LOCUS       NM_001198766            3130 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus periostin, osteoblast specific factor (Postn),
            transcript variant 3, mRNA.
ACCESSION   NM_001198766
VERSION     NM_001198766.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3130)
  AUTHORS   Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U.,
            Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M.,
            Richter,M., Schneider,A., Meiners,S., Gautel,M. and Braun,T.
  TITLE     The deubiquitinase USP5 prevents accumulation of protein aggregates
            in cardiomyocytes
  JOURNAL   Sci Adv 11 (4), eado3852 (2025)
   PUBMED   39841822
REFERENCE   2  (bases 1 to 3130)
  AUTHORS   Wang,H., Yao,L., Chen,J., Li,Y., Su,Z., Liu,Y., Li,W., Xiong,Y.,
            Gao,H., Zhang,X. and Zhou,Y.
  TITLE     The dual role of POSTN in maintaining glioblastoma stem cells and
            the immunosuppressive phenotype of microglia in glioblastoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 252 (2024)
   PUBMED   39227950
  REMARK    GeneRIF: The dual role of POSTN in maintaining glioblastoma stem
            cells and the immunosuppressive phenotype of microglia in
            glioblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3130)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3130)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   5  (bases 1 to 3130)
  AUTHORS   Lazaropoulos,M.P., Gibb,A.A., Chapski,D.J., Nair,A.A., Reiter,A.N.,
            Roy,R., Eaton,D.M., Bedi,K.C. Jr., Margulies,K.B., Wellen,K.E.,
            Estaras,C., Vondriska,T.M. and Elrod,J.W.
  TITLE     Nuclear ATP-citrate lyase regulates chromatin-dependent activation
            and maintenance of the myofibroblast gene program
  JOURNAL   Nat Cardiovasc Res 3 (7), 869-882 (2024)
   PUBMED   39196175
REFERENCE   6  (bases 1 to 3130)
  AUTHORS   Yoshioka,N., Fuji,S., Shimakage,M., Kodama,K., Hakura,A.,
            Yutsudo,M., Inoue,H. and Nojima,H.
  TITLE     Suppression of anchorage-independent growth of human cancer cell
            lines by the TRIF52/periostin/OSF-2 gene
  JOURNAL   Exp Cell Res 279 (1), 91-99 (2002)
   PUBMED   12213217
  REMARK    GeneRIF: Human cancer cell lines with reduced endogenous periostin
            gene expression that were infected with a recombinant rat periostin
            gene had reduced anchorage-independent growth
REFERENCE   7  (bases 1 to 3130)
  AUTHORS   Kruzynska-Frejtag,A., Machnicki,M., Rogers,R., Markwald,R.R. and
            Conway,S.J.
  TITLE     Periostin (an osteoblast-specific factor) is expressed within the
            embryonic mouse heart during valve formation
  JOURNAL   Mech Dev 103 (1-2), 183-188 (2001)
   PUBMED   11335131
REFERENCE   8  (bases 1 to 3130)
  AUTHORS   Horiuchi,K., Amizuka,N., Takeshita,S., Takamatsu,H., Katsuura,M.,
            Ozawa,H., Toyama,Y., Bonewald,L.F. and Kudo,A.
  TITLE     Identification and characterization of a novel protein, periostin,
            with restricted expression to periosteum and periodontal ligament
            and increased expression by transforming growth factor beta
  JOURNAL   J Bone Miner Res 14 (7), 1239-1249 (1999)
   PUBMED   10404027
REFERENCE   9  (bases 1 to 3130)
  AUTHORS   Sugiura,T., Takamatsu,H., Kudo,A. and Amann,E.
  TITLE     Expression and characterization of murine osteoblast-specific
            factor 2 (OSF-2) in a baculovirus expression system
  JOURNAL   Protein Expr Purif 6 (3), 305-311 (1995)
   PUBMED   7663166
REFERENCE   10 (bases 1 to 3130)
  AUTHORS   Takeshita,S., Kikuno,R., Tezuka,K. and Amann,E.
  TITLE     Osteoblast-specific factor 2: cloning of a putative bone adhesion
            protein with homology with the insect protein fasciclin I
  JOURNAL   Biochem J 294 (Pt 1) (Pt 1), 271-278 (1993)
   PUBMED   8363580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC139043.6.
            
            Summary: This gene encodes a secreted extracellular matrix protein
            that functions in tissue development and regeneration, including
            wound healing and ventricular remodeling following myocardial
            infarction. The encoded protein binds to integrins to support
            adhesion and migration of epithelial cells. This protein plays a
            role in cancer stem cell maintenance and metastasis. Mice lacking
            this gene exhibit cardiac valve disease, and skeletal and dental
            defects. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. It encodes
            isoform 3, which is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031449.1, AK154049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC139043.6         108820-108980       c
            162-260             AC139043.6         107362-107460       c
            261-325             AC139043.6         104119-104183       c
            326-483             AC139043.6         102429-102586       c
            484-648             AC139043.6         100774-100938       c
            649-795             AC139043.6         99743-99889         c
            796-937             AC139043.6         99115-99256         c
            938-1150            AC139043.6         97871-98083         c
            1151-1285           AC139043.6         97183-97317         c
            1286-1434           AC139043.6         96234-96382         c
            1435-1571           AC139043.6         94933-95069         c
            1572-1702           AC139043.6         93920-94050         c
            1703-1833           AC139043.6         93267-93397         c
            1834-1936           AC139043.6         93074-93176         c
            1937-2004           AC139043.6         92855-92922         c
            2005-2050           AC139043.6         92481-92526         c
            2051-2140           AC139043.6         86610-86699         c
            2141-2230           AC139043.6         85514-85603         c
            2231-2308           AC139043.6         84802-84879         c
            2309-2350           AC139043.6         80707-80748         c
            2351-3130           AC139043.6         79046-79825         c
FEATURES             Location/Qualifiers
     source          1..3130
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.46 cM"
     gene            1..3130
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /note="periostin, osteoblast specific factor"
                     /db_xref="GeneID:50706"
                     /db_xref="MGI:MGI:1926321"
     exon            1..161
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..2388
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; periostin-like factor; osteoblast-specific
                     factor 2; osteoblast specific factor 2 (fasciclin I-like)"
                     /codon_start=1
                     /product="periostin isoform 3 precursor"
                     /protein_id="NP_001185695.1"
                     /db_xref="CCDS:CCDS57212.1"
                     /db_xref="GeneID:50706"
                     /db_xref="MGI:MGI:1926321"
                     /translation="MVPLLPLYALLLLFLCDINPANANSYYDKVLAHSRIRGRDQGPN
                     VCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDH
                     VYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWENLDSDIRRGLENNVN
                     VELLNALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQ
                     IATNGVVHVIDRVLTQIGTSIQDFLEAEDDLSSFRAAAITSDLLESLGRDGHFTLFAP
                     TNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIG
                     CEGDSISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQ
                     LGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQI
                     LETIGGKQLRVFVYRTAICIENSCMVRGSKQGRNGAIHIFREIIQPAEKSLHDKLRQD
                     KRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKGMTSEERELLIGDKNALQNIIL
                     YHLTPGVYIGKGFEPGVTNILKTTQGSKIYLKGVNETLLVNELKSKESDIMTTNGVIH
                     VVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYRPAMTKIQIEG
                     DPDFRLIKEGETVTEVIHGEPVIKKYTKIIDGVPVEITEKQTREERIITGPEIKYTRI
                     STGGGETGETLQKFLQKDTPAKKIPANKRVQGPRRRSREGRSQ"
     exon            162..260
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            261..325
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            326..483
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            484..648
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            649..795
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            796..937
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1150
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1285
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1434
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1571
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1702
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1833
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1936
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2004
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2050
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2140
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2230
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2308
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2350
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..3130
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /note="hexamer: AATAAA"
     polyA_site      3130
                     /gene="Postn"
                     /gene_synonym="A630052E07Rik; OSF-2; Osf2; PLF; PN"
                     /note="major polyA site"
ORIGIN      
        1 gccagatctc ttcctggacg gagctcaggg ctgaagatgg ttcctctcct gcccttatat
       61 gctctgctgc tgctgttcct gtgtgatatt aaccctgcaa atgccaacag ttactatgac
      121 aaggtcctgg ctcacagccg catcaggggt cgggatcagg gcccaaacgt ctgtgccctc
      181 cagcaaattc tgggcaccaa aaagaaatac ttcagctcct gtaagaactg gtatcaaggt
      241 gctatctgcg ggaagaaaac cactgtgcta tatgaatgct gccctggcta tatgagaatg
      301 gaagggatga aaggctgccc cgcagtgatg cctattgacc atgtttatgg cacgctgggc
      361 attgtgggag ccactaccac tcagcactac tccgatgtct cgaagctgag agaagagatt
      421 gaaggaaaag ggtcatacac gtacttcgcg ccgagtaacg aggcttggga gaacctggat
      481 tctgacattc gcagaggact ggagaacaat gtcaatgttg agctactgaa tgccttacac
      541 agccacatgg ttaataagag aatgttaacc aaggacctga aacacggcat ggttattcct
      601 tcaatgtaca acaatctggg gctttttatt aaccattatc ccaatggggt tgtcactgtg
      661 aactgtgctc gagtcatcca tgggaaccag attgccacaa atggtgtcgt ccatgtcatt
      721 gaccgtgtcc tgacacaaat tggtacctcc atccaagact tccttgaagc agaagacgac
      781 ctttcatcat ttagagcagc cgccatcacc tctgacctct tggagtccct tggaagagat
      841 ggtcacttca cgctctttgc tcccaccaat gaagctttcg agaaactgcc acgaggtgtc
      901 ctagaaagga tcatgggaga caaagtggct tctgaagctc tcatgaagta ccacatccta
      961 aataccctcc agtgctctga ggccatcact ggaggagccg tgtttgagac catggaagga
     1021 aacactattg agatagggtg cgaaggggac agtatctcca ttaacggaat caagatggtg
     1081 aacaagaaag acattgtgac taagaatggt gtcatccacc tgattgatga agtcctcatt
     1141 cctgattctg ccaaacaagt tattgagctg gctggaaaac agcaaaccac tttcaccgac
     1201 ctggtagccc aattaggctt ggcatcctct ctgaagccag atggagagta caccttatta
     1261 gcacctgtga acaatgcgtt ctctgatgac actctgagca tggaccaacg ccttcttaag
     1321 ctaattctgc aaaatcacat attgaaagta aaagttggcc ttagcgacct ctacaatgga
     1381 cagatactgg aaaccattgg aggcaaacaa ctccgagtct ttgtgtatcg gacggctatc
     1441 tgcatagaaa actcatgcat ggtgagagga agcaagcagg gaaggaatgg tgccattcac
     1501 atattccgag aaatcatcca accagcagag aaatccctgc acgacaagct gcggcaagac
     1561 aagcgcttta gcatcttcct cagcctcctt gaagctgcag atttgaaaga tctcctgaca
     1621 cagcccggag attggacctt gtttgcacca accaatgatg ccttcaaggg aatgactagc
     1681 gaagaaaggg agcttctgat tggggataaa aatgctctcc aaaacatcat tctttatcac
     1741 ctgaccccag gggtttatat tggaaaggga ttcgaacccg gagtcactaa tatcctgaag
     1801 accacacagg gaagcaaaat ctatctgaaa ggagtaaacg aaacgcttct agtgaatgag
     1861 ttgaagtcca aagaatctga catcatgacg acaaatggtg tcatccacgt cgtggacaaa
     1921 ctcctctatc cagcagatat tccagttgga aatgatcagc tcttggaatt actgaacaaa
     1981 ctgataaaat acatccaaat caagtttgtt cgtggcagca ccttcaaaga aatccccatg
     2041 actgtctata gacctgcaat gacgaagatc caaattgaag gtgatcccga cttcaggctg
     2101 attaaagaag gcgaaacggt gacagaagtg atccacggag agccagtcat taaaaagtac
     2161 accaaaatca tagatggagt tcctgttgaa ataactgaaa aacagactcg ggaagaacga
     2221 atcattacag gtcctgagat aaaatatacc aggatttcca caggaggtgg agaaacagga
     2281 gagaccttgc agaaattctt gcaaaaagac acacctgcaa agaagatacc agccaacaaa
     2341 agggttcaag ggcctagaag acgatcaaga gaaggccgtt ctcagtgaaa acccagaggc
     2401 cagaccacag agtttatata atcctaaatc aacgatctga ttttaaggga aattgtaaga
     2461 gccaccacac tgacttcaga atctgaaatg acaaccaaca gaagccaatc ttcaagcaag
     2521 tccaaacaca gagttcatgt ctttgtttct gcatgagaaa tataagaaaa tgatagctag
     2581 tctcctgtgg ggtaggaact gaggaaatat aggaccatgc agggatttta tctcaatgag
     2641 aaaacttctg attaaagtag aatccaccaa agaacatcat tgtgactggg tccatacagc
     2701 taagtctttg cacagtaaaa accttccgcc tcaggaagag gctggaaaaa cccaaagcac
     2761 acagttacct ttccagggga ggctaaggta tcaaaagggg tgttcagtta tacaacatgc
     2821 aaacaaacct accaaattac gaacagtggt gttacatatt tctcatgcaa tgtgggtttc
     2881 ctgctaaatt ttgttatttt tacacttgat ttatatcctc gagatgattg tcataagctt
     2941 cttgcaatac aaatgttttc tctcaaacat ttcaataaaa ccattcttca ggtataaaga
     3001 gaattactgc agagttggta attcagaaaa ctcaaggttt aagttaaaag tgagtttaga
     3061 ctttggaata ggacttcata ccttttttta ttgttaacaa gtactcaata aaggaaactg
     3121 aataaactaa
//
