LOCUS       NM_011136               2566 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus POU domain, class 2, associating factor 1 (Pou2af1),
            mRNA.
ACCESSION   NM_011136
VERSION     NM_011136.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2566)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2566)
  AUTHORS   Sun,W., Hughes,E.P., Kim,H., Perovanovic,J., Charley,K.R.,
            Perkins,B., Du,J., Ibarra,A., Syage,A.R., Hale,J.S., Williams,M.A.
            and Tantin,D.
  TITLE     OCA-B/Pou2af1 is sufficient to promote CD4+ T cell memory and
            prospectively identifies memory precursors
  JOURNAL   Proc Natl Acad Sci U S A 121 (9), e2309153121 (2024)
   PUBMED   38386711
  REMARK    GeneRIF: OCA-B/Pou2af1 is sufficient to promote CD4[+] T cell
            memory and prospectively identifies memory precursors.
            Erratum:[Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2405830121.
            doi: 10.1073/pnas.2405830121.. PMID: 38588436]
REFERENCE   3  (bases 1 to 2566)
  AUTHORS   Yanagi,M., Ikegami,I., Kamekura,R., Sato,T., Sato,T., Kamiya,S.,
            Murayama,K., Jitsukawa,S., Ito,F., Yorozu,A., Kihara,M., Abe,T.,
            Takaki,H., Kawata,K., Shigehara,K., Miyajima,S., Nishikiori,H.,
            Sato,A., Tohse,N., Takano,K.I., Chiba,H. and Ichimiya,S.
  TITLE     Bob1 maintains T follicular helper cells for long-term humoral
            immunity
  JOURNAL   Commun Biol 7 (1), 185 (2024)
   PUBMED   38360857
  REMARK    GeneRIF: Bob1 maintains T follicular helper cells for long-term
            humoral immunity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2566)
  AUTHORS   Betzler,A.C., Ezic,J., Abou Kors,T., Hoffmann,T.K., Wirth,T. and
            Brunner,C.
  TITLE     T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center
            Response and T Helper Cell Differentiation
  JOURNAL   Front Immunol 13, 889564 (2022)
   PUBMED   35603192
  REMARK    GeneRIF: T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal
            Center Response and T Helper Cell Differentiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2566)
  AUTHORS   Lombard-Vadnais,F., Lacombe,J., Chabot-Roy,G., Ferron,M. and
            Lesage,S.
  TITLE     OCA-B does not act as a transcriptional coactivator in T cells
  JOURNAL   Immunol Cell Biol 100 (5), 338-351 (2022)
   PUBMED   35285071
REFERENCE   6  (bases 1 to 2566)
  AUTHORS   Kim,U., Qin,X.F., Gong,S., Stevens,S., Luo,Y., Nussenzweig,M. and
            Roeder,R.G.
  TITLE     The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is
            essential for normal production of immunoglobulin isotypes
  JOURNAL   Nature 383 (6600), 542-547 (1996)
   PUBMED   8849728
REFERENCE   7  (bases 1 to 2566)
  AUTHORS   Schubart,D.B., Rolink,A., Kosco-Vilbois,M.H., Botteri,F. and
            Matthias,P.
  TITLE     B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune
            response and germinal centre formation
  JOURNAL   Nature 383 (6600), 538-542 (1996)
   PUBMED   8849727
REFERENCE   8  (bases 1 to 2566)
  AUTHORS   Schubart,D.B., Sauter,P., Massa,S., Friedl,E.M., Schwarzenbach,H.
            and Matthias,P.
  TITLE     Gene structure and characterization of the murine homologue of the
            B cell-specific transcriptional coactivator OBF-1
  JOURNAL   Nucleic Acids Res 24 (10), 1913-1920 (1996)
   PUBMED   8657574
  REMARK    Erratum:[Nucleic Acids Res 1996 Jun 15;24(12):2462]
REFERENCE   9  (bases 1 to 2566)
  AUTHORS   Knoepfel,L., Georgiev,O., Nielsen,P. and Schaffner,W.
  TITLE     Cloning and characterization of the murine B-cell specific
            transcriptional coactivator Bob1
  JOURNAL   Biol Chem Hoppe Seyler 377 (2), 139-145 (1996)
   PUBMED   8868069
REFERENCE   10 (bases 1 to 2566)
  AUTHORS   Pfisterer,P., Zwilling,S., Hess,J. and Wirth,T.
  TITLE     Functional characterization of the murine homolog of the B
            cell-specific coactivator BOB.1/OBF.1
  JOURNAL   J Biol Chem 270 (50), 29870-29880 (1995)
   PUBMED   8530384
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC160052.2.
            
            On Nov 17, 2006 this sequence version replaced NM_011136.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U43788.1, BC058611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC160052.2         85098-85209         c
            113-243             AC160052.2         66537-66667         c
            244-286             AC160052.2         66009-66051         c
            287-552             AC160052.2         65656-65921         c
            553-2566            AC160052.2         58820-60833         c
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 27.95 cM"
     gene            1..2566
                     /gene="Pou2af1"
                     /gene_synonym="Bob-1; BOB.1; Bob1; OBF-1; OBF.1; OCA-B;
                     OCAB"
                     /note="POU domain, class 2, associating factor 1"
                     /db_xref="GeneID:18985"
                     /db_xref="MGI:MGI:105086"
     exon            1..112
                     /gene="Pou2af1"
                     /gene_synonym="Bob-1; BOB.1; Bob1; OBF-1; OBF.1; OCA-B;
                     OCAB"
                     /inference="alignment:Splign:2.1.0"
     exon            113..243
                     /gene="Pou2af1"
                     /gene_synonym="Bob-1; BOB.1; Bob1; OBF-1; OBF.1; OCA-B;
                     OCAB"
                     /inference="alignment:Splign:2.1.0"
     exon            244..286
                     /gene="Pou2af1"
                     /gene_synonym="Bob-1; BOB.1; Bob1; OBF-1; OBF.1; OCA-B;
                     OCAB"
                     /inference="alignment:Splign:2.1.0"
     exon            287..552
                     /gene="Pou2af1"
                     /gene_synonym="Bob-1; BOB.1; Bob1; OBF-1; OBF.1; OCA-B;
                     OCAB"
                     /inference="alignment:Splign:2.1.0"
     exon            553..2566
                     /gene="Pou2af1"
                     /gene_synonym="Bob-1; BOB.1; Bob1; OBF-1; OBF.1; OCA-B;
                     OCAB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taaacggtgg ttccacggga ggaaagcacg cccagtcaca ttaaagaagc caaactgtct
       61 gcttcaaaga gaaaaggcaa catcctgtca caagccatgc tctggcaaaa atccacagct
      121 ccagagcaag ctcctgcccc accaaggcca taccagggtg ttcgagtcaa ggagccagtg
      181 aaggagctac tgagaagaaa gcgtggccat accagcgttg gggcagctgg gccaccgacc
      241 gcggtggtac tgccccacca gcccctggcc acctacagca ctgtgggtcc ttcctgcctt
      301 gacatggagg tttctgcttc cacagtgaca gaggagggaa cattatgtgc tggctggctc
      361 tcccaacctg ccccggccac tcttcagcca ttggctccat ggacacccta cacggagtat
      421 gtgtcccatg aagctgtcag ctgcccctac tccactgaca tgtacgtgca gcctgtgtgc
      481 cccagctaca cagtggtggg accctcctcg gtgttgacct atgcttctcc accactcatc
      541 actaatgtca cgccaagaag cactgctaca cccgcggtgg ggccccagct ggagggtccc
      601 gagcaccagg cgcccctcac ttatttcccg tggcctcagc ccctttccac actgcccacc
      661 tccagcctgc agtatcaacc tcctgcccca accctgtctg ggccccagtt tgtccagctc
      721 cccatctcta tcccagagcc agtccttcag gacatggatg accccagaag ggccatcagc
      781 tccctgacca ttgacaagct gcttctggag gaagaggaaa gcaacacgta cgagctcaac
      841 cacaccctct ccgtggaggg cttttagggc tggcttgcat ctaacagatg tttcacccat
      901 agctgagatt ttaaaagtgt tcaatagagc ccagacttct gtttgaagta gctatttcac
      961 aggcttcctt tcttcctaaa gctaaattgt atcccttctt ttctcccttc ttccttccct
     1021 cgcttccttc cttcccccac tgccatcttg cttatttctt atttctcctt ccagttttct
     1081 tcctctggag cggcaaatga tagtgatatt atgaacaacg ctttatacgg aatgtcacca
     1141 agtctgcagc tcagggtttt cctttggtgg cacatcattg gggaagcaac cttctttcag
     1201 gtgccccctg tttcctggta gcagtagctt tatagatcta ctctatgata cgttctgcgc
     1261 cccagttttg ttttgtgtgc tgttctcagc cttggccaga tatactatct aagtggatgt
     1321 ttctggtctg gttacagggg gatgggacag gaccatcagg gtgggtaggg acagtgagtg
     1381 agtgatggga gacggggctg aggagcagca ggacacacat gtgtgtctgt ggttagagag
     1441 ggagtgagga ggggcagggg aaggagtgat ctaacagctc tgaaaaaaaa taccacttta
     1501 atgtggttta gctgttcttg tcagcgatta ggaggaaagc tggatatggt atggaggata
     1561 aatgacgagt ctgcttattt ctgcctctct gcaggcccgc taacatgatg ccagcactta
     1621 aaatacttct gtcagcatat tgccatagca acaggaaaag aaacaggtga agccgatcat
     1681 tgaggaggct tgcacttagt ccttccacgt gggcttttaa ttcctgttgt gactcaccca
     1741 gggccatcct gacgcgttgc tatggattct tgcgcccact caccggctgt ctctggggtc
     1801 ctgaagtcct ggtcagcagg cccactggcc ttcattttca gttttatcag ttttattgca
     1861 gtttttgctg gagaagcata acacttgctg ttgagtgttt tgctgtctcc tagtgctttg
     1921 ctcctgaagt ggatgtgtct ttgggaactg gcccattgtt tactaatgat accatcatta
     1981 cacatacaca agttttagtc tgtagaatcc atgtagaacc aatagatctt ctagaaatga
     2041 cagtttcttt gatatcccac cctctttctt tctgcttcca atgaaaactt agagctacct
     2101 gttttttttt tcttcttctt cttctttctt tctctgcttt gtgtttattt tgattcagac
     2161 atctcattat ctacctgaag tcctggtata cttagcttga atttgttatt cctctttaat
     2221 atttagatta aatgctagat ctgaatggta ggtttacact tctgttggtg gttaccatga
     2281 acaagaaagg gagagggaag cctcagccta tttaattaag accttgttgc acttaaaaac
     2341 actatttaag atttcccagc tacttgggag tttgaggcaa tcacagagga gttaacactg
     2401 ggaaaacaaa caaaacagca aagaaagtag tgtgagcggt tgctgggatt gaattggcat
     2461 ctttttcgct tcttatcttg agacctcacg tcttggctgc aggcatccaa acagatttcc
     2521 tccagagcct catttgcaac attttcaata aagattggtt agatga
//
