LOCUS       NM_138944               3207 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus POU domain, class 4, transcription factor 2 (Pou4f2),
            mRNA.
ACCESSION   NM_138944
VERSION     NM_138944.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3207)
  AUTHORS   Negueruela,S., Morenilla-Palao,C., Sala,S., Ordono,P., Herrera,M.,
            Coca,Y., Lopez-Cascales,M.T., Florez-Paz,D., Gomis,A. and
            Herrera,E.
  TITLE     Proper Frequency of Perinatal Retinal Waves Is Essential for the
            Precise Wiring of Visual Axons in Nonimage-Forming Nuclei
  JOURNAL   J Neurosci 44 (40), e1408232024 (2024)
   PUBMED   39151955
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3207)
  AUTHORS   Mehta,K., Daghsni,M., Raeisossadati,R., Xu,Z., Davis,E.,
            Naidich,A., Wang,B., Tao,S., Pi,S., Chen,W., Kostka,D., Liu,S.,
            Gross,J.M., Kuwajima,T. and Aldiri,I.
  TITLE     A cis-regulatory module underlies retinal ganglion cell genesis and
            axonogenesis
  JOURNAL   Cell Rep 43 (6), 114291 (2024)
   PUBMED   38823017
REFERENCE   3  (bases 1 to 3207)
  AUTHORS   Xu,M., Li,S., Xie,X., Guo,L., Yu,D., Zhuo,J., Lin,J., Kol,L. and
            Gan,L.
  TITLE     ISL1 and POU4F1 Directly Interact to Regulate the Differentiation
            and Survival of Inner Ear Sensory Neurons
  JOURNAL   J Neurosci 44 (8), e1718232024 (2024)
   PUBMED   38267260
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3207)
  AUTHORS   Yogendran,V., Mele,L., Prysyazhna,O. and Budhram-Mahadeo,V.S.
  TITLE     Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription
            factor in aortic vascular smooth muscle cells is linked to
            deregulation of calcium signalling pathways
  JOURNAL   Cell Death Dis 14 (11), 770 (2023)
   PUBMED   38007517
  REMARK    GeneRIF: Vascular dysfunction caused by loss of Brn-3b/POU4F2
            transcription factor in aortic vascular smooth muscle cells is
            linked to deregulation of calcium signalling pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3207)
  AUTHORS   Li,Y., Xiao,D., Chen,H., Zheng,X.F.S. and Xiang,M.
  TITLE     Maf1 controls retinal neuron number by both RNA Pol III- and Pol
            II-dependent mechanisms
  JOURNAL   iScience 26 (12), 108544 (2023)
   PUBMED   38089586
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3207)
  AUTHORS   Xiang,M., Zhou,L., Macke,J.P., Yoshioka,T., Hendry,S.H., Eddy,R.L.,
            Shows,T.B. and Nathans,J.
  TITLE     The Brn-3 family of POU-domain factors: primary structure, binding
            specificity, and expression in subsets of retinal ganglion cells
            and somatosensory neurons
  JOURNAL   J Neurosci 15 (7 Pt 1), 4762-4785 (1995)
   PUBMED   7623109
REFERENCE   7  (bases 1 to 3207)
  AUTHORS   Morris,P.J., Theil,T., Ring,C.J., Lillycrop,K.A., Moroy,T. and
            Latchman,D.S.
  TITLE     The opposite and antagonistic effects of the closely related POU
            family transcription factors Brn-3a and Brn-3b on the activity of a
            target promoter are dependent on differences in the POU domain
  JOURNAL   Mol Cell Biol 14 (10), 6907-6914 (1994)
   PUBMED   7935408
REFERENCE   8  (bases 1 to 3207)
  AUTHORS   Turner,E.E., Jenne,K.J. and Rosenfeld,M.G.
  TITLE     Brn-3.2: a Brn-3-related transcription factor with distinctive
            central nervous system expression and regulation by retinoic acid
  JOURNAL   Neuron 12 (1), 205-218 (1994)
   PUBMED   7904822
REFERENCE   9  (bases 1 to 3207)
  AUTHORS   Okamoto,K., Okazawa,H., Okuda,A., Sakai,M., Muramatsu,M. and
            Hamada,H.
  TITLE     A novel octamer binding transcription factor is differentially
            expressed in mouse embryonic cells
  JOURNAL   Cell 60 (3), 461-472 (1990)
   PUBMED   1967980
REFERENCE   10 (bases 1 to 3207)
  AUTHORS   He,X., Treacy,M.N., Simmons,D.M., Ingraham,H.A., Swanson,L.W. and
            Rosenfeld,M.G.
  TITLE     Expression of a large family of POU-domain regulatory genes in
            mammalian brain development
  JOURNAL   Nature 340 (6228), 35-41 (1989)
   PUBMED   2739723
  REMARK    Erratum:[Nature 1989 Aug 24;340(6235):662]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133181.2.
            
            On Feb 6, 2019 this sequence version replaced NM_138944.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087546.1, AK084240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-537               AC133181.2         118792-119328       c
            538-3207            AC133181.2         115690-118359       c
FEATURES             Location/Qualifiers
     source          1..3207
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 36.99 cM"
     gene            1..3207
                     /gene="Pou4f2"
                     /gene_synonym="Brn-3.2; Brn-3b; Brn3b; mBrn3-3R;
                     Pou4f-rs1"
                     /note="POU domain, class 4, transcription factor 2"
                     /db_xref="GeneID:18997"
                     /db_xref="MGI:MGI:102524"
     exon            1..537
                     /gene="Pou4f2"
                     /gene_synonym="Brn-3.2; Brn-3b; Brn3b; mBrn3-3R;
                     Pou4f-rs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1479
                     /gene="Pou4f2"
                     /gene_synonym="Brn-3.2; Brn-3b; Brn3b; mBrn3-3R;
                     Pou4f-rs1"
                     /note="brain-3B; brain-specific homeobox/POU domain
                     protein 3B; POU domain, class 4, transcription factor,
                     related sequence 1"
                     /codon_start=1
                     /product="POU domain, class 4, transcription factor 2"
                     /protein_id="NP_620394.2"
                     /db_xref="CCDS:CCDS22429.1"
                     /db_xref="GeneID:18997"
                     /db_xref="MGI:MGI:102524"
                     /translation="MMMMSLNSKQAFSMPHAGSLHVEPKYSALHSASPGSSAPAAPSA
                     SSPSSSSNAGGGGGGGGGGGGGGRSSSSSSSGSGGSGGGGGSEAMRRACLPTPPSNIF
                     GGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSS
                     VPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGTVVSTP
                     AHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGV
                     TQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHRE
                     KLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVR
                     VWFCNQRQKQKRMKYSAGI"
     exon            538..3207
                     /gene="Pou4f2"
                     /gene_synonym="Brn-3.2; Brn-3b; Brn3b; mBrn3-3R;
                     Pou4f-rs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3167..3172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pou4f2"
                     /gene_synonym="Brn-3.2; Brn-3b; Brn3b; mBrn3-3R;
                     Pou4f-rs1"
                     /note="hexamer: ATTAAA"
     polyA_site      3191
                     /gene="Pou4f2"
                     /gene_synonym="Brn-3.2; Brn-3b; Brn3b; mBrn3-3R;
                     Pou4f-rs1"
ORIGIN      
        1 actttggggt gctgaggtct gaagccagag ccacccggag cagggcaacc tctcgggcag
       61 acctagcggg agacacagga gcggagctag cggccacact gggagaaccg ggcctggaag
      121 cagtggcggc tgagcacaac tttgcagtgt tgttccctct gctgctccgg ccgggtactt
      181 ctccggaggg tcgggtagct gggaccggag tgcgccagcg acgagcgcgc cgcgcaagga
      241 aagatgatga tgatgtccct gaacagcaag caggcgttca gcatgcctca cgcaggcagc
      301 ctgcacgtgg agcccaagta ctcggcgcta cacagtgcct ccccgggctc ctctgcgccc
      361 gcggcgccct cggccagttc ccctagcagc tccagcaacg ctggcggcgg cggcggtggc
      421 ggcggaggcg gaggcggcgg cggccggagc agcagttcca gcagcagtgg cagcggcggc
      481 agcggcggcg gcgggggctc ggaggcgatg cggagagctt gtcttccaac cccaccgagc
      541 aatatattcg gcgggctgga tgagagtctg ctggcccgtg ccgaggctct ggccgccgtg
      601 gacatcgtct cccagagtaa gagccaccac caccatccgc cccaccacag ccccttcaag
      661 ccggacgcca cttaccacac catgaacacc atcccgtgca cgtcggcagc ctcctcttct
      721 tctgtgccca tctcgcaccc gtccgctctg gctggcaccc atcaccacca ccaccaccac
      781 catcaccacc atcaccagcc gcaccaggcg ctggagggcg agctgcttga gcacctaagc
      841 cccgggctgg ccctgggagc tatggcgggc cccgacggca cggtggtgtc cactccggct
      901 cacgcaccac acatggccac catgaacccc atgcaccaag cagccctgag catggcccac
      961 gcacatgggc tgccctcgca catgggctgc atgagcgacg tggatgcaga cccgcgggac
     1021 ctggaggcgt tcgccgagcg tttcaagcag cgacgcatca agctgggagt gacccaggca
     1081 gatgtgggct cggcgctggc caacctcaag atcccgggcg tgggctcgct cagccagagc
     1141 accatctgca ggtttgagtc tctcacgctg tcacacaaca acatgatcgc gctcaagccc
     1201 atcctgcagg cgtggctgga ggaagctgag aaatcccacc gcgagaagct cactaagccg
     1261 gagctcttca atggcgcgga gaagaagcgc aagcgcacgt ccatcgcggc gccggagaag
     1321 cgctctctgg aagcctactt cgccatccag ccaaggccct cctcggagaa gatcgcggcc
     1381 atcgccgaaa agctggatct caagaaaaat gtggtgcgcg tctggttctg caaccagagg
     1441 cagaaacaga agagaatgaa atactctgcc ggcatttagg gacccttctc cagggatggc
     1501 cctttccctt cgccctcttt ttttctaacc cccttcttgt ctcttctgcc tctttccttt
     1561 ctactttggc tatcagaaaa caattccggt aaatgtgaac ccagaccaag ccaggagcaa
     1621 agaagcaagc agctgagccc aaatcagaga gattgtgaac cggtttcgca gtgaagaaaa
     1681 accaaaacca caaacaacac aacacgaaaa ggaatttgtc aagttgtagc agagctgtcc
     1741 cctttaactg cacctgggct gctcggcttc atcagagaaa gcgaggagct gactgtcaac
     1801 aggaaggtag agggacaagc ttttgaaaac cctgcaagaa tgagcaagta agatttgttt
     1861 ttgttcttac agacgtcacc ttgttcatgt ttaaaagtac actttgcagc tatttttcag
     1921 aaatagaaat tgattcagga ctgaaactcg aagctagagt tgatgcttaa tgtgatatga
     1981 tagagacatc tctaaagtat tttgaattaa aaaaagatgg cagattttct gcatttacac
     2041 tgtatattat atatatattt ttactgtggt tcttatcgct ttcttccttc tctgaagtgt
     2101 taacacttat ggaaggagtt gcgcctgctg tgttcactga tcttgacagc tattattaga
     2161 ttattgccgt acaaccctct gtaaattatt aatttatctc tctggcaact taattttgtg
     2221 cacatcctaa ttaattaaac ttctttagtc tgaaaaataa aaccggcgga tacgtatagc
     2281 tagtgatgct caaaacattt ttcttttttt ctttttggtc ctggattttt acagcttccc
     2341 acttagactg tgttcgcttt ggcctagttg tatattctca ctttgaatga agattgtttc
     2401 ttccctttgt ttttgactgg tagtgatcta atttgtgagc tgacacttta taattgatgt
     2461 cttaaccgtg tagaccagat tcactgtccg aagtcttgtt tacttcctta catatttaat
     2521 ggggattccc atattgtccc cgcggcacac gtgctctctc actcacctta catgcctaca
     2581 cacaaacaca catacacatc tctaacagaa gagaagaagc agctggaggt accaacgatg
     2641 agcagtgtat actttcccag ccttaggtgc agtctccact tggtgcttac tctgctggat
     2701 tctaagattt caccaaggta tttccatctc ccagttttcg attgctttgt tgctacattt
     2761 tgacctttat aggggtcctt cattttttcc ttttaggagg tttgtttgta gggggaaaaa
     2821 tttggaacta taagaaagac agtgcactgc ttgtaaattc acagtgtttg gtagaatcct
     2881 tttggagcac acacacaaat aggtacaaag tgactggtac cttatctatt gtaaatattt
     2941 cattcaaaat gatgcacata tgaatatatt cttacagaat ttgctgtaat tgctgatcca
     3001 tttgaggctc tccaaagttc tgagttctgt atatgacctc gtttcttgtt tttgttaatg
     3061 ggttatttac tatagtaatg tattaagtta ttttgagtgt tgtttcattg tctttcattg
     3121 aagagatgat tttaatgttt tactggcaaa gtatgctgct tttttcatta aaatatgcta
     3181 ttaatattaa atgactttta aaacgtg
//
