,R., Scholer,H.R. and Artzt,K.
  TITLE     Structure, expression and chromosomal location of the Oct-4 gene
  JOURNAL   Mech Dev 35 (3), 171-179 (1991)
   PUBMED   1768618
REFERENCE   8  (bases 1 to 1353)
  AUTHORS   Siracusa,L.D., Rosner,M.H., Vigano,M.A., Gilbert,D.J., Staudt,L.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of the octamer transcription factors, Otf-1,
            Otf-2, and Otf-3, defines multiple Otf-3-related sequences
            dispersed in the mouse genome
  JOURNAL   Genomics 10 (2), 313-326 (1991)
   PUBMED   1676977
REFERENCE   9  (bases 1 to 1353)
  AUTHORS   Uehara,H.
  TITLE     Mouse Oct-3 maps between the tcl12 embryonic lethal gene and the Qa
            gene in the H-2 complex
  JOURNAL   Immunogenetics 34 (4), 266-269 (1991)
   PUBMED   1680810
REFERENCE   10 (bases 1 to 1353)
  AUTHORS   Scholer,H.R., Ruppert,S., Suzuki,N., Chowdhury,K. and Gruss,P.
  TITLE     New type of POU domain in germ line-specific protein Oct-4
  JOURNAL   Nature 344 (6265), 435-439 (1990)
   PUBMED   1690859
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CU467494.10, AK145321.1 and
            BY390845.1.
            
            On Nov 15, 2011 this sequence version replaced NM_013633.2.
            
            Summary: The protein encoded by this gene belongs to the POU domain
            family of transcription factors. POU domain transcription factors
            bind to a specific octamer DNA motif and regulate cell
            type-specific differentiation pathways. The encoded protein plays a
            key role in embryonic development and stem cell pluripotency.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145321.1, BC068268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                CU467494.10        85101-85130
            31-1345             AK145321.1         2-1316
            1346-1353           BY390845.1         416-423
FEATURES             Location/Qualifiers
     source          1..1353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.69 cM"
     gene            1..1353
                     /gene="Pou5f1"
                     /gene_synonym="NF-A3; Oct-3; Oct-3/4; Oct-4; Oct3; Oct3/4;
                     Oct4; Otf-3; Otf-4; Otf3; Otf3-rs7; Otf3g; Otf4"
                     /note="POU domain, class 5, transcription factor 1"
                     /db_xref="GeneID:18999"
                     /db_xref="MGI:MGI:101893"
     exon            1..452
                     /gene="Pou5f1"
                     /gene_synonym="NF-A3; Oct-3; Oct-3/4; Oct-4; Oct3; Oct3/4;
                     Oct4; Otf-3; Otf-4; Otf3; Otf3-rs7; Otf3g; Otf4"
                     /inference="alignment:Splign:2.1.0"
     exon            453..573
                     /gene="Pou5f1"
                     /gene_synonym="NF-A3; Oct-3; Oct-3/4; Oct-4; Oct3; Oct3/4;
                     Oct4; Otf-3; Otf-4; Otf3; Otf3-rs7; Otf3g; Otf4"
                     /inference="alignment:Splign:2.1.0"
     exon            574..704
                     /gene="Pou5f1"
                     /gene_synonym="NF-A3; Oct-3; Oct-3/4; Oct-4; Oct3; Oct3/4;
                     Oct4; Otf-3; Otf-4; Otf3; Otf3-rs7; Otf3g; Otf4"
                     /inference="alignment:Splign:2.1.0"
     exon            705..863
                     /gene="Pou5f1"
                     /gene_synonym="NF-A3; Oct-3; Oct-3/4; Oct-4; Oct3; Oct3/4;
                     Oct4; Otf-3; Otf-4; Otf3; Otf3-rs7; Otf3g; Otf4"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1353
                     /gene="Pou5f1"
                     /gene_synonym="NF-A3; Oct-3; Oct-3/4; Oct-4; Oct3; Oct3/4;
                     Oct4; Otf-3; Otf-4; Otf3; Otf3-rs7; Otf3g; Otf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtgaaac cgtccctagg tgagccgtct ttccaccagg cccccggctc ggggtgccca
       61 ccttccccat ggctggacac ctggcttcag acttcgcctt ctcaccccca ccaggtgggg
      121 gtgatgggtc agcagggctg gagccgggct gggtggatcc tcgaacctgg ctaagcttcc
      181 aagggcctcc aggtgggcct ggaatcggac caggctcaga ggtattgggg atctccccat
      241 gtccgcccgc atacgagttc tgcggaggga tggcatactg tggacctcag gttggactgg
      301 gcctagtccc ccaagttggc gtggagactt tgcagcctga gggccaggca ggagcacgag
      361 tggaaagcaa ctcagaggga acctcctctg agccctgtgc cgaccgcccc aatgccgtga
      421 agttggagaa ggtggaacca actcccgagg agtcccagga catgaaagcc ctgcagaagg
      481 agctagaaca gtttgccaag ctgctgaagc agaagaggat caccttgggg tacacccagg
      541 ccgacgtggg gctcaccctg ggcgttctct ttggaaaggt gttcagccag accaccatct
      601 gtcgcttcga ggccttgcag ctcagcctta agaacatgtg taagctgcgg cccctgctgg
      661 agaagtgggt ggaggaagcc gacaacaatg agaaccttca ggagatatgc aaatcggaga
      721 ccctggtgca ggcccggaag agaaagcgaa ctagcattga gaaccgtgtg aggtggagtc
      781 tggagaccat gtttctgaag tgcccgaagc cctccctaca gcagatcact cacatcgcca
      841 atcagcttgg gctagagaag gatgtggttc gagtatggtt ctgtaaccgg cgccagaagg
      901 gcaaaagatc aagtattgag tattcccaac gagaagagta tgaggctaca gggacacctt
      961 tcccaggggg ggctgtatcc tttcctctgc ccccaggtcc ccactttggc accccaggct
     1021 atggaagccc ccacttcacc acactctact cagtcccttt tcctgagggc gaggcctttc
     1081 cctctgttcc cgtcactgct ctgggctctc ccatgcattc aaactgaggc accagccctc
     1141 cctggggatg ctgtgagcca aggcaaggga ggtagacaag agaacctgga gctttggggt
     1201 taaattcttt tactgaggag ggattaaaag cacaacaggg gtggggggtg ggatggggaa
     1261 agaagctcag tgatgctgtt gatcaggagc ctggcctgtc tgtcactcat cattttgttc
     1321 ttaaataaag actgggacac acagtagata gct
//
