LOCUS       NM_008849               2029 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus POU domain, class 1, transcription factor 1 (Pou1f1),
            transcript variant 1, mRNA.
ACCESSION   NM_008849
VERSION     NM_008849.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2029)
  AUTHORS   Rader,E.P., McKinstry,K.A. and Baker,B.A.
  TITLE     Transcriptional and morphological responses following distinct
            muscle contraction protocols for Snell dwarf (Pit1dw/dw) mice
  JOURNAL   Physiol Rep 12 (17), e70027 (2024)
   PUBMED   39227324
  REMARK    GeneRIF: Transcriptional and morphological responses following
            distinct muscle contraction protocols for Snell dwarf (Pit1[dw/dw])
            mice.
REFERENCE   2  (bases 1 to 2029)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2029)
  AUTHORS   Dong,Q.Q., Tu,Y.C., Gao,P., Liao,Q.Q., Zhou,P., Zhang,H., Shu,H.P.,
            Sun,L.L., Feng,L. and Yao,L.J.
  TITLE     SGK3 promotes vascular calcification via Pit-1 in chronic kidney
            disease
  JOURNAL   Theranostics 14 (2), 861-878 (2024)
   PUBMED   38169564
  REMARK    GeneRIF: SGK3 promotes vascular calcification via Pit-1 in chronic
            kidney disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2029)
  AUTHORS   Stege,N.M., Eijgenraam,T.R., Oliveira Nunes Teixeira,V.,
            Feringa,A.M., Schouten,E.M., Kuster,D.W.D., van der Velden,J.,
            Wolters,A.H.G., Giepmans,B.N.G., Makarewich,C.A., Bassel-Duby,R.,
            Olson,E.N., de Boer,R.A. and Sillje,H.H.W.
  TITLE     DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model
            by Reducing Abnormal Sarcoplasmic Reticulum Clusters
  JOURNAL   Circ Res 133 (12), 1006-1021 (2023)
   PUBMED   37955153
  REMARK    GeneRIF: DWORF Extends Life Span in a PLN-R14del Cardiomyopathy
            Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters.
REFERENCE   5  (bases 1 to 2029)
  AUTHORS   Li,Y., Wang,J., Wang,R., Chang,Y. and Wang,X.
  TITLE     Gut bacteria induce IgA expression in pituitary hormone-secreting
            cells during aging
  JOURNAL   iScience 26 (10), 107747 (2023)
   PUBMED   37692284
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2029)
  AUTHORS   Taniuchi,S., Maeda,K., Kudo,T., Takahashi,S. and Takeuchi,S.
  TITLE     Identification of mammalian Pit-1w, possibly involved in
            spermatogenesis in mice
  JOURNAL   Gen Comp Endocrinol 173 (2), 289-294 (2011)
   PUBMED   21745476
  REMARK    GeneRIF: Mouse Pit-1 w plays a role in spermatogenesis. This is the
            first report demonstrating the expression of Pit-1 variants arising
            from alternative promoters in mammals.
REFERENCE   7  (bases 1 to 2029)
  AUTHORS   Lin,C., Lin,S.C., Chang,C.P. and Rosenfeld,M.G.
  TITLE     Pit-1-dependent expression of the receptor for growth hormone
            releasing factor mediates pituitary cell growth
  JOURNAL   Nature 360 (6406), 765-768 (1992)
   PUBMED   1334535
REFERENCE   8  (bases 1 to 2029)
  AUTHORS   Dumont,F., Robert,F. and Bischoff,P.
  TITLE     T and B lymphocytes in pituitary dwarf Snell-Bagg mice
  JOURNAL   Immunology 38 (1), 23-31 (1979)
   PUBMED   315916
REFERENCE   9  (bases 1 to 2029)
  AUTHORS   Bartke,A., Goldman,B.D., Bex,F. and Dalterio,S.
  TITLE     Effects of prolactin (PRL) on pituitary and testicular function in
            mice with hereditary PRL deficiency
  JOURNAL   Endocrinology 101 (6), 1760-1766 (1977)
   PUBMED   590190
REFERENCE   10 (bases 1 to 2029)
  AUTHORS   Schneider,G.B.
  TITLE     Immunological competence in Snell-Bagg pituitary dwarf mice:
            response to the contact-sensitizing agent oxazolone
  JOURNAL   Am J Anat 145 (3), 371-393 (1976)
   PUBMED   1266774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118240.8 and CT009578.7.
            
            On Jun 18, 2019 this sequence version replaced NM_008849.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X57512.1, CB236100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AC118240.8         208662-208920
            260-331             AC118240.8         211713-211784
            332-556             AC118240.8         217880-218104
            557-721             AC118240.8         219980-220144
            722-782             AC118240.8         221044-221104
            783-1731            AC118240.8         221921-222869
            1732-2029           CT009578.7         6899-7196
FEATURES             Location/Qualifiers
     source          1..2029
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 37.25 cM"
     gene            1..2029
                     /gene="Pou1f1"
                     /gene_synonym="dw; dwarf; GHF-1; Hmp1; Pit-1; Pit1;
                     Pit1-rs1"
                     /note="POU domain, class 1, transcription factor 1"
                     /db_xref="GeneID:18736"
                     /db_xref="MGI:MGI:97588"
     exon            1..259
                     /gene="Pou1f1"
                     /gene_synonym="dw; dwarf; GHF-1; Hmp1; Pit-1; Pit1;
                     Pit1-rs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..993
                     /gene="Pou1f1"
                     /gene_synonym="dw; dwarf; GHF-1; Hmp1; Pit-1; Pit1;
                     Pit1-rs1"
                     /note="isoform a is encoded by transcript variant 1; POU
                     domain, class 1, transcription factor 1 (Pit1, growth
                     hormone factor 1); pituitary specific transcription factor
                     1, related sequence 1"
                     /codon_start=1
                     /product="pituitary-specific positive transcription factor
                     1 isoform a"
                     /protein_id="NP_032875.1"
                     /db_xref="CCDS:CCDS57033.1"
                     /db_xref="GeneID:18736"
                     /db_xref="MGI:MGI:97588"
                     /translation="MSCQSFTSADTFITLNSDASAALPLRMHHSAAECLPASNHATNV
                     MSTATGLHYSVPSCHYGNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPLHQPLLAEDP
                     AASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAV
                     HGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRR
                     TTISVAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSL
                     NQSLFSISKEHLECR"
     exon            260..331
                     /gene="Pou1f1"
                     /gene_synonym="dw; dwarf; GHF-1; Hmp1; Pit-1; Pit1;
                     Pit1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..556
                     /gene="Pou1f1"
                     /gene_synonym="dw; dwarf; GHF-1; Hmp1; Pit-1; Pit1;
                     Pit1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..721
                     /gene="Pou1f1"
                     /gene_synonym="dw; dwarf; GHF-1; Hmp1; Pit-1; Pit1;
                     Pit1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..782
                     /gene="Pou1f1"
                     /gene_synonym="dw; dwarf; GHF-1; Hmp1; Pit-1; Pit1;
                     Pit1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..2029
                     /gene="Pou1f1"
                     /gene_synonym="dw; dwarf; GHF-1; Hmp1; Pit-1; Pit1;
                     Pit1-rs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctgtcc tgatgtatat atgcaagtac ggagaagtga atcagccctt tgatacagta
       61 atataataaa agtgaactgg caagcagcgg gtcttagttt tctactttct tgtgggaatg
      121 agttgccaat ctttcacctc ggctgatacc tttataactc tgaattctga cgcttctgct
      181 gccctgcctc tgagaatgca ccacagtgcc gctgagtgtc tcccagcctc caaccacgcc
      241 accaacgtga tgtccacagc gacaggactt cattactctg tgccttcctg tcattatgga
      301 aaccagccat ccacctatgg agtgatggca ggcagtttaa ccccttgtct ttacaagttt
      361 ccagaccaca ccctgagtca tggatttccc cccctgcacc agcctctgct ggcagaggac
      421 cccgcggcct ctgagtttaa gcaggaactc aggcggaaaa gcaaattggt ggaagagcca
      481 atagacatgg actccccaga aatccgagaa ctggagcagt ttgccaacga gtttaaagtg
      541 agaagaatta agttaggata cacccagaca aacgtgggcg aagcgctggc tgctgtccac
      601 ggctcagaat tcagtcaaac aaccatctgt cgatttgaaa acttgcagct cagtttcaaa
      661 aatgcttgta aactcaaagc aattttatcc aagtggctgg aggaagctga gcaggtcgga
      721 gctttgtaca atgagaaggt gggagcaaac gaaaggaaga ggaaacggag gacaaccatc
      781 agtgtagctg ctaaggatgc tctggagaga cacttcgggg agcacagcaa gccttcctcg
      841 caggagatca tgcggatggc tgaagaactg aatctcgaga aagaagtagt acgagtgtgg
      901 ttctgcaacc gaaggcagag agaaaaacga gtgaaaacaa gtctcaatca gagcctgttc
      961 tctatttcca aggaacatct agagtgcaga taaggctggc gtgtgatagc catgtgtggt
     1021 agctactcca cttctttcag ttttcaagaa aaatcagaag ttagtcactt ggttaaaaac
     1081 tagattgaat cagtaactcc tgcagttttt gtctcacttc tttctttctt tctttctttc
     1141 tttctttctt tctttctttc tttctttctt tctttctttc tttccttcct tccttccttc
     1201 cttccttcct tccttccttc cttcctttct ttctttcttt ctttctttct ttctttcttt
     1261 ctttctttcc tttctgtctg tctttccttt ctttctttct ttctttcttt ctttctttct
     1321 ttctttcttt ctttcttttc tttcctgtct tttctttttt tctcttttct tttcttttct
     1381 tttcttttct cttccttcct tccttccttt ctttttcttt ctttctttct ttctttcttt
     1441 ctttctttcc ttccttcctt ccttccttcc ttcctttctt ttttctttct ttctttcttt
     1501 ctttctttct ttctttcttt ctctctctct ctctctctct ctctctctct ctctttctct
     1561 ctctctctct ctctctctct ctctttcttt ctttctttct ttctttcttt ctctctctct
     1621 ctctctctct ttctttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt
     1681 tagatctaat tacttaaaat gagacatttt atctagttgt tcccagaatt catagcgttc
     1741 actttcatcc aaaacactac caggaaagtc cctcacaaca ccccttccaa ttccgcctct
     1801 gcacctaaca ctcagtgagg tagtgctaac tgggagggaa gccagcacac atgtgaatat
     1861 agtagtttac aatttccttt tgtaaggcaa ttcattgttg ttgctgtttt ttaattttta
     1921 acctccatca gtactagcca tgcaagtggt gcacagatat acatgtaggc aaaacactcc
     1981 tacccataaa ataaaatgaa acaaaataaa tgaatctata aacaaaaaa
//
