LOCUS       NM_198932              12906 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus POU domain, class 2, transcription factor 1 (Pou2f1),
            transcript variant 2, mRNA.
ACCESSION   NM_198932
VERSION     NM_198932.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12906)
  AUTHORS   Feng,N., Yu,H., Wang,Y., Zhang,Y., Xiao,H. and Gao,W.
  TITLE     Exercise training attenuates angiotensin II-induced cardiac
            fibrosis by reducing POU2F1 expression
  JOURNAL   J Sport Health Sci 12 (4), 464-476 (2023)
   PUBMED   36374849
  REMARK    GeneRIF: Exercise training attenuates angiotensin II-induced
            cardiac fibrosis by reducing POU2F1 expression.
REFERENCE   2  (bases 1 to 12906)
  AUTHORS   Perovanovic,J., Wu,Y., Abewe,H., Shen,Z., Hughes,E.P., Gertz,J.,
            Chandrasekharan,M.B. and Tantin,D.
  TITLE     Oct1 cooperates with the Smad family of transcription factors to
            promote mesodermal lineage specification
  JOURNAL   Sci Signal 16 (781), eadd5750 (2023)
   PUBMED   37071732
  REMARK    GeneRIF: Oct1 cooperates with the Smad family of transcription
            factors to promote mesodermal lineage specification.
REFERENCE   3  (bases 1 to 12906)
  AUTHORS   Alam,S.S., Kumar,S., Beauchamp,M.C., Bareke,E., Boucher,A.,
            Nzirorera,N., Dong,Y., Padilla,R., Zhang,S.J., Majewski,J. and
            Jerome-Majewska,L.A.
  TITLE     Snrpb is required in murine neural crest cells for proper splicing
            and craniofacial morphogenesis
  JOURNAL   Dis Model Mech 15 (6) (2022)
   PUBMED   35593225
REFERENCE   4  (bases 1 to 12906)
  AUTHORS   Kotnova,A.P., Stepchenko,A.G., Ilyin,Y.V., Georgieva,S.G. and
            Pankratova,E.V.
  TITLE     5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1
            Isoform in Namalwa Burkitt's Lymphoma Cell Culture
  JOURNAL   Dokl Biochem Biophys 503 (1), 76-79 (2022)
   PUBMED   35538282
  REMARK    GeneRIF: 5-Azacytidine Suppresses the Expression of Tissue-Specific
            Oct-1 Isoform in Namalwa Burkitt's Lymphoma Cell Culture.
REFERENCE   5  (bases 1 to 12906)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   6  (bases 1 to 12906)
  AUTHORS   Verrijzer,C.P., Alkema,M.J., van Weperen,W.W., Van Leeuwen,H.C.,
            Strating,M.J. and van der Vliet,P.C.
  TITLE     The DNA binding specificity of the bipartite POU domain and its
            subdomains
  JOURNAL   EMBO J 11 (13), 4993-5003 (1992)
   PUBMED   1361172
REFERENCE   7  (bases 1 to 12906)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   8  (bases 1 to 12906)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   9  (bases 1 to 12906)
  AUTHORS   Stepchenko,A.G.
  TITLE     The nucleotide sequence of mouse OCT-1 cDNA
  JOURNAL   Nucleic Acids Res 20 (6), 1419 (1992)
   PUBMED   1561098
REFERENCE   10 (bases 1 to 12906)
  AUTHORS   Siracusa,L.D., Rosner,M.H., Vigano,M.A., Gilbert,D.J., Staudt,L.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of the octamer transcription factors, Otf-1,
            Otf-2, and Otf-3, defines multiple Otf-3-related sequences
            dispersed in the mouse genome
  JOURNAL   Genomics 10 (2), 313-326 (1991)
   PUBMED   1676977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093371.6.
            
            On Aug 26, 2011 this sequence version replaced NM_198932.2.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, compared to variant 1. It encodes isoform Z, which
            is shorter than isoform A.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF508939.1, SRR7345562.3818744.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC093371.6         1091-1163
            74-139              AC093371.6         71998-72063
            140-240             AC093371.6         86703-86803
            241-294             AC093371.6         88562-88615
            295-417             AC093371.6         90376-90498
            418-606             AC093371.6         92249-92437
            607-733             AC093371.6         94719-94845
            734-828             AC093371.6         96946-97040
            829-1002            AC093371.6         101412-101585
            1003-1144           AC093371.6         105959-106100
            1145-1290           AC093371.6         107143-107288
            1291-1470           AC093371.6         108641-108820
            1471-1576           AC093371.6         111810-111915
            1577-1922           AC093371.6         123250-123595
            1923-2011           AC093371.6         126660-126748
            2012-12906          AC093371.6         127677-138571
FEATURES             Location/Qualifiers
     source          1..12906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 73.21 cM"
     gene            1..12906
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /note="POU domain, class 2, transcription factor 1"
                     /db_xref="GeneID:18986"
                     /db_xref="MGI:MGI:101898"
     exon            1..73
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2322
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /note="isoform Z is encoded by transcript variant 2;
                     ubiquitous transcription factor; octamer-binding protein
                     1; octamer-binding transcription factor 1"
                     /codon_start=1
                     /product="POU domain, class 2, transcription factor 1
                     isoform Z"
                     /protein_id="NP_945150.2"
                     /db_xref="CCDS:CCDS48430.1"
                     /db_xref="GeneID:18986"
                     /db_xref="MGI:MGI:101898"
                     /translation="MADGGAASQDESSAAAAAAADSRMNNPSETNKSSMESEDASTGT
                     QTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTSLQAAAQSLNVQSKSSEESG
                     DSQQSSQPSSQPPSVQSAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAA
                     VQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVL
                     VHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQPQPSITLTSQPTTP
                     TRTIAAASVQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVG
                     LAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSTASSPSAL
                     NSPGLGAEGLNRRRKKRTSIETNIRVALEKSFMENQKPTSEDITLIAEQLNMEKEVIR
                     VWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPASLVATTPSLVTSSTATTLTVNPVL
                     PLTSAAVTNLSLTGTTDSTSNNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASS
                     ASETNTTQTTSTPLPSPLGASQVMVTTPGLQTAAAALQGAAQLPANASLAAMAAAAGL
                     SPGLMAPSQFAAGGALLSLSPGTLGSALSPALMSNSTLATIQALASSGSLPITSLDAT
                     GNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASTGNSAPTASLHASST
                     STESIQSSLFTVASASGPASTTTAASKAQ"
     exon            74..139
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            140..240
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            241..294
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..417
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..606
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..733
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..828
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1002
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1144
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1290
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1470
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1576
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1922
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2011
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..12906
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12885..12890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /note="hexamer: ATTAAA"
     polyA_site      12906
                     /gene="Pou2f1"
                     /gene_synonym="2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1;
                     Otf1"
                     /note="major polyA site"
ORIGIN      
        1 aaaatattca aaatggcgga cggaggagca gcgagtcaag atgagagttc agccgcggcg
       61 gcagcagcag cagactcaag aatgaataat ccatcagaaa ccaataaatc atctatggag
      121 agtgaagatg ccagcacagg cacacaaacc aatggtctgg actttcagaa acagcccgtg
      181 cccgttggag gagcgatctc cacagcccag gcccaggcct tcctcggaca tcttcaccag
      241 gtccagctag ctgggacaag tttacaggct gctgctcagt ctttaaatgt acagtctaaa
      301 tccagtgaag agtcgggaga ttcgcagcag tcgagccagc cttcttccca gccgccttca
      361 gtgcagtcag ccattcccca gacccagcta atgctggctg ggggacagat aactgggctc
      421 acgttgaccc cagcccagca acagttactg ctacagcagg cgcaggccca ggcccagctc
      481 ctggccgctg cagtgcagca acactccgcc agccaacagc acagtgctgc tggggccacc
      541 atctcagcct ccgccgccac acccatgacg cagatccccc tgtctcagcc catacagatt
      601 gcacaggatc ttcaacaatt gcaacagctt cagcagcaaa atctcaactt gcaacagttt
      661 gtgttggtgc acccaaccac caacctgcaa ccagcacagt ttatcatctc acagaccccc
      721 cagggccagc agggtctcct gcaagcgcaa aatcttttaa cgcaactacc tcagcaaagc
      781 caagccaacc tcctacagcc acagccaagc atcaccctca cgtcccagcc taccacccca
      841 actcgcacaa tagcagcagc ctcagttcag acacttccac agagccagtc aacaccaaag
      901 cgaattgaca ctcccagctt ggaggagccc agtgaccttg aggagcttga gcagtttgcc
      961 aagactttca aacaaagacg aatcaaactt ggattcactc agggtgatgt tgggctcgct
     1021 atggggaaat tatatggaaa tgacttcagc caaaccacca tctctcgctt tgaagccttg
     1081 aacctcagct ttaagaacat gtgcaagtta aagccccttt tagagaagtg gctaaatgat
     1141 gcagagaacc tctcatctga ttctacagca tctagcccaa gtgctttgaa ttctccagga
     1201 ttgggggctg agggcttgaa tcgtaggagg aaaaaacgca ccagcataga gaccaacatc
     1261 cgtgtggcct tagagaagag tttcatggag aatcaaaagc ctacctcgga agacatcacc
     1321 ttgattgctg aacagctcaa tatggaaaag gaggtgattc gtgtttggtt ttgtaaccgc
     1381 cgccagaagg agaaaagaat caacccgccc agcagtggtg ggaccagcag ctcacctatc
     1441 aaagcaattt tccccagccc agcctcattg gtggcaacca ctccaagcct tgtgacaagc
     1501 agtacggcaa ctaccctcac agtcaaccct gtcctccctt taaccagtgc tgctgtgact
     1561 aatctctctc ttacaggcac tacagactcg acgtccaaca acaacacggc cacggtgatt
     1621 tccacagcac cccctgcttc ctcagcagtc acatcccctt ccttgagtcc ctctccctct
     1681 gcctcggcct ccacctcaga ggcctccagt gccagtgaga ccaacacgac acagaccacc
     1741 tccacgcctc ttccctcccc tctcggagcc agccaggtga tggtgaccac gcccggctta
     1801 cagacagcag ccgccgctct ccaaggagcg gcacagttgc cagcaaacgc cagtcttgct
     1861 gctatggctg ctgctgcggg actcagccca ggcctcatgg caccctcaca gtttgctgct
     1921 ggaggtgcct tactcagtct cagtccgggg actctgggca gtgctctcag cccagcccta
     1981 atgagcaaca gtacactggc aacgattcaa gctcttgctt ctagtggctc tcttccaata
     2041 acgtctctgg atgcaactgg gaacctggta tttgccaatg caggaggagc cccgaacatc
     2101 gtgactgcac ctctgttcct gaaccctcag aacctctctc tgctcaccag caacccagta
     2161 agcttggttt ctgccgctgc agcctccaca gggaactctg cacctacagc cagccttcat
     2221 gcctcctcca cctcaactga gtccatccag agctctctgt tcacagtcgc ctctgccagt
     2281 gggcctgctt ccaccaccac agctgcctcc aaggcacagt gagctgagtg cagagctggg
     2341 ttgccacagg ctttcctcac tacagggtga taggctggct accagctgct taagaaaatg
     2401 acacctgtca ttggcttcct cccaccatgt tgtgaggagg aagaagacat ggagagaaga
     2461 aaaaattaca cataccagaa aaaggaaaga atggagacag gacagcattt gcctaatttt
     2521 ataataaaac aatgtctttt caggattgct tcatggattg gagaactttc taaccaaaaa
     2581 ttttaaaaga aaaaaaaaaa aaaagaaaca aaaacagaca gacaaaacta agtgaaaggc
     2641 ctacttacca tgtccagcag tcatgacgac aagctaaggt gggtcaccag ttccaggaga
     2701 ggaaggggtc tttttctttt tctttctttc ttttatgtta ttgttttggt ttggtttttt
     2761 tggttttttt ttttctttta aaaaaaaaat catttttata ggtctgttgt acagaccatt
     2821 aagtcataac aaggtgttta taatcatatc aattgtgttg ggggttcctt tcttaactgg
     2881 tacaatttag gcaggcctgt attactgtat ctctgatatt gtttgtttat acatatatat
     2941 atatatatat atctatatat atatattgaa catgtttatc tcttgctcct ggatcctgtt
     3001 tcagtgagcg cccacactgt ggggagggag ggtttgggat caagggagac ttaggtcctt
     3061 aactcctggg aatgttcgtg ctggtttcct tatccttggt gactcttaca gaggtgctag
     3121 aaaacgattt tcttttgcca cttatgcaag aggcttggtg cagaagctga aggcagtgtg
     3181 tgcaaacact tctgccttac acacgcccct ccccatcagg cggtgccttt ggagcacttg
     3241 tgtgtaggaa ggaattcctg ctgagccgtg gctctcactc accccgaatc attgagcagc
     3301 ctgaggccca gaccctgtgg tgcaacagtg acgcttcctt ctacttccca tgggaacagc
     3361 tgtgcctgtt gcagggcagg gtttggttcc gaagagcaaa gactactgca gacacctgac
     3421 ttggtggctc tcctgatttc ttatctctta aaaaaatgct cctactgtta gtgtttgttt
     3481 gtttgcttgt ttgttttttc attttatgaa aaattttcat ccaaacttcc ttttatttac
     3541 ttggtcagaa tcgaattggc atactgaagt tgtgcgacag ttctctccct tgttttctaa
     3601 agcaattctg ttgaactgtt ttctactaac gaggtatccc agagaggtca gtatgaagag
     3661 cctgagcgag tgtaccaccg ttctctagag agtcacagac ttcctgtcca ctgagtgggt
     3721 cacaagtttc tccaagcctg agagtctcct cagtcccctg actgacagag gccctttcct
     3781 ggctgggcaa gggatctgtg gaacttcaga gagatgctga gcaagaactt ctcagcctca
     3841 agtgtctctt ggttggttag gcccctgcta agtagatctg atgacgacat gcatctccta
     3901 tttgatgtaa aaagtgattt cctcctgtaa ttgctttcag ggtgtttcta gactacataa
     3961 atgagcccat tgaaaaggaa gaacttgtga aaatggatga agatggatga gggcaattta
     4021 gagactaaat tcccccattt gtcaatatcc tattattata ctatctgtac cagaattttt
     4081 acaaatgacg gaatcactgc agtgaagctc tgagttgccc ttactggagt taaaggttcc
     4141 catttggcgt ctgagggcac ttgcttcagt tcctggtggt ctgcactttg agctgggagt
     4201 gactctcctt ctgattgctt tgctttgccg caggaaactg tgcatttgtt tctctgcaga
     4261 gaaaaagttc agcgaggcag tagcagacac agatgtgtac cttttttgtt gttgtttctc
     4321 agttgggaga aggtcatact aatattaaag gtcaaaaaca ttttgatccc tttaattttt
     4381 tttagttcct tttggttatt tcccagagta tttaattttc acccctgaat aatttctttt
     4441 acctttaact tttcctaaaa tccctccaaa aatcagtgaa ctgcaagcag ggaaactcac
     4501 agatgctcat ccacctattt tgtatggtgt gggtgttttg tttgttttgt tttgtttttt
     4561 aaactaagct tgaaccaaag tcaattctta gcaagctgct gtactaatgg actaatggtt
     4621 ataatgtgca gttcaaacac agtgaggaga tagatgctac tgacaattct tactcatttt
     4681 tcttgattaa ttttatgtga aagttgctgc ttgtttttat cttttatgtt ggtaaattgt
     4741 aatatcctct gggcagacat taccttgatt ttagctagtt tgtttaagtc agtgtgtaaa
     4801 taggatggcg tgccagttac tacttctccc ctccccacca gcctttctct cttgttaatt
     4861 taatgttttc tcttgactta acactctaat cttagtctgc atgtggtttt aggcctgtca
     4921 atactgtttc tgccctagca gagagtccct cccttgggag tgaggaggtt aggaagaatt
     4981 cagggagaga aatgctgatt acctaccaga cagattagca gttatagcat taatttccag
     5041 aattgctacc aaaggaagta gagagtccca agaggctctg gcccggggac taaggaggac
     5101 agagggactg ttttgtcata cgtggttaaa aggatctttt tcccaaataa gagtccccta
     5161 cagactttga ttttaaaaat gatactaagt tttatgtttt tgtcaatcct tcctctgtag
     5221 tctctagtgg gtttgagaaa ggattgctgc ctttttatgt agttaatttt ttgaggatag
     5281 actttaaaac cagcataaat actgtattga gaagaaaagg atctttagat aaagataact
     5341 ttaatttttt cctacccttt ttcatgtgtt taaaattaaa ttgtaaaatg aaaggtactt
     5401 tatacatatg tatacatgaa acactactaa agttttctgg tgggtgttca ggctaaaata
     5461 ccttccgtga ccatccctaa atggtcgtta acctactata cacaaaccct tgggtagttt
     5521 ttacttgata ccattttttt taatgatctc aaatgctttt taaactgaca actgtcttct
     5581 aaggtaaagt actcagactt aaaggttcag ctgcctttta tgaaagaatg tagaaaccaa
     5641 agaggttatt tgactaaaag acacatacag ttgagtttct acagttcctg agtaaacagg
     5701 ttgttaaacc tgttagttca ttctcctttt cttccccttg atatttatgc ttgctttatt
     5761 tcatccctaa atttagttaa cacatagtaa gccaaagact aattctaaat acatttaggg
     5821 gatactatat ttgcctgtga taatgggccc tccctggaga gtagtgaatg taattgttta
     5881 atcctgttta agcaatgcag tttggcataa actttattta tttcctgtgt aaatctaaat
     5941 gacaacagaa aaatctataa ggtttctcac aagagcagtc ttactgttgt aggaatagta
     6001 agtgctctgt taccttgaat gtctctgaag ccctataggc agctccataa aatgaggaaa
     6061 cattattcct agccatttgc ttccttaatg tgttgtcaga aaggtcagcc ccgtcctgtg
     6121 tctgtaactt gttactccaa aatggaacca aaggaatccg gctttcagct tgtggaggac
     6181 cagcctgttt atattctcat aagctttatt agaaattgtt aaagggatat cagtgaaaag
     6241 gttttaggtg tgatcatctt gccaacatgt tctatatcat catccatttg ttttagggaa
     6301 aaagcacaat tatacctctc taatattatt gtgtctatta tctattcttc aattatttga
     6361 aaaatagggg aaataatctc ttcactatcc agaagcacag gtttttgctt gacaatattt
     6421 cagttcagct cagtcattat taacatttaa cttgctggaa atgccaggta catttataaa
     6481 tatagggatg ttatgtaagg aaaaaatact atagttccta gtctgaagtt cttcttaagc
     6541 catgtcatcc tcacaaatct ttcttgacca aaacaaagag acatctattt tctgttcttc
     6601 cccaagaggg gagaaatgct gccctagtgt gcaggagaca gtgtcctgct ggcagcctgg
     6661 gttggccctg gccctgagga actcacggac cagtctataa cctgagcatg tggtgaggca
     6721 gaaagaaggg cctcagcagc tcagcaagag agcttgagca gaaactttac gttggcttct
     6781 gaagctgatg aacataaagt gtacttattc ctcaaactct attagaactg taaacattta
     6841 agactaccag tactaatgta aggaaaatac ttaaaagacc tgaaacccat agttatacaa
     6901 gtgggcagaa attgatgtag taatttattt ataactgtta tgagttcact ttcatttgtg
     6961 gatatgaaca gtatttacca tgttatattg tccatataaa gagatccatg actattttga
     7021 agtcattttc agatacttgt aaaaataaga cttccctaat attttgattt tgaagaagaa
     7081 aagcaattct tctttgccat tcctctgaga ataaaacact gttccacagg tttgcatgga
     7141 ttgcacacac aagcataaat agaaaaggcg gaaataaggt cctttgatta ttaaaggttg
     7201 atggaataat ctttgcctca tcctctaatt caccaatgga aagtaagtgt aaggttctag
     7261 cagggtggtc aggaaacctc ttcctcagca ttcgtccagt tcatacccgg tgtatggtag
     7321 gatttgtgaa ctgggtttct tccaaccatc attctcttca tgaaccaatt ccttagtttg
     7381 acccttctgc tcttggcctt tgctggaagc agtaaacttg agtatatcac gtgtcgattc
     7441 agtgatctgg atctctctgt ctcttttcct tctcttattc atttgagtgg tggtacctta
     7501 ttctgtgaga ataatgctca tggggaacag cttctggcac cttcataaaa tacctcagca
     7561 tagcttagca ttgttacaga actggtttta gactgaaaaa ccaaataagt ataagaaaaa
     7621 atctttataa atagtggaaa taattctagc tgtagtattt agttgaacta atgtttatta
     7681 tgattgttaa acatgattga tgctgtatgt atttggggtc ctgtttatag agttagggag
     7741 ggttgggttg ggagaaagga gaaattgatt atgttagaag gaaaatattg cttgtgtgta
     7801 tttgtttttc tttatatctg tcttgccaaa ggaaacttga tattccctat gaatgggttg
     7861 ggggtttgag gcctctctgt gatctgatat gcagcacagt atgcagaacc atgcaggtga
     7921 tgtgtggggt gtccagtggg ttcaggatgc ccaggcacag gttacaaccc tccctgtctg
     7981 tggctgtcat gcccttgccc caagacctgc caggctctcc tgacgatcca ttacctctgt
     8041 gcatagctaa agcttaggca aaggaagagt gtgcacgtgt ccaggtgtgc agatgaaaag
     8101 acagatatga acgtgaaccc gaggaatgga gcggtgagtg atgtatcttg agctcggaaa
     8161 attaacatga aatgagtcat cttttgtcat gttagtgatt gctgtgctag tagtagccca
     8221 acatttttaa aactttattt ccttttctta taccaaggat aattttgtct agaccaaaac
     8281 acaaaagaaa accaagccaa gaagttgaaa gctaacacaa gtcaaaagct aaccctaccc
     8341 tgtactaagg tggggcattt aaggactggg tgatgagatg gaagaagagt tgttcttcct
     8401 tttgggaaat gtgaataaga aattatgttg gtttaggaaa aaattaaaaa cctttctgcc
     8461 cttgttctgt ctgggacaga ctttcttagc tccctgagtt ctaatgtaaa ctatatctca
     8521 agaactaatt ttttatctca cagaacttga gtgggatttg attttgatac caaagacaac
     8581 tgctaaacca ttgcttctca agttttccag acactcaaag gccatagagc aaacactgag
     8641 gttggaaagc ttcgtctcgt ctctgttctc cccatcggcc tcaccccttc ctcacttttg
     8701 gaagatgtct ttttggttac tctagctttg ggaagagatt ggttttgttc ctccctgctg
     8761 ctcggttgag attggtagag tttgctcagc ataacactga tactctgact gagaaagaaa
     8821 cttggagtgc aaaaaatagt agtagaactt ttacttacct ttatctagtt catacaaata
     8881 aaactaggcc atccaacctg ttggagtacc agtcaggatt tagttaggaa gagcagacta
     8941 cagccgaatg acatctcctt cctctcctgt agagctgttt ttgctgcaca gtgtgttagg
     9001 atacggctgc tgggaggcta agaggcttct tatgtcggca ggctttagat aaacagacag
     9061 tgagagagga aagaccaaca accatgatca ggttgctaaa tttcatgaaa gctttacttg
     9121 ttatcattct gacattatgt aagtagtgtt agtgctgtgt ggttttttct aagcgttagg
     9181 taggtttgta tggtataggg atattgaaga taagagcacg gaaacaaatg ctgtgagaag
     9241 cagtgtgtgg gtcgtgaaca ccatttcagc tgtgaaaggg acgctcccag gttcagggag
     9301 ggaaacagtt tgtgatcttt ctgcatccct cagtctgccc acgctgcaca gagctctacc
     9361 acccttgcca cgtcctggtt caaatccaga accctgtcag aaagttaaga aactttccaa
     9421 actaatgtac cggaggaggg aggagctgag gtccgctgca aagttgttca tcactgcaac
     9481 agccacaacc tcacaaaagc agctagaagc ttctttgcta aattggcaat gctattgatc
     9541 actacatccc aaggtctgca ggcagctggt gacagtgcag ttccaacagt gcagcatctg
     9601 catgggagat ctttatgtga tcttgttaga gaaaaagtag acagccaatg cccatccatc
     9661 ccagagagtg tctaagaact acaggaggaa acaaaatgtt ctcacacggg tgtgacagtg
     9721 tctctgagga gcactgtgat aggctgggtg ggttccattc ctacatgagt ctgcagaagg
     9781 cacgtgttgt ttgtaagagt gacatgaact agttagtgct agcctggtta gatttaaagt
     9841 tgcaaactgt gggagtgggg gtagtgtgtt caacaagact gaccatatta caacattgac
     9901 tttctacaat atagatggta aatggtgaga ggaagacttc ttcccactgc ttacctctgc
     9961 ttccatggga atgtgtgcat tactcagtcc acaggagggc tcactgaggg aagtgtcctg
    10021 cccctagagt ggccctcagc cattgctctc ctctgtggta gtgaaggcta ggtgagtaag
    10081 agtgggggtt tctgcccacc acctgtccag gagctgtcgt atacctcatt tctaactcta
    10141 actcgcttta acttcctctc aaccctacag agttgccaag tctgccctcc ctcttctcag
    10201 caacattaaa ctctggccta tagcatcata agacctgtcg cctggggtgg gactgtcccg
    10261 ccccacccca ccccaaagcc tctgaatgtc tctgctttta agctactaga aactgagggc
    10321 aaattgcaat ctcctgtttg tctttgttgc taggggtcct cacaggtttt ttaccatgtc
    10381 cccaccacct tgccttcaag gatggccagc tctcctctcc ccatccaccc tgtatttcaa
    10441 agtgctggat agacagcagc ttctgtcctt gcttttccaa gtggtctcaa ggctgacctt
    10501 tcccttctga agccttgggg ctctgctcat tgccaggact tggtagaaag gacacgaagg
    10561 ttcatttaag ctgacctaag ctacacattt cacttgtttc ccgtgtgaca tgaccaaaaa
    10621 gaattccaaa tatttaagtt tattattaat atattataat aatagttatt attatttgac
    10681 aatcttatat ccgacgggct ttctggaagc tgcttctccg gccctttcaa cgttttcttt
    10741 gaatgtagtt cttaacttgc aatttccacc cccaaagttg gaggggggga aagctcagcc
    10801 aggtcaggtc ataatactgc tgctataagc caggggaggg tggtttcttt gatttgtttt
    10861 gtttttccat ttccagccaa aaccaaagat ttcttaatga ttgtataaac tcaaaacaaa
    10921 caaaaaaacc aaagaaaagg gaagtcttcg gccccaatgc agtctgtggc gtcctggcac
    10981 ttggaggcat gccaaagggt aggtggggac acctggccag ctcagagggg caggcaagtc
    11041 ttttctaagt tgagagattc attcagatgc atgcccagga gttttggccc ttgctcactt
    11101 ctgagtagag catgcatgaa agaaattgga acatcagatt tttcaaaagt cccatcctca
    11161 ccacaactca tgtgacagca gccagggtca tcaccagagc tgagcacagg gccttagagc
    11221 tgggagctgc tactgggtgg ccatggactc cacagagtgg ggatgctgaa gacgctggca
    11281 caggattggc tactctgctg ggtgctttca cctttggggc gggctcttaa cccaagggtc
    11341 cttgtgagtt ctgaaccttc tctctctctt ctgttcccga actgcactgc ttggaagtgg
    11401 ctgtcctgtt tgtgaggaaa catgcagaac aattgtcaaa ctttttttta atcttgtttc
    11461 tagttttgtt tccttttgca gcaccactgt gcaactatgc attgtatttc ataacctttg
    11521 tgctaggtag acgcctgtga ctttttaact tgggggtggg tgggttgcgg gttgcaaatg
    11581 aaggaaattt ttacatggat ctttttaatc tcagttgatt gggggagggg ggttttggtt
    11641 ctagggtcat acaagctcta tcccaaagca aaatccaaat gttaataata ctagcctgat
    11701 gcagatacca aagacaattt ctttcctgca gaaccttaga cttgtgtact aagtacgatt
    11761 atccggcact tgcattagtc taacctcagt aattccaaag cttagatgta tattttggta
    11821 tatttccagg atattaaaaa aaatgtcgtt taacttcttg tttgtttcag tgtaatgctc
    11881 ttaaagtcat cgcatgaaat aactgcgctg tcctattctt ggtagtttga aataatagta
    11941 tttttgtatg ttttgggtgt gtctgtatgt attaacataa cagttttcac tgcctaggtg
    12001 ttcatataaa agtgagaggt tctgagtgta catactatta aataacaatc tctaccagtg
    12061 tccacggagt gtctggaggc actgatgact gcccagctgg gatctggttt taaagagacg
    12121 gtgattgtgt tttctaaaga tgtttgcttc tgtctttaaa tatcttaact tccccacttg
    12181 ttttttccta cttttttaat tactattgat tcaggggtgt ttttccactg ttgtcaaggg
    12241 aggaacacaa gggaactggc accttggcct cccaaaatat gttattttat gtattttaaa
    12301 atgtgagttt tgagttcttc tttgtggaaa cttacaacat gatgtacatg attctttccg
    12361 gagttgccca gcagctttaa tgaggcagca gcagcagccg ttcctgggta gtttattggg
    12421 tgtcctctga catttctcct taagatgaat ttgcagtctg ggtggctatt gtgtagcctc
    12481 actgccccag aacgtctgta gccatttccc cttcaatggg gatattttat aagattcagc
    12541 tgatagctcg gagcactggc cctgttatct gtgcccatgg gaaatgtgtt tttcttgatt
    12601 tggaaaacct gaaacccaaa cacttctact aactgggcat agcagatagc tcctgaggcc
    12661 tggggaagtg gtgactgtga gaggtgctgt ctctttaaaa aaaaaagtgc cctttttgtg
    12721 agcccctccg gggatcacca gagggcgggg cttgggagag attgtgtggg cgccagtgaa
    12781 tcagagtgaa atgctgggtt ttatgtagat gcatttgtct gctgtaattt tttatatata
    12841 ttaaacttac tgtaactgta cagttcccat ttctgttgta aaacattaaa ccattttcca
    12901 agtgtt
//
