LOCUS       NM_025390               1250 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus processing of precursor 4, ribonuclease P/MRP family,
            (S. cerevisiae) (Pop4), transcript variant 1, mRNA.
ACCESSION   NM_025390
VERSION     NM_025390.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1250)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1250)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1250)
  AUTHORS   Schallschmidt,T., Lebek,S., Altenhofen,D., Damen,M., Schulte,Y.,
            Knebel,B., Herwig,R., Rasche,A., Stermann,T., Kamitz,A.,
            Hallahan,N., Jahnert,M., Vogel,H., Schurmann,A., Chadt,A. and
            Al-Hasani,H.
  TITLE     Two Novel Candidate Genes for Insulin Secretion Identified by
            Comparative Genomics of Multiple Backcross Mouse Populations
  JOURNAL   Genetics 210 (4), 1527-1542 (2018)
   PUBMED   30341086
  REMARK    GeneRIF: Two genes, Atp4a and Pop4, fulfilled the criteria from our
            candidate gene approaches. The knockdown of both genes in MIN6
            cells led to decreased glucose-stimulated insulin secretion,
            indicating a regulatory role of both genes in insulin secretion,
            thereby possibly contributing to the phenotype linked to Nbg7p
REFERENCE   4  (bases 1 to 1250)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1250)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 1250)
  AUTHORS   Xiao,S., Scott,F., Fierke,C.A. and Engelke,D.R.
  TITLE     Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes
  JOURNAL   Annu Rev Biochem 71, 165-189 (2002)
   PUBMED   12045094
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157552.10.
            
            On Mar 23, 2023 this sequence version replaced NM_025390.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054466.1, BC011465.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AC157552.10        177462-177694       c
            234-286             AC157552.10        175217-175269       c
            287-513             AC157552.10        173684-173910       c
            514-591             AC157552.10        172442-172519       c
            592-653             AC157552.10        172215-172276       c
            654-755             AC157552.10        170643-170744       c
            756-1250            AC157552.10        169130-169624       c
FEATURES             Location/Qualifiers
     source          1..1250
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 25.36 cM"
     gene            1..1250
                     /gene="Pop4"
                     /gene_synonym="1110023P21Rik; Rpp29"
                     /note="processing of precursor 4, ribonuclease P/MRP
                     family, (S. cerevisiae)"
                     /db_xref="GeneID:66161"
                     /db_xref="MGI:MGI:1913411"
     exon            1..233
                     /gene="Pop4"
                     /gene_synonym="1110023P21Rik; Rpp29"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..892
                     /gene="Pop4"
                     /gene_synonym="1110023P21Rik; Rpp29"
                     /EC_number="3.1.26.5"
                     /note="POP4 (processing of precursor, S. cerevisiae)
                     homolog"
                     /codon_start=1
                     /product="ribonuclease P protein subunit p29"
                     /protein_id="NP_079666.1"
                     /db_xref="CCDS:CCDS39915.1"
                     /db_xref="GeneID:66161"
                     /db_xref="MGI:MGI:1913411"
                     /translation="MKAAIYHAFSHKEAKDHDVQELGSQRAEAFVRAFLKQSIPHMSQ
                     EDCESHLQRKAVILEYFTRLKPRPRPKKKSKGLSAKQRRDMRLFDIKPEQQRYSLFLP
                     LHELWKQYIRDLCNGLKPDTQPQMIQAKLLKADLHGAIISVTKSKCPSYVGVTGILLQ
                     ETKHVFKIITREDHLKVIPKLNCVFTIEIDDFISYIYGSKFQLRASERSAKKFKAKGS
                     IDL"
     exon            234..286
                     /gene="Pop4"
                     /gene_synonym="1110023P21Rik; Rpp29"
                     /inference="alignment:Splign:2.1.0"
     exon            287..513
                     /gene="Pop4"
                     /gene_synonym="1110023P21Rik; Rpp29"
                     /inference="alignment:Splign:2.1.0"
     exon            514..591
                     /gene="Pop4"
                     /gene_synonym="1110023P21Rik; Rpp29"
                     /inference="alignment:Splign:2.1.0"
     exon            592..653
                     /gene="Pop4"
                     /gene_synonym="1110023P21Rik; Rpp29"
                     /inference="alignment:Splign:2.1.0"
     exon            654..755
                     /gene="Pop4"
                     /gene_synonym="1110023P21Rik; Rpp29"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1250
                     /gene="Pop4"
                     /gene_synonym="1110023P21Rik; Rpp29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1226..1231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pop4"
                     /gene_synonym="1110023P21Rik; Rpp29"
                     /note="hexamer: AATAAA"
     polyA_site      1246
                     /gene="Pop4"
                     /gene_synonym="1110023P21Rik; Rpp29"
                     /note="major polyA site"
ORIGIN      
        1 agagaggcgc ccgatccgaa atctggtcgc catcccctga cgcagggtgg agcaagtccg
       61 tgcactttgt taattgtctc ttgggcttat cggatttttc cagtggaatt ttaaacaaaa
      121 aagcagcgtc ccggcgggag aaagccgctg aacaaagcga agaaaggaaa ggaatgagtg
      181 aggcctgaag gagacatcgc cagagagctc cggaagctgg ccgacaatga aggctgccat
      241 ctaccatgcc ttttctcata aagaagccaa ggaccacgat gtgcaggagc tgggaagcca
      301 gcgggctgag gcctttgtgc gggccttcct gaagcagagc atacctcaca tgagccaaga
      361 agactgtgag agccatctgc agcgcaaggc cgtgatcttg gaatatttca ctcgcctaaa
      421 gccaaggcca aggccaaaga agaaatccaa aggcctctct gccaaacaga ggagagacat
      481 gcggctcttt gacattaaac cagagcaaca gagatacagc ctgttcctcc ctctccatga
      541 actctggaaa cagtacatcc gggacctgtg caatgggctc aagccggaca cgcagccaca
      601 gatgattcag gccaagctcc taaaggcaga tcttcatggt gctattattt cagtcacgaa
      661 atccaagtgc ccctcctatg tgggagttac aggaatcctt ctgcaggaga ccaaacatgt
      721 ctttaagatc atcaccagag aagaccacct aaaagtcatc cccaagctga attgtgtgtt
      781 caccatagaa attgatgact tcatttccta catttatgga agcaaattcc agcttcgggc
      841 aagtgagcgg tctgccaaga agttcaaagc aaagggatca attgacctgt gaactctgcc
      901 actggagaca gatgtccctg acactgaaga actggaaact ccctaaatac tcactttttc
      961 ttgaagagcc tctggctgta gcccgtctgt agtccaggga aaacagaggg gctgaagagc
     1021 atcgaacaac tcgggagaaa gctaggggta aatatttgta ctgttaggtg accttaagtt
     1081 agctttagtt ccacagggag gaaagactag cagaaacaca ccaggattaa ccttgggtca
     1141 tctgaagaag ggggcattta ggctctgcct ttcctacttc tctgtgtatc ctgaacattc
     1201 taacaaaatc agctattgaa ataataataa aaccagacca cgggcataaa
//
