LOCUS       NM_001081984            2203 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus popeye domain containing 2 (Popdc2), transcript
            variant 1, mRNA.
ACCESSION   NM_001081984
VERSION     NM_001081984.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Swan,A.H., Schindler,R.F.R., Savarese,M., Mayer,I., Rinne,S.,
            Bleser,F., Schanzer,A., Hahn,A., Sabatelli,M., Perna,F.,
            Chapman,K., Pfuhl,M., Spivey,A.C., Decher,N., Udd,B., Tasca,G. and
            Brand,T.
  TITLE     Differential effects of mutations of POPDC proteins on heteromeric
            interaction and membrane trafficking
  JOURNAL   Acta Neuropathol Commun 11 (1), 4 (2023)
   PUBMED   36624536
  REMARK    Erratum:[Acta Neuropathol Commun. 2023 Jul 11;11(1):114. doi:
            10.1186/s40478-023-01591-0.. PMID: 37434226]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Rinne,S., Ortiz-Bonnin,B., Stallmeyer,B., Kiper,A.K.,
            Fortmuller,L., Schindler,R.F.R., Herbort-Brand,U., Kabir,N.S.,
            Dittmann,S., Friedrich,C., Zumhagen,S., Gualandi,F., Selvatici,R.,
            Rapezzi,C., Arbustini,E., Ferlini,A., Fabritz,L., Schulze-Bahr,E.,
            Brand,T. and Decher,N.
  TITLE     POPDC2 a novel susceptibility gene for conduction disorders
  JOURNAL   J Mol Cell Cardiol 145, 74-83 (2020)
   PUBMED   32535041
  REMARK    GeneRIF: POPDC2 a novel susceptibility gene for conduction
            disorders.
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Smith,S.J., Towers,N., Saldanha,J.W., Shang,C.A., Mahmood,S.R.,
            Taylor,W.R. and Mohun,T.J.
  TITLE     The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is
            essential for heart chamber outgrowth and acts on muscle actin
            filament assembly
  JOURNAL   Dev Biol 416 (2), 373-388 (2016)
   PUBMED   27217161
REFERENCE   4  (bases 1 to 2203)
  AUTHORS   Dupays,L., Shang,C., Wilson,R., Kotecha,S., Wood,S., Towers,N. and
            Mohun,T.
  TITLE     Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A
            Mechanism for Spatiotemporal Regulation of Enhancers during
            Cardiogenesis
  JOURNAL   Cell Rep 13 (1), 183-195 (2015)
   PUBMED   26411676
  REMARK    GeneRIF: Sequential binding of MEIS1 and NKX2-5 on the Popdc2 gene
            demonstrate a mechanism for spatiotemporal regulation of enhancers
            during cardiogenesis.
REFERENCE   5  (bases 1 to 2203)
  AUTHORS   Brand,T., Simrick,S.L., Poon,K.L. and Schindler,R.F.
  TITLE     The cAMP-binding Popdc proteins have a redundant function in the
            heart
  JOURNAL   Biochem Soc Trans 42 (2), 295-301 (2014)
   PUBMED   24646234
  REMARK    Review article
REFERENCE   6  (bases 1 to 2203)
  AUTHORS   Froese,A., Breher,S.S., Waldeyer,C., Schindler,R.F., Nikolaev,V.O.,
            Rinne,S., Wischmeyer,E., Schlueter,J., Becher,J., Simrick,S.,
            Vauti,F., Kuhtz,J., Meister,P., Kreissl,S., Torlopp,A.,
            Liebig,S.K., Laakmann,S., Muller,T.D., Neumann,J., Stieber,J.,
            Ludwig,A., Maier,S.K., Decher,N., Arnold,H.H., Kirchhof,P.,
            Fabritz,L. and Brand,T.
  TITLE     Popeye domain containing proteins are essential for stress-mediated
            modulation of cardiac pacemaking in mice
  JOURNAL   J Clin Invest 122 (3), 1119-1130 (2012)
   PUBMED   22354168
  REMARK    GeneRIF: Popdc1 and Popdc2 proteins interact with the potassium
            channel TREK-1, which leads to increased cell surface expression
            and enhanced current density
REFERENCE   7  (bases 1 to 2203)
  AUTHORS   Kalsotra,A., Xiao,X., Ward,A.J., Castle,J.C., Johnson,J.M.,
            Burge,C.B. and Cooper,T.A.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   8  (bases 1 to 2203)
  AUTHORS   Froese,A. and Brand,T.
  TITLE     Expression pattern of Popdc2 during mouse embryogenesis and in the
            adult
  JOURNAL   Dev Dyn 237 (3), 780-787 (2008)
   PUBMED   18189275
  REMARK    GeneRIF: Popdc2 is expressed in various muscle and nonmuscle cell
            types during embryonic development and in postnatal life
REFERENCE   9  (bases 1 to 2203)
  AUTHORS   Andree,B., Hillemann,T., Kessler-Icekson,G., Schmitt-John,T.,
            Jockusch,H., Arnold,H.H. and Brand,T.
  TITLE     Isolation and characterization of the novel popeye gene family
            expressed in skeletal muscle and heart
  JOURNAL   Dev Biol 223 (2), 371-382 (2000)
   PUBMED   10882522
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY236921.1 and BC064005.1.
            
            On Apr 1, 2015 this sequence version replaced NM_001081984.1.
            
            Summary: This gene encodes a member of the Popeye domain containing
            family of membrane proteins. Proteins of this family contain three
            helical transmembrane domains and a conserved intracellular Popeye
            domain. In the adult mouse, this gene is expressed at high levels
            in cardiac myocytes, and mice deficient for this gene develop
            stress-induced cardiac pacemaker dysfunction. The protein binds to
            a two-pore domain potassium channel and recruits it to the plasma
            membrane. Cyclic adenosine monophosphate negatively regulates this
            interaction through the Popeye domain. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064005.1, SRR1660817.89988.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY236921.1         3-21
            20-2203             BC064005.1         1-2184
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.79 cM"
     gene            1..2203
                     /gene="Popdc2"
                     /gene_synonym="Pop2"
                     /note="popeye domain containing 2"
                     /db_xref="GeneID:64082"
                     /db_xref="MGI:MGI:1930150"
     exon            1..958
                     /gene="Popdc2"
                     /gene_synonym="Pop2"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..1583
                     /gene="Popdc2"
                     /gene_synonym="Pop2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     popeye domain-containing protein 2"
                     /codon_start=1
                     /product="popeye domain-containing protein 2 isoform 1"
                     /protein_id="NP_001075453.1"
                     /db_xref="CCDS:CCDS37343.1"
                     /db_xref="GeneID:64082"
                     /db_xref="MGI:MGI:1930150"
                     /translation="MSANGSSVAQLLWQPPVCRSWKPDVEGAVYHLANCFLLMGFMAG
                     SGVYGCFYLFGILGPGYLCCVLWGWFDACGLDIVLWNVLLTVACLLQLAQLVYRVRVN
                     TLPEEFNLLYRTLCLPLQVPLQVYKEIVHCCHEQVLTLATEQTYAVEGETPINRLSLL
                     LSGRVRVSQDGQFLHYIFPYQFMDSPEWESLHPSEEGTFQVTLTAETECSYISWPRKN
                     LYLLLNRERYISRLFSALLGYDISEKLYTLNDKLFAKFGLRFDIRLPSLYHVLSPSAS
                     DGEPESEKDDEEALEAAVSPAQARPICIVPTPPCSAPPATTNFPVPLPRARMPRMPRP
                     DSGNLGEDSTSLVLEDFEEVSGSESFMDYRSDGEYMR"
     exon            959..1067
                     /gene="Popdc2"
                     /gene_synonym="Pop2"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1626
                     /gene="Popdc2"
                     /gene_synonym="Pop2"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..2188
                     /gene="Popdc2"
                     /gene_synonym="Pop2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2167..2172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Popdc2"
                     /gene_synonym="Pop2"
                     /note="hexamer: AATAAA"
     polyA_site      2188
                     /gene="Popdc2"
                     /gene_synonym="Pop2"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgcttc ccctgctggc tctccactcc gcgttctgcc tgggaacgac agagagcaga
       61 atgtggctgc ttcgtcccgt gttgctgaag ttcatggtgt cgagttccta cttcctctca
      121 ggacaatgta tgctgtttgc taaggactaa atatgaagac cagcctaaga aagccggagc
      181 caaagaggtt taccagagca ctgcgggagg gacaagagct tcgctgagag agagagaaag
      241 agaggaacga ggaaaagaaa aatcccaaac aacaaactta ggctttcaag cttccatgaa
      301 gtgtactatg ctcctgcgtt ctttctcaga gccaccggaa gcattcctgc cagcaaggtt
      361 gcattggtag tgagaagcca cctgggagga caaactgact gattttcccc tcagtttcct
      421 ttgtggagac cgttttggag cctgcaaagg cctcgagggc cccaaagatg agtgccaatg
      481 gcagctcggt ggctcagctc ctctggcagc cgcccgtgtg caggagctgg aaaccggatg
      541 tagaaggagc tgtctatcac ctggccaact gtttcttgct tatgggcttt atggcaggca
      601 gtggagtgta tggatgcttc tatcttttcg gcatcctggg cccaggctac ctctgctgcg
      661 tgctgtgggg ctggtttgat gcttgtggac tagacatcgt cctttggaac gtcctcctga
      721 cagtggcttg cctgcttcag ctggcacagc tggtctatcg tgtccgggtg aataccctcc
      781 cggaggaatt caatctcctc tacaggacac tgtgcctgcc cctgcaggtg cccctgcagg
      841 tctacaagga gattgtccac tgctgccatg agcaggtctt gacgctggcc acagagcaga
      901 cctacgctgt ggagggggag acccccatca atcgcctgtc cctgctcctc tcaggccggg
      961 ttcgagtgag ccaagacggg cagtttctgc actacatctt tccgtatcag ttcatggact
     1021 ctcctgaatg ggaatcactg catccttctg aagaggggac cttccaggtg acgctgactg
     1081 cggagaccga atgtagctac atttcctggc cccggaaaaa tctttacctt cttctgaaca
     1141 gagagcgata catctcccgc ctcttctcag ccctgctggg ctatgacatc tcggagaagc
     1201 tctataccct caatgacaag ctgtttgcca agtttgggtt acgcttcgac atccgccttc
     1261 ccagcctcta ccacgttctg agtccctctg cctcagacgg ggaaccagag tctgagaaag
     1321 atgatgaaga agcccttgag gcagctgtgt cccctgctca ggccaggccc atctgcatcg
     1381 tgccaacacc cccttgttcc gcgcctccag caaccaccaa ctttcccgtg cctctgcccc
     1441 gggccaggat gcccaggatg cccaggccgg acagcggcaa cctgggtgag gactccacca
     1501 gtctggtgct ggaggatttt gaggaggttt caggatcaga gtcgtttatg gattatagga
     1561 gcgatgggga gtacatgagg tgagggcgga actaacacgg gcacagtcac cggctcagga
     1621 tcctaccctc tagacgtcct ctccagaact cttctcaagt tatgtccaga tcccaggccc
     1681 ctctggctcc aattcacact cctgagctct aaggatcaca gagctgtcgt ctctgtagcc
     1741 agatggcact cctccatgtt ccccggatgg ccacttatac tctcacccct cctcttagcc
     1801 ctccagaaag atgtgtggca agctggggga tggacatgac gtgaagaaac tcaccttcag
     1861 gagccttcct tacagcagga gggtccagag gcacctggcc tgactccatc ctttatgggt
     1921 tgcaggacat tgccaggttt acacggcctc tgagcctgga ctgtgaggct aggaactcac
     1981 gtcacagggt tgttgtgagg atccagtgag ctgattgggt agagcaccta tgacaggaca
     2041 tggcgtcctg caagcatgca ataaaacgct tcacgcctct ccccgtgttg ttgctttaaa
     2101 ttgtctgaaa gaatccaatg acttttaccc atgcttattt tactcccaaa attaattttc
     2161 aattgaaata aaaaatttta aatcccaaaa aaaaaaaaaa aaa
//
