LOCUS       NM_008900               4443 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus POU domain, class 3, transcription factor 3 (Pou3f3),
            mRNA.
ACCESSION   NM_008900 XM_980424
VERSION     NM_008900.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4443)
  AUTHORS   Flores,M.A., Garcia-Forn,M., von Mueffling,A., Ola,P., Park,Y.,
            Boitnott,A. and De Rubeis,S.
  TITLE     A subpopulation of cortical neurons altered by mutations in the
            autism risk gene DDX3X
  JOURNAL   Biol Open 14 (1) (2025)
   PUBMED   39878593
REFERENCE   2  (bases 1 to 4443)
  AUTHORS   Barao,S., Xu,Y., Llongueras,J.P., Vistein,R., Goff,L.,
            Nielsen,K.J., Bae,B.I., Smith,R.S., Walsh,C.A., Stein-O'Brien,G.
            and Muller,U.
  TITLE     Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion
  JOURNAL   Nat Commun 15 (1), 8043 (2024)
   PUBMED   39271675
  REMARK    GeneRIF: Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4443)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4443)
  AUTHORS   Xu,J., Zhou,X., Zhang,T., Zhang,B. and Xu,P.X.
  TITLE     Smarca4 deficiency induces Pttg1 oncogene upregulation and
            hyperproliferation of tubular and interstitial cells during kidney
            development
  JOURNAL   Front Cell Dev Biol 11, 1233317 (2023)
   PUBMED   37727504
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4443)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4443)
  AUTHORS   Schonemann,M.D., Ryan,A.K., McEvilly,R.J., O'Connell,S.M.,
            Arias,C.A., Kalla,K.A., Li,P., Sawchenko,P.E. and Rosenfeld,M.G.
  TITLE     Development and survival of the endocrine hypothalamus and
            posterior pituitary gland requires the neuronal POU domain factor
            Brn-2
  JOURNAL   Genes Dev 9 (24), 3122-3135 (1995)
   PUBMED   8543156
REFERENCE   7  (bases 1 to 4443)
  AUTHORS   Avraham,K.B., Cho,B.C., Gilbert,D., Fujii,H., Okamoto,K.,
            Shimazaki,T., Ito,T., Shoji,H., Wakamatsu,Y., Kondoh,H. et al.
  TITLE     Murine chromosomal location of four class III POU transcription
            factors
  JOURNAL   Genomics 18 (1), 131-133 (1993)
   PUBMED   8276397
REFERENCE   8  (bases 1 to 4443)
  AUTHORS   Xia,Y.R., Andersen,B., Mehrabian,M., Diep,A.T., Warden,C.H.,
            Mohandas,T., McEvilly,R.J., Rosenfeld,M.G. and Lusis,A.J.
  TITLE     Chromosomal organization of mammalian POU domain factors
  JOURNAL   Genomics 18 (1), 126-130 (1993)
   PUBMED   8276396
REFERENCE   9  (bases 1 to 4443)
  AUTHORS   Hara,Y., Rovescalli,A.C., Kim,Y. and Nirenberg,M.
  TITLE     Structure and evolution of four POU domain genes expressed in mouse
            brain
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3280-3284 (1992)
   PUBMED   1565620
REFERENCE   10 (bases 1 to 4443)
  AUTHORS   He,X., Treacy,M.N., Simmons,D.M., Ingraham,H.A., Swanson,L.W. and
            Rosenfeld,M.G.
  TITLE     Expression of a large family of POU-domain regulatory genes in
            mammalian brain development
  JOURNAL   Nature 340 (6228), 35-41 (1989)
   PUBMED   2739723
  REMARK    Erratum:[Nature 1989 Aug 24;340(6235):662]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122898.4.
            
            On Jun 18, 2019 this sequence version replaced NM_008900.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR14777535.896685.1,
                                        SRR14777535.3717839.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4443              AC122898.4         32500-36942         c
FEATURES             Location/Qualifiers
     source          1..4443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 21.21 cM"
     gene            1..4443
                     /gene="Pou3f3"
                     /gene_synonym="Brn-1; Brn1; HST011; Otf8; Skin1; urehr2"
                     /note="POU domain, class 3, transcription factor 3"
                     /db_xref="GeneID:18993"
                     /db_xref="MGI:MGI:102564"
     exon            1..4443
                     /gene="Pou3f3"
                     /gene_synonym="Brn-1; Brn1; HST011; Otf8; Skin1; urehr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1379..2872
                     /gene="Pou3f3"
                     /gene_synonym="Brn-1; Brn1; HST011; Otf8; Skin1; urehr2"
                     /note="octamer-binding transcription factor 8;
                     brain-specific homeobox/POU domain protein 1; OTF-8;
                     oct-8; brain-1; octamer-binding protein 8"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 3"
                     /protein_id="NP_032926.2"
                     /db_xref="CCDS:CCDS14917.1"
                     /db_xref="GeneID:18993"
                     /db_xref="MGI:MGI:102564"
                     /translation="MATAASNPYLPGNSLLTAGSIVHSDAAGAGGGGGGGGGGGGGAG
                     GGGGGMQPGSAAVTSGAYRGDPSSVKMVQSDFMQGAMAASNGGHMLSHAHQWVTALPH
                     AAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGREDLHAG
                     TALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQS
                     LLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHH
                     AHPHPPHPHHAQGPPHHGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLG
                     FTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPT
                     SIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVW
                     FCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTPPPHHGLQTSVQ"
     regulatory      4423..4428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pou3f3"
                     /gene_synonym="Brn-1; Brn1; HST011; Otf8; Skin1; urehr2"
                     /note="hexamer: AATAAA"
     polyA_site      4443
                     /gene="Pou3f3"
                     /gene_synonym="Brn-1; Brn1; HST011; Otf8; Skin1; urehr2"
                     /note="major polyA site"
ORIGIN      
        1 attcgacagt ccctgctctg agagggaggg acggagagcg aactgtcaga tcctagcggg
       61 agcgggcgct cgagagaagg agagagggag agagagagtg agagagagag ggaaagtgag
      121 acagagagaa agagagagaa tccgggcgca gagctagctc cggctgcaac tctgccccgg
      181 cacgcctgct cccgcgcccg ccgtcgggta ctctaggagc ggtacaacgt gcccacagga
      241 gttggttgtg tatcaaggat tccctgtatg cacacacaca tctccacctc caccaatgca
      301 ctcttcttcc tcctccttct ccagacaact gccggggaaa aaataaaaca tcaaccccaa
      361 ccttcagcaa caaggtaaca gaacaattcg acattttttt ttcctgttca atttttgcct
      421 tgttatattt gtttcctaat ttctacccaa aaggaaagat gtcgcaccag actgtgagtg
      481 tcgcgaggaa catgaaaagg gactcttgtt tcagagacgt ccaagagctc cggcaataac
      541 aacttcagag aaatgcacca tcgcaagaag ttttcctagg acaaaacaaa acttgaaaga
      601 agcgaaccag gggggcagaa caggagccag ccgccccact ccgcagacgc gagccgccag
      661 catcaccacg cctgtaagga ccggaaaagt tttactatag taaggggaaa cagtaagatg
      721 tgttgctgaa gatcagggaa gacagcggac caactaggag cggccagatt gctggccacc
      781 cacaatttgg ccaaggaaga aaggaaccgc ttcgtccttt gttgtctccc gtgaaacctt
      841 cgcttagcag gtggacagag ccctgtgccg ggccagagtc cgcactcgtc cgaggacagg
      901 aggagccgcg gagcccttgc tccccgagag agcgcccgaa gtacgggtcc ccgccccagt
      961 gggcgagcct cgctggagcc agccgatcgc tcccggccag gggggagacc acgacccccc
     1021 ctgaaggggc tggccacgga gctcgcccgg agaagcgatc ccccctcccc agggcgctgc
     1081 tcctgctgca gcggcggctg ctgctgaccg aggctagccg gcgacccccg cgccctgcca
     1141 agcggccttg cagctgcagc cccgggccgc ggcggcggcg gcgggggcgg aggcggcgga
     1201 ggaggaggcg gcggagaagg cggcggggcc ggcggggacc cggggcgggg gaggaggagc
     1261 ggggggggag gaggcgggag gcgggggggg cgcggcggcg gcggcggcgg ctgcggccgc
     1321 ggctgctgct gcggcggcgg cggtggtggc ggcggtgggg tggcgggagc ggagcggcat
     1381 ggccacggcg gcttctaacc cctacctgcc ggggaacagc ctgctcacgg ccggctccat
     1441 tgtgcactcg gacgcggccg gggcgggcgg cggcggaggg ggcggcggcg gcggcggcgg
     1501 cggggcgggg ggcggcggcg gcggcatgca gccgggaagc gccgccgtga cctcgggcgc
     1561 ctaccggggg gacccgtcct cggtcaagat ggtccagagc gacttcatgc agggggccat
     1621 ggccgccagc aacggcggcc atatgctgag ccacgcgcac cagtgggtca ccgccctgcc
     1681 ccacgctgcc gccgctgccg ccgctgctgc cgccgctgcc gtggaagcca gctcaccgtg
     1741 gtcgggcagt gcggtgggca tggccggcag cccccagcag ccgccacagc cgccgccgcc
     1801 gccgcctcag ggccccgacg tgaagggagg cgctggacgc gaagacctgc acgccggtac
     1861 cgcgctgcat caccgcggac cgccgcacct cgggcccccg ccgccgcccc ctcaccaagg
     1921 acaccctggg ggctgggggg ccgcagccgc cgccgccgct gccgccgcag ccgccgccgc
     1981 tgccgctcac ctcccgtcca tggcgggtgg ccagcagccg ccgccgcaga gtctgctgta
     2041 ctcgcagccc ggaggcttca cggtgaacgg catgctgagc gcgcccccgg ggcccggcgg
     2101 tggcggcggt ggagcgggcg gtggagccca gagcctggtt caccccgggc tagtgcgcgg
     2161 ggacacgccc gagttggcgg agcatcatca ccaccatcac caccacgcgc acccgcaccc
     2221 gccgcacccg caccacgcgc agggaccccc gcatcacggc ggcggcggcg cggggccagg
     2281 gctcaacagc cacgaccctc actcggacga ggacacgccg acgtctgacg acctggagca
     2341 gttcgctaag cagttcaaac agcggcgcat caagctgggt ttcacccagg cggacgtggg
     2401 gctggctctg ggtacgctct atggcaacgt gttctcgcag accactatct gccgcttcga
     2461 ggccctgcag ctcagtttca agaacatgtg caagctcaag ccgctactga acaagtggct
     2521 ggaggaggct gactcgagca ctggcagtcc caccagcatt gacaagatcg cagcgcaggg
     2581 ccgcaagcgc aagaagcgga cctccatcga ggttagcgtc aaaggcgcgc tggagagcca
     2641 cttcctcaag tgccctaaac cctcggcgca ggaaatcacc aacttggccg acagcctaca
     2701 gctggaaaag gaggtcgtgc gggtctggtt ctgcaaccga cgccaaaagg aaaaacgcat
     2761 gacgccccct ggcatccagc agcagacgcc ggacgatgtc tactcgcagg tgggtaccgt
     2821 gagcgctgac acaccgccac cgcaccacgg gcttcagacc agcgtgcagt gaatgccggg
     2881 gcgcagcgcg aagagggccg ccgccgccgc cgccacctcc gcagccgctg tcagcaccgc
     2941 catggtcgcc gtcgccgccg tctccgagcc gccgccgccg agaaccaccg ctgctgctgc
     3001 tgccgccgcc gccgccgtca ccgtcgccgc cgccgccgct gccgccgcgc agacccagca
     3061 cctggccagt gccagggcat ctaggcctcc tcccctccgc ccaaagacag gcgtgccacg
     3121 gccccaggag gggggaggac agctggagac cgatgagact ctttctgaag tccaagaaag
     3181 gagggaccaa aaaaattttt aagcataata aataccaaga ctgttttata tgcatatata
     3241 acaaacaaaa ccggaagagg aaaaggggca acagggacat ctcgtttata ctgtggtggt
     3301 gttctgcttc tgttttgaaa gaagggtgaa gatgcctaac gcacctaaac tgcacacttg
     3361 aggtactgtc cacaccgaga tgtcctgcat ggcgtcgtcg gtggagaaca cctgcctcgg
     3421 agataagaga gagacacccc ccccctcttt cttccacttc ttccaaaagg gctgcctaaa
     3481 agatccatgg aaactttctt tatggggagc gacctgaaaa gaaagacgca ccaggtttcc
     3541 tgcaggtctg actctgctct tggacagtgt ttttcttggc catattcaag tctttgggga
     3601 acaaataaat caactaagaa atgggaagaa gggagaaaca gagtctgggg gggaagattc
     3661 gccgcttctg aagttcacag actgaacaag aaagccaaaa gaaagcatcc tccgcagtaa
     3721 acttggaaat aaaagcatcg cgaaagagcc aaggctgggt gaggctgaag ggtaggtacg
     3781 tccagccgca atccactagc ggagagggca caaaagcggg gcccgggccc agcctctgag
     3841 accgcccaca agggccaggc ctccaccacc aaacccgggc tttgctgact gccgctcggg
     3901 gtggaccatg cctaaagatt ccgccgctaa tatttttttt attaacattt tttatttttt
     3961 atttctggac tgactccgat aaaagggtgt ggaaagacag caccaaccgc gcacttccct
     4021 tgacttctgc cctcaatgcg ttgccaactt tgattgaatg ggtgctgcgg atgtgattat
     4081 gtaatactgc catttccaag cagtgttttt ggtaggtttt aataaacaga cttttcaaat
     4141 gacggcaata tagaatcgtt agatccgttg ttgatctaaa aatatttgct ttatattttc
     4201 attaaatgac ttcttttaat attttattca aaatacttat gaactgctgc aaaacggtaa
     4261 tttatttttc cccagatctt gtattacgtg tttttttcag acgagcacaa atcaaaatga
     4321 aatgaaaata tggacagttg ttaggtaata agggtatctt ttgatgtgat catttgattg
     4381 taatttaatt tgagtagtga ttccgtaaga gctgattgag aaaataaatt tgttagaatg
     4441 aaa
//
