LOCUS       NM_030229               2514 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus polymerase (RNA) III (DNA directed) polypeptide H
            (Polr3h), mRNA.
ACCESSION   NM_030229
VERSION     NM_030229.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2514)
  AUTHORS   Franca,M.M., Han,X., Funari,M.F.A., Lerario,A.M., Nishi,M.Y.,
            Fontenele,E.G.P., Domenice,S., Jorge,A.A.L., Garcia-Galiano,D.,
            Elias,C.F. and Mendonca,B.B.
  TITLE     Exome Sequencing Reveals the POLR3H Gene as a Novel Cause of
            Primary Ovarian Insufficiency
  JOURNAL   J Clin Endocrinol Metab 104 (7), 2827-2841 (2019)
   PUBMED   30830215
  REMARK    GeneRIF: Loss-of-function Polr3h mutation in mice caused early
            embryonic lethality. Mice with homozygous point mutation
            (Polr3hD50G) were viable but showed delayed pubertal development,
            characterized by late first estrus or preputial separation. The
            Polr3hD50G female and male mice showed decreased fertility later in
            life, associated with small litter size and increased time to
            pregnancy or to impregnate a female.
REFERENCE   2  (bases 1 to 2514)
  AUTHORS   Yeganeh,M., Praz,V., Carmeli,C., Villeneuve,D., Rib,L., Guex,N.,
            Herr,W., Delorenzi,M. and Hernandez,N.
  CONSRTM   CycliX consortium
  TITLE     Differential regulation of RNA polymerase III genes during liver
            regeneration
  JOURNAL   Nucleic Acids Res 47 (4), 1786-1796 (2019)
   PUBMED   30597109
  REMARK    GeneRIF: Pol III regulation in the liver thus entails both highly
            expressed housekeeping genes and genes whose expression can adapt
            to increased demand.
REFERENCE   3  (bases 1 to 2514)
  AUTHORS   Mange,F., Praz,V., Migliavacca,E., Willis,I.M., Schutz,F. and
            Hernandez,N.
  CONSRTM   CycliX Consortium
  TITLE     Diurnal regulation of RNA polymerase III transcription is under the
            control of both the feeding-fasting response and the circadian
            clock
  JOURNAL   Genome Res 27 (6), 973-984 (2017)
   PUBMED   28341772
  REMARK    GeneRIF: Pol III transcription during the diurnal cycle is
            regulated both in response to nutrients and by the circadian clock,
            which allows anticipatory Pol III transcription.
REFERENCE   4  (bases 1 to 2514)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC102103.10.
            
            On May 1, 2007 this sequence version replaced NM_030229.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019868.2, BC010793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               AC102103.10        180834-181261       c
            429-525             AC102103.10        177457-177553       c
            526-612             AC102103.10        173723-173809       c
            613-676             AC102103.10        173316-173379       c
            677-878             AC102103.10        172248-172449       c
            879-2514            AC102103.10        170078-171713       c
FEATURES             Location/Qualifiers
     source          1..2514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.26 cM"
     gene            1..2514
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
                     /note="polymerase (RNA) III (DNA directed) polypeptide H"
                     /db_xref="GeneID:78929"
                     /db_xref="MGI:MGI:1926179"
     exon            1..428
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..932
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
                     /EC_number="2.7.7.6"
                     /note="RNA polymerase III subunit C7; DNA-directed RNA
                     polymerase III subunit H"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase III subunit RPC8"
                     /protein_id="NP_084505.2"
                     /db_xref="CCDS:CCDS27676.1"
                     /db_xref="GeneID:78929"
                     /db_xref="MGI:MGI:1926179"
                     /translation="MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGL
                     CICLFDITKLEDAYVFPGDGASHTKVHFRYVVFHPFLDEILIGKIKGCSPEGVHVSLG
                     FFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDT
                     SPTGPSSAEAASSSEELPKKEAPYTLVGSISEPGLGLLSWWTSN"
     exon            429..525
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
                     /inference="alignment:Splign:2.1.0"
     exon            526..612
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
                     /inference="alignment:Splign:2.1.0"
     exon            613..676
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
                     /inference="alignment:Splign:2.1.0"
     exon            677..878
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
                     /inference="alignment:Splign:2.1.0"
     exon            879..2514
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1440..1445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
                     /note="hexamer: AATAAA"
     polyA_site      1465
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
                     /note="major polyA site"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
                     /note="hexamer: ATTAAA"
     polyA_site      2163
                     /gene="Polr3h"
                     /gene_synonym="5031409G22Rik; RPC8"
ORIGIN      
        1 gatttggttt ggcaagcgca gcgttgctgg acgcgcgtgg ctcccgcgcg tggtgcggac
       61 ggaacgaggc cagggtggca tccggggacg gggagccggc gctcctccaa ggctggcggg
      121 agcgggcctc agtttcctcc gggagacgag cgtagcttcc agaattggag cccaggccct
      181 cccgcgcagc tcggctgcag gtttggcttg tcagaggctg agaagggacg gaggaggctc
      241 gggtcccccc caccccatca cagctcgcag gcccccgtgc ttggcagcct ctccggtctc
      301 cagagcccta gcgcaggatg ttcgtgctgg tggagatggt ggacaccgtg cgcatacccc
      361 cgtggcagtt tgagcggaaa ctcaacgatt ccattgctga ggagctgaac aagaaattgg
      421 ccaacaaggt cgtatacaac gtgggactct gcatctgtct gtttgatatc accaagctgg
      481 aggacgccta tgtgttccca ggggatggag catcccacac caaagtccat ttccgctacg
      541 tggtgtttca ccccttcctg gatgagatcc tcattgggaa gatcaaaggc tgcagcccag
      601 agggtgtgca cgtctcttta gggttctttg atgacattct catcccccct gagtcactgc
      661 agcagcctgc caagtttgat gaagcggagc aagtgtgggt gtgggagtac gagacggagg
      721 aaggagcgca tgacctgtac atggacactg gggaggagat ccgcttcagg gtggtggatg
      781 agagctttgt ggacacatcc cccacaggac ccagttccgc cgaggctgcc tcttcaagcg
      841 aggagctgcc caagaaggaa gcaccatata cacttgtggg atctatcagt gagccaggac
      901 taggccttct ctcctggtgg acgagcaact agccctggag ctcacagtga ctgcccagcc
      961 tgaagaccct gtccagactt gggaaagtag agagcagttt gagtgttctc cagagccaag
     1021 cttggtggga ccaggagcag tgacaagtgc ttgtcctctc cctccccagc actgcttctc
     1081 tggtctggag ccaccctgaa tcgtctccag agtgtcatgg atccaggctg gcttctcact
     1141 tgctgtatag catagagtag cctggagttt ctgatcctcc agctgggatt ccaggtgtgc
     1201 agtgccacct tgagcctatg tggaaggtag ggatgggtcc caggactcgt gcacaccagg
     1261 gaggcattct cccaggggag ctgcttcccc atcacaagga ctgtttggtg gtttttgtaa
     1321 tttcttcagg gctgaggatg gaacccaggg cctctttcat gttaggtggg tgttgtacta
     1381 ctgagctagg cccagtctat cctatgaact tctggctttc agtgacgcag aatacattta
     1441 ataaatactg gtggcagagc aggaacctcc ccttttcatt agctgacatc accatctaag
     1501 gtcactgaat tgtcaatctg ggatagcatg tcctgcctca ccccaaggtc catttagaga
     1561 tgacctctcc caagcccaca ggcagtagat ctttgtttat gggaccagac tgagtactga
     1621 acctagtggc ggtgtgataa aggtaaaggt cactggacgg gggttttggg tcggtgctgt
     1681 cagctgctgc tgacgtgaga ataccgagca gcacccttac tgccagagtc tggtaggcag
     1741 agccttccaa atgagccaaa cccctccctg tctagaaagt ggagatggag gcctactcat
     1801 aggaagcctg gggctgctgc tgcctcagct gaccatgagg gcagccccag gtccacagat
     1861 gactgtctag tcctactgtc cctttctcac tggcacttgt gtgataaata ctgttttgtg
     1921 acatactgcc atggcctgcc tgggccttta catgtgagat ttagctgatg cagcctaatg
     1981 gagagagcct gtctcctcac atctctgctg cggaggctag aggggcagac agcatgcagc
     2041 atttgattat tagctgtgtc ctggggcaga ttccttctca ggctgtttta actctgtagt
     2101 ctacactgga cttgaactca gacccatctg cctctgccag gattaaagtg tgtgccacta
     2161 gcagcagcag cagcaacaac agctttgttt ttaaggtagg cgctgtgcct actctcaagg
     2221 taaagaccag gtctagtact gtagccccgg gggaacagag gaggtagctc ttggtctctg
     2281 aagctctcct ctactgcagg tacttgtgac cagggtccag atgtgaccaa ggcctgatgg
     2341 aatctttgct tgaaaaaccc tccattagct catgctggta atagtagaca tcaatcactc
     2401 aggcagaaca ttaatagata tggatctttt tttttttctt ttaagaacaa gtttctctaa
     2461 aatccttcag ccaccagtga aatgatcagg cagaataaaa acttctgtag aggg
//
