LOCUS       NP_080674                169 aa            linear   ROD 02-MAY-2024
DEFINITION  ribonuclease P/MRP protein subunit POP5 isoform 1 [Mus musculus].
ACCESSION   NP_080674 XP_998924 XP_998945
VERSION     NP_080674.1
DBSOURCE    REFSEQ: accession NM_026398.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 169)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 169)
  AUTHORS   Nakahara,M., Tateyama,H., Araki,M., Nakagata,N., Yamamura,K. and
            Araki,K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   3  (residues 1 to 169)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   4  (residues 1 to 169)
  AUTHORS   Xiao,S., Scott,F., Fierke,C.A. and Engelke,D.R.
  TITLE     Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes
  JOURNAL   Annu Rev Biochem 71, 165-189 (2002)
   PUBMED   12045094
  REMARK    Review article
REFERENCE   5  (residues 1 to 169)
  AUTHORS   van Eenennaam,H., Lugtenberg,D., Vogelzangs,J.H., van Venrooij,W.J.
            and Pruijn,G.J.
  TITLE     hPop5, a protein subunit of the human RNase MRP and RNase P
            endoribonucleases
  JOURNAL   J Biol Chem 276 (34), 31635-31641 (2001)
   PUBMED   11413139
REFERENCE   6  (residues 1 to 169)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145070.10.
            
            On or before May 4, 2006 this sequence version replaced
            XP_998945.1, XP_998924.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1943730.1,
                                           SRR17784648.1201861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..169
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.01 cM"
     Protein         1..169
                     /product="ribonuclease P/MRP protein subunit POP5 isoform
                     1"
                     /EC_number="3.1.26.5"
                     /note="ribonuclease P/MRP protein subunit POP5"
                     /calculated_mol_wt=19154
     Region          7..115
                     /region_name="RNase_P_Rpp14"
                     /note="Rpp14/Pop5 family; pfam01900"
                     /db_xref="CDD:460379"
     Site            157
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9DB28.1)"
     Site            159
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9DB28.1)"
     CDS             1..169
                     /gene="Pop5"
                     /gene_synonym="1500019J17Rik; 2700077E03Rik; Rnasep3"
                     /coded_by="NM_026398.5:610..1119"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19583.1"
                     /db_xref="GeneID:117109"
                     /db_xref="MGI:MGI:2151221"
ORIGIN      
        1 mvrfkhryll celvsedarc rlslddrvlg glvrdtiarv hgafgaaacs vgfavrylna
       61 ytgvvllrcr kdfyqlvwsa lpfitylenk ghrypcffnt lhvggtirtc qkfliqynrr
      121 qllillqnct degereaikk svsrsclldr epveelsdsa geevaeame
//
