LOCUS       NM_173006               6383 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus paraoxonase 3 (Pon3), transcript variant 1, mRNA.
ACCESSION   NM_173006 NM_008897
VERSION     NM_173006.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6383)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6383)
  AUTHORS   Mutchler,S.M., Whelan,S.C.M., Marciszyn,A., Chen,J., Kleyman,T.R.
            and Shi,S.
  TITLE     Role of paraoxonase 3 in regulating ENaC-mediated Na+ transport in
            the distal nephron
  JOURNAL   J Physiol 602 (4), 737-757 (2024)
   PUBMED   38345534
  REMARK    GeneRIF: Role of paraoxonase 3 in regulating ENaC-mediated Na[+]
            transport in the distal nephron.
REFERENCE   3  (bases 1 to 6383)
  AUTHORS   Shi,S., Montalbetti,N., Wang,X., Rush,B.M., Marciszyn,A.L.,
            Baty,C.J., Tan,R.J., Carattino,M.D. and Kleyman,T.R.
  TITLE     Paraoxonase 3 functions as a chaperone to decrease functional
            expression of the epithelial sodium channel
  JOURNAL   J Biol Chem 295 (15), 4950-4962 (2020)
   PUBMED   32079677
  REMARK    GeneRIF: Paraoxonase 3 functions as a chaperone to decrease
            functional expression of the epithelial sodium channel.
REFERENCE   4  (bases 1 to 6383)
  AUTHORS   Teiber,J.F., Xiao,J., Kramer,G.L., Ogawa,S., Ebner,C., Wolleb,H.,
            Carreira,E.M., Shih,D.M. and Haley,R.W.
  TITLE     Identification of biologically active delta-lactone eicosanoids as
            paraoxonase substrates
  JOURNAL   Biochem Biophys Res Commun 505 (1), 87-92 (2018)
   PUBMED   30241945
REFERENCE   5  (bases 1 to 6383)
  AUTHORS   Shih,D.M., Yu,J.M., Vergnes,L., Dali-Youcef,N., Champion,M.D.,
            Devarajan,A., Zhang,P., Castellani,L.W., Brindley,D.N., Jamey,C.,
            Auwerx,J., Reddy,S.T., Ford,D.A., Reue,K. and Lusis,A.J.
  TITLE     PON3 knockout mice are susceptible to obesity, gallstone formation,
            and atherosclerosis
  JOURNAL   FASEB J 29 (4), 1185-1197 (2015)
   PUBMED   25477283
  REMARK    GeneRIF: study suggests a role for PON3 in the metabolism of lipid
            and bile acid as well as protection against atherosclerosis,
            gallstone disease, and obesity
REFERENCE   6  (bases 1 to 6383)
  AUTHORS   Stoltz,D.A., Ozer,E.A., Ng,C.J., Yu,J.M., Reddy,S.T., Lusis,A.J.,
            Bourquard,N., Parsek,M.R., Zabner,J. and Shih,D.M.
  TITLE     Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum
            sensing in murine tracheal epithelia
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 292 (4), L852-L860 (2007)
   PUBMED   17122353
REFERENCE   7  (bases 1 to 6383)
  AUTHORS   Ono,R., Nakamura,K., Inoue,K., Naruse,M., Usami,T.,
            Wakisaka-Saito,N., Hino,T., Suzuki-Migishima,R., Ogonuki,N.,
            Miki,H., Kohda,T., Ogura,A., Yokoyama,M., Kaneko-Ishino,T. and
            Ishino,F.
  TITLE     Deletion of Peg10, an imprinted gene acquired from a
            retrotransposon, causes early embryonic lethality
  JOURNAL   Nat Genet 38 (1), 101-106 (2006)
   PUBMED   16341224
REFERENCE   8  (bases 1 to 6383)
  AUTHORS   Ono,R., Shiura,H., Aburatani,H., Kohda,T., Kaneko-Ishino,T. and
            Ishino,F.
  TITLE     Identification of a large novel imprinted gene cluster on mouse
            proximal chromosome 6
  JOURNAL   Genome Res 13 (7), 1696-1705 (2003)
   PUBMED   12840045
REFERENCE   9  (bases 1 to 6383)
  AUTHORS   McNally,E.M., Ly,C.T. and Kunkel,L.M.
  TITLE     Human epsilon-sarcoglycan is highly related to alpha-sarcoglycan
            (adhalin), the limb girdle muscular dystrophy 2D gene
  JOURNAL   FEBS Lett 422 (1), 27-32 (1998)
   PUBMED   9475163
REFERENCE   10 (bases 1 to 6383)
  AUTHORS   Primo-Parmo,S.L., Sorenson,R.C., Teiber,J. and La Du,B.N.
  TITLE     The human serum paraoxonase/arylesterase gene (PON1) is one member
            of a multigene family
  JOURNAL   Genomics 33 (3), 498-507 (1996)
   PUBMED   8661009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164289.3.
            
            On Sep 1, 2022 this sequence version replaced NM_173006.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.8240.1,
                                           SRR10223971.6532.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC164289.3         15225-15305
            82-152              AC164289.3         16872-16942
            153-208             AC164289.3         25125-25180
            209-374             AC164289.3         30480-30645
            375-501             AC164289.3         34460-34586
            502-702             AC164289.3         38934-39134
            703-784             AC164289.3         40628-40709
            785-913             AC164289.3         40929-41057
            914-6383            AC164289.3         49736-55205
FEATURES             Location/Qualifiers
     source          1..6383
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.99 cM"
     gene            1..6383
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /note="paraoxonase 3"
                     /db_xref="GeneID:269823"
                     /db_xref="MGI:MGI:106686"
     exon            1..81
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1072
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /EC_number="3.1.1.2"
                     /EC_number="3.1.8.1"
                     /EC_number="3.1.1.81"
                     /note="isoform 1 is encoded by transcript variant 1; serum
                     paraoxonase/lactonase 3"
                     /codon_start=1
                     /product="serum paraoxonase/lactonase 3 isoform 1"
                     /protein_id="NP_766594.1"
                     /db_xref="CCDS:CCDS19899.1"
                     /db_xref="GeneID:269823"
                     /db_xref="MGI:MGI:106686"
                     /translation="MGKLVALTLLGACLALIGERLLNFRERVSTTREIKATEPQNCHL
                     IEGLENGSEDIDILPSGLAFISTGLKYPGMPAFAPDKPGRIFLMDLNEQNPEAQALEI
                     SGGLDQESLNPHGISTFIDKDNTAYLYVVNHPNMDSTVEIFKFEEQQRSLIHLKTLKH
                     ELLKSVNDIVVLGPEQFYATRDHYFTSYFLVLLEMILDPHWTSVVFYSPKEVKVVAQG
                     FSSANGITVSLDQKFVYVADVTAKNIHIMKKHDNWDLTPVKVIQLGTLVDNLTVDPAT
                     GDILAGCHPNPMKLLIYNPEDPPGSEVLRIQDSLSDKPRVSTLYANNGSVLQGSTVAS
                     VYHKRMLIGTIFHKALYCDL"
     exon            82..152
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /inference="alignment:Splign:2.1.0"
     exon            153..208
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /inference="alignment:Splign:2.1.0"
     exon            209..374
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /inference="alignment:Splign:2.1.0"
     exon            375..501
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /inference="alignment:Splign:2.1.0"
     exon            502..702
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /inference="alignment:Splign:2.1.0"
     exon            703..784
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /inference="alignment:Splign:2.1.0"
     exon            785..913
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /inference="alignment:Splign:2.1.0"
     exon            914..6383
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1104..1109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /note="hexamer: AGTAAA"
     polyA_site      1128
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /note="major polyA site"
     regulatory      5817..5822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /note="hexamer: ATTACA"
     polyA_site      5838
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /note="major polyA site"
     regulatory      6361..6366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
                     /note="hexamer: AATAAA"
     polyA_site      6383
                     /gene="Pon3"
                     /gene_synonym="2810004E20"
ORIGIN      
        1 agacaccatg gggaagcttg tggcgctgac cttgctggga gcctgtctgg ccttaatagg
       61 ggaaaggctg ctgaatttta gagaacgagt tagtacaact cgagaaataa aggccacaga
      121 accacaaaac tgccacctga ttgagggcct cgagaatggc tctgaagata ttgatatact
      181 tcctagcggg ctggctttta tctccactgg attaaaatat ccgggcatgc cagcgtttgc
      241 accggacaaa ccaggaagaa tctttctgat ggatctgaat gagcaaaacc cagaggcgca
      301 agcactggaa atcagtggtg ggcttgacca ggagtcacta aatcctcacg ggatcagcac
      361 tttcatcgac aaagacaaca ctgcttatct ttatgtcgtg aatcacccca acatggactc
      421 cactgtggag atatttaagt ttgaagaaca acaacgctct ctcatccacc tgaaaactct
      481 aaaacatgaa cttctcaaga gtgtgaatga cattgtggtt cttgggccag agcagttcta
      541 tgccacaaga gaccattact ttaccagtta tttcttggta cttctggaga tgatcttgga
      601 ccctcactgg acttccgtcg ttttctacag cccaaaagag gtcaaagttg tggcccaagg
      661 attcagttct gccaacggaa tcacagtctc actagaccag aagtttgtct atgtagctga
      721 tgtaacagct aagaacattc acataatgaa aaaacatgat aattgggatt taactccagt
      781 gaaggtcatt cagctgggaa ccttagtgga taacttgacc gttgatccag ccacgggaga
      841 tattttggca ggctgccacc ctaaccccat gaagctgttg atctataacc ctgaggatcc
      901 tccagggtca gaagtactac gcatccagga ctctttgtca gataagccca gggtgagcac
      961 actgtatgcg aacaacggct ctgtgcttca gggcagcacc gtggcttctg tgtatcataa
     1021 gagaatgctc ataggtacta tatttcacaa agctctgtac tgtgacctct agatctttct
     1081 aaaacgtctt tatatttggc aaaagtaaaa ttgtaatttg tatgctaagg ggaactgtaa
     1141 ttatttacaa ttatcagtga ttgtatgtat ggtttttctt atggagaaaa gtaaaggagt
     1201 atagaaacgt atatccatga aatcaagaat caagttagtg agtggcaacc agatacccat
     1261 gtgtccttta ctgtatgtgc ccaacaccct gtatactctg tgatgcgtag gctgtatcgg
     1321 cttacatttc ccattcactt gaatttgtgc tccttgttaa gtgttcacta aaaccacctc
     1381 cgaccgctgt gatagtctga ggcttctgca gtccacagag tgaagaagcg aatggctaac
     1441 tattacgatt cccattctct gtctgtctcg tatatggtac catcttccag tcacagatcc
     1501 tgactctcat ctttaaactc taaagccttt cttgaacaca gatttgccat acagggagca
     1561 agattctgga aatctgaaaa accgcatcag ctagcttggt gcatgctatg ctcgtgtact
     1621 tctttgaata aggcttttta taccaatatt tccattatgt caccaatctt ggctctgagt
     1681 gtatgagaag gccccgggac agttaccttc agccatgttc atcttctcta ctagttaata
     1741 aacacttagt aagcagcctc cagctgatgg gaaccaataa atccaaaatg aaaaaaaata
     1801 tatgcccaaa tggcatgtac taatggacaa atctaaattt aatttgatga gaataaataa
     1861 agaattcctt tcttggttaa aacaacaaac aaacaaacaa aaaccaatga tttgtagttc
     1921 ataaccacct cccttcccgt agggaacatt aagaccaagt tttctgcaca aagatttatt
     1981 tgccccagag ggacagataa ggaacaaaca caggagatag aggaagaggg agaaggaaca
     2041 gcaacaatgg agagggggca gagacaaggg agaaagggaa gaggtattta tcccatagtg
     2101 ggggtggtgg gggcggtggg ggcagtgggg gcggggtggg gagaggactg tctctgaata
     2161 gggaggatac aggcatggag cacaggcaaa tggtgattat aaaggtaaaa tggaaaccct
     2221 ccatattagg atgaggtgtt tatttattaa tttttattta ttattggggg gagtaataca
     2281 gggtttctct gtgtaacagt cctggctgtc ctttgaattc ttcttacaga ccaggctatc
     2341 ctcaaactca caggaatccg actgcctctg cctcctgagt gcagtgctgg gattaaaggt
     2401 gtatgctacc acacaaggtg attaatttta gttgggcatg ttaatttggt gagtcaaaga
     2461 ggacatctga ttgctagact tcaatacttt cataggtgaa ccttggtagt cagctttggg
     2521 aggagaagtg gccaaataag ggaatagatc ttggggactg gctttaggaa tgtgatctaa
     2581 gaatttttag caaggcagag ggaataggag agaagggaga ggcctgctag agctacattt
     2641 gccacactag agcttcgaga gtcctgtcat cccctcccac aaggtgtatt tggtaatggg
     2701 gaattaagga gacctgttta tattctaaag aacactgctt agttaaaagt tttgtaaata
     2761 gttttatgcc aggacaaaat aatactcttt acttttaacc tgtgcaatca ttttttattc
     2821 agacattaag attttataac tttcattact tcaaggaagg aatagcccag ctgaatgtta
     2881 gagggagatg tcacctttta agttccaaaa cacagccgta tgttgccgag agcttagctg
     2941 ttcgactctt tgccttgtaa gcatgaggaa caaactttga tccccaacac ccacataaaa
     3001 gagctaggtg tgtggtttgt gtttgtagtg ccagcaccgg gcaaggagat tcctggtact
     3061 ttctggctaa aagcctagca tatttagtat actttaggcc agtgagaagc tgcctcaaac
     3121 aacaacaaca acaacaccac attgtagttg atgccctaca gagcaacccc agaagctgtc
     3181 ttctggcctt cacgtacata tgcatgcaag catgcacaac tccatgcatg cacaaaatgt
     3241 agttattgag aagactccaa ataaaactaa tgattaaaag ccatgcacac ttgtaactcg
     3301 gtccattttg aaaaatatga taatttcttt tttatcctat gcatcataac tactggatta
     3361 cttaacattt gactattaag gctttaactg aataaaagaa gcataagcta aatccaaggg
     3421 gagtgggata gtgaaccata tcctagaaaa tccaagagtt caaagagctg aattcccagc
     3481 ttaggttaaa gtcagtgtga agtggcccca cattccactc ccagaagcct gaacagacag
     3541 ttgctttggc attgagaaaa acagaaggaa gagatcagat gtaggtgaga gatgataatc
     3601 atatgtctgc cgtcactcag tttcccattg aatggtcaaa gccattctga agccccaaga
     3661 agttgagagt agattggtag ttaccagaga ccaagagagt aggggttttc tgggaatgga
     3721 ggaggggtac tgagggctta atcattgagt tctaagttac agttaaatag agtgaaggag
     3781 atgaagagag ttattaccca aggcaactgc tatagatgac agaaatgctc tcattatttc
     3841 aaaaatcttg gagaaagaat catgaatatt ttcaccacct agaatgacca atgtttgagg
     3901 agatattttc agtctgactt aaatattaca caaagtataa cgcttcaaaa tatcacagca
     3961 atagaagata tcaagttatg agcttactta tgccatgtta gtaaactaac aaacacctcc
     4021 ttagcagaac caaatgcagg ccctcttatg actttatact atgcactaca aaaacgcttg
     4081 gatctcaaca tccatctttg aatctactga gggcaaataa tttgttgcct gttgaggtta
     4141 tgcaggctgt aagaaaatat caggtcaaag catactcata taaggcaatg gatgactggg
     4201 tgagtcacgt ggagcataat ctagacttgt ttttaagaaa catatgctcc gcccagggag
     4261 tggcactatt agaaggtatg gccctgttgg agtaggtgtg tcactgtggg tgtgtgcttt
     4321 aagactctca tcctagcttc ctggaaggag tattctgcta tcagccatca gatgaagatg
     4381 tagaactctc agctcctctt acaccatgcc ggcctggatg ctgccatgtt catgacttga
     4441 tgataatgga ctgaacctct gaagctgtaa gccagcccca attaaatgtt gtctttataa
     4501 gatttgcctt ggtcatggtg tctgttcaga gcagtaaaac cctaagacac atatggttgt
     4561 atcaggtagt aagactggaa aaaggagaac aaaaacaaaa acaaacaaac aggaaaggaa
     4621 gtgggtgagg gacaaagaga ggaagagaaa gaaatggata aactcaacca gagatgatac
     4681 agagctggag agagtgaaat gagaggtagc ccatgggaga gtatatgcaa gaaaatgata
     4741 tacttaacag aaaacgtaga catgcacatc tgagagagag agacatggtg gctaaagtaa
     4801 gggatttagc ttgtgacaaa ttgaaatccg agaagaaagg aatatagaat ttgtaataaa
     4861 taaataaata aataaataaa taaataaata aataaataaa taagtgatca cattgcaaat
     4921 tagaaataca tatcatatct tggtaaaatt gcagaatatc aaatccaaag tctttagaaa
     4981 gagtcagaag cgaaaagcct ggcatcatca aaaagaaaac attaccatgg tcaaaaggga
     5041 aaccccagaa ggtgccacac actccggttg agtcagcttg acaggccaag aggcctggaa
     5101 gcacttaaga ggcagagagt ttcacggaaa ctcaacttct ggagtttggc gttctcattc
     5161 aaccacatac tcatacacta ttcccgagtt agtctggtgt atggatccac gtgctctctt
     5221 ttagtattat cttattataa gtgcctttta agattgaatt ctgacatagc taagcctttg
     5281 ccagtgttct aatgtcctag aaagtccttg agctgaccat gggcttggaa ttcagtaaga
     5341 atgttgccta ttcagtgaca ttcagaattg cctctgatat tacactatca ctttgaataa
     5401 aaactaagtg actgccctac acaggaattt accatcatct aggaagaagg aagtttgaga
     5461 cctaaggagg aaccagagta gatacttaga actatagatg gctgagttac acccatacac
     5521 acatatttac aatggcctag ggggaaggta gactatacaa tagactaaaa taggaactat
     5581 ggcaagggca tgaagccctt gaccctggct tctaagatta agtggacctt aggtggagct
     5641 ctttttgatc ccagttgtta acaatgaatt ctatcccagg tggttcctgt cagaccttct
     5701 gtgtttgcat tcctctgttt tgtgtaagaa tccagtaacc tctttgtacc ttgttggtgt
     5761 gtcacccaac ttccctattt tcttctgtat aaaaagtttg atgcttgatt tgacaaatta
     5821 cattcagatt ctacacaacc tctcctgtgt tggtctgtct gtcattccct ctgacgcttt
     5881 gcccacctgc cccatagacc cgttctacac agacaatggg atccagaggg tctgcggcaa
     5941 gaaggtccaa taacttcaga gtcttctgaa gtgtatgcta agtgtgtgtg gcggtacctt
     6001 cagagtccag aggaaggtat cagatcctgt gcagctggag gtacaagtag ccatgtacag
     6061 ctcagcacag gagctgggaa tggaacttgg ctcctctaca aaagcagtgt acattcttca
     6121 ccatggaaac attctgacaa gcttcctgga gagccttaaa aaatggtcac cctgtttcta
     6181 atgaaaactt tgaataaacg atgacttata tagggagata taagaatgaa aacacaaata
     6241 aattgtcata atagagcact ggttttaatt atattcatta ggtattagta tatatagaaa
     6301 ttttagaaat atataagtag gatacaaata aaagcaaact gtatcgagta gagttaatat
     6361 aataaaaact tgtaccaatc ttt
//
