LOCUS       NM_001417133            4288 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus POU domain, class 2, transcription factor 2 (Pou2f2),
            transcript variant 6, mRNA.
ACCESSION   NM_001417133 XM_030242223
VERSION     NM_001417133.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4288)
  AUTHORS   Deska-Gauthier,D., Borowska-Fielding,J., Jones,C., Zhang,H.,
            MacKay,C.S., Michail,R., Bennett,L.A., Bikoff,J.B. and Zhang,Y.
  TITLE     Embryonic temporal-spatial delineation of excitatory spinal V3
            interneuron diversity
  JOURNAL   Cell Rep 43 (1), 113635 (2024)
   PUBMED   38160393
REFERENCE   2  (bases 1 to 4288)
  AUTHORS   Yang,J., Guo,Q., Wang,L. and Yu,S.
  TITLE     POU Domain Class 2 Transcription Factor 2 Inhibits Ferroptosis in
            Cerebral Ischemia Reperfusion Injury by Activating Sestrin2
  JOURNAL   Neurochem Res 48 (2), 658-670 (2023)
   PUBMED   36306010
  REMARK    GeneRIF: POU Domain Class 2 Transcription Factor 2 Inhibits
            Ferroptosis in Cerebral Ischemia Reperfusion Injury by Activating
            Sestrin2.
REFERENCE   3  (bases 1 to 4288)
  AUTHORS   Puri,N.M., Romano,G.R., Lin,T.Y., Mai,Q.N. and Irannejad,R.
  TITLE     The organic cation transporter 2 regulates dopamine D1 receptor
            signaling at the Golgi apparatus
  JOURNAL   Elife 11, e75468 (2022)
   PUBMED   35467530
  REMARK    GeneRIF: The organic cation transporter 2 regulates dopamine D1
            receptor signaling at the Golgi apparatus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4288)
  AUTHORS   Sagner,A., Zhang,I., Watson,T., Lazaro,J., Melchionda,M. and
            Briscoe,J.
  TITLE     A shared transcriptional code orchestrates temporal patterning of
            the central nervous system
  JOURNAL   PLoS Biol 19 (11), e3001450 (2021)
   PUBMED   34767545
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4288)
  AUTHORS   Song,S., Cao,C., Choukrallah,M.A., Tang,F., Christofori,G.,
            Kohler,H., Wu,F., Fodor,B.D., Frederiksen,M., Willis,S.N.,
            Jackson,J.T., Nutt,S.L., Dirnhofer,S., Stadler,M.B. and Matthias,P.
  TITLE     OBF1 and Oct factors control the germinal center transcriptional
            program
  JOURNAL   Blood 137 (21), 2920-2934 (2021)
   PUBMED   33512466
  REMARK    GeneRIF: OBF1 and Oct factors control the germinal center
            transcriptional program.
REFERENCE   6  (bases 1 to 4288)
  AUTHORS   Watson,M.L., Rao,J.K., Gilkeson,G.S., Ruiz,P., Eicher,E.M.,
            Pisetsky,D.S., Matsuzawa,A., Rochelle,J.M. and Seldin,M.F.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   7  (bases 1 to 4288)
  AUTHORS   Kang,S.M., Tsang,W., Doll,S., Scherle,P., Ko,H.S., Tran,A.C.,
            Lenardo,M.J. and Staudt,L.M.
  TITLE     Induction of the POU domain transcription factor Oct-2 during
            T-cell activation by cognate antigen
  JOURNAL   Mol Cell Biol 12 (7), 3149-3154 (1992)
   PUBMED   1620122
REFERENCE   8  (bases 1 to 4288)
  AUTHORS   Stoykova,A.S., Sterrer,S., Erselius,J.R., Hatzopoulos,A.K. and
            Gruss,P.
  TITLE     Mini-Oct and Oct-2c: two novel, functionally diverse murine Oct-2
            gene products are differentially expressed in the CNS
  JOURNAL   Neuron 8 (3), 541-558 (1992)
   PUBMED   1550677
REFERENCE   9  (bases 1 to 4288)
  AUTHORS   Rudert,F., Saunders,A.M., Rebstock,S., Thompson,J.A. and
            Zimmermann,W.
  TITLE     Characterization of murine carcinoembryonic antigen gene family
            members
  JOURNAL   Mamm Genome 3 (5), 262-273 (1992)
   PUBMED   1638085
REFERENCE   10 (bases 1 to 4288)
  AUTHORS   Stepchenko,A.G.
  TITLE     [Interaction of Oct-binding transcription factors with a large
            series of 'noncanonical' oct-sequences. Primary sequence of murine
            Oct-2B cDNA]
  JOURNAL   Dokl Akad Nauk 325 (1), 175-178 (1992)
   PUBMED   1425197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120393.16.
            
            On Feb 27, 2023 this sequence version replaced XM_030242223.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3032688.1,
                                           SRR17784648.267967.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC120393.16        154679-154845       c
            168-228             AC120393.16        140640-140700       c
            229-294             AC120393.16        101935-102000       c
            295-329             AC120393.16        101803-101837       c
            330-386             AC120393.16        101620-101676       c
            387-569             AC120393.16        96817-96999         c
            570-848             AC120393.16        96250-96528         c
            849-954             AC120393.16        80917-81022         c
            955-1046            AC120393.16        80731-80822         c
            1047-1160           AC120393.16        78433-78546         c
            1161-1302           AC120393.16        78172-78313         c
            1303-1451           AC120393.16        77921-78069         c
            1452-1628           AC120393.16        77669-77845         c
            1629-1695           AC120393.16        75569-75635         c
            1696-1897           AC120393.16        74264-74465         c
            1898-1971           AC120393.16        74067-74140         c
            1972-4288           AC120393.16        71465-73781         c
FEATURES             Location/Qualifiers
     source          1..4288
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.73 cM"
     gene            1..4288
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /note="POU domain, class 2, transcription factor 2"
                     /db_xref="GeneID:18987"
                     /db_xref="MGI:MGI:101897"
     exon            1..167
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            168..228
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            229..294
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..2297
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /note="isoform 5 is encoded by transcript variant 6;
                     octamer-binding protein 2; octamer-binding transcription
                     factor 2; lymphoid-restricted immunoglobulin
                     octamer-binding protein NF-A2"
                     /codon_start=1
                     /product="POU domain, class 2, transcription factor 2
                     isoform 5"
                     /protein_id="NP_001404062.1"
                     /db_xref="GeneID:18987"
                     /db_xref="MGI:MGI:101897"
                     /translation="MSKPLEAEKQSLDSPSEHTDTERNGPDINHQNPQNKASPFSVSP
                     TGPSTKVGILSGLHLTFWGPGPCLSPPQIKAEDPSGDSAPAAPPPPQPAQPHLPQAQL
                     MLTGSQLAGLSALIPAQQQLLLQQAQAQLLAAAVQQSSAAAANAAAAAAAASTSSSTS
                     SASSSTSQTPASSGGGDLPPSQPTSQPPGTPQLTLSQPIQLTAQDIQQLLQLQQLVLV
                     PGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLE
                     PPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEAL
                     NLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIE
                     TNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPM
                     LPSPGKPTSYSPHLVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGG
                     GGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSAGSTMVGLSSGLSP
                     ALMSNNPLATIQALASGGTLPLTSLDGSGNLVLGAAGAAPGSPSLVTSPLFLNHTGLP
                     LLSAPPGVGLVSAAAAAVAASISSKSPGLSSSSSSSSSSTCSDVAAQTPGGPGGPEAG
                     SKAE"
     exon            295..329
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..386
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            387..569
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            570..848
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..954
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1046
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1160
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1302
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1451
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1628
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1695
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1897
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1971
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..4288
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4288
                     /gene="Pou2f2"
                     /gene_synonym="Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2;
                     Otf2"
                     /note="major polyA site"
ORIGIN      
        1 actgtggcta gcggtcactg aaggatgaca ggctgagctg tgttctgagg agggggatcg
       61 ccccgaggca tgggccgagg gtcacacaac agggtacatc ggattccctt gaggaaagag
      121 tcaggcagac cccgaaaggg ctccgatggt ccggatggtt ctgccaggtt ctcggctgga
      181 ccgggttggt ggcctgaatg tattagcttt gctctgtctg cccaagagaa ataagaatgt
      241 ctaagcccct ggaggccgag aagcaaagtc tggactcccc gtcagagcac acagacaccg
      301 aaagaaatgg acccgacatt aaccatcaga acccccagaa taaagcgtcc ccattctctg
      361 tgtccccaac tggccccagc accaaggtgg gcattctctc tggcctccac ttaacattct
      421 ggggtcccgg accctgcctc tctcctcccc agatcaaggc tgaagacccc agtggcgatt
      481 cagccccagc agcacccccg cccccccagc cggctcagcc tcatctgccc caggcccaac
      541 tcatgctgac gggcagccag ctagctgggc tctcagcact gatacctgct cagcagcaac
      601 tcctccttca gcaagctcag gcccagctgc tggccgctgc cgtccagcag tccagcgccg
      661 ctgccgccaa cgctgctgct gccgccgctg ccgcctccac ctcctcctcc acctcttccg
      721 cctcctcctc cacctcgcag accccagcct cctctggggg aggcgacctg ccaccatcac
      781 agcctaccag ccagccccca gggaccccac agctcacctt gtcccaaccc atccagctca
      841 cagcacagga catacagcaa ctcctccagc tccagcagct ggtgcttgtc cccggccacc
      901 acctccagcc acctgctcag ttcctgctgc cacaggcaca gcagagtcag ccaggcctgc
      961 taccaacgcc aaatctattc cagctacctc aacaaaccca gggagctctc ctgacctccc
     1021 agccccgggc tgggcttcct acacagcccc cgaaatgctt ggagccgccc tcccacccgg
     1081 aggagcccag cgatctggag gagctggaac agtttgctcg caccttcaag caacgccgca
     1141 tcaagctggg cttcacacag ggtgatgtgg gcctggccat gggcaagctc tatggcaacg
     1201 acttcagcca aacgaccatt tcccgcttcg aggccctcaa cctgagcttc aagaacatgt
     1261 gtaaactcaa gcccctcctg gagaagtggc tcaacgacgc agagactatg tctgtggatt
     1321 caagcctacc cagcccaaac cagctgagca gccccagcct gggtttcgac gggctgccgg
     1381 ggcggagacg caagaagagg accagcatcg agacgaatgt ccgcttcgcc ttagagaaga
     1441 gtttcctagc gaaccagaag cctacctcag aggagatcct gctgatcgca gagcagctgc
     1501 acatggagaa ggaagtgatc cgcgtctggt tctgcaaccg gcgccagaag gagaaacgca
     1561 tcaacccttg cagtgcggcc cccatgctgc ccagcccggg aaagccgacc agctacagcc
     1621 ctcacctggt cacaccccaa gggggcgcag ggaccttacc attgtcccaa gcttctagca
     1681 gtctgagcac aacagttact accttatcct cagctgtggg gacgctccat cccagccgga
     1741 cagcaggagg gggtgggggt gggggcggag ctgcgccccc cctcaattcc atcccctctg
     1801 tcactccccc acccccggcc accaccaaca gcacaaaccc gagccctcaa ggcagccact
     1861 cggctattgg cttgtcgggc ctgaacccca gcgcgggaag cacaatggtg gggttgagct
     1921 ctgggctgag tccagccctc atgagcaaca accctttggc cactatccaa gccctggcct
     1981 ctggtggaac cctgcccctt accagccttg atggcagcgg gaacctggtg ctgggggcag
     2041 ccggtgcggc cccagggagt cccagcttag taacctcgcc tctcttcttg aaccacaccg
     2101 gtctgccgct gctcagtgcc ccaccaggcg tgggcctggt ctcagcggcg gctgcagccg
     2161 tagcagcatc catctccagc aagtctcctg gcctctcctc gtcttcttca tcctcatcat
     2221 cctccacgtg cagtgatgtg gcagcacaga cccctggagg ccccggagga cccgaggcgg
     2281 ggtccaaggc tgagtgagag ccggccatgc ctcccctcct actcctctga atctcccgac
     2341 cttggtcccc tgcccaagag agggtaagga ggctggtggg ggatacggtg ggtccttgga
     2401 gcaggagtga caaaggagga aaagaccaaa aatccaacca aaaagaaaag aaaagaaaaa
     2461 acgacaaaac aaaaaaaata aataaataaa caaaaaaaca aagagaccaa ccaacaaaaa
     2521 agaaaaccaa aaatattcac aacagaaacc agctgcccta aaggaaacag atggaaaaca
     2581 aagaaacgaa caactacaac aaaacaacaa caacaacaac aaaaaacacc tccaaactaa
     2641 ccaaacaccc ccacccccaa accaaacaaa ccaaaaacca gtcttgagcc agatcttgga
     2701 gtgctcactg ctatgacacc aaataagaac cttcagccag gagcggagca gcctccagca
     2761 ggtcggacct catgccgcgg agccctggct gtgggaccaa ctcctaacct taccccactg
     2821 agggtgggca gagaaggaac cagagaatgt gccagcttgc tggcccagcc ccagctctgg
     2881 gccaatggag acaggtactg cctggggcag gaggcccagg gcccagagcc acctaccaaa
     2941 tggtcttttc cacaaggtaa aagagaaagg acccgaacaa ccttacacca aatactcagt
     3001 agcttcatcc aaaggatgta cagagttttc agcgttgcgc tcaacagaat gtgtgtccct
     3061 tctacgtgtt tcctcccccc ccagcccccc agctctcccc aacagggcag ggggtctcgc
     3121 tttaacccct ccccccgcca cccccagtct ggggagagtt cagaggaagg cctgggaatg
     3181 ggcttttttg tcctctgccc ctttctttct ccctttgaag ggtgggctag gccatttttt
     3241 gccgagttcc agctctcaaa agcccctcct gagctccccc atcacctttc tgctctggag
     3301 tctacctcct ccccagactg tgggaaggtg gtcggttcaa gcaaaggggg atacagtgag
     3361 ggcaaccaag ttgtctttct tcccatcctg tctgtcagtt tccctgaaaa aaaaaatcat
     3421 attccagtgc ctatccgtgg gatcttcacg ttctttgaca ttaaccagaa accaaaaaga
     3481 ttaactcgcc tcgctctgcc caccctacac cccctatgat actggcagat acctctcctg
     3541 tccccttccc tccccacctt ccaatgcaca cacgcacaca ccccagtggt gggctcctcc
     3601 ggatggcatc tccatcagaa ccacatggtg gtgacatcac tatgacctgt ggttccccat
     3661 gcaagtggct accactccca cgagacctcc acgagtattg gctggaccct gtatttgcct
     3721 agctctggac aaatctcaac agtggacaga ggagatgcta ctgggagcca ccatgccctc
     3781 ctaccatgga ggccaacaaa gttttgaacc aaaaaaaaaa aaccaaacca aacaaacaaa
     3841 cacacacaaa acccaacaaa aaacaaaaac agaaaaccaa acaaacaata aattaaaact
     3901 agaaaaaaga atttatagat atatatatag atatatatat atatgggaaa gaagatgtgg
     3961 actcttcaag acaagaatga gccgcaagat ggagccaagc cctgcagggt gatccaggcc
     4021 tttggttgcc ggggcggatg gaacgatgga cgcttctttc tcttcacaaa tacctcatgg
     4081 acgtcgtctt cggaaagccg gaggggggtg cggctggggc agggcctgtc cctcagccag
     4141 ggtggatgga agcgggtggg tggggctgag aaagggtgtc agggacatgg gtgaaagaga
     4201 ccccaagctc cctccctgcc aatcaaccga aaaagcttta aaagaaaaaa aaaaggagaa
     4261 gcaaaaagaa tggacgaagg aaaaccaa
//
