LOCUS       NP_080616               1015 aa            linear   ROD 30-APR-2024
DEFINITION  ribonucleases P/MRP protein subunit POP1 isoform 2 [Mus musculus].
ACCESSION   NP_080616
VERSION     NP_080616.1
DBSOURCE    REFSEQ: accession NM_026340.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1015)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1015)
  AUTHORS   de Almeida,L., Devi,S., Indramohan,M., Huang,Q.Q.,
            Ratsimandresy,R.A., Pope,R.M., Dorfleutner,A. and Stehlik,C.
  TITLE     POP1 inhibits MSU-induced inflammasome activation and ameliorates
            gout
  JOURNAL   Front Immunol 13, 912069 (2022)
   PUBMED   36225929
  REMARK    GeneRIF: POP1 inhibits MSU-induced inflammasome activation and
            ameliorates gout.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1015)
  AUTHORS   de Almeida,L., Khare,S., Misharin,A.V., Patel,R.,
            Ratsimandresy,R.A., Wallin,M.C., Perlman,H., Greaves,D.R.,
            Hoffman,H.M., Dorfleutner,A. and Stehlik,C.
  TITLE     The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly
            and Ameliorates Inflammatory Disease
  JOURNAL   Immunity 43 (2), 264-276 (2015)
   PUBMED   26275995
REFERENCE   4  (residues 1 to 1015)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   5  (residues 1 to 1015)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (residues 1 to 1015)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 1015)
  AUTHORS   Xiao,S., Scott,F., Fierke,C.A. and Engelke,D.R.
  TITLE     Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes
  JOURNAL   Annu Rev Biochem 71, 165-189 (2002)
   PUBMED   12045094
  REMARK    Review article
REFERENCE   8  (residues 1 to 1015)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN722321.1, AK016547.1 and BM204185.2.
            
            Transcript Variant: This variant (2) lacks an alternate coding
            exon, compared to variant 1. The resulting protein (isoform 2) is
            shorter when it is compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016547.1, SRR7974084.13072.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1015
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.34 cM"
     Protein         1..1015
                     /product="ribonucleases P/MRP protein subunit POP1 isoform
                     2"
                     /EC_number="3.1.26.5"
                     /note="processing of precursors 1; ribonucleases P/MRP
                     protein subunit homolog"
                     /calculated_mol_wt=113898
     Region          107..257
                     /region_name="POP1"
                     /note="Ribonucleases P/MRP protein subunit POP1;
                     pfam06978"
                     /db_xref="CDD:429227"
     Region          617..708
                     /region_name="POPLD"
                     /note="POPLD (NUC188) domain; pfam08170"
                     /db_xref="CDD:462391"
     CDS             1..1015
                     /gene="Pop1"
                     /gene_synonym="4932434G09Rik"
                     /coded_by="NM_026340.3:108..3155"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS27419.1"
                     /db_xref="GeneID:67724"
                     /db_xref="MGI:MGI:1914974"
ORIGIN      
        1 msnakerkha kkmrnqpsnv tlssgfmaer dgkhhfgkgk psqsqkqelh sgtsrqwqik
       61 msphllpesd vneqsssktm fkkkggwkag pegtsqeipk yitastfaqa raaeisamlk
      121 avtqkssnsl vfqtlprhmr rramshnvkr lprrlqemak keaekaahqk kehsknkchk
      181 arrchinrtl efnrrqqkni wlethiwhak rfhmvkkwgy clgerptaks hracyramtn
      241 lcllqdlsyy cclelkgkee ellkalsqmc sidagltfaa vhclsgkrqg slmlyranky
      301 premlgpvtf iwksrmtped asedrqlwiw lhptlklavl eeikttchcs epvksnicmp
      361 dplltpaped iqaglagdki skkrkrrddg esvsrakkti gdgtrdacqp rswrspttgi
      421 ivsdltmemn rfrligplsh ciltsalraa pvhtgeedae etphhwwtdt crssdgrslh
      481 qrqeavfell ggisspaeip agtilgltvr dprvnlppqr sralpdpery qanervkqll
      541 legvpvacah sfiwdqdicr svtenklldq dlnrmrsell vpgsqldlga reskipilli
      601 qqpgkvtged rlgwgsgwdv lipkgwgmaf wipfiyrgar vgglkeatvh sqyrrspnip
      661 gdfpdcragv lfaedqakdl lekyrrrppa krpnyvklgt lapfccpweq ltrdwesrvh
      721 aqeaaiiasm pgaqetdprr lgvpcvpkei cqlsneagia enqprkpevt gcqaqegtkv
      781 amewnaseah mattgsqlcv vrsrkllkql sswcgpssei rrapcraqqe ltsnvclsil
      841 ndfpralvwv slsllrkgsp ephtmicvps kedlhrlsqd qcyhgpwesr hsdpfkslil
      901 kekekkkkek rqdgehrase gqaagppiag qealtqglws gplpgltshc srlllgfvtq
      961 gdfsmaagcg ealgfvsmtg llemlssqsa amrglvllrp ptslqyrfar itiev
//
