LOCUS       NM_029037               3601 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus protein-O-mannose kinase (Pomk), mRNA.
ACCESSION   NM_029037
VERSION     NM_029037.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3601)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3601)
  AUTHORS   Okuma,H., Hord,J.M., Chandel,I., Venzke,D., Anderson,M.E.,
            Walimbe,A.S., Joseph,S., Gastel,Z., Hara,Y., Saito,F., Matsumura,K.
            and Campbell,K.P.
  TITLE     N-terminal domain on dystroglycan enables LARGE1 to extend
            matriglycan on alpha-dystroglycan and prevents muscular dystrophy
  JOURNAL   Elife 12, e82811 (2023)
   PUBMED   36723429
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3601)
  AUTHORS   Walimbe,A.S., Okuma,H., Joseph,S., Yang,T., Yonekawa,T., Hord,J.M.,
            Venzke,D., Anderson,M.E., Torelli,S., Manzur,A., Devereaux,M.,
            Cuellar,M., Prouty,S., Ocampo Landa,S., Yu,L., Xiao,J., Dixon,J.E.,
            Muntoni,F. and Campbell,K.P.
  TITLE     POMK regulates dystroglycan function via LARGE1-mediated elongation
            of matriglycan
  JOURNAL   Elife 9, e61388 (2020)
   PUBMED   32975514
  REMARK    GeneRIF: POMK regulates dystroglycan function via LARGE1-mediated
            elongation of matriglycan.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3601)
  AUTHORS   Nagae,M., Mishra,S.K., Neyazaki,M., Oi,R., Ikeda,A., Matsugaki,N.,
            Akashi,S., Manya,H., Mizuno,M., Yagi,H., Kato,K., Senda,T.,
            Endo,T., Nogi,T. and Yamaguchi,Y.
  TITLE     3D structural analysis of protein O-mannosyl kinase, POMK, a
            causative gene product of dystroglycanopathy
  JOURNAL   Genes Cells 22 (4), 348-359 (2017)
   PUBMED   28251761
  REMARK    GeneRIF: Study elucidated the atomic structure of mouse POMK
            catalytic domain in both the absence and presence of donor and
            acceptor substrates.
REFERENCE   5  (bases 1 to 3601)
  AUTHORS   Di Costanzo,S., Balasubramanian,A., Pond,H.L., Rozkalne,A.,
            Pantaleoni,C., Saredi,S., Gupta,V.A., Sunu,C.M., Yu,T.W.,
            Kang,P.B., Salih,M.A., Mora,M., Gussoni,E., Walsh,C.A. and
            Manzini,M.C.
  TITLE     POMK mutations disrupt muscle development leading to a spectrum of
            neuromuscular presentations
  JOURNAL   Hum Mol Genet 23 (21), 5781-5792 (2014)
   PUBMED   24925318
REFERENCE   6  (bases 1 to 3601)
  AUTHORS   Yoshida-Moriguchi,T., Willer,T., Anderson,M.E., Venzke,D.,
            Whyte,T., Muntoni,F., Lee,H., Nelson,S.F., Yu,L. and Campbell,K.P.
  TITLE     SGK196 is a glycosylation-specific O-mannose kinase required for
            dystroglycan function
  JOURNAL   Science 341 (6148), 896-899 (2013)
   PUBMED   23929950
REFERENCE   7  (bases 1 to 3601)
  AUTHORS   Vogel,P., Read,R.W., Hansen,G.M., Payne,B.J., Small,D., Sands,A.T.
            and Zambrowicz,B.P.
  TITLE     Congenital hydrocephalus in genetically engineered mice
  JOURNAL   Vet Pathol 49 (1), 166-181 (2012)
   PUBMED   21746835
  REMARK    GeneRIF: Congenital hydrocephalus and defective neuronal migration
            in cerebellar development in 4930444A02Rik mice
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093366.9.
            
            On Apr 30, 2007 this sequence version replaced NM_029037.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043620.1, AK032677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC093366.9         169933-169967
            36-127              AC093366.9         174313-174404
            128-273             AC093366.9         176414-176559
            274-560             AC093366.9         177522-177808
            561-3601            AC093366.9         180410-183450
FEATURES             Location/Qualifiers
     source          1..3601
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 14.25 cM"
     gene            1..3601
                     /gene="Pomk"
                     /gene_synonym="4930444A02Rik; Sgk196"
                     /note="protein-O-mannose kinase"
                     /db_xref="GeneID:74653"
                     /db_xref="MGI:MGI:1921903"
     exon            1..35
                     /gene="Pomk"
                     /gene_synonym="4930444A02Rik; Sgk196"
                     /inference="alignment:Splign:2.1.0"
     exon            36..127
                     /gene="Pomk"
                     /gene_synonym="4930444A02Rik; Sgk196"
                     /inference="alignment:Splign:2.1.0"
     exon            128..273
                     /gene="Pomk"
                     /gene_synonym="4930444A02Rik; Sgk196"
                     /inference="alignment:Splign:2.1.0"
     exon            274..560
                     /gene="Pomk"
                     /gene_synonym="4930444A02Rik; Sgk196"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1331
                     /gene="Pomk"
                     /gene_synonym="4930444A02Rik; Sgk196"
                     /EC_number="2.7.1.183"
                     /note="sugen kinase 196; probable inactive protein
                     kinase-like protein SgK196"
                     /codon_start=1
                     /product="protein O-mannose kinase"
                     /protein_id="NP_083313.1"
                     /db_xref="CCDS:CCDS22204.1"
                     /db_xref="GeneID:74653"
                     /db_xref="MGI:MGI:1921903"
                     /translation="MGQQHGTRNGLTHRELPRGVGLLLAMALMNVALYLCLDQLFISP
                     GRSTADSRRCPPGYFRMGRMRNCSRWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEH
                     KVALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVGYCEEDGTILTEYHPLGSLSNLE
                     ETLNLSKYQDVNTWQHRLQLAMEYVSIINYLHHSPLGTRVMCDSNDLPKTLSQYLLTS
                     NFSIVANDLDALPLVDHDSGVLIKCGHRELHGDFVAPEQLWPYGEDTPFQDDLMPSYN
                     EKVDIWKIPDVSSFLLGHVEGSDMVRFHLFDIHKACKSQIPAERPTAQNVLDAYQRVF
                     HSLRDTVMSQTKEML"
     exon            561..3601
                     /gene="Pomk"
                     /gene_synonym="4930444A02Rik; Sgk196"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2761..2766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pomk"
                     /gene_synonym="4930444A02Rik; Sgk196"
                     /note="hexamer: AATAAA"
     polyA_site      2780
                     /gene="Pomk"
                     /gene_synonym="4930444A02Rik; Sgk196"
                     /note="major polyA site"
ORIGIN      
        1 gtcctggaat gcgagccgga tttggtggtc gccaggcatt ttgtgaaaga aggaagatcc
       61 tgtctgctgc atggataatg gactggaaca cagaaagacc atgcagggtt cggctgtaga
      121 aggccagtat ctccagaggc cagaagacac catcagatct cctgggactg gagttataga
      181 ggttgtgagc tgccatgttg aaccaagcag gtcactgagg gacacaggca tgtggatgga
      241 aaccctgctg ggagaaaaaa gaaactgctg aagggactga catgggacag caacatggaa
      301 ccaggaatgg tctcacgcat agagagctcc cccggggcgt ggggctgctg ctcgccatgg
      361 cccttatgaa cgtggcgctc tacctctgcc ttgatcagct tttcatctcc cctggacgat
      421 ccaccgcgga ctctaggcgc tgtcctccgg gctacttcag aatggggcgg atgagaaact
      481 gctcacgctg gctgtcctgt gaagagctga ggacagaagt caggcagctg aagcgcgttg
      541 gggagggagc cgtgaagaga gtctttctgt ctgaatggaa ggaacacaaa gtcgctctct
      601 cccggctcac caggctggag atgaaggagg acttcctgca tgggctgcag atgctgaagt
      661 ctctacagag tgagcacgtg gtcacgctgg tgggctactg tgaggaagat ggcactattc
      721 tcaccgaata tcacccctta ggttccttga gcaacctgga agaaacacta aacctttcaa
      781 agtaccaaga cgtgaacact tggcagcaca ggctgcagct ggccatggag tacgtcagca
      841 tcattaacta tctgcatcac agccccctgg gcacgagggt catgtgtgac tctaacgacc
      901 tgcccaaaac attgtcccag tacctgctaa caagtaactt cagcattgtg gcaaacgacc
      961 tggacgctct gcccctggta gaccatgact ctggggtact tataaagtgt ggccacagag
     1021 agctccatgg ggattttgtg gctccagagc agctgtggcc ctacggagaa gacacgccct
     1081 tccaagacga tctcatgcct tcctacaatg agaaggttga catctggaag attccagatg
     1141 tctccagttt cctcttgggg cacgtggaag ggagtgatat ggttagattc catttgtttg
     1201 atatccataa ggcgtgcaag agccagatcc cggcagaaag acccactgct cagaacgtgc
     1261 tagacgctta ccagagggtt ttccattcac tccgagacac tgtgatgtcg cagacgaaag
     1321 aaatgctgta aaaatgagcc atcgagtgac gtgcttgatg gctgaatggc atcccagctg
     1381 ttccgctctt gatgatggaa gagctttgca tggatggatg ttgaccctgg ctgttcagcc
     1441 acgtaggcct cctctacgtc tgcctgcatg tttgagtgtt ctgctctcct ggcagcccgg
     1501 atggaagctg ccaagcgaga aagcctggct tcaggatgct ccctggtgaa gatgcagagg
     1561 attctggatc tgcatagttt caagggagtg atcaaacggt gaccttgaag acatgctgcc
     1621 tgccttggta actttttata gactagtagg aaacagaaat cttttggggg agggggggac
     1681 aacccactag ttcctcagag acaatttctt ctcattcaga aagccctgtt ggaagctggg
     1741 gatgttttaa ctccgtggca gggcacttgc ctagttgtgt gcaaagcctt ggatctgacc
     1801 catggcatgt gcacacacac aaatgctcaa agaaaatccc agacgccaga agtgtgcccc
     1861 tttcttgtca ataaggtcat tgtcagtacc ggagatgatt ttttttatga agcgtttatg
     1921 ctgactcgtg tcactgagcc aagtgtgcat ggtcgttagc tactttgtgg gttcttcttt
     1981 cttctaccct acttcttccc tttccacccc ctaacactag ataggagaga ggagagagaa
     2041 aggaaagtgg gcactgttat attgttggac gacttcttgc tgattaaggg gtgtcgagtt
     2101 ccttggagca atgatctttg ctgccaagat atctcatttc ttcttgtttc ttcttcgccc
     2161 acgaccactt cacaaacacc gaccaacagc aaacaacaac ccaccccgct tctcgggggc
     2221 cctagcactt atgtacttct gaaaagtccc cagaaattcc aatcatcaca cactcagaga
     2281 aactgtctgc tgctggcaaa actacacccc tgctagagca tgaggcaaat catagtcagc
     2341 tgctgtggac agtctgaagc agcctggcat cccacacctg agattaaaac aaaaacattc
     2401 ttacctgtgt tttgtttttg ttttaagaaa ccaaagtgca ccaagatagc atgctcttga
     2461 gattgtggct gtctagagat ttttggaaca gcaagttgaa ggaactttct tacctgcctt
     2521 gaatggtgct ttgaacttcc tgctgacctg gagtttctgt gtgaatattt ctatccagtg
     2581 tccccctgta ccggaaagta caaagtctgc tctgggcttg catgcctgaa cactttaaaa
     2641 cactgtggag ccaggaataa tggtacccac ctgtaatccc agcacctggg agacaggagg
     2701 aaccaggagt tcagggttat cctgggctat ataccgtgac cctgtctacc cccacacccc
     2761 aataaaaaaa caaaaaggtc tccctgtggt gctggcatcc ttatttggga gacatgagaa
     2821 atctgacatg tattaatggt ctctcataag gtgcctcttg tcttctcctt gagtcacaga
     2881 tcggggccca cctcagagtc tctagcttca cagatctaga atgaagttca tgaatttgta
     2941 acaggtttcc tgtgctgctg ctgctgctgc tgctcctcat catcatcatt ccctcctcct
     3001 ccttgtcctc tccctcctcc tcctttcctt cctcctttct tctcctcttc ctctccctcc
     3061 ttttctcctc ttcctcctcc tccctctcct cttctttctc ttcttccctc ctcctcttcc
     3121 tcctcctcat agaatcacca tctgagacga attgcctctt tgaggcaaac aggtacaaca
     3181 gacaaaagaa ataggtgacg ctggcattgt ctccgtcttc tgtaccccgt ggctgattgg
     3241 agggtgaact tgcagggtat ctgagctggc ccttgaagca cacatgaccc cgttcactcg
     3301 gggtttacaa aaactccccc aaacccatca gctcaaagac attagcacgt gttgacaagg
     3361 acatggagta attggaaccc ttgctatgtt gctcgtggga acttaacagt gcaaaagcat
     3421 tttgggaaaa ctgtcgggca gttcctcaca cgcccctgca gttagtcctt ccaaggataa
     3481 acccaggagg atcaaaaact tgttcacatt atccgttaac actggtggca cagttactca
     3541 gagtagacaa aaggtgaaga ataacccaaa tgttggtcaa taataaagta tacgtatatc
     3601 c
//
