LOCUS       NM_024286               1851 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus popeye domain containing 3 (Popdc3), mRNA.
ACCESSION   NM_024286
VERSION     NM_024286.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1851)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1851)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1851)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   4  (bases 1 to 1851)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1851)
  AUTHORS   Froese,A., Breher,S.S., Waldeyer,C., Schindler,R.F., Nikolaev,V.O.,
            Rinne,S., Wischmeyer,E., Schlueter,J., Becher,J., Simrick,S.,
            Vauti,F., Kuhtz,J., Meister,P., Kreissl,S., Torlopp,A.,
            Liebig,S.K., Laakmann,S., Muller,T.D., Neumann,J., Stieber,J.,
            Ludwig,A., Maier,S.K., Decher,N., Arnold,H.H., Kirchhof,P.,
            Fabritz,L. and Brand,T.
  TITLE     Popeye domain containing proteins are essential for stress-mediated
            modulation of cardiac pacemaking in mice
  JOURNAL   J Clin Invest 122 (3), 1119-1130 (2012)
   PUBMED   22354168
REFERENCE   6  (bases 1 to 1851)
  AUTHORS   Matsubara,S., Takahashi,T. and Kimura,A.P.
  TITLE     Epigenetic patterns at the mouse prolyl oligopeptidase gene locus
            suggest the CpG island in the gene body to be a novel regulator for
            gene expression
  JOURNAL   Gene 465 (1-2), 17-29 (2010)
   PUBMED   20600704
REFERENCE   7  (bases 1 to 1851)
  AUTHORS   Andree,B., Fleige,A., Arnold,H.H. and Brand,T.
  TITLE     Mouse Pop1 is required for muscle regeneration in adult skeletal
            muscle
  JOURNAL   Mol Cell Biol 22 (5), 1504-1512 (2002)
   PUBMED   11839816
REFERENCE   8  (bases 1 to 1851)
  AUTHORS   Andree,B., Hillemann,T., Kessler-Icekson,G., Schmitt-John,T.,
            Jockusch,H., Arnold,H.H. and Brand,T.
  TITLE     Isolation and characterization of the novel popeye gene family
            expressed in skeletal muscle and heart
  JOURNAL   Dev Biol 223 (2), 371-382 (2000)
   PUBMED   10882522
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052325.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052325.1, BC114993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.35 cM"
     gene            1..1851
                     /gene="Popdc3"
                     /gene_synonym="Pop3"
                     /note="popeye domain containing 3"
                     /db_xref="GeneID:78977"
                     /db_xref="MGI:MGI:1930153"
     exon            1..271
                     /gene="Popdc3"
                     /gene_synonym="Pop3"
                     /inference="alignment:Splign:2.1.0"
     exon            272..990
                     /gene="Popdc3"
                     /gene_synonym="Pop3"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..1381
                     /gene="Popdc3"
                     /gene_synonym="Pop3"
                     /note="popeye protein 3; popeye 3"
                     /codon_start=1
                     /product="popeye domain-containing protein 3"
                     /protein_id="NP_077248.1"
                     /db_xref="CCDS:CCDS23827.1"
                     /db_xref="GeneID:78977"
                     /db_xref="MGI:MGI:1930153"
                     /translation="MEKNSSLWKSLVTEHPLCTTWKQEAEGAIYHLASILFVVGFMGG
                     SGFFGLLYVFSLLGLGFLSSAVWAWVDICAADIFSWNFVLFVICFMQFVHIAYQVHSI
                     TFARDFHVLYSSLFKPLGIPLPVFRTIALSSEVVSLEKEHCYAMQGKTSIDRLSVLIS
                     GRIRVTVDGEFLHYISPFQFLDSPEWDSLRPTEEGIFQVTLTADTDCRYVSWRRKKLY
                     LLFAQHRYISRLFSVLIGSDIADKLYALNDRVYIGKKHHYDIRLPNYYHMSTPDLSRS
                     PLTEQFRNSRQHCNK"
     exon            991..1099
                     /gene="Popdc3"
                     /gene_synonym="Pop3"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1851
                     /gene="Popdc3"
                     /gene_synonym="Pop3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1501..1506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Popdc3"
                     /gene_synonym="Pop3"
                     /note="hexamer: AATAAA"
     polyA_site      1525
                     /gene="Popdc3"
                     /gene_synonym="Pop3"
                     /note="major polyA site"
     regulatory      1825..1830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Popdc3"
                     /gene_synonym="Pop3"
                     /note="hexamer: AATAAA"
     polyA_site      1845
                     /gene="Popdc3"
                     /gene_synonym="Pop3"
                     /note="major polyA site"
ORIGIN      
        1 gagttccgca ccctgctggc acccgctggc tgcccgcctg cctcggagcg cgcgcccgag
       61 cccgtccccg ccgctgggag cggctctgat cggctgcgcc ctgcttgagc gggcgcggga
      121 ggacgcgtcc gggatcccgg cgggtgcggg cgggcagcgg ggcgagagcg gttcggaccg
      181 tgggttttcg agtcaccaga gccgcctgcc actgctcact cggctggaaa gttctacggg
      241 ctccatcggg agcgtcgtga aggccgggaa ggaaatagca aaacctttgt ggacttcatc
      301 tgaatcagga gtccagatga gcttaaagaa actggggctg aacccatagc tctttcggct
      361 ccacacccac tgaagccccc tccatgccag cccccgagtc tcccggcctg tggagtgcac
      421 tgctgtgtga tgggaaagcg aaggactctg tcactggcct cagggtcctc taaagcgaac
      481 tgacagggaa gcagatagtg cagccatgga gaagaattca agcttatgga aaagcttggt
      541 gactgaacac ccactctgca ccacctggaa gcaggaggcc gaaggggcca tttaccacct
      601 cgccagtatc ttgtttgtag taggttttat gggtggcagt ggattctttg ggctccttta
      661 tgtcttcagc ttgctggggc tgggtttcct cagttctgcg gtctgggcgt gggtggacat
      721 ctgtgccgct gacatatttt cctggaattt tgtgctgttt gtcatctgct tcatgcagtt
      781 cgttcacatc gcgtatcaag ttcacagcat aaccttcgcc cgagatttcc atgtgttgta
      841 cagctcgctc ttcaagcccc tcgggatccc tttgcccgtc ttcagaacaa ttgctctgag
      901 ctctgaagtg gttagtttgg agaaggagca ctgctacgcc atgcagggga aaacctccat
      961 tgatcgactc tccgtgctca tctcaggaag aatcagagtg acagtcgatg gcgaatttct
     1021 gcattatatt tccccctttc agttcctgga ttctcctgag tgggattcgc taagacccac
     1081 agaggaaggc atttttcagg taactctcac agcagacacc gattgccgat atgtgtcttg
     1141 gaggagaaaa aaattgtatc tactctttgc gcagcatcgg tacatctccc gcctgttttc
     1201 ggttttaatt ggcagtgaca ttgcagataa actctatgcc ttgaacgaca gggtgtacat
     1261 aggaaagaaa catcactatg atattcggtt acccaactac taccatatgt caactccaga
     1321 cttgtccaga tcacccctaa cagaacagtt ccggaattcc agacaacatt gtaacaaatg
     1381 acatcaaaac ctgaagttgt gtgactgctg caaaaaagac ttcatcattc cccccagaca
     1441 attcagaatc aagatgccat tgccagctgt ttactaattc atttcaactt ctgcattgca
     1501 aataaaattt aaaaattttc acgtattcct tactgttata atgggagatg aatacggatg
     1561 ggcagtttgc cccttttctg catcagaact gagagaatgt gatttcgtat tctctgatat
     1621 ttcccccaat gtgctgcctg gtactgttgg cgcaggagaa gcagctaaca aatgtcagca
     1681 tgagagcagg ttgctattat ggtccacaga cccacttcta gaatctgctt ttctgggaca
     1741 atctctgatg aatgtaagtt acattgttgt tgtgggaagc aatttctttt atatgtgaag
     1801 ttctttgacg ggactaaaca gaagaataaa tgtaagaaac aataacatgc c
//
