LOCUS       NM_011139               2522 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus POU domain, class 2, transcription factor 3 (Pou2f3),
            mRNA.
ACCESSION   NM_011139
VERSION     NM_011139.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2522)
  AUTHORS   Billipp,T.E., Fung,C., Webeck,L.M., Sargent,D.B., Gologorsky,M.B.,
            Chen,Z., McDaniel,M.M., Kasal,D.N., McGinty,J.W., Barrow,K.A.,
            Rich,L.M., Barilli,A., Sabat,M., Debley,J.S., Wu,C., Myers,R.,
            Howitt,M.R. and von Moltke,J.
  TITLE     Tuft cell-derived acetylcholine promotes epithelial chloride
            secretion and intestinal helminth clearance
  JOURNAL   Immunity 57 (6), 1243-1259 (2024)
   PUBMED   38744291
REFERENCE   2  (bases 1 to 2522)
  AUTHORS   Ushio,A., Matsuda-Lennikov,M., Kalle-Youngoue,F., Shimizu,A.,
            Abdelmaksoud,A., Kelly,M.C., Ishimaru,N. and Takahama,Y.
  TITLE     Functionally diverse thymic medullary epithelial cells interplay to
            direct central tolerance
  JOURNAL   Cell Rep 43 (4), 114072 (2024)
   PUBMED   38581680
REFERENCE   3  (bases 1 to 2522)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2522)
  AUTHORS   Li,Y., Han,M., Singh,S., Breckenridge,H.A., Kreger,J.E.,
            Stroupe,C.C., Sawicky,D.A., Kuo,S., Goldsmith,A.M., Ke,F.,
            Shenoy,A.T., Bentley,J.K., Matsumoto,I. and Hershenson,M.B.
  TITLE     Tuft cells are required for a rhinovirus-induced asthma phenotype
            in immature mice
  JOURNAL   JCI Insight 9 (2), e166136 (2024)
   PUBMED   38061015
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2522)
  AUTHORS   Kim,D.H., Wang,Y., Jung,H., Field,R.L., Zhang,X., Liu,T.C., Ma,C.,
            Fraser,J.S., Brestoff,J.R. and Van Dyken,S.J.
  TITLE     A type 2 immune circuit in the stomach controls mammalian
            adaptation to dietary chitin
  JOURNAL   Science 381 (6662), 1092-1098 (2023)
   PUBMED   37676935
REFERENCE   6  (bases 1 to 2522)
  AUTHORS   Ohno,H., Goto,S., Taki,S., Shirasawa,T., Nakano,H., Miyatake,S.,
            Aoe,T., Ishida,Y., Maeda,H., Shirai,T. et al.
  TITLE     Targeted disruption of the CD3 eta locus causes high lethality in
            mice: modulation of Oct-1 transcription on the opposite strand
  JOURNAL   EMBO J 13 (5), 1157-1165 (1994)
   PUBMED   8131747
REFERENCE   7  (bases 1 to 2522)
  AUTHORS   Yukawa,K., Yasui,T., Yamamoto,A., Shiku,H., Kishimoto,T. and
            Kikutani,H.
  TITLE     Epoc-1: a POU-domain gene expressed in murine epidermal basal cells
            and thymic stromal cells
  JOURNAL   Gene 133 (2), 163-169 (1993)
   PUBMED   8224904
REFERENCE   8  (bases 1 to 2522)
  AUTHORS   Lerner,A., D'Adamio,L., Diener,A.C., Clayton,L.K. and Reinherz,E.L.
  TITLE     CD3 zeta/eta/theta locus is colinear with and transcribed antisense
            to the gene encoding the transcription factor Oct-1
  JOURNAL   J Immunol 151 (6), 3152-3162 (1993)
   PUBMED   8376772
REFERENCE   9  (bases 1 to 2522)
  AUTHORS   Andersen,B., Schonemann,M.D., Flynn,S.E., Pearse,R.V. 2nd, Singh,H.
            and Rosenfeld,M.G.
  TITLE     Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors
            expressed in epidermis
  JOURNAL   Science 260 (5104), 78-82 (1993)
   PUBMED   7682011
  REMARK    Erratum:[Science. 1993 Dec 3;262(5139):1499.. PMID: 8248794]
REFERENCE   10 (bases 1 to 2522)
  AUTHORS   Goldsborough,A., Ashworth,A. and Willison,K.
  TITLE     Cloning and sequencing of POU-boxes expressed in mouse testis
  JOURNAL   Nucleic Acids Res 18 (6), 1634 (1990)
   PUBMED   1970171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC173346.1, AK153697.1 and AC110169.7.
            
            On Dec 9, 2006 this sequence version replaced NM_011139.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164134
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC173346.1         172122-172223       c
            103-2421            AK153697.1         193-2511
            2422-2522           AC110169.7         43341-43441
FEATURES             Location/Qualifiers
     source          1..2522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.21 cM"
     gene            1..2522
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /note="POU domain, class 2, transcription factor 3"
                     /db_xref="GeneID:18988"
                     /db_xref="MGI:MGI:102565"
     exon            1..102
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1370
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /note="oct-11; octamer-binding protein 11; octamer-binding
                     transcription factor 11"
                     /codon_start=1
                     /product="POU domain, class 2, transcription factor 3"
                     /protein_id="NP_035269.2"
                     /db_xref="CCDS:CCDS40596.1"
                     /db_xref="GeneID:18988"
                     /db_xref="MGI:MGI:102565"
                     /translation="MVNLEPMHTEIKMSGDVADSTDTRSTFGQVEPGNDRNGLDFNRQ
                     IKTEDLGDSLQQTLSHRPCHLSQGPTMMPGNQMSGDMASLHPLQQLVLVPGHLQSVSQ
                     FLLSQTPPGQQGLQPNLLSFPQQQSTLLLPQTGPGLASQAVGRPGLSGSSLEPHLDAP
                     QHLPGPKHLPGPGGNDEPTDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFS
                     QTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSASTPSSYPTLSEVFGRKRK
                     KRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINC
                     PVATPVKPPIYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLH
                     ASSPTASQNNSKAAMNSSSSSSFNSSGSWYRWNHPTYLH"
     exon            103..171
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     exon            172..206
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     exon            207..311
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     exon            312..414
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     exon            415..497
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     exon            498..680
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     exon            681..822
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     exon            823..959
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1121
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1188
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1330
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..2522
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2480..2485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
                     /note="hexamer: AATATA"
     polyA_site      2518
                     /gene="Pou2f3"
                     /gene_synonym="Epoc-1; Oct-11a; Oct11; Otf-11; Otf11;
                     Skin; Skin-1a; Skn-1a; Skn-li"
ORIGIN      
        1 cttccccggg ggccaggctg gggcagcagc gagggacctg ggggggcgca ggctttggcc
       61 ccgcctgggg caggatggtg aatctggagc ccatgcacac agagatcaag atgagtgggg
      121 atgtcgctga ttccacggac acccgcagca ctttcggtca agtggagcca ggaaatgatc
      181 gaaatggcct agatttcaac agacagatta agacggagga tctgggtgac tctctacagc
      241 agaccctctc ccacaggcca tgccacctga gccaaggacc taccatgatg cctggaaacc
      301 aaatgtctgg ggacatggct tctctccatc cactccagca gctcgtgctg gtccctggcc
      361 acttgcagtc tgtatcccag ttcctgcttt cccagacccc acctgggcag caaggtctgc
      421 agccgaatct tctctccttt ccacagcaac aaagcactct actcctccca cagacagggc
      481 ctggccttgc ctcccaggca gttgggcgcc ctgggctatc aggatcctct ttagagcccc
      541 acctggacgc tcctcaacac ctgccagggc ccaagcatct gcctggcccc ggagggaatg
      601 atgagcccac tgacctggag gagctggaga agttcgccaa gaccttcaag cagagacgca
      661 ttaagctagg cttcacacag ggagatgtgg gactggcgat gggaaagctg tatggcaatg
      721 acttcagcca gactaccatc tcgcgatttg aggccctcaa cctgagcttc aagaacatgt
      781 gcaaactcaa gccactgctg gagaagtggt tgaatgatgc agagtcctcc ccgtcagacc
      841 cttcagcgag cacacccagc tcctacccca ctctcagcga agtgtttggc aggaagagga
      901 agaaacggac cagcatcgag accaacatac gcctgacttt ggagaagcga tttcaagata
      961 acccgaaacc cagctcggaa gagatctcca tgattgcgga gcagttatcg atggagaagg
     1021 aggtggtgag agtctggttc tgcaatcgac gccaaaagga gaagagaatc aactgccccg
     1081 tggccacccc tgtcaaacca cccatctaca actcccggct ggtctctccc tcagggtctc
     1141 tgggccccct ctcagtccct cctgtccaca gcaccatgcc tggaacagta acgtcatcct
     1201 gttcccctgg gaacaacagc aggccttcgt ctcctggttc aggactccat gccagcagcc
     1261 ccacagcatc tcaaaataac tccaaagcag caatgaactc ctcctcctcc tccagcttta
     1321 actcctcggg atcatggtac cgttggaatc atcctaccta cctccactga gaccaaaaac
     1381 ttcctccctt tccacctggc ccctagttcc caaaaggagg aagagagtcg tgccttccac
     1441 atagggacag acactttgag aagaatggga gcaatggcca ctgctgaaga gcaaacccat
     1501 agtcttgcct tctcctggat ccagagcttt cggagaacct aactgtgacc aaaggccgca
     1561 ctcttgcctt gggctcttca tcaccccgct gggagtttac tgtgttcgcc tgccttgggg
     1621 ccccctccat gctctcctgg tggcttgacc tcttggagaa agggcattct gccattgtta
     1681 gttttcagct cacccatggg cttctaggac agccttttgc tcggtgtgcc aaactgcaag
     1741 aagggtagat tatggctttg actctgacct cagccacaat cccgaacaga tcccaaattc
     1801 tatggaaaga ctgaaatctc acgtctccac caaagcctta tcttgttaaa ttagcacagt
     1861 tttcccatgg aatctccatt tttgcccaat tttctttcag cccttactcc cttttctaca
     1921 accaaatctg tctattcctg ggtcctacaa agtcccttcc tctctacaaa tggctgagct
     1981 accctctggc catgttgttc catccacagg tactcctctg ttacccacat gtacccaaat
     2041 tccaggacat tgtcttttct ctgctccctg tgggtctcct tgtccggtcc cctctccttt
     2101 ctcctggcca cagaaaagtg atggctgcgt tcttgtacat agtcctttcc tattctgcac
     2161 catgaccttt ctttaatgtg taatttccag caagatgttt aactcaggtg tgaactttga
     2221 agatgtttct atattatttt atcttccatt agaaaaggaa gggggatacc aaagtgtgta
     2281 ataccccaca gagttccccc gtgagctggg gttctgttga cttgggggga accttatatg
     2341 tggagtctcc ttctgtggat ctgtatgtaa agctgtcaca tgaaagccat cccagaaatg
     2401 gtaccttttt tttttttttt ttcctaaaga ctgaatatcc aggaaactgt tgagactcaa
     2461 aggaatctct ctgtttctaa atatatttgt acagcaatga cataaagtat tccactgtta
     2521 at
//
