LOCUS       NM_008899               6272 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus POU domain, class 3, transcription factor 2 (Pou3f2),
            mRNA.
ACCESSION   NM_008899 XM_909343
VERSION     NM_008899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6272)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   2  (bases 1 to 6272)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6272)
  AUTHORS   Barao,S., Xu,Y., Llongueras,J.P., Vistein,R., Goff,L.,
            Nielsen,K.J., Bae,B.I., Smith,R.S., Walsh,C.A., Stein-O'Brien,G.
            and Muller,U.
  TITLE     Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion
  JOURNAL   Nat Commun 15 (1), 8043 (2024)
   PUBMED   39271675
  REMARK    GeneRIF: Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6272)
  AUTHORS   Espinoza,F., Carrazana,R., Retamal-Fredes,E., Avila,D., Papes,F.,
            Muotri,A.R. and Avila,A.
  TITLE     Tcf4 dysfunction alters dorsal and ventral cortical neurogenesis in
            Pitt-Hopkins syndrome mouse model showing sexual dimorphism
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167178 (2024)
   PUBMED   38636614
REFERENCE   5  (bases 1 to 6272)
  AUTHORS   Wei,Y., Wang,X., Ma,Z., Xiang,P., Liu,G., Yin,B., Hou,L., Shu,P.,
            Liu,W. and Peng,X.
  TITLE     Sirt6 regulates the proliferation of neural precursor cells and
            cortical neurogenesis in mice
  JOURNAL   iScience 27 (2), 108706 (2023)
   PUBMED   38288355
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6272)
  AUTHORS   Atanasoski,S., Toldo,S.S., Malipiero,U., Schreiber,E., Fries,R. and
            Fontana,A.
  TITLE     Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and
            assignment to chromosome 6q16
  JOURNAL   Genomics 26 (2), 272-280 (1995)
   PUBMED   7601453
REFERENCE   7  (bases 1 to 6272)
  AUTHORS   Abbott,C. and Chambers,D.
  TITLE     Analysis of CAG trinucleotide repeats from mouse cDNA sequences
  JOURNAL   Ann Hum Genet 58 (2), 87-94 (1994)
   PUBMED   7979162
REFERENCE   8  (bases 1 to 6272)
  AUTHORS   Xia,Y.R., Andersen,B., Mehrabian,M., Diep,A.T., Warden,C.H.,
            Mohandas,T., McEvilly,R.J., Rosenfeld,M.G. and Lusis,A.J.
  TITLE     Chromosomal organization of mammalian POU domain factors
  JOURNAL   Genomics 18 (1), 126-130 (1993)
   PUBMED   8276396
REFERENCE   9  (bases 1 to 6272)
  AUTHORS   Hara,Y., Rovescalli,A.C., Kim,Y. and Nirenberg,M.
  TITLE     Structure and evolution of four POU domain genes expressed in mouse
            brain
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3280-3284 (1992)
   PUBMED   1565620
REFERENCE   10 (bases 1 to 6272)
  AUTHORS   He,X., Treacy,M.N., Simmons,D.M., Ingraham,H.A., Swanson,L.W. and
            Rosenfeld,M.G.
  TITLE     Expression of a large family of POU-domain regulatory genes in
            mammalian brain development
  JOURNAL   Nature 340 (6228), 35-41 (1989)
   PUBMED   2739723
  REMARK    Erratum:[Nature 1989 Aug 24;340(6235):662]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772230.20.
            
            On Aug 27, 2011 this sequence version replaced NM_008899.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: X66602.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6272              AL772230.20        104472-110743       c
FEATURES             Location/Qualifiers
     source          1..6272
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 9.73 cM"
     gene            1..6272
                     /gene="Pou3f2"
                     /gene_synonym="9430075J19Rik; A230098E07Rik; Brn-2; Brn2;
                     oct-7; OTF-7; Otf7"
                     /note="POU domain, class 3, transcription factor 2"
                     /db_xref="GeneID:18992"
                     /db_xref="MGI:MGI:101895"
     exon            1..6272
                     /gene="Pou3f2"
                     /gene_synonym="9430075J19Rik; A230098E07Rik; Brn-2; Brn2;
                     oct-7; OTF-7; Otf7"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1573
                     /gene="Pou3f2"
                     /gene_synonym="9430075J19Rik; A230098E07Rik; Brn-2; Brn2;
                     oct-7; OTF-7; Otf7"
                     /note="brain-2 class III POU-domain protein;
                     octamer-binding protein 7; octamer-binding transcription
                     factor 7; brain-specific homeobox/POU domain protein 2;
                     nervous system-specific octamer-binding transcription
                     factor N-Oct-3"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 2"
                     /protein_id="NP_032925.1"
                     /db_xref="CCDS:CCDS18005.1"
                     /db_xref="GeneID:18992"
                     /db_xref="MGI:MGI:101895"
                     /translation="MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGD
                     YGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPD
                     IKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHA
                     ANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLR
                     DAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFA
                     KQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWL
                     EEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADS
                     LQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ"
     regulatory      4099..4104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pou3f2"
                     /gene_synonym="9430075J19Rik; A230098E07Rik; Brn-2; Brn2;
                     oct-7; OTF-7; Otf7"
                     /note="hexamer: AATAAA"
     polyA_site      4122
                     /gene="Pou3f2"
                     /gene_synonym="9430075J19Rik; A230098E07Rik; Brn-2; Brn2;
                     oct-7; OTF-7; Otf7"
                     /note="major polyA site"
     regulatory      4153..4158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pou3f2"
                     /gene_synonym="9430075J19Rik; A230098E07Rik; Brn-2; Brn2;
                     oct-7; OTF-7; Otf7"
                     /note="hexamer: CATAAA"
     polyA_site      4174
                     /gene="Pou3f2"
                     /gene_synonym="9430075J19Rik; A230098E07Rik; Brn-2; Brn2;
                     oct-7; OTF-7; Otf7"
                     /note="major polyA site"
     regulatory      6033..6038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pou3f2"
                     /gene_synonym="9430075J19Rik; A230098E07Rik; Brn-2; Brn2;
                     oct-7; OTF-7; Otf7"
                     /note="hexamer: AATAAA"
     polyA_site      6054
                     /gene="Pou3f2"
                     /gene_synonym="9430075J19Rik; A230098E07Rik; Brn-2; Brn2;
                     oct-7; OTF-7; Otf7"
                     /note="major polyA site"
     regulatory      6214..6219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pou3f2"
                     /gene_synonym="9430075J19Rik; A230098E07Rik; Brn-2; Brn2;
                     oct-7; OTF-7; Otf7"
                     /note="hexamer: ATTAAA"
     polyA_site      6239
                     /gene="Pou3f2"
                     /gene_synonym="9430075J19Rik; A230098E07Rik; Brn-2; Brn2;
                     oct-7; OTF-7; Otf7"
ORIGIN      
        1 gggcgggcgg gcgggaggca gcgcggcagc agcagtaata gcaagagcag caacagaagg
       61 cgtcggagcg ggcgtcggag ctgcccgcta ggggagagag agagagagag agagagagtg
      121 agagagagag agtgggagaa gcgggcgagc gaggagagag agagcccaag gcagaaaagt
      181 aactgtcaaa tgcgcggctc ctttaaccag agcgcccagt ccggctccga gagtcatggc
      241 gaccgcagcg tctaaccact acagcctgct cacctccagc gcctccatcg tacatgccga
      301 gccgcctggc ggcatgcagc agggcgcagg gggctaccgc gaggcgcaga gcctggtgca
      361 gggcgactac ggcgcgctgc agagcaacgg gcacccgctc agccacgctc accagtggat
      421 caccgcgctg tcccacggcg gcggcggcgg gggcggcggc ggcggtggag gaggcggggg
      481 aggcggcggg ggaggcggcg acggctcccc gtggtccacc agccccctag gccagccgga
      541 catcaagccc tcggtggtgg tacagcaggg tggccgaggc gacgagctgc acgggccagg
      601 agcgctgcag caacagcatc aacagcaaca gcaacagcag cagcagcagc agcagcagca
      661 gcagcagcaa cagcagcagc aacaacagcg accgccacat ctggtgcacc acgctgccaa
      721 ccaccatccc gggcccgggg catggcggag tgcggcggct gcagctcacc tccctccctc
      781 catgggagct tccaacggcg gtttgctcta ttcgcagccg agcttcacgg tgaacggcat
      841 gctgggcgca ggagggcagc cggctgggct gcaccaccac ggcctgaggg acgcccacga
      901 tgagccacac catgcagacc accacccgca tccgcactct cacccacacc agcaaccgcc
      961 cccgccacct cccccacaag gcccaccggg ccacccaggc gcgcaccacg acccgcactc
     1021 ggacgaggac acgccgacct cagacgacct ggagcagttc gccaagcaat tcaagcagag
     1081 gcggatcaaa ctcggattta ctcaagcaga cgtggggctg gcgcttggca ccctgtacgg
     1141 caacgtgttc tcgcagacca ccatctgcag gtttgaggcc ctgcagctga gcttcaagaa
     1201 catgtgcaag ctgaagcctt tgttgaacaa gtggttggaa gaggcagact catcctcggg
     1261 cagccccacc agcatagaca agatcgcagc gcaagggcgc aaacggaaaa agcggacctc
     1321 catcgaggtg agcgtcaagg gggctctgga gagccatttc ctcaaatgcc ctaagccctc
     1381 ggcccaggag atcacctccc tcgcggacag cttacagctg gagaaggagg tggtgagagt
     1441 ttggttttgt aacaggagac agaaagagaa aaggatgacc cctcccggag ggactctgcc
     1501 gggcgccgag gatgtgtatg ggggtagtag ggacacgcca ccacaccacg gggtgcagac
     1561 gcccgtccag tgaactcaag cgggggaggg gcagagcttg gggctcccct cccctttggt
     1621 ccacagtctt tcctgggacc tctgttttcc ctctaacttc tgattgtttt tttttttttt
     1681 ttaattatta ttttcccggt cccttaaaaa aggagaaaaa aaatagagaa aataggagaa
     1741 aggaaagtaa aacactggac tatcctatat caggtagcag gtgtaataat ggttttttga
     1801 cctttgcagg cgagagtacc caggcaatga agtagaatga atgtctccta gtgagaatga
     1861 agtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtggagaga gagagagagg
     1921 gagagagaga gagagagaga gagagagaga gagagagaga gagagagaaa gtcctggcaa
     1981 aactaaataa ataaattacc aaaaagagaa aacacacaca cacacaaaac tgcagcttcc
     2041 caatgctcaa agttgacacg tgctgctgtg tttatttaat atggatccac atcaggaaag
     2101 agggaataat acacttttta aaatataggc aaattttaac cacaagaatt tgcactgcaa
     2161 gaaaattgaa gtttacacta acaagttcaa cttttttctc tctctcttaa tacccacttt
     2221 taattttgaa actgtccttt gggttctgtt ttgttttgcc ttatccagtg gagaggacag
     2281 aagccagctc ttggccaccc tccattccca gtgttctgat gtcccttgtt cttattgctc
     2341 ctgaactttg ttttcttcag atcccccaga cctggtgtaa cacttattgg ctcttttcac
     2401 caaagcgaaa tgattggctt cacacaaaat aaataaatgt tggcattcag gaaatgtgtt
     2461 tggtttgccc gctttatgca aggcaaagtg ttgatcatcg gtttttgaaa accacaaagt
     2521 aaacttcatc ttcaggcagt atttctgggt aggagagaaa aagaaacaac tatagtgaag
     2581 tgatcagtca tttcattttt ttttttttca agcaagggct gttttgaaag aactcaaaaa
     2641 aataaaaata aaaacaatgt gaggtttaat atattgctag acttgtccaa cagacagaaa
     2701 attagaactc tgagaacttg gaaacacaca gtgtagttct ctgcctttgg gtttaataac
     2761 ttaattataa gggattagtc ctgatggcag cagtggttca actttgttcc tctatttggt
     2821 cttattgttt ttttaactta aagaaaataa cccgggaact tgacatcata tgcatagact
     2881 gtgtttctta acacacaaat ggacatacta tacttgcgta tatatatggg atagacaggt
     2941 tttgtctcca acttcattgt ttatgaagtc atattttggg ttttacacca tctccccccc
     3001 ataagttatt acagaaaaat atcagtttag attggacaaa gttcttcccc ctctcattaa
     3061 aaaagacaaa tgaaggagag ggatacattt taaatatttc ctttctcccc ctttgttaat
     3121 atttcagtgc atttttttta ccttgtctac atgggaaatg gcttactccc cacacaatag
     3181 aatattctgg aaggtgtagg taagaaaaca aaacagaaaa ggcaatggct atactgaaat
     3241 taacaccatt aaaactgtga tcagtttaaa aaattaaata gttatcagca caaaagggcg
     3301 ttaaaaggga aaacactttt ttattaacct taaatgtttc ggattttatt tctttgttag
     3361 gtatcagata aatgttattt caaacaatta aattctcact accataaaat tatggttcag
     3421 catcagatta gcactgcact ccgtagttaa ggttttagga aaaatgcttt atccagtatt
     3481 gtctttacaa acatctgtga ttgtttcatt ttcaatgttt ttacaagata aatggtgact
     3541 tataatgggc atatttattt gcctgtattt catttccccc aatgaatgtc acaggagatg
     3601 ccatagagct atttcaggtt atatcacact gcttgttcct gatgtgtggg gactggcctt
     3661 cagtgaagca atccagagaa gggcaaatag ccaatggtaa aaggaggaaa tgaatgtgca
     3721 gataccaagt aggtaaggtc cgaagctggg gttctctctt gctctcttag gcttacaaag
     3781 atggacatta ccactgaacc ttaccatatg tatatatgtt taatatctgt cttttgaaat
     3841 gcagaaatag tttaaatgtt tctttgtcta tttttctttt tctttttttt aaatgctacc
     3901 cagggaaata ttttcatatc gttttacgtg gcctgcctca atgtatattt atttctttgg
     3961 agcaaaaagg ttctgaaaac tggttttctg tagctttaaa tgagtaggta gcaagatcta
     4021 tatgggatgt catttttttg ttcagtttct ttttaaaaaa tgctttgttt tgatacattt
     4081 ggttgtgctt gtggggaaaa taaaagcgca gagatcctta tatatttatg ttaaagtaat
     4141 attttattat tacataaaac agaaatgcac aataccttca tagtttgttc taattattga
     4201 aatatcttta ttttattttt aaagatagtg ccaagttcta agaatcgagg aagccctacc
     4261 tagacctgac tgagctgagt tgtgtataaa atagttccct tcctttatac gtcataaagt
     4321 tttggaataa attttatgca tatattgcca gctttcatgt ttataacttc cagaggcatt
     4381 tccttgtttt tttgtttttt tttgtttttg tttgtttgtt tgttttaatg aagactgttc
     4441 agacttttct ttgcagaaac tatcatgggg cccaaatatt ttcttcacca ccctgtagaa
     4501 ttaaatcaaa ggagtcattg ggtttcagct tcaatttgtt tgccatttcc tgaacaaacg
     4561 aataaacata cttgccttgt aaataaatac atgcccaggt ccctatgcct tttccccagg
     4621 ttagccgcac ctttgccaat gggttgttga ggaaaacatc agtggaacta gatggacctt
     4681 agcctctgcc acaggttctt agataacctg ggaccttcag aaaagtgaga cttagaaagg
     4741 aattattatg cataattaac aaatatcttt cagcaacaaa aatcttgaca aaatatgcca
     4801 tataccatat taccaactga ttaaaagtag attctacaca ttattcctgt taggtttaca
     4861 gggaaaaata ctttttacaa aggtttttac aacagtgtat ctctctcatc aggcaaacaa
     4921 acaacaagct ctacaataaa agaggaggga aagaatgtat tggagagatt caagccatgg
     4981 tgggaatggt ttgtttcaga aggttttaga tagagctctg cacctaaaac aacaaacaaa
     5041 caaacaaaaa gatagtgttt aatgatagtg aagtgtccaa tcagtgttgg attagtttat
     5101 atatttgttg gtgtatttaa agtccttctt ggaacactga cgtaaaatat aaatgttcat
     5161 ttaggaaagt agtttctggg cttattacat ctgatcatct tttctaattc ctagtcaata
     5221 ttacatgggc cccaaacaga ttctaccaaa tgatcttatc aatagtctga acaagaagtg
     5281 acagaaagaa gaagtgtttt gtgaccacag acatgctgat gggtaaaatg tttaagctag
     5341 gtatagattt gagttctggg tcaatatccc tcctctgaag gaggaaagcg agctgcatcc
     5401 gccctctgca gggcgtttgg acagaccttg agaaggcatt tttgttctta gccacaggcg
     5461 ctatgaacag acctggaaac atcatatatt aaacagacac actatgttcc cgactcatgc
     5521 tggccattca ggtcctaaag ctgctctggt aacttccgtg ctaagtctta gaatgtattc
     5581 ccactactta aaaaaaaaaa aaaaaaaaaa aaaaaaaaga ctacagagcc actaatacaa
     5641 gtctgtgggg cagttgtaag atacagacaa gccatctcta tcctaaagaa aaaatgcagt
     5701 gtttgtgttt gctgaaaaca tgccatattt tagatttatg atatatctat atatatatac
     5761 tggggaagaa attatcatat atgaaaaagt atgtgaaggt cataagaatg gaatggccaa
     5821 aaataatatt atgcttggtg tttttttttt aaatacattc tcagttcccc tgaagaaatg
     5881 ttctttatgt ttcagatagt agtagtaaaa ctgccctcct catcctctca cctcctgctc
     5941 ctatagagga ggtcacacac tgtcagaatt ttctggtgaa atggttttga tggagacact
     6001 catctctcta tcttattcct tcaaaagtaa ccaataaaac aatacaacag caaaggtggg
     6061 tggctcttgc atgtgttgct cccagccatg cgtctccact ggccctttag tttccttatg
     6121 gaagcttgga tgaaattatc atcttattac gcctctcttt gatttgtctt tgttgatttt
     6181 tcaatcaatt catggaactg tgctctggat tctattaaat tcctatacaa attttaaaat
     6241 aggacagaga atggagtttg tacgtggggg gg
//
