LOCUS       NM_001368678            3406 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus periostin, osteoblast specific factor (Postn),
            transcript variant 6, mRNA.
ACCESSION   NM_001368678 XM_006501653
VERSION     NM_001368678.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3406)
  AUTHORS   Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U.,
            Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M.,
            Richter,M., Schneider,A., Meiners,S., Gautel,M. and Braun,T.
  TITLE     The deubiquitinase USP5 prevents accumulation of protein aggregates
            in cardiomyocytes
  JOURNAL   Sci Adv 11 (4), eado3852 (2025)
   PUBMED   39841822
REFERENCE   2  (bases 1 to 3406)
  AUTHORS   Wang,H., Yao,L., Chen,J., Li,Y., Su,Z., Liu,Y., Li,W., Xiong,Y.,
            Gao,H., Zhang,X. and Zhou,Y.
  TITLE     The dual role of POSTN in maintaining glioblastoma stem cells and
            the immunosuppressive phenotype of microglia in glioblastoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 252 (2024)
   PUBMED   39227950
  REMARK    GeneRIF: The dual role of POSTN in maintaining glioblastoma stem
            cells and the immunosuppressive phenotype of microglia in
            glioblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3406)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3406)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   5  (bases 1 to 3406)
  AUTHORS   Lazaropoulos,M.P., Gibb,A.A., Chapski,D.J., Nair,A.A., Reiter,A.N.,
            Roy,R., Eaton,D.M., Bedi,K.C. Jr., Margulies,K.B., Wellen,K.E.,
            Estaras,C., Vondriska,T.M. and Elrod,J.W.
  TITLE     Nuclear ATP-citrate lyase regulates chromatin-dependent activation
            and maintenance of the myofibroblast gene program
  JOURNAL   Nat Cardiovasc Res 3 (7), 869-882 (2024)
   PUBMED   39196175
REFERENCE   6  (bases 1 to 3406)
  AUTHORS   Yoshioka,N., Fuji,S., Shimakage,M., Kodama,K., Hakura,A.,
            Yutsudo,M., Inoue,H. and Nojima,H.
  TITLE     Suppression of anchorage-independent growth of human cancer cell
            lines by the TRIF52/periostin/OSF-2 gene
  JOURNAL   Exp Cell Res 279 (1), 91-99 (2002)
   PUBMED   12213217
  REMARK    GeneRIF: Human cancer cell lines with reduced endogenous periostin
            gene expression that were infected with a recombinant rat periostin
            gene had reduced anchorage-independent growth
REFERENCE   7  (bases 1 to 3406)
  AUTHORS   Kruzynska-Frejtag,A., Machnicki,M., Rogers,R., Markwald,R.R. and
            Conway,S.J.
  TITLE     Periostin (an osteoblast-specific factor) is expressed within the
            embryonic mouse heart during valve formation
  JOURNAL   Mech Dev 103 (1-2), 183-188 (2001)
   PUBMED   11335131
REFERENCE   8  (bases 1 to 3406)
  AUTHORS   Horiuchi,K., Amizuka,N., Takeshita,S., Takamatsu,H., Katsuura,M.,
            Ozawa,H., Toyama,Y., Bonewald,L.F. and Kudo,A.
  TITLE     Identification and characterization of a novel protein, periostin,
            with restricted expression to periosteum and periodontal ligament
            and increased expression by transforming growth factor beta
  JOURNAL   J Bone Miner Res 14 (7), 1239-1249 (1999)
   PUBMED   10404027
REFERENCE   9  (bases 1 to 3406)
  AUTHORS   Sugiura,T., Takamatsu,H., Kudo,A. and Amann,E.
  TITLE     Expression and characterization of murine osteoblast-specific
            factor 2 (OSF-2) in a baculovirus expression system
  JOURNAL   Protein Expr Purif 6 (3), 305-311 (1995)
   PUBMED   7663166
REFERENCE   10 (bases 1 to 3406)
  AUTHORS   Takeshita,S., Kikuno,R., Tezuka,K. and Amann,E.
  TITLE     Osteoblast-specific factor 2: cloning of a putative bone adhesion
            protein with homology with the insect protein fasciclin I
  JOURNAL   Biochem J 294 (Pt 1) (Pt 1), 271-278 (1993)
   PUBMED   8363580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC117594.8 and AC139043.6.
            
            On Feb 14, 2019 this sequence version replaced XM_006501653.2.
            
            Summary: This gene encodes a secreted extracellular matrix protein
            that functions in tissue development and regeneration, including
            wound healing and ventricular remodeling following myocardial
            infarction. The encoded protein binds to integrins to support
            adhesion and migration of epithelial cells. This protein plays a
            role in cancer stem cell maintenance and metastasis. Mice lacking
            this gene exhibit cardiac valve disease, and skeletal and dental
            defects. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (6) contains an alternate exon in
            the 5' UTR and two alternate in-frame exons in the 3' coding
            region, compared to variant 1. It encodes isoform 6, which is
            longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.262180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC117594.8         627-701             c
            76-272              AC139043.6         108820-109016       c
            273-371             AC139043.6         107362-107460       c
            372-436             AC139043.6         104119-104183       c
            437-594             AC139043.6         102429-102586       c
            595-759             AC139043.6         100774-100938       c
            760-906             AC139043.6         99743-99889         c
            907-1048            AC139043.6         99115-99256         c
            1049-1261           AC139043.6         97871-98083         c
            1262-1396           AC139043.6         97183-97317         c
            1397-1545           AC139043.6         96234-96382         c
            1546-1682           AC139043.6         94933-95069         c
            1683-1813           AC139043.6         93920-94050         c
            1814-1944           AC139043.6         93267-93397         c
            1945-2047           AC139043.6         93074-93176         c
            2048-2115           AC139043.6         92855-92922         c
            2116-2161           AC139043.6         92481-92526         c
            2162-2242           AC139043.6         89595-89675         c
            2243-2332           AC139043.6         86610-86699         c
            2333-2422           AC139043.6         85514-85603         c
            2423-2500           AC139043.6         84802-84879         c
            2501-2584           AC139043.6         84333-84416         c
            2585-2626           AC139043.6         80707-80748         c
            2627-3406           AC139043.6         79046-79825         c
FEATURES             Location/Qualifiers
     source          1..3406
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.46 cM"
     gene            1..3406
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /note="periostin, osteoblast specific factor"
                     /db_xref="GeneID:50706"
                     /db_xref="MGI:MGI:1926321"
     exon            1..75
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            76..272
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2664
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /note="isoform 6 precursor is encoded by transcript
                     variant 6; periostin-like factor; osteoblast-specific
                     factor 2; osteoblast specific factor 2 (fasciclin I-like)"
                     /codon_start=1
                     /product="periostin isoform 6 precursor"
                     /protein_id="NP_001355607.1"
                     /db_xref="CCDS:CCDS89624.1"
                     /db_xref="GeneID:50706"
                     /db_xref="MGI:MGI:1926321"
                     /translation="MVPLLPLYALLLLFLCDINPANANSYYDKVLAHSRIRGRDQGPN
                     VCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDH
                     VYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWENLDSDIRRGLENNVN
                     VELLNALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQ
                     IATNGVVHVIDRVLTQIGTSIQDFLEAEDDLSSFRAAAITSDLLESLGRDGHFTLFAP
                     TNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIG
                     CEGDSISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQ
                     LGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQI
                     LETIGGKQLRVFVYRTAICIENSCMVRGSKQGRNGAIHIFREIIQPAEKSLHDKLRQD
                     KRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKGMTSEERELLIGDKNALQNIIL
                     YHLTPGVYIGKGFEPGVTNILKTTQGSKIYLKGVNETLLVNELKSKESDIMTTNGVIH
                     VVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYTTKIITKVVEP
                     KIKVIQGSLQPIIKTEGPAMTKIQIEGDPDFRLIKEGETVTEVIHGEPVIKKYTKIID
                     GVPVEITEKQTREERIITGPEIKYTRISTGGGETGETLQKFLQKEVSKVTKFIEGGDG
                     HLFEDEEIKRLLQGDTPAKKIPANKRVQGPRRRSREGRSQ"
     exon            273..371
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            372..436
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            437..594
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            595..759
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            760..906
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1048
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1261
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1396
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1545
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1682
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1813
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1944
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2047
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2115
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2161
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2242
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2332
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2422
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2500
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2584
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2626
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..3406
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3383..3388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /note="hexamer: AATAAA"
     polyA_site      3406
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /note="major polyA site"
ORIGIN      
        1 tccctgatgt cattactgat cctaattggt aaatattttc gaagggttgg catttgttga
       61 cttgatgaga gtttgcccag agctatataa actcagctct ccagagcaca ggccagatct
      121 cttcctggac ggagctcagg gctgaagatg gttcctctcc tgcccttata tgctctgctg
      181 ctgctgttcc tgtgtgatat taaccctgca aatgccaaca gttactatga caaggtcctg
      241 gctcacagcc gcatcagggg tcgggatcag ggcccaaacg tctgtgccct ccagcaaatt
      301 ctgggcacca aaaagaaata cttcagctcc tgtaagaact ggtatcaagg tgctatctgc
      361 gggaagaaaa ccactgtgct atatgaatgc tgccctggct atatgagaat ggaagggatg
      421 aaaggctgcc ccgcagtgat gcctattgac catgtttatg gcacgctggg cattgtggga
      481 gccactacca ctcagcacta ctccgatgtc tcgaagctga gagaagagat tgaaggaaaa
      541 gggtcataca cgtacttcgc gccgagtaac gaggcttggg agaacctgga ttctgacatt
      601 cgcagaggac tggagaacaa tgtcaatgtt gagctactga atgccttaca cagccacatg
      661 gttaataaga gaatgttaac caaggacctg aaacacggca tggttattcc ttcaatgtac
      721 aacaatctgg ggctttttat taaccattat cccaatgggg ttgtcactgt gaactgtgct
      781 cgagtcatcc atgggaacca gattgccaca aatggtgtcg tccatgtcat tgaccgtgtc
      841 ctgacacaaa ttggtacctc catccaagac ttccttgaag cagaagacga cctttcatca
      901 tttagagcag ccgccatcac ctctgacctc ttggagtccc ttggaagaga tggtcacttc
      961 acgctctttg ctcccaccaa tgaagctttc gagaaactgc cacgaggtgt cctagaaagg
     1021 atcatgggag acaaagtggc ttctgaagct ctcatgaagt accacatcct aaataccctc
     1081 cagtgctctg aggccatcac tggaggagcc gtgtttgaga ccatggaagg aaacactatt
     1141 gagatagggt gcgaagggga cagtatctcc attaacggaa tcaagatggt gaacaagaaa
     1201 gacattgtga ctaagaatgg tgtcatccac ctgattgatg aagtcctcat tcctgattct
     1261 gccaaacaag ttattgagct ggctggaaaa cagcaaacca ctttcaccga cctggtagcc
     1321 caattaggct tggcatcctc tctgaagcca gatggagagt acaccttatt agcacctgtg
     1381 aacaatgcgt tctctgatga cactctgagc atggaccaac gccttcttaa gctaattctg
     1441 caaaatcaca tattgaaagt aaaagttggc cttagcgacc tctacaatgg acagatactg
     1501 gaaaccattg gaggcaaaca actccgagtc tttgtgtatc ggacggctat ctgcatagaa
     1561 aactcatgca tggtgagagg aagcaagcag ggaaggaatg gtgccattca catattccga
     1621 gaaatcatcc aaccagcaga gaaatccctg cacgacaagc tgcggcaaga caagcgcttt
     1681 agcatcttcc tcagcctcct tgaagctgca gatttgaaag atctcctgac acagcccgga
     1741 gattggacct tgtttgcacc aaccaatgat gccttcaagg gaatgactag cgaagaaagg
     1801 gagcttctga ttggggataa aaatgctctc caaaacatca ttctttatca cctgacccca
     1861 ggggtttata ttggaaaggg attcgaaccc ggagtcacta atatcctgaa gaccacacag
     1921 ggaagcaaaa tctatctgaa aggagtaaac gaaacgcttc tagtgaatga gttgaagtcc
     1981 aaagaatctg acatcatgac gacaaatggt gtcatccacg tcgtggacaa actcctctat
     2041 ccagcagata ttccagttgg aaatgatcag ctcttggaat tactgaacaa actgataaaa
     2101 tacatccaaa tcaagtttgt tcgtggcagc accttcaaag aaatccccat gactgtctat
     2161 acaactaaaa ttataaccaa agtcgtggaa ccaaaaatta aagtcattca aggcagtctt
     2221 cagcctatta tcaaaacgga aggacctgca atgacgaaga tccaaattga aggtgatccc
     2281 gacttcaggc tgattaaaga aggcgaaacg gtgacagaag tgatccacgg agagccagtc
     2341 attaaaaagt acaccaaaat catagatgga gttcctgttg aaataactga aaaacagact
     2401 cgggaagaac gaatcattac aggtcctgag ataaaatata ccaggatttc cacaggaggt
     2461 ggagaaacag gagagacctt gcagaaattc ttgcaaaaag aggtctccaa ggtcacaaag
     2521 ttcattgaag gtggcgatgg tcacttattt gaagatgagg agattaaaag actgcttcag
     2581 ggagacacac ctgcaaagaa gataccagcc aacaaaaggg ttcaagggcc tagaagacga
     2641 tcaagagaag gccgttctca gtgaaaaccc agaggccaga ccacagagtt tatataatcc
     2701 taaatcaacg atctgatttt aagggaaatt gtaagagcca ccacactgac ttcagaatct
     2761 gaaatgacaa ccaacagaag ccaatcttca agcaagtcca aacacagagt tcatgtcttt
     2821 gtttctgcat gagaaatata agaaaatgat agctagtctc ctgtggggta ggaactgagg
     2881 aaatatagga ccatgcaggg attttatctc aatgagaaaa cttctgatta aagtagaatc
     2941 caccaaagaa catcattgtg actgggtcca tacagctaag tctttgcaca gtaaaaacct
     3001 tccgcctcag gaagaggctg gaaaaaccca aagcacacag ttacctttcc aggggaggct
     3061 aaggtatcaa aaggggtgtt cagttataca acatgcaaac aaacctacca aattacgaac
     3121 agtggtgtta catatttctc atgcaatgtg ggtttcctgc taaattttgt tatttttaca
     3181 cttgatttat atcctcgaga tgattgtcat aagcttcttg caatacaaat gttttctctc
     3241 aaacatttca ataaaaccat tcttcaggta taaagagaat tactgcagag ttggtaattc
     3301 agaaaactca aggtttaagt taaaagtgag tttagacttt ggaataggac ttcatacctt
     3361 tttttattgt taacaagtac tcaataaagg aaactgaata aactaa
//
