LOCUS       NM_011134               1380 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus paraoxonase 1 (Pon1), transcript variant 1, mRNA.
ACCESSION   NM_011134
VERSION     NM_011134.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1380)
  AUTHORS   Witucki,L. and Jakubowski,H.
  TITLE     Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and
            Accelerates Amyloid Beta Accumulation in Mice
  JOURNAL   Cells 12 (5), 746 (2023)
   PUBMED   36899882
  REMARK    GeneRIF: Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR,
            Autophagy, and Accelerates Amyloid Beta Accumulation in Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1380)
  AUTHORS   Sikora,M. and Jakubowski,H.
  TITLE     Changes in redox plasma proteome of Pon1-/- mice are exacerbated by
            a hyperhomocysteinemic diet
  JOURNAL   Free Radic Biol Med 169, 169-180 (2021)
   PUBMED   33838286
  REMARK    GeneRIF: Changes in redox plasma proteome of Pon1-/- mice are
            exacerbated by a hyperhomocysteinemic diet.
REFERENCE   3  (bases 1 to 1380)
  AUTHORS   Kofman,O., Lan,A., Raykin,E., Zega,K. and Brodski,C.
  TITLE     Developmental and social deficits and enhanced sensitivity to
            prenatal chlorpyrifos in PON1-/- mouse pups and adults
  JOURNAL   PLoS One 15 (9), e0239738 (2020)
   PUBMED   32976529
  REMARK    GeneRIF: Developmental and social deficits and enhanced sensitivity
            to prenatal chlorpyrifos in PON1-/- mouse pups and adults.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1380)
  AUTHORS   Luciano-Mateo,F., Cabre,N., Fernandez-Arroyo,S., Baiges-Gaya,G.,
            Hernandez-Aguilera,A., Rodriguez-Tomas,E., Mercado-Gomez,M.,
            Menendez,J.A., Camps,J. and Joven,J.
  TITLE     Chemokine (C-C motif) ligand 2 gene ablation protects low-density
            lipoprotein and paraoxonase-1 double deficient mice from liver
            injury, oxidative stress and inflammation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1555-1566 (2019)
   PUBMED   30905786
  REMARK    GeneRIF: Ccl2 gene ablation protects LDL receptor and PON1 double
            deficient mice from liver injury, oxidative stress and
            inflammation.
REFERENCE   5  (bases 1 to 1380)
  AUTHORS   Gilad,D., Atiya,S., Mozes-Autmazgin,Z., Ben-Shushan,R.S.,
            Ben-David,R., Amram,E., Tamir,S., Chuyun,D. and Szuchman-Sapir,A.
  TITLE     Paraoxonase 1 in endothelial cells impairs vasodilation induced by
            arachidonic acid lactone metabolite
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1864 (3), 386-393 (2019)
   PUBMED   30572120
REFERENCE   6  (bases 1 to 1380)
  AUTHORS   Clendenning,J.B., Humbert,R., Green,E.D., Wood,C., Traver,D. and
            Furlong,C.E.
  TITLE     Structural organization of the human PON1 gene
  JOURNAL   Genomics 35 (3), 586-589 (1996)
   PUBMED   8812495
REFERENCE   7  (bases 1 to 1380)
  AUTHORS   Tong,L. and Perez-Polo,J.R.
  TITLE     Effect of nerve growth factor on AP-1, NF-kappa B, and Oct DNA
            binding activity in apoptotic PC12 cells: extrinsic and intrinsic
            elements
  JOURNAL   J Neurosci Res 45 (1), 1-12 (1996)
   PUBMED   8811508
REFERENCE   8  (bases 1 to 1380)
  AUTHORS   Primo-Parmo,S.L., Sorenson,R.C., Teiber,J. and La Du,B.N.
  TITLE     The human serum paraoxonase/arylesterase gene (PON1) is one member
            of a multigene family
  JOURNAL   Genomics 33 (3), 498-507 (1996)
   PUBMED   8661009
REFERENCE   9  (bases 1 to 1380)
  AUTHORS   Shih,D.M., Gu,L., Hama,S., Xia,Y.R., Navab,M., Fogelman,A.M. and
            Lusis,A.J.
  TITLE     Genetic-dietary regulation of serum paraoxonase expression and its
            role in atherogenesis in a mouse model
  JOURNAL   J Clin Invest 97 (7), 1630-1639 (1996)
   PUBMED   8601628
REFERENCE   10 (bases 1 to 1380)
  AUTHORS   Sorenson,R.C., Primo-Parmo,S.L., Kuo,C.L., Adkins,S., Lockridge,O.
            and La Du,B.N.
  TITLE     Reconsideration of the catalytic center and mechanism of mammalian
            paraoxonase/arylesterase
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7187-7191 (1995)
   PUBMED   7638166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074225.4.
            
            On Aug 2, 2022 this sequence version replaced NM_011134.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012706.1, U32684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC074225.4         189061-189209       c
            150-220             AC074225.4         182319-182389       c
            221-276             AC074225.4         180683-180738       c
            277-445             AC074225.4         180131-180299       c
            446-572             AC074225.4         176824-176950       c
            573-773             AC074225.4         172595-172795       c
            774-855             AC074225.4         171127-171208       c
            856-984             AC074225.4         167126-167254       c
            985-1380            AC074225.4         163486-163881       c
FEATURES             Location/Qualifiers
     source          1..1380
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.99 cM"
     gene            1..1380
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /note="paraoxonase 1"
                     /db_xref="GeneID:18979"
                     /db_xref="MGI:MGI:103295"
     exon            1..149
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1143
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /EC_number="3.1.1.2"
                     /EC_number="3.1.8.1"
                     /EC_number="3.1.1.81"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; serum paraoxonase/arylesterase 1; PON 1;
                     A-esterase 1; aromatic esterase 1; serum
                     aryldialkylphosphatase 1"
                     /codon_start=1
                     /product="serum paraoxonase/arylesterase 1 isoform 1
                     precursor"
                     /protein_id="NP_035264.2"
                     /db_xref="CCDS:CCDS19898.1"
                     /db_xref="GeneID:18979"
                     /db_xref="MGI:MGI:103295"
                     /translation="MAKLLALTLVGLVLALYKNHRSSYQTRLNAFREVTPVELPNCNL
                     VKGIETGAEDLEILPNGLTFFSTGLKYPGIKSFDPSKPGKILLMDLNKKEPAVSELEI
                     IGNTLDISSFNPHGISTFTDEDNTVYLLVVNHPDSSSTVEVFKFQEEERSLLHLKTIT
                     HELLPSINDIAAIGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVQVVAE
                     GFDFANGIGISLDGKYVYIAELLAHKIHVYEKHANWTLTPLKVLNFDTLVDNISVDPV
                     TGDLWVGCHPNGMRIFFYDAENPPGSEVLRIQNILSEDPKITVVYAENGTVLQGTTVA
                     SVYKGKLLIGTVFHKALYCDL"
     exon            150..220
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /inference="alignment:Splign:2.1.0"
     exon            221..276
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /inference="alignment:Splign:2.1.0"
     exon            277..445
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /inference="alignment:Splign:2.1.0"
     exon            446..572
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /inference="alignment:Splign:2.1.0"
     exon            573..773
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /inference="alignment:Splign:2.1.0"
     exon            774..855
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /inference="alignment:Splign:2.1.0"
     exon            856..984
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1380
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1356..1361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /note="hexamer: ATTAAA"
     polyA_site      1380
                     /gene="Pon1"
                     /gene_synonym="Pon"
                     /note="major polyA site"
ORIGIN      
        1 actgggctgc aggtctcagg actgaccagt gttgctgcac ttgtccatcc tcagcctgtc
       61 catctgtctc aggccatggc gaagctgcta gcactcaccc tcgtgggact ggtgttggca
      121 ctttacaaga accatcggtc ttcctatcaa acaagattaa atgctttccg tgaagtaacg
      181 ccagtagaac ttcctaactg taatttagtt aaaggaatcg agacgggtgc tgaagactta
      241 gagattctgc ctaatggact aactttcttt agcactgggc taaagtatcc tggaataaaa
      301 agtttcgatc ccagtaagcc tggaaaaata cttctgatgg acttgaacaa gaaggagcca
      361 gcagtgtcag agttagaaat tataggaaat acattggata tatcttcatt taaccctcat
      421 gggattagta cattcacaga tgaagataac actgtgtacc tactggtggt aaaccatcca
      481 gactcctcgt ccactgtgga ggtatttaaa tttcaagaag aggaaagatc actcttgcat
      541 ctgaaaacca tcacacatga acttctgcct agcatcaacg atatagctgc tattggacct
      601 gagagctttt atgccacaaa tgatcactat tttgctgacc catacttacg gtcctgggaa
      661 atgtacttgg gtctgtcgtg gtccaatgtt gtttactaca gtccagataa agtccaggtg
      721 gtagcagaag ggtttgattt cgcgaatggc attggcattt cccttgatgg caagtatgtc
      781 tatatagctg aattgctggc tcacaagatt catgtgtatg aaaagcatgc taattggact
      841 ttaacaccat tgaaggtcct caactttgac acccttgtgg ataacatctc tgtggatcct
      901 gtgacagggg acctctgggt gggatgccat cccaacggaa tgaggatctt tttctatgac
      961 gcagagaatc ctcccggctc agaggtgctt cgaatccaga acattttatc cgaagacccc
     1021 aaaataactg tagtttatgc agagaatggt accgtcctgc aaggcaccac ggtcgcctct
     1081 gtgtacaaag ggaaactgct gattggcact gtgttccaca aagctcttta ctgtgatctg
     1141 tgacaagcca gctgcacgca cgtcatcgaa agtgaggcca ttatttcaat cctttgccat
     1201 actgtaaggt gcctaccaca gtgatctctg ctaactaatg aatgctgacc ttagtctcag
     1261 acataagaag gtatgagagt ttcctggcaa tagatcctaa ctagcaaggg tttcttgagt
     1321 attactctta gactacttaa agacaccact tatcaattaa aaaaattttt ttcaccaaaa
//
