LOCUS       NM_026340               3303 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus processing of precursor 1, ribonuclease P/MRP family,
            (S. cerevisiae) (Pop1), transcript variant 2, mRNA.
ACCESSION   NM_026340
VERSION     NM_026340.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3303)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3303)
  AUTHORS   de Almeida,L., Devi,S., Indramohan,M., Huang,Q.Q.,
            Ratsimandresy,R.A., Pope,R.M., Dorfleutner,A. and Stehlik,C.
  TITLE     POP1 inhibits MSU-induced inflammasome activation and ameliorates
            gout
  JOURNAL   Front Immunol 13, 912069 (2022)
   PUBMED   36225929
  REMARK    GeneRIF: POP1 inhibits MSU-induced inflammasome activation and
            ameliorates gout.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3303)
  AUTHORS   de Almeida,L., Khare,S., Misharin,A.V., Patel,R.,
            Ratsimandresy,R.A., Wallin,M.C., Perlman,H., Greaves,D.R.,
            Hoffman,H.M., Dorfleutner,A. and Stehlik,C.
  TITLE     The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly
            and Ameliorates Inflammatory Disease
  JOURNAL   Immunity 43 (2), 264-276 (2015)
   PUBMED   26275995
REFERENCE   4  (bases 1 to 3303)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   5  (bases 1 to 3303)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 3303)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3303)
  AUTHORS   Xiao,S., Scott,F., Fierke,C.A. and Engelke,D.R.
  TITLE     Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes
  JOURNAL   Annu Rev Biochem 71, 165-189 (2002)
   PUBMED   12045094
  REMARK    Review article
REFERENCE   8  (bases 1 to 3303)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN722321.1, AK016547.1 and BM204185.2.
            
            On Dec 12, 2009 this sequence version replaced NM_026340.2.
            
            Transcript Variant: This variant (2) lacks an alternate coding
            exon, compared to variant 1. The resulting protein (isoform 2) is
            shorter when it is compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016547.1, SRR7974084.13072.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               CN722321.1         1-105
            106-2851            AK016547.1         93-2838
            2852-3303           BM204185.2         1-452               c
FEATURES             Location/Qualifiers
     source          1..3303
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.34 cM"
     gene            1..3303
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /note="processing of precursor 1, ribonuclease P/MRP
                     family, (S. cerevisiae)"
                     /db_xref="GeneID:67724"
                     /db_xref="MGI:MGI:1914974"
     exon            1..105
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            106..249
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..3155
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /EC_number="3.1.26.5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     processing of precursors 1; ribonucleases P/MRP protein
                     subunit homolog"
                     /codon_start=1
                     /product="ribonucleases P/MRP protein subunit POP1 isoform
                     2"
                     /protein_id="NP_080616.1"
                     /db_xref="CCDS:CCDS27419.1"
                     /db_xref="GeneID:67724"
                     /db_xref="MGI:MGI:1914974"
                     /translation="MSNAKERKHAKKMRNQPSNVTLSSGFMAERDGKHHFGKGKPSQS
                     QKQELHSGTSRQWQIKMSPHLLPESDVNEQSSSKTMFKKKGGWKAGPEGTSQEIPKYI
                     TASTFAQARAAEISAMLKAVTQKSSNSLVFQTLPRHMRRRAMSHNVKRLPRRLQEMAK
                     KEAEKAAHQKKEHSKNKCHKARRCHINRTLEFNRRQQKNIWLETHIWHAKRFHMVKKW
                     GYCLGERPTAKSHRACYRAMTNLCLLQDLSYYCCLELKGKEEELLKALSQMCSIDAGL
                     TFAAVHCLSGKRQGSLMLYRANKYPREMLGPVTFIWKSRMTPEDASEDRQLWIWLHPT
                     LKLAVLEEIKTTCHCSEPVKSNICMPDPLLTPAPEDIQAGLAGDKISKKRKRRDDGES
                     VSRAKKTIGDGTRDACQPRSWRSPTTGIIVSDLTMEMNRFRLIGPLSHCILTSALRAA
                     PVHTGEEDAEETPHHWWTDTCRSSDGRSLHQRQEAVFELLGGISSPAEIPAGTILGLT
                     VRDPRVNLPPQRSRALPDPERYQANERVKQLLLEGVPVACAHSFIWDQDICRSVTENK
                     LLDQDLNRMRSELLVPGSQLDLGARESKIPILLIQQPGKVTGEDRLGWGSGWDVLIPK
                     GWGMAFWIPFIYRGARVGGLKEATVHSQYRRSPNIPGDFPDCRAGVLFAEDQAKDLLE
                     KYRRRPPAKRPNYVKLGTLAPFCCPWEQLTRDWESRVHAQEAAIIASMPGAQETDPRR
                     LGVPCVPKEICQLSNEAGIAENQPRKPEVTGCQAQEGTKVAMEWNASEAHMATTGSQL
                     CVVRSRKLLKQLSSWCGPSSEIRRAPCRAQQELTSNVCLSILNDFPRALVWVSLSLLR
                     KGSPEPHTMICVPSKEDLHRLSQDQCYHGPWESRHSDPFKSLILKEKEKKKKEKRQDG
                     EHRASEGQAAGPPIAGQEALTQGLWSGPLPGLTSHCSRLLLGFVTQGDFSMAAGCGEA
                     LGFVSMTGLLEMLSSQSAAMRGLVLLRPPTSLQYRFARITIEV"
     exon            250..417
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            418..593
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            594..842
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            843..930
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1118
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1375
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1469
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1581
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1701
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1817
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2009
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2164
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2512
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..3303
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3275..3280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3298
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /note="major polyA site"
ORIGIN      
        1 tgcgcacgcg ccctcagccc gctcgctcac cctctgtggt gggagcttct agggatctca
       61 gaaccttgtc attcttaccg gcgaagccct cggaactttt ggcagaaatg tctaatgcaa
      121 aggaaagaaa acatgctaag aaaatgagaa accagcccag taacgtgact ctgtcctccg
      181 gctttatggc tgagagagat ggaaagcatc attttggaaa ggggaagccg tcccaatctc
      241 agaaacaaga gcttcattct ggaacctcaa ggcagtggca aatcaagatg agtccccact
      301 tgcttcctga gtctgatgtg aatgagcaat cttcctccaa aaccatgttt aagaaaaagg
      361 gaggctggaa agcaggtcct gagggcactt ctcaggagat ccccaagtat ataactgctt
      421 ctacttttgc tcaagcacga gccgctgaaa tcagtgccat gttaaaagct gtgacccaga
      481 agtcatctaa ctcactggtt ttccagactc ttccaaggca catgcgacgt agagccatga
      541 gccacaatgt caaacgcctt cctagacggt tgcaggagat ggccaaaaaa gaggcggaga
      601 aagctgctca tcagaaaaaa gaacattcaa aaaataaatg ccacaaagcc cgaagatgtc
      661 acataaaccg gactctggaa tttaaccgca gacaacagaa gaacatatgg ttagagactc
      721 acatctggca cgccaaacgg tttcatatgg tgaagaagtg gggttactgc cttggggaga
      781 ggcccacggc caagagccac cgagcctgct atcgagccat gacaaacctc tgcctcctgc
      841 aggatttatc atattactgc tgtttggagt tgaaaggcaa agaggaagaa ctactgaaag
      901 cgctctctca aatgtgtagc atagacgcag gcctgacttt tgctgcagtt cactgcttgt
      961 ctgggaagcg gcaagggagc ctcatgcttt accgggcaaa taagtatccc agggaaatgc
     1021 ttgggccggt taccttcatc tggaagtcta ggatgacccc agaggatgct tctgaggata
     1081 ggcagctgtg gatctggctt cacccaactc ttaaactggc tgtcctagaa gaaataaaaa
     1141 caacatgcca ctgttcagaa cccgtcaagt caaatatctg catgcctgac ccactcctga
     1201 caccagcccc ggaagacatt caagcaggac tagctggtga caaaatcagc aagaaaagaa
     1261 aaaggagaga cgatggggag agtgttagcc gagctaagaa gaccattggt gacgggacac
     1321 gagatgcctg ccagcctcgg tcatggcgat ctcccactac agggattata gtcagtgact
     1381 tgacaatgga gatgaacagg ttccggctga taggccctct ttcgcactgt atcctgacct
     1441 cagcactgag ggctgctcct gtacacacag gggaagagga tgccgaggag acaccacatc
     1501 actggtggac tgacacttgc aggagctctg atggtcgttc tcttcaccaa agacaagaag
     1561 cagtgtttga gttgttggga gggatatcat caccagcaga aattccagca ggtactattc
     1621 tgggattgac agttagggat ccgagagtaa atttgccccc acagcgatcc agagctttgc
     1681 ctgatccaga aagataccaa gctaatgagc gagtgaagca gctgcttctg gagggtgtgc
     1741 ctgtggcatg tgcacacagc ttcatctggg accaggatat ctgtaggagt gtcaccgaga
     1801 ataaactctt ggatcaggat ttaaaccgga tgagaagtga gttgctggtg cccggatcgc
     1861 aacttgattt aggggctcgt gaatctaaga tacccatact tctgattcag cagccaggaa
     1921 aagtgactgg cgaagaccga ctgggctggg gcagtggctg ggatgtcctc attcccaagg
     1981 gctggggcat ggctttttgg attccattta tctaccgagg tgcacgagtt ggtggactaa
     2041 aagaggctac agtgcattct caatacagac ggtctcctaa catcccaggc gatttcccag
     2101 actgccgtgc tggagttctg tttgctgaag atcaagctaa ggatcttcta gagaagtaca
     2161 gacgacgccc tcctgctaaa aggcccaact atgttaagct tggcacactg gctcctttct
     2221 gttgtccctg ggaacagctg actcgggact gggagtccag ggttcatgcc caagaggcag
     2281 ctattatagc ttcaatgcct ggtgctcagg agactgaccc aagacggctt ggagtgcctt
     2341 gtgtccccaa agagatctgc caactatcta atgaggcagg catagctgaa aaccaaccca
     2401 ggaagccaga agttacaggc tgtcaagcgc aggaggggac caaagtggcc atggaatgga
     2461 atgccagtga ggctcatatg gctaccacag gtagccagct ctgtgttgtt cggagtagga
     2521 aactgctgaa gcagctctcg tcctggtgtg ggcccagttc tgagatcagg agggctccct
     2581 gcagagctca gcaagaactg actagtaacg tctgcttgtc cattctgaat gacttcccca
     2641 gagccctggt gtgggtcagc ttgtccctgc tcaggaaggg cagcccagag cctcacacca
     2701 tgatctgtgt cccatctaag gaggacctgc accggctcag tcaggatcag tgctaccatg
     2761 gaccctggga atccagacac agcgacccat ttaaaagcct gattctgaag gagaaagaaa
     2821 agaagaaaaa ggagaagagg caggatgggg aacacagagc ctccgagggc caggccgcag
     2881 ggccgcccat agctgggcag gaagctctga cgcaggggct gtggtcaggc ccccttccag
     2941 gactaacctc acactgctcc aggctcctcc taggctttgt cacacaggga gatttttcta
     3001 tggctgctgg ctgtggagaa gccttagggt ttgttagtat gaccggcttg ctggaaatgt
     3061 tgtccagcca gtcagcagcc atgaggggcc tggtgctgct gcggcctcca acctcactgc
     3121 agtatcggtt tgcaagaatt accattgagg tgtgaattta agtttatagc ctggtcttaa
     3181 attataacta ttttggtcaa agctcacaga aagtcctggc tgtctctgtc accatctgat
     3241 ttaagatata ttgtggaact gcgtggaaac aagaattaaa attatgtaat catgtggatg
     3301 atg
//
