LOCUS       NM_138945               1146 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus POU domain, class 4, transcription factor 3 (Pou4f3),
            mRNA.
ACCESSION   NM_138945
VERSION     NM_138945.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1146)
  AUTHORS   Wu,M., Jia,G., Liu,Y., Lou,Y., Li,Y., Xia,M., Li,H. and Li,W.
  TITLE     PKM2 controls cochlear development through lactate-dependent
            transcriptional regulation
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2410829122 (2025)
   PUBMED   39773029
REFERENCE   2  (bases 1 to 1146)
  AUTHORS   Jarvis,J.E., Miao,L., Hallaert,P., Martin,M.R., Collado,L.,
            Hill,N.T. and Brownell,I.
  TITLE     POU4F3 Is Necessary for Normal Merkel Cell Formation, whereas
            POU4F1 Is Dispensable
  JOURNAL   J Invest Dermatol 145 (1), 193-196 (2025)
   PUBMED   39009281
REFERENCE   3  (bases 1 to 1146)
  AUTHORS   Wang,G., Gu,Y. and Liu,Z.
  TITLE     Deciphering the genetic interactions between Pou4f3, Gfi1, and
            Rbm24 in maintaining mouse cochlear hair cell survival
  JOURNAL   Elife 12, 90025 (2024)
   PUBMED   38483314
  REMARK    GeneRIF: Deciphering the genetic interactions between Pou4f3, Gfi1,
            and Rbm24 in maintaining mouse cochlear hair cell survival.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1146)
  AUTHORS   Jauregui,E.J., Scheinman,K.L., Bibriesca Mejia,I.K., Pruett,L.,
            Zaini,H., Finkbeiner,C., Phillips,J.A., Gantz,J.A., Nguyen,T.B.,
            Phillips,J.O. and Stone,J.S.
  TITLE     Sensorineural correlates of failed functional recovery after
            natural regeneration of vestibular hair cells in adult mice
  JOURNAL   Front Neurol 15, 1322647 (2024)
   PUBMED   38523617
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1146)
  AUTHORS   Tran,H.N., Nguyen,Q.H. and Jeong,Y.
  TITLE     Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron
            fate and regulates differentiation of the dorsal midbrain into the
            inferior and superior colliculi
  JOURNAL   Front Cell Dev Biol 12, 1336308 (2024)
   PUBMED   38344749
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1146)
  AUTHORS   Xiang,M., Zhou,L., Macke,J.P., Yoshioka,T., Hendry,S.H., Eddy,R.L.,
            Shows,T.B. and Nathans,J.
  TITLE     The Brn-3 family of POU-domain factors: primary structure, binding
            specificity, and expression in subsets of retinal ganglion cells
            and somatosensory neurons
  JOURNAL   J Neurosci 15 (7 Pt 1), 4762-4785 (1995)
   PUBMED   7623109
REFERENCE   7  (bases 1 to 1146)
  AUTHORS   Morris,P.J., Theil,T., Ring,C.J., Lillycrop,K.A., Moroy,T. and
            Latchman,D.S.
  TITLE     The opposite and antagonistic effects of the closely related POU
            family transcription factors Brn-3a and Brn-3b on the activity of a
            target promoter are dependent on differences in the POU domain
  JOURNAL   Mol Cell Biol 14 (10), 6907-6914 (1994)
   PUBMED   7935408
REFERENCE   8  (bases 1 to 1146)
  AUTHORS   Theil,T., Zechner,U., Klett,C., Adolph,S. and Moroy,T.
  TITLE     Chromosomal localization and sequences of the murine Brn-3 family
            of developmental control genes
  JOURNAL   Cytogenet Cell Genet 66 (4), 267-271 (1994)
   PUBMED   8162704
REFERENCE   9  (bases 1 to 1146)
  AUTHORS   Theil,T., McLean-Hunter,S., Zornig,M. and Moroy,T.
  TITLE     Mouse Brn-3 family of POU transcription factors: a new
            aminoterminal domain is crucial for the oncogenic activity of
            Brn-3a
  JOURNAL   Nucleic Acids Res 21 (25), 5921-5929 (1993)
   PUBMED   8290353
REFERENCE   10 (bases 1 to 1146)
  AUTHORS   Gerrero,M.R., McEvilly,R.J., Turner,E., Lin,C.R., O'Connell,S.,
            Jenne,K.J., Hobbs,M.V. and Rosenfeld,M.G.
  TITLE     Brn-3.0: a POU-domain protein expressed in the sensory, immune, and
            endocrine systems that functions on elements distinct from known
            octamer motifs
  JOURNAL   Proc Natl Acad Sci U S A 90 (22), 10841-10845 (1993)
   PUBMED   8248179
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125110.4 and AK039639.1.
            
            On Jul 2, 2009 this sequence version replaced NM_138945.1.
            
            Sequence Note: Sequence Note: This RefSeq record was created from
            transcript and genomic sequence data because no single transcript
            from the same strain was available for the full length of the gene.
            The extent of this transcript is supported by transcript
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145941.1, SRR7345562.3068595.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC125110.4         149824-149989
            167-1146            AK039639.1         41-1020
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 22.58 cM"
     gene            1..1146
                     /gene="Pou4f3"
                     /gene_synonym="Brn3.1; Brn3c; ddl; dreidel"
                     /note="POU domain, class 4, transcription factor 3"
                     /db_xref="GeneID:18998"
                     /db_xref="MGI:MGI:102523"
     exon            1..166
                     /gene="Pou4f3"
                     /gene_synonym="Brn3.1; Brn3c; ddl; dreidel"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1063
                     /gene="Pou4f3"
                     /gene_synonym="Brn3.1; Brn3c; ddl; dreidel"
                     /note="brain-specific homeobox POU domain protein 3C;
                     brn-3C; brain-3C"
                     /codon_start=1
                     /product="POU domain, class 4, transcription factor 3"
                     /protein_id="NP_620395.2"
                     /db_xref="CCDS:CCDS29212.1"
                     /db_xref="GeneID:18998"
                     /db_xref="MGI:MGI:102523"
                     /translation="MMAMNAKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGN
                     IFGSFDESLLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSPTVPISHPAA
                     LTSHPHHAVHQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMG
                     MSHPHAVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIP
                     GVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKR
                     KRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKY
                     SAVH"
     exon            167..1146
                     /gene="Pou4f3"
                     /gene_synonym="Brn3.1; Brn3c; ddl; dreidel"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcttgattc catgtccccc gctgcctccc tgccagactc ccgaagatga tggccatgaa
       61 cgccaagcag cctttcggca tgcaccccgt actgcaagaa cccaaattct ccagcctaca
      121 ctccggctct gaggccatgc gccgagtttg tctcccagcc ccgcagctgc agggtaatat
      181 atttggaagc tttgatgaga gcctgctggc acgcgccgaa gctctggcgg cggtggatat
      241 cgtctcccac ggcaagaatc atccgttcaa gcccgacgcc acctaccata ccatgagcag
      301 cgtgccctgc acttctacct cgcccacggt gcccatctct cacccggctg cactcacctc
      361 gcacccgcat cacgcggtac atcagggcct cgagggcgac ttacttgagc acatctcgcc
      421 cacgctgagc gtgagtggcc taggggcccc ggagcactcg gtgatgccgg cgcagatcca
      481 cccgcatcat ctaggcgcca tgggccactt gcatcaggcc atgggcatga gtcacccgca
      541 tgccgtagca ccgcacagtg ccatgcccgc gtgtctcagc gatgtggagt cagaccctcg
      601 agagctggaa gcgttcgccg agcgcttcaa gcagaggcgc atcaagttgg gggtcaccca
      661 ggcggacgtg ggcgcggctt tagccaatct taagatcccc ggtgtgggct cgctcagcca
      721 gagcaccatc tgcaggttcg agtctcttac tctgtcgcac aacaacatga tcgctctcaa
      781 gccggtcctc caggcctggc tggaggaggc cgaggccgcc taccgagaga agaacagcaa
      841 gccagagctc ttcaacggca gtgagcgtaa gcgcaaacgc acgtccatcg ccgcgccaga
      901 gaagcgctca ctcgaagcct atttcgccat ccagccacgt ccttcatccg agaagatcgc
      961 ggccatcgcg gagaaactgg accttaaaaa gaatgtggtg agggtctggt tctgtaacca
     1021 gagacagaaa cagaaacgaa tgaaatactc tgctgtccac tgattgcggc gggtgctgcg
     1081 tccggaggag cctggagagc ctaatggcat cgcccccttc cgatgggagg ggacgttacg
     1141 ggacac
//
