LOCUS       NM_001278584            1008 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus pro-opiomelanocortin-alpha (Pomc), transcript variant
            5, mRNA.
ACCESSION   NM_001278584
VERSION     NM_001278584.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1008)
  AUTHORS   Yu,H., Chiang,A., Rubinstein,M. and Low,M.J.
  TITLE     The homeodomain transcription factor Six3 regulates hypothalamic
            Pomc expression and its absence from POMC neurons induces
            hyperphagia and mild obesity in male mice
  JOURNAL   Mol Metab 87, 101993 (2024)
   PUBMED   39025297
  REMARK    GeneRIF: The homeodomain transcription factor Six3 regulates
            hypothalamic Pomc expression and its absence from POMC neurons
            induces hyperphagia and mild obesity in male mice.
REFERENCE   2  (bases 1 to 1008)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   3  (bases 1 to 1008)
  AUTHORS   Constantin,S., Sokanovic,S.J., Mochimaru,Y., Dams,A.L.,
            Smiljanic,K., Previde,R.M., Nessa,N., Carmona,G.N. and
            Stojilkovic,S.S.
  TITLE     Protein Tyrosine Phosphatase Receptors N and N2 Control Pituitary
            Melanotroph Development and POMC Expression
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   38923438
  REMARK    GeneRIF: Protein Tyrosine Phosphatase Receptors N and N2 Control
            Pituitary Melanotroph Development and POMC Expression.
REFERENCE   4  (bases 1 to 1008)
  AUTHORS   Yaswen,L., Diehl,N., Brennan,M.B. and Hochgeschwender,U.
  TITLE     Obesity in the mouse model of pro-opiomelanocortin deficiency
            responds to peripheral melanocortin
  JOURNAL   Nat Med 5 (9), 1066-1070 (1999)
   PUBMED   10470087
REFERENCE   5  (bases 1 to 1008)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Adrenocorticotropic cell distribution in adult and embryonic
            pituitaries of the little (lit) mutant mouse
  JOURNAL   Anat Embryol (Berl) 186 (4), 347-353 (1992)
   PUBMED   1329576
REFERENCE   6  (bases 1 to 1008)
  AUTHORS   Karelus,K. and Nelson,J.F.
  TITLE     Aging impairs estrogenic suppression of hypothalamic
            proopiomelanocortin messenger ribonucleic acid in the mouse
  JOURNAL   Neuroendocrinology 55 (6), 627-633 (1992)
   PUBMED   1378571
REFERENCE   7  (bases 1 to 1008)
  AUTHORS   Uhler,M., Herbert,E., D'Eustachio,P. and Ruddle,F.D.
  TITLE     The mouse genome contains two nonallelic pro-opiomelanocortin genes
  JOURNAL   J Biol Chem 258 (15), 9444-9453 (1983)
   PUBMED   6308009
REFERENCE   8  (bases 1 to 1008)
  AUTHORS   Notake,M., Tobimatsu,T., Watanabe,Y., Takahashi,H., Mishina,M. and
            Numa,S.
  TITLE     Isolation and characterization of the mouse
            corticotropin-beta-lipotropin precursor gene and a related
            pseudogene
  JOURNAL   FEBS Lett 156 (1), 67-71 (1983)
   PUBMED   6303853
REFERENCE   9  (bases 1 to 1008)
  AUTHORS   Uhler,M. and Herbert,E.
  TITLE     Complete amino acid sequence of mouse pro-opiomelanocortin derived
            from the nucleotide sequence of pro-opiomelanocortin cDNA
  JOURNAL   J Biol Chem 258 (1), 257-261 (1983)
   PUBMED   6129251
REFERENCE   10 (bases 1 to 1008)
  AUTHORS   Roberts,J.L., Seeburg,P.H., Shine,J., Herbert,E., Baxter,J.D. and
            Goodman,H.M.
  TITLE     Corticotropin and beta-endorphin: construction and analysis of
            recombinant DNA complementary to mRNA for the common precursor
  JOURNAL   Proc Natl Acad Sci U S A 76 (5), 2153-2157 (1979)
   PUBMED   221916
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC111092.10, AK017581.1,
            BB026464.1 and BB025409.1.
            
            Summary: This gene encodes a polypeptide hormone precursor that
            undergoes extensive, tissue-specific, post-translational
            processing. Processing yields several biologically active peptides,
            which are involved in diverse cellular functions, such as energy
            homeostasis, steroidogenesis, and increased melanin production in
            melanocytes. In mouse deficiency of this gene is associated with
            obesity, defects in adrenal development, and altered pigmentation.
            A pseudogene of this gene is located on chromosome 19. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jun 2013].
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB234671.1, AK017581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC111092.10        107162-107167
            7-983               AK017581.1         2-978
            984-1007            BB026464.1         265-288
            1008-1008           BB025409.1         274-274
FEATURES             Location/Qualifiers
     source          1..1008
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 1.99 cM"
     gene            1..1008
                     /gene="Pomc"
                     /gene_synonym="ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH;
                     beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1"
                     /note="pro-opiomelanocortin-alpha"
                     /db_xref="GeneID:18976"
                     /db_xref="MGI:MGI:97742"
     exon            1..102
                     /gene="Pomc"
                     /gene_synonym="ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH;
                     beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1"
                     /inference="alignment:Splign:2.1.0"
     exon            103..257
                     /gene="Pomc"
                     /gene_synonym="ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH;
                     beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..833
                     /gene="Pomc"
                     /gene_synonym="ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH;
                     beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1"
                     /note="corticotropin-lipotropin; beta-endorphin; adrenal
                     corticotropic hormone; alpha-melanocyte stimulating
                     hormone; adrenocorticotropic hormone; corticotropin-like
                     intermediary peptide; met-enkephalin; melanotropin gamma"
                     /codon_start=1
                     /product="pro-opiomelanocortin preproprotein"
                     /protein_id="NP_001265513.1"
                     /db_xref="CCDS:CCDS25785.1"
                     /db_xref="GeneID:18976"
                     /db_xref="MGI:MGI:97742"
                     /translation="MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLL
                     ACIRACKLDLSLETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGSAAQRR
                     AEEEAVWGDGSPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPL
                     EFKRELEGERPLGLEQVLESDAEKDDGPYRVEHFRWSNPPKDKRYGGFMTSEKSQTPL
                     VTLFKNAIIKNAHKKGQ"
     exon            258..1008
                     /gene="Pomc"
                     /gene_synonym="ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH;
                     beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      921..926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pomc"
                     /gene_synonym="ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH;
                     beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1"
                     /note="hexamer: AATAAA"
     polyA_site      941
                     /gene="Pomc"
                     /gene_synonym="ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH;
                     beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1"
                     /note="major polyA site"
     regulatory      960..965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pomc"
                     /gene_synonym="ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH;
                     beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1"
                     /note="hexamer: AATAAA"
     regulatory      975..980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pomc"
                     /gene_synonym="ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH;
                     beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1"
                     /note="hexamer: AATAAA"
     polyA_site      987
                     /gene="Pomc"
                     /gene_synonym="ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH;
                     beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1"
     polyA_site      1008
                     /gene="Pomc"
                     /gene_synonym="ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH;
                     beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1"
ORIGIN      
        1 gggaccaaac gggaggcgac ggaagagaaa agaggttaag agcagtgact aagagaggcc
       61 actgaacatc tttgtcccca gagagctgcc tttccgcgac agagactagg cctgacacgt
      121 ggaagatgcc gagattctgc tacagtcgct caggggccct gttgctggcc ctcctgcttc
      181 agacctccat agatgtgtgg agctggtgcc tggagagcag ccagtgccag gacctcacca
      241 cggagagcaa cctgctggct tgcatccggg cttgcaaact cgacctctcg ctggagacgc
      301 ccgtgtttcc tggcaacgga gatgaacagc ccctgactga aaacccccgg aagtacgtca
      361 tgggtcactt ccgctgggac cgcttcggcc ccaggaacag cagcagtgct ggcagcgcgg
      421 cgcagaggcg tgcggaggaa gaggcggtgt ggggagatgg cagtccagag ccgagtccac
      481 gcgagggcaa gcgctcctac tccatggagc acttccgctg gggcaagccg gtgggcaaga
      541 aacggcgccc ggtgaaggtg taccccaacg ttgctgagaa cgagtcggcg gaggcctttc
      601 ccctagagtt caagagggag ctggaaggcg agcggccatt aggcttggag caggtcctgg
      661 agtccgacgc ggagaaggac gacgggccct accgggtgga gcacttccgc tggagcaacc
      721 cgcccaagga caagcgttac ggtggcttca tgacctccga gaagagccag acgcccctgg
      781 tgacgctctt caagaacgcc atcatcaaga acgcgcacaa gaagggccag tgagggtgca
      841 ggggtcttct cattccaagg ccccctccct gcatgggcga gctgatgacc tctagcctct
      901 tagagttacc tgtgttagga aataaaacct ttcagatttc acagtcggct ctgatcttca
      961 ataaaaactg cgtaaataaa gtcaaaacac aactgtccag ttacacta
//
