LOCUS       NM_023638               1900 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus porcupine O-acyltransferase (Porcn), transcript
            variant d, mRNA.
ACCESSION   NM_023638
VERSION     NM_023638.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Young,C.A., Burt,E. and Munnamalai,V.
  TITLE     A cochlear progenitor pool influences patterning of the mammalian
            sensory epithelium via MYBL2
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39254648
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Sato,N., Rosa,V.S., Makhlouf,A., Kretzmer,H., Sampath Kumar,A.,
            Grosswendt,S., Mattei,A.L., Courbot,O., Wolf,S., Boulanger,J.,
            Langevin,F., Wiacek,M., Karpinski,D., Elosegui-Artola,A.,
            Meissner,A., Zernicka-Goetz,M. and Shahbazi,M.N.
  TITLE     Basal delamination during mouse gastrulation primes pluripotent
            cells for differentiation
  JOURNAL   Dev Cell 59 (10), 1252-1268 (2024)
   PUBMED   38579720
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Duarte,P., Brattig Correia,R., Novoa,A. and Mallo,M.
  TITLE     Regulatory changes associated with the head to trunk developmental
            transition
  JOURNAL   BMC Biol 21 (1), 170 (2023)
   PUBMED   37553620
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Kraiczy,J., McCarthy,N., Malagola,E., Tie,G., Madha,S.,
            Boffelli,D., Wagner,D.E., Wang,T.C. and Shivdasani,R.A.
  TITLE     Graded BMP signaling within intestinal crypt architecture directs
            self-organization of the Wnt-secreting stem cell niche
  JOURNAL   Cell Stem Cell 30 (4), 433-449 (2023)
   PUBMED   37028407
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Oliver,B.L., Young,C.A. and Munnamalai,V.
  TITLE     Spatial and temporal expression of PORCN is highly dynamic in the
            developing mouse cochlea
  JOURNAL   Gene Expr Patterns 42, 119214 (2021)
   PUBMED   34547456
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Means,G.D., Boyd,Y., Willis,C.R. and Derry,J.M.
  TITLE     Transgenic rescue of the tattered phenotype by using a BAC encoding
            Ebp
  JOURNAL   Mamm Genome 12 (4), 323-325 (2001)
   PUBMED   11309666
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Tanaka,K., Okabayashi,K., Asashima,M., Perrimon,N. and Kadowaki,T.
  TITLE     The evolutionarily conserved porcupine gene family is involved in
            the processing of the Wnt family
  JOURNAL   Eur J Biochem 267 (13), 4300-4311 (2000)
   PUBMED   10866835
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   Means,G.D., Toy,D.Y., Baum,P.R. and Derry,J.M.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Derry,J.M., Gormally,E., Means,G.D., Zhao,W., Meindl,A.,
            Kelley,R.I., Boyd,Y. and Herman,G.E.
  TITLE     Mutations in a delta 8-delta 7 sterol isomerase in the tattered
            mouse and X-linked dominant chondrodysplasia punctata.
            jderry@immunex.com
  JOURNAL   Nat Genet 22 (3), 286-290 (1999)
   PUBMED   10391218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663032.9, BF462782.1, BQ556448.1, BU707440.1, AK010405.1 and
            AI839581.1.
            
            On May 7, 2015 this sequence version replaced NM_023638.3.
            
            Transcript Variant: This variant (d) contains two alternate
            in-frame exons compared to variant a. The encoded isoform (D) is
            longer than isoform A.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB036749.1, SRR17784643.1553954.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL663032.9         158879-158897       c
            20-569              BF462782.1         2-551
            570-870             BQ556448.1         376-676
            871-904             BU707440.1         277-310
            905-1897            AK010405.1         333-1325
            1898-1900           AI839581.1         19-21               c
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.7 cM"
     gene            1..1900
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /note="porcupine O-acyltransferase"
                     /db_xref="GeneID:53627"
                     /db_xref="MGI:MGI:1890212"
     exon            1..151
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            152..320
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1570
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /EC_number="2.3.1.250"
                     /note="isoform D is encoded by transcript variant d;
                     probable protein-cysteine N-palmitoyltransferase
                     porcupine; protein-serine O-palmitoleoyltransferase
                     porcupine; porcupine homolog"
                     /codon_start=1
                     /product="protein-serine O-palmitoleoyltransferase
                     porcupine isoform D"
                     /protein_id="NP_076127.1"
                     /db_xref="CCDS:CCDS29991.1"
                     /db_xref="GeneID:53627"
                     /db_xref="MGI:MGI:1890212"
                     /translation="MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWR
                     LGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVT
                     ILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLY
                     FVGTIVFGPWISFHSYLQAVQGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYF
                     IPLDGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEE
                     KDHLEWDLTVSRPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTY
                     AASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLAQILSACILSKRCLPDCSHRHRLG
                     LGVRALNLLFGALAIFHLSYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVT
                     FGCWIFYRLIG"
     exon            321..513
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            514..557
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            558..739
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            740..870
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            871..888
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            889..903
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1029
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1130
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1207
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1271
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1357
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1468
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1900
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1875..1880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /note="hexamer: AATAAA"
     polyA_site      1898
                     /gene="Porcn"
                     /gene_synonym="2410004O13Rik; DXHXS7465e; Mg61; mMg61;
                     Mporc; porc; Ppn"
                     /note="major polyA site"
ORIGIN      
        1 gggatttaaa gggcccgctc ggccgcgccg ccctgggagc cactgctggt cccggccttg
       61 cggcctgcgg gggaggctgc caggaggagg tggcgacagt ggcagcggtg cgcgtccccg
      121 gcccccagga ccacggcttc ctttctgcca gctccatctg tccatccatc tgtgtgggtc
      181 cacaatggcc accttcagcc gccaggaatt tttccagcag ctactgcagg gctgtctcct
      241 gcctactgtc caacagggcc ttgaccagat ctggctgctt cttaccatct gcttcgcctg
      301 ccgcctcctt tggaggctgg ggttaccgtc ttacctgaag catgcaagca ccgtggcagg
      361 tggcttcttc agcctctacc acttcttcca gctgcacatg gtttgggtcg tgctgctgag
      421 cctcctgtgc tacctcgtgc tgttcctctg ccgacactcc tcccaccgag gcgtcttcct
      481 ctccgtcacc atcctcatct acctgctcat gggtgagatg cacatggtgg acaccgtgac
      541 atggcacaag atgcgagggg cccagatgat cgtggccatg aaggcggtgt ctctgggctt
      601 cgacctggac cggggcgagg tgggtgcagt gccctcacct gtggagttca tgggctacct
      661 ctactttgtg ggcaccatcg tctttgggcc ctggatatcc ttccacagct acctacaggc
      721 tgtccaaggc cgcccactga gccgccgatg gctgaagaag gtggcccgga gcctggcgct
      781 ggccctgctg tgccttgtac tgtccacttg tgtgggcccc tacctcttcc cctacttcat
      841 ccccctcgac ggtgaccgac tccttcgcaa caagaaacgc aaagccaggg gcaccatggt
      901 aaggtggcta cgagcctacg agagtgctgt ctccttccac ttcagcaact attttgtggg
      961 ctttctgtct gaggccacag ccacattggc cggggctggc ttcacggagg agaaggacca
     1021 cctggaatgg gacctgacag tctctagacc gttgaatgtg gagctgcccc ggtccatggt
     1081 ggaagttgtc acaagctgga acctgcccat gtcttattgg ttaaataatt atgttttcaa
     1141 aaatgccctt cgcctgggga ccttctctgc tgtgctggtc acctatgcag ccagtgccct
     1201 cctgcatggc ttcagtttcc acctggctgc tgtgctgctg tccctggcat tcatcactta
     1261 tgtggaacat gtcctcagaa agcgcctggc tcagatcctc agtgcctgca tcttgtcaaa
     1321 gcgttgtctg ccagactgtt cacatcggca tcgcttgggc ctgggggtac gagccttaaa
     1381 cttgctcttt ggggccctgg ctatcttcca cctgtcctac ctgggctccc tgtttgatgt
     1441 cgatgtggac gacaccacag aggagcaggg ctacggcatg gcatacactg tccacaagtg
     1501 gtcagagctc agctgggcca gtcactgggt cacttttgga tgctggatct tctaccgtct
     1561 cataggctga ggcatatgac catcataatc cccttcaata cccctcctta gggtgccaac
     1621 tctgatgggg gatgagaaaa gaccctttct ctactccttt tcccttatcc attcttgacc
     1681 cccaacaccc ctccacacaa cataggaaca cacacaactt tctatgcctg tcaatcctca
     1741 ccccgccacc aggcaggaag ggggtggtcc ttattgggcc aaggaacgat ggatacttgg
     1801 gaaagcagac aggagcagat ccagggcctc tgcgcctgcc gtctcccttt tttatatgca
     1861 gtttgttatt gtcgaataaa agtagaactt acacaacagg
//
