LOCUS       NM_028370               4341 bp    mRNA    linear   ROD 02-OCT-2023
DEFINITION  Mus musculus protection of telomeres 1B (Pot1b), transcript variant
            1, mRNA.
ACCESSION   NM_028370 XM_355022
VERSION     NM_028370.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4341)
  AUTHORS   Takasugi T, Gu P, Liang F, Staco I and Chang S.
  TITLE     Pot1b -/- tumors activate G-quadruplex-induced DNA damage to
            promote telomere hyper-elongation
  JOURNAL   Nucleic Acids Res 51 (17), 9227-9247 (2023)
   PUBMED   37560909
  REMARK    GeneRIF: Pot1b -/- tumors activate G-quadruplex-induced DNA damage
            to promote telomere hyper-elongation.
REFERENCE   2  (bases 1 to 4341)
  AUTHORS   Martinez P, Sanchez-Vazquez R, Ferrara-Romeo I, Serrano R, Flores
            JM and Blasco MA.
  TITLE     A mouse model for Li-Fraumeni-Like Syndrome with cardiac
            angiosarcomas associated to POT1 mutations
  JOURNAL   PLoS Genet 18 (6), e1010260 (2022)
   PUBMED   35727838
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4341)
  AUTHORS   Gu P, Jia S, Takasugi T, Tesmer VM, Nandakumar J, Chen Y and Chang
            S.
  TITLE     Distinct functions of POT1 proteins contribute to the regulation of
            telomerase recruitment to telomeres
  JOURNAL   Nat Commun 12 (1), 5514 (2021)
   PUBMED   34535663
  REMARK    GeneRIF: Distinct functions of POT1 proteins contribute to the
            regulation of telomerase recruitment to telomeres.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4341)
  AUTHORS   Mizuno T, Hirabayashi K, Miyazawa S, Kobayashi Y, Shoji K,
            Kobayashi M, Hanaoka F, Imamoto N and Torigoe H.
  TITLE     The intrinsically disordered N-terminal region of mouse DNA
            polymerase alpha mediates its interaction with POT1a/b at telomeres
  JOURNAL   Genes Cells 26 (6), 360-380 (2021)
   PUBMED   33711210
  REMARK    GeneRIF: The intrinsically disordered N-terminal region of mouse
            DNA polymerase alpha mediates its interaction with POT1a/b at
            telomeres.
REFERENCE   5  (bases 1 to 4341)
  AUTHORS   Markiewicz-Potoczny M, Lobanova A, Loeb AM, Kirak O, Olbrich T,
            Ruiz S and Lazzerini Denchi E.
  TITLE     TRF2-mediated telomere protection is dispensable in pluripotent
            stem cells
  JOURNAL   Nature 589 (7840), 110-115 (2021)
   PUBMED   33239785
REFERENCE   6  (bases 1 to 4341)
  AUTHORS   Guo X, Deng Y, Lin Y, Cosme-Blanco W, Chan S, He H, Yuan G, Brown
            EJ and Chang S.
  TITLE     Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage
            response to suppress tumorigenesis
  JOURNAL   EMBO J 26 (22), 4709-4719 (2007)
   PUBMED   17948054
  REMARK    GeneRIF: Tripeptidyl peptidase I (Tpp1) confers telomere end
            protection by recruiting Pot1a and Pot1b to telomeres.
REFERENCE   7  (bases 1 to 4341)
  AUTHORS   Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan
            CE, de Lange T and Hammer GD.
  TITLE     Telomere protection by mammalian Pot1 requires interaction with
            Tpp1
  JOURNAL   Nat Struct Mol Biol 14 (8), 754-761 (2007)
   PUBMED   17632522
  REMARK    GeneRIF: Tpp1 is required for the protective function of Pot1
            proteins.
            Erratum:[Nat Struct Mol Biol. 2009 May;16(5):572]
REFERENCE   8  (bases 1 to 4341)
  AUTHORS   He H, Multani AS, Cosme-Blanco W, Tahara H, Ma J, Pathak S, Deng Y
            and Chang S.
  TITLE     POT1b protects telomeres from end-to-end chromosomal fusions and
            aberrant homologous recombination
  JOURNAL   EMBO J 25 (21), 5180-5190 (2006)
   PUBMED   17053789
  REMARK    GeneRIF: shRNA mediated depletion of endogenous Pot1b in Pot1a
            deficient cells resulted in increased chromosomal aberrations
REFERENCE   9  (bases 1 to 4341)
  AUTHORS   Hockemeyer D, Daniels JP, Takai H and de Lange T.
  TITLE     Recent expansion of the telomeric complex in rodents: Two distinct
            POT1 proteins protect mouse telomeres
  JOURNAL   Cell 126 (1), 63-77 (2006)
   PUBMED   16839877
REFERENCE   10 (bases 1 to 4341)
  AUTHORS   Wu L, Multani AS, He H, Cosme-Blanco W, Deng Y, Deng JM, Bachilo O,
            Pathak S, Tahara H, Bailey SM, Deng Y, Behringer RR and Chang S.
  TITLE     Pot1 deficiency initiates DNA damage checkpoint activation and
            aberrant homologous recombination at telomeres
  JOURNAL   Cell 126 (1), 49-62 (2006)
   PUBMED   16839876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154443.2 and AC182748.2.
            
            On Oct 12, 2017 this sequence version replaced NM_028370.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.343577.1,
                                           SRR9219382.175150.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC154443.2         34749-34845
            98-165              AC154443.2         36479-36546
            166-212             AC154443.2         41233-41279
            213-327             AC154443.2         47279-47393
            328-458             AC154443.2         48798-48928
            459-749             AC182748.2         999-1289
            750-905             AC182748.2         3439-3594
            906-1075            AC182748.2         8358-8527
            1076-1164           AC182748.2         22176-22264
            1165-1227           AC182748.2         23423-23485
            1228-1384           AC182748.2         26420-26576
            1385-1590           AC182748.2         29699-29904
            1591-1726           AC182748.2         30533-30668
            1727-1815           AC182748.2         31911-31999
            1816-1907           AC182748.2         33762-33853
            1908-2013           AC182748.2         41444-41549
            2014-4341           AC182748.2         42798-45125
FEATURES             Location/Qualifiers
     source          1..4341
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 28.93 cM"
     gene            1..4341
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /note="protection of telomeres 1B"
                     /db_xref="GeneID:72836"
                     /db_xref="MGI:MGI:1920086"
     exon            1..97
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            98..165
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            166..212
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..2126
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="protection of telomeres 1B isoform 1"
                     /protein_id="NP_082646.1"
                     /db_xref="CCDS:CCDS50147.1"
                     /db_xref="GeneID:72836"
                     /db_xref="MGI:MGI:1920086"
                     /translation="MSSAPVAPSTYTPLNLLKEGTVVNVCGVVKFFKPPYLSKGTDYC
                     SVVTIVDQTNVKLTCMLFSRDYDTLPSVYKVGDIVCFQGLKIQAYKNELQAISKFGFA
                     SLTFDGTLGAPIILRTLSKRFNFTAQDYSMVEALRTWASTHISASSNLVQLSDAQPMQ
                     YYDLTCQLLGKAQVDGVSFLLKVWDGTRTKIPSWRVCIQDVAFEGDLSHILQLQNLVV
                     DIVVYDNHVQVAKSLKIGSFLRIYSLHTKLQPINSESTTSLVRLEFHLHGGTSYGRGI
                     RVLPESNYDVDQLKKALESVDLEAIQTSDDTYQSDNVENCLTSSSSESDLVSLYEVER
                     CQPLCATTLTGYHHLEKTSLCDILKQRAPRQYRIRAKLRSYKPRRLPQSVKLFCPKCH
                     LLQEIPSEENVDKILQDATATAPDCKLQDTPLYDSEVWTTEGQGGRQVAVHFVKNDGV
                     LPHSSECLVLIEGGRLCEISRLSSMFHSVIPVRSGPEDLELVDLAAPFLIRGKVCHYG
                     CKQCSNLKTIQNLSIIPNKRLWIPSSVAEVLGIVPLQYVFVMTFMFDDGTGVLDVYLK
                     DSEKFFQIPASEVLTDDDLQRNLEQIMNVICPPGIKIDAHPWLECLIKSYNVTSGTEH
                     QICYQIFDTMIAEDII"
     exon            213..327
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            328..458
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            459..749
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            750..905
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1075
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1164
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1227
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1384
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1590
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1726
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1815
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1907
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2013
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..4341
                     /gene="Pot1b"
                     /gene_synonym="2810458H16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggttggagt gcgcatgcgt gtgtcccacg gctccggaag tcgaagtcgc gtctctgcag
       61 gttgaaaaag ttgccgggat cctcggtgtt ctgtgaggga aaaaactgtt atttcttcag
      121 tttttggaag ttaagcagct gctttgaaga ttagacctta ataagggttg gggtaaatct
      181 gtaaagggat tttccacaga gcaatgtctt cggccccagt agcaccttct acatacacac
      241 ccctaaatct acttaaggaa ggcactgttg tcaatgtctg tggtgttgtg aagttcttta
      301 agcctccgta cttaagcaaa ggaacagatt attgctctgt tgtcacgatt gtggaccaga
      361 caaatgtgaa gttaacatgc atgctcttta gtagagacta cgataccctt cccagcgttt
      421 ataaagttgg agacatcgtt tgcttccaag ggctgaagat ccaagcatat aaaaatgagc
      481 ttcaggcaat cagcaagttt ggttttgcat ctttgacatt tgatggcacc ttaggggctc
      541 ctatcatact gcgtacttta agcaagagat ttaacttcac tgctcaggac tacagtatgg
      601 tagaagcctt gcgaacgtgg gcatccacac acatttcagc ttcttccaac ttagtgcagc
      661 tttctgatgc tcagcccatg cagtattacg acctgacctg tcagctcctg ggcaaagcac
      721 aagtggatgg agtgtcattt ctcctaaagg tatgggatgg caccaggaca aagattccct
      781 cttggagagt ctgcatacaa gacgttgctt ttgaaggtga cttaagtcac attctgcagc
      841 tacagaatct ggtggtagac attgtcgttt atgataatca tgtccaagtg gcaaaatccc
      901 taaagatcgg aagctttctt agaatctata gtctccatac caaacttcag ccaattaatt
      961 cagagtccac aacttccttg gtaagactcg aatttcatct tcatggagga actagttatg
     1021 gtcgtgggat cagagtctta ccagaaagta actatgatgt ggatcagctg aaaaaagctt
     1081 tagaatctgt agacttggaa gccattcaga cctcagatga cacctaccaa tccgacaatg
     1141 tggagaattg tttaacatct tcaagctccg aatcagacct agtttccctg tatgaggtgg
     1201 aaagatgtca accactctgt gctacaacac ttacaggtta ccatcattta gagaagacat
     1261 cgttgtgtga cattttgaag caaagagctc ctcgacagta tcgtatcaga gcaaagctaa
     1321 gatcatacaa gcccagaaga cttcctcagt ctgttaaact tttttgtcct aaatgccatt
     1381 tattgcaaga aattccatct gaggaaaatg tggataaaat tttacaagat gctacagcta
     1441 cagccccaga ctgcaagctg caagatacac cattgtatga ctcagaggtc tggaccactg
     1501 aaggccaagg aggacggcag gttgctgtcc attttgtaaa gaatgacggc gtccttcctc
     1561 actcaagtga atgtctggtt ttgatcgaag gaggccggct ctgtgaaatc tctagactgt
     1621 caagcatgtt tcacagtgtg atccctgtgc ggtctggccc tgaggacctg gagctcgtag
     1681 atctcgcagc accattcctc atacgaggga aggtgtgtca ctatggatgt aaacagtgct
     1741 caaacttgaa aaccatacaa aacttaagta tcattcctaa taaaagacta tggattcctt
     1801 cctctgtggc agaagttctg ggcattgtac ctctacagta tgtgtttgtt atgactttca
     1861 tgtttgatga tggaaccgga gtattggatg tctacctcaa ggattctgag aagtttttcc
     1921 agatcccagc atcagaagtc cttactgatg atgaccttca gagaaatctg gaacagatca
     1981 tgaatgtcat ttgtcctcca ggaataaaaa tagatgcgca cccatggctg gagtgcctca
     2041 tcaagtccta caacgtcaca agtggaacag aacatcaaat atgttaccag atatttgaca
     2101 ccatgattgc agaagacatc atctagcgct gctgttgtgt gtagtgggtg ggtggcatgg
     2161 ggggtaacag tcttacagaa agttaggact gtgactctaa aaaggcattc tgtgttgttg
     2221 aattatccat tcccatttct actatagctt taaggtctct tatacagaaa gacattgtat
     2281 tgttatttat accttcttgt gaatatgttg aaatgtgttt tttctcaaca tgcccagggt
     2341 gacaattaga ttacaaaata agaccacatc ttgtgtggag aaacccagat tttcattttc
     2401 ccttcaggta atctctattg ttaccagaca ttgtaggtct gtcttctgca caagacactt
     2461 gtttttgtgc tgttcactta ccatccttgg ttgggtttat attcctgtcc tgagttttat
     2521 acaagcagtt gatgataatg tgagtgtaga taataacaca ttctattctt gagtctctta
     2581 gctcagtggt ggctaccttt ctttcatcct cttccatttt acttgggaga gagaagaaag
     2641 caatcacaag tggagaggga gggagggacc tgggaaggaa agtggaaggg gagaggggaa
     2701 cctgatctgg tattgggtga gggaaaagaa ctgaagccct aagggccagc agaaagaatg
     2761 aaaacaggca acctcaggaa ataggaggct agtgaaccct ccagaatgta ccagagacct
     2821 gggatgtgag agactctcag gaatcaaagg gagggacctt agatgaaatg cctgacagta
     2881 gggagaggga acttatagag cccaccacca gcaggaagac agaacatcaa gtgagggatg
     2941 gggttgccat cccacagtca catctctgac ccataattct tcctgtctga aagaattaca
     3001 gggatggaaa tggagaggag cctgaggaaa agaagatcca gtgacaagtc caaaatggga
     3061 tccagctcaa agggaggtcc caaggcctga cactattact gaggctatgg agcactcaca
     3121 aaaagggacc taacatgact gccctctgaa agaccaacag gcagctgaaa gagtcagatt
     3181 cagatatctg cacccaacca atggacagaa gcagctgacc cctgttgttg aattagggaa
     3241 ggctgaaaga agctgaggag aagggtgatc ctgtaggagg accagcagtc tcaattaatc
     3301 tggacccctg agatctctca aacactggac caccaaacag acaacagtac accagctgat
     3361 atgagacccc caacacacat acagtagagg acttccaggt ctgttcattc agagatgatg
     3421 cacctaacct tcaagagaca ggaggcccca gggagtttag aggtcaggtg gggtgggggg
     3481 tgggggcttc catgtggaaa cgggtgttgt ggaggagatg tggggtgtgg agcagtcagg
     3541 gtggatggtg ggggtggggt ggggaatgca atatggagtg taaaaattaa taaaaaaaag
     3601 aaagaaatca attatattca ttatcaacca cactccagtg cagtgggcag ctccccacct
     3661 cctgaaaaaa gtctgaatgc tttgtgaact ttatgtcact gcatcttatt tgggtatttg
     3721 tgtgtgtgtg tgtatgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tgtgtgtgtg
     3781 tgaattcata tatttacttg aaatttattt cttcacactt tattcttata tttcctagtt
     3841 ccaacaattt gcctgcaaat ttcacaatgt tcttattttt aatagatgag taatatctca
     3901 ttgttaaatg caccacattt tctttatcta ttttttagtt gaagactatc taggttgttt
     3961 tgctataaac atgtttgaga aagtgtcctt gtggtgtggt agaacagttt ttgggaatgt
     4021 tccccagagt agtgtaggtc ttgattccca atcttctgag aaacagcaaa aattgatttc
     4081 ccatttaact tcagttttac acagaggaat tgcctagcca gtcctggtgt aagaaaactt
     4141 cctgtgcatt cacatgagta tcttgttaac tgagttcccc ttgaacaaat ttttgtcttg
     4201 agtgagtcac tgatgtacta tgacaagtct ttaatgagac atggcataga tctttgaagt
     4261 agaataacac tacttttttt ctgtaataag gaaaatgaac taccgtttcc taattttgta
     4321 attaaaccat ttctgcttgc t
//
