LOCUS       NM_011143               3801 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus POU domain, class 4, transcription factor 1 (Pou4f1),
            mRNA.
ACCESSION   NM_011143 XM_135366
VERSION     NM_011143.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3801)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 3801)
  AUTHORS   Jarvis,J.E., Miao,L., Hallaert,P., Martin,M.R., Collado,L.,
            Hill,N.T. and Brownell,I.
  TITLE     POU4F3 Is Necessary for Normal Merkel Cell Formation, whereas
            POU4F1 Is Dispensable
  JOURNAL   J Invest Dermatol 145 (1), 193-196 (2025)
   PUBMED   39009281
REFERENCE   3  (bases 1 to 3801)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   4  (bases 1 to 3801)
  AUTHORS   Mehta,K., Daghsni,M., Raeisossadati,R., Xu,Z., Davis,E.,
            Naidich,A., Wang,B., Tao,S., Pi,S., Chen,W., Kostka,D., Liu,S.,
            Gross,J.M., Kuwajima,T. and Aldiri,I.
  TITLE     A cis-regulatory module underlies retinal ganglion cell genesis and
            axonogenesis
  JOURNAL   Cell Rep 43 (6), 114291 (2024)
   PUBMED   38823017
REFERENCE   5  (bases 1 to 3801)
  AUTHORS   Zhang,K., Zhang,T., He,Q., Liang,H., Guo,J., Zeng,M. and Chen,S.
  TITLE     Shootin1 Regulates Retinal Ganglion Cell Neurite Development:
            Insights From an RGC Direct Somatic Cell Reprogramming Model
  JOURNAL   Invest Ophthalmol Vis Sci 65 (6), 41 (2024)
   PUBMED   38935030
REFERENCE   6  (bases 1 to 3801)
  AUTHORS   Xiang,M., Zhou,L., Macke,J.P., Yoshioka,T., Hendry,S.H., Eddy,R.L.,
            Shows,T.B. and Nathans,J.
  TITLE     The Brn-3 family of POU-domain factors: primary structure, binding
            specificity, and expression in subsets of retinal ganglion cells
            and somatosensory neurons
  JOURNAL   J Neurosci 15 (7 Pt 1), 4762-4785 (1995)
   PUBMED   7623109
REFERENCE   7  (bases 1 to 3801)
  AUTHORS   Sanz,L., Moscat,J. and Diaz-Meco,M.T.
  TITLE     Molecular characterization of a novel transcription factor that
            controls stromelysin expression
  JOURNAL   Mol Cell Biol 15 (6), 3164-3170 (1995)
   PUBMED   7760812
REFERENCE   8  (bases 1 to 3801)
  AUTHORS   Turner,E.E., Jenne,K.J. and Rosenfeld,M.G.
  TITLE     Brn-3.2: a Brn-3-related transcription factor with distinctive
            central nervous system expression and regulation by retinoic acid
  JOURNAL   Neuron 12 (1), 205-218 (1994)
   PUBMED   7904822
REFERENCE   9  (bases 1 to 3801)
  AUTHORS   Goldsborough,A., Ashworth,A. and Willison,K.
  TITLE     Cloning and sequencing of POU-boxes expressed in mouse testis
  JOURNAL   Nucleic Acids Res 18 (6), 1634 (1990)
   PUBMED   1970171
REFERENCE   10 (bases 1 to 3801)
  AUTHORS   He,X., Treacy,M.N., Simmons,D.M., Ingraham,H.A., Swanson,L.W. and
            Rosenfeld,M.G.
  TITLE     Expression of a large family of POU-domain regulatory genes in
            mammalian brain development
  JOURNAL   Nature 340 (6228), 35-41 (1989)
   PUBMED   2739723
  REMARK    Erratum:[Nature 1989 Aug 24;340(6235):662]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121997.3.
            
            On Sep 6, 2007 this sequence version replaced NM_011143.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY706205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               AC121997.3         73459-73847         c
            390-1576            AC121997.3         71533-72719         c
            1577-3801           AC121997.3         68168-70392         c
FEATURES             Location/Qualifiers
     source          1..3801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 54.21 cM"
     gene            1..3801
                     /gene="Pou4f1"
                     /gene_synonym="Brn-3; Brn-3.0; Brn3; Brn3.0; Brn3a;
                     E130119J07Rik"
                     /note="POU domain, class 4, transcription factor 1"
                     /db_xref="GeneID:18996"
                     /db_xref="MGI:MGI:102525"
     exon            1..389
                     /gene="Pou4f1"
                     /gene_synonym="Brn-3; Brn-3.0; Brn3; Brn3.0; Brn3a;
                     E130119J07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1532
                     /gene="Pou4f1"
                     /gene_synonym="Brn-3; Brn-3.0; Brn3; Brn3.0; Brn3a;
                     E130119J07Rik"
                     /note="brn-3A; brain-3A; brain-specific homeobox/POU
                     domain protein 3A"
                     /codon_start=1
                     /product="POU domain, class 4, transcription factor 1"
                     /protein_id="NP_035273.3"
                     /db_xref="CCDS:CCDS27319.1"
                     /db_xref="GeneID:18996"
                     /db_xref="MGI:MGI:102525"
                     /translation="MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQS
                     NLFASLDETLLARAEALAAVDIAVSQGKSHPFKPDATYHTMNSVPCTSTSTVPLAHHH
                     HHHHHHQALEPGDLLDHISSPSLALMAGAGGAGAAGGGGGAHDGPGGGGGPGGGGGPG
                     GGGPGGGGGGGGPGGGGGGPGGGLLGGSAHPHPHMHGLGHLSHPAAAAAMNMPSGLPH
                     PGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAER
                     FKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAW
                     LEEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAE
                     KLDLKKNVVRVWFCNQRQKQKRMKFSATY"
     exon            390..1576
                     /gene="Pou4f1"
                     /gene_synonym="Brn-3; Brn-3.0; Brn3; Brn3.0; Brn3a;
                     E130119J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..3801
                     /gene="Pou4f1"
                     /gene_synonym="Brn-3; Brn-3.0; Brn3; Brn3.0; Brn3a;
                     E130119J07Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2086
                     /gene="Pou4f1"
                     /gene_synonym="Brn-3; Brn-3.0; Brn3; Brn3.0; Brn3a;
                     E130119J07Rik"
                     /note="major polyA site"
     regulatory      2579..2584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pou4f1"
                     /gene_synonym="Brn-3; Brn-3.0; Brn3; Brn3.0; Brn3a;
                     E130119J07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2592
                     /gene="Pou4f1"
                     /gene_synonym="Brn-3; Brn-3.0; Brn3; Brn3.0; Brn3a;
                     E130119J07Rik"
                     /note="major polyA site"
     polyA_site      2604
                     /gene="Pou4f1"
                     /gene_synonym="Brn-3; Brn-3.0; Brn3; Brn3.0; Brn3a;
                     E130119J07Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagctctcgg agaagcggga tcgcgggacc tgcgcgcggg ccggcgggcg ggcgctctgc
       61 gcggtcggtc cgaggcagcg ggctgcgctc gccggcgcag cagcggcagc agcagcagca
      121 gcagcccccg cggcgagcct ccgagcggag ccgccgagca gtgcgagcga gcgcagcctc
      181 gggacggagg ccgggcgagc cggcgtgcgc actttgccgc ggactttgcg agtgttttgt
      241 ggatttttac atgccaaggc gccaagatga tgtccatgaa cagcaagcag cctcactttg
      301 ccatgcatcc caccctccct gagcacaagt acccgtcgct gcactccagc tccgaggcca
      361 tccggcgggc ctgcctgccc acgccgccgc tgcagagcaa cctcttcgcc agcctggacg
      421 agacgctgct ggcgcgggcc gaggcgctgg cggccgtgga catcgcggtg tcccagggca
      481 agagccaccc tttcaagccg gacgccacgt accacacgat gaatagcgtg ccctgcacgt
      541 ccacgtccac cgtgccgctg gcgcaccacc accaccacca ccaccaccac caggcgctcg
      601 agcccggtga cctgctggac cacatctcgt cgccgtcgct cgcgctcatg gccggcgcag
      661 ggggcgcagg cgcggcggga ggcggcggcg gcgcccacga cggccccggg ggcggaggcg
      721 gaccgggggg cggcggtggc ccgggcggcg gcggccccgg gggtggcggc ggcggcggcg
      781 gcccgggggg cggcggcggc ggcccgggcg gcgggctctt gggcggctcg gcgcatccgc
      841 acccgcacat gcacggcctg ggccacctgt cgcaccccgc ggcggcggcg gccatgaaca
      901 tgccgtccgg gctgccgcat cccgggctcg tggccgcggc ggcgcaccac ggcgcggcgg
      961 cggcagcggc ggcggcggcg gcggggcagg tggcggcggc gtcggccgcg gcggcggtgg
     1021 tgggcgcggc gggcctggcg tccatctgcg actcggacac ggacccgcgc gagctcgagg
     1081 cgttcgccga gcgcttcaag cagcggcgca tcaagctggg cgtgacgcag gccgacgtgg
     1141 gctcggcgct ggccaacctc aagatcccgg gcgtgggctc gctcagccag agcaccatct
     1201 gcaggttcga gtcgctcacg ctctcgcaca acaacatgat cgcgctcaag cccatcctgc
     1261 aggcgtggct ggaggaggcc gagggcgcgc agcgtgagaa aatgaacaag ccggagctct
     1321 tcaacggcgg cgagaagaag cgcaagcgga cttccatcgc cgcgcccgag aagcgctccc
     1381 tcgaggccta ttttgccgta caaccccggc cctcgtctga gaagatcgcc gccatcgccg
     1441 agaaactgga cctcaaaaag aacgtggtgc gggtgtggtt ttgcaaccag agacagaagc
     1501 agaagcggat gaaattctct gccacttact gaggagggtg tgagacgccg ggtggggcac
     1561 actggggagc tgaggggtcc ctgtctccct cctttggaga accgtgaagt tgttgaaaag
     1621 ctgagaagtt tctgctctca tttgggggca ggagtcccat gtaagaaaaa tcacctaaaa
     1681 tcccagaaga aaggaagaga tttaaagatt taaagcccct cccaccttgt tcgtttcaaa
     1741 taggtctgca cttacctggg ggaaggggaa cagtgtttcc ctgttgttgt tgttgttctt
     1801 gttgttgtta ttcaaggatc atttattacc ggggataaat gttgagtcac aaaaacttca
     1861 atttgcacta tgagtttcca aaatagaaaa tcatgtgtga tatttcatac taataatcca
     1921 agctgctgac ggattttaag gaaaaatttt ttgagaaaga cagtttgaga aagaaagaga
     1981 gagagagaga aatgtggttt agtgaaatgc ctgctttgtt gtgtagaaga tcccctttgg
     2041 atctcatgtg gagatggtct gttactatca tttaaccata actaaagatg aaaacggaag
     2101 agataagggg ggaagcactg tttaacaaga ctgaaatcat gcatggctcg aaaggtgcag
     2161 aaagaaatgt gattaggtct cactctgggt aggcgttgtt atttatttaa ttatgttgta
     2221 tgtcattgtt tgcagcacaa aacattctat gcatttgaaa ctgagcacta aactgggcta
     2281 gctttctggt agaccatttt tttgtggata gtgtgatttc acagtctact gcctgtttcc
     2341 actgaaaaca cattattgta aatattttct ttcatgcaca ggcccacaca cagtggttac
     2401 aaactgccag tgttaatcct gaaatgtctc actgactgat cctcctgtcc atgttgtgtc
     2461 tgcagagctc tctccttggt tatgtcttcg ctctattgcc cccaccccca ccccacccca
     2521 tcagaaccat ttctgtgcgc caacatacaa cagggagatg tgtcccagtc cacttccaaa
     2581 taaaacatga ctgaaagaag agcagtttta tgatctgggt gcatttttgt gtttatattg
     2641 agccaagtcc tggtagggcc ggtcaacaaa tgagagaaaa caacaaaaca aaacaaataa
     2701 cccacaccaa acagaaagcc tcaaccaaac tttaaaatca cgcaagaggg ggaggcaggg
     2761 gaggcagtgg gagtgaaagg atgagtttta gggttttgtt ttggtgtttg tttgtttgtt
     2821 tgtttgtttt tcctgaatga gaattcagtt tcagataggt catgggaact ggtgctctga
     2881 ggaaggtaac ttactcgtcc attttatcaa agttttaatt ttatctgcag aagcttttaa
     2941 gccacttcgt tggtttcaga gtggtgatgg taagctgtaa acaaccaggc acctgcaaag
     3001 tatttaagtt gaaggtcagg gattcaggca tcgagaggtt tgaatgtgct gttctactcg
     3061 aaaaacacat ctaaaaaaaa aaaaaaaaaa caaaaaacaa aaaacaaaaa acgttgtaac
     3121 taaaggactt ttcgttggca gttaatgaat tagaaaagta tcctatgatc tgccccaaca
     3181 acttgtcaaa tgcttcactt catttagaac attctgcata ccacctattg cttcacattg
     3241 acaagaggtg ttctatttct ttctcttttt tctttttctt ttggtgacct ggaactagat
     3301 caaatgccaa atgtacaaac tttcttaata gttgggacta tatcctctga agtcatccta
     3361 ttttagctaa atctttttaa cttcaccggc atatctgtga aagaaaagtg ttcagaaaag
     3421 aatagtacat tttaaaaagg tgtgatttta aaacagttgt taatatttta aaaagcacta
     3481 gaggtatttt taaaaataga tctcttccat caaaattgat ttgtttctgt tattgacttg
     3541 agatatcatc agagtttcta ataaaataca tttgtaaaag aacacattat tttatagaaa
     3601 agtatgacca gatttcattg ttggagatcc agggatgaac aaataaaaag atttacaaag
     3661 gttgtttttc taataatctg ctcaaacaga aatgttgcag gcaaatacat ttgtattata
     3721 taataatgga taatgtatgt attaagaatt taagcatttg ttttgtacta agtaaatcct
     3781 tgcccagtac aaaaaaaaaa a
//
