LOCUS       NM_178602               2265 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus polymerase (RNA) II (DNA directed) polypeptide M
            (Polr2m), transcript variant 1, mRNA.
ACCESSION   NM_178602
VERSION     NM_178602.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2265)
  AUTHORS   Stavast,C.J., van Zuijen,I., Karkoulia,E., Ozcelik,A., van
            Hoven-Beijen,A., Leon,L.G., Voerman,J.S.A., Janssen,G.M.C., van
            Veelen,P.A., Burocziova,M., Brouwer,R.W.W., van IJcken,W.F.J.,
            Maas,A., Bindels,E.M., van der Velden,V.H.J., Schliehe,C.,
            Katsikis,P.D., Alberich-Jorda,M. and Erkeland,S.J.
  TITLE     The tumor suppressor MIR139 is silenced by POLR2M to promote AML
            oncogenesis
  JOURNAL   Leukemia 36 (3), 687-700 (2022)
   PUBMED   34741119
  REMARK    GeneRIF: The tumor suppressor MIR139 is silenced by POLR2M to
            promote AML oncogenesis.
REFERENCE   2  (bases 1 to 2265)
  AUTHORS   Jishage,M., Ito,K., Chu,C.S., Wang,X., Yamaji,M. and Roeder,R.G.
  TITLE     Transcriptional down-regulation of metabolic genes by Gdown1
            ablation induces quiescent cell re-entry into the cell cycle
  JOURNAL   Genes Dev 34 (11-12), 767-784 (2020)
   PUBMED   32381628
  REMARK    GeneRIF: Transcriptional down-regulation of metabolic genes by
            Gdown1 ablation induces quiescent cell re-entry into the cell
            cycle.
REFERENCE   3  (bases 1 to 2265)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 2265)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   5  (bases 1 to 2265)
  AUTHORS   Matsuda,K., Fletcher,M., Kamiya,Y. and Yuzaki,M.
  TITLE     Specific assembly with the NMDA receptor 3B subunit controls
            surface expression and calcium permeability of NMDA receptors
  JOURNAL   J Neurosci 23 (31), 10064-10073 (2003)
   PUBMED   14602821
REFERENCE   6  (bases 1 to 2265)
  AUTHORS   Wydner,K.S., Mohan Raj,B.K., Sciorra,L.J. and Roginski,R.S.
  TITLE     The mouse orthologue of the human ionotropic glutamate
            receptor-like gene (GRINL1A) maps(1) to mouse chromosome 9
  JOURNAL   Cytogenet Cell Genet 95 (3-4), 240-241 (2001)
   PUBMED   12063408
REFERENCE   7  (bases 1 to 2265)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 2265)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ443340.1, AK052037.1 and BE993895.1.
            
            On Sep 18, 2009 this sequence version replaced NM_178602.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052037.1, AK014316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BQ443340.1         17-64
            49-2226             AK052037.1         3-2180
            2227-2265           BE993895.1         1-39                c
FEATURES             Location/Qualifiers
     source          1..2265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 39.85 cM"
     gene            1..2265
                     /gene="Polr2m"
                     /gene_synonym="D9Wsu138e; Grinl1a; mKIAA4185"
                     /note="polymerase (RNA) II (DNA directed) polypeptide M"
                     /db_xref="GeneID:28015"
                     /db_xref="MGI:MGI:107282"
     exon            1..300
                     /gene="Polr2m"
                     /gene_synonym="D9Wsu138e; Grinl1a; mKIAA4185"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1288
                     /gene="Polr2m"
                     /gene_synonym="D9Wsu138e; Grinl1a; mKIAA4185"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein GRINL1A; glutamate receptor-like protein 1A;
                     glutamate receptor, ionotropic, N-methyl D-aspartate-like
                     1A; DNA-directed RNA polymerase II subunit M; DNA-directed
                     RNA polymerase II subunit GRINL1A"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase II subunit GRINL1A
                     isoform 1"
                     /protein_id="NP_848717.1"
                     /db_xref="CCDS:CCDS23326.1"
                     /db_xref="GeneID:28015"
                     /db_xref="MGI:MGI:107282"
                     /translation="MFSLPRGFEPPAPEDLGRQSSAELRERLRRQERLLRNEKFICKL
                     PDKGKKISDTVAKLKAAISEREEVRGRSELFHPVSVDCKLRQKATTRADTDVDKAQSS
                     DLMLDTSSLDPDCSSIDIKSSKSTSETQGPTHLTHRGNEETLEAGYTVNSSPAAHIRA
                     RAPSSEVKEHLPQHSVSSQEEEISSSIDSLFITKLQKITIADQSEPSEENTSTENFPE
                     LQSETPKKPHYMKVLEMRARNPVPPPHKFKTNVLPTQQSDSPSHCQRGQSPASSEEQR
                     RRARQHLDDITAARLLPLHHLPAQLLSIEESLALQREQKQNYEEMQAKLAAQKLAERL
                     NIKMQSYNPEGESSGRYREVRDEADAQSSDEC"
     exon            301..939
                     /gene="Polr2m"
                     /gene_synonym="D9Wsu138e; Grinl1a; mKIAA4185"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1144
                     /gene="Polr2m"
                     /gene_synonym="D9Wsu138e; Grinl1a; mKIAA4185"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..2248
                     /gene="Polr2m"
                     /gene_synonym="D9Wsu138e; Grinl1a; mKIAA4185"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2195..2200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr2m"
                     /gene_synonym="D9Wsu138e; Grinl1a; mKIAA4185"
                     /note="hexamer: AATAAA"
     polyA_site      2215
                     /gene="Polr2m"
                     /gene_synonym="D9Wsu138e; Grinl1a; mKIAA4185"
                     /note="major polyA site"
ORIGIN      
        1 ccctcgtcct ggcctgtccg tttccggcat ttcaataaag ctcccttcgg ctcggagaag
       61 ccgtgctctt ccgggaaaat ggcgactccc gctcgcgctc cagagtcgcc gccggccgcg
      121 gagccagcgc ccgccgtggg ccccgccggg gatccctgcc cgccgcgcca gccgcagccc
      181 gtgcgcaatg ttctcgctgc cccgcggctt cgagccccca gctcccgagg acttggggcg
      241 gcagagttcg gcggagctgc gggagaggtt gaggcgccag gagagacttt tgcgcaacga
      301 aaaattcatt tgcaaattgc ccgacaaagg taaaaagatc tcagacacag ttgccaaact
      361 gaaagctgcc atttcagaac gtgaagaggt tagagggaga agtgaactgt ttcatcctgt
      421 tagtgtagac tgtaagctaa ggcaaaaagc aaccacaaga gctgacaccg atgtagacaa
      481 ggcccagagt tctgacctga tgcttgatac ttcatcatta gatcctgact gttcctcaat
      541 agacattaag tcatctaaat caacctcaga aacacaggga cctacacatc tcactcacag
      601 aggcaatgaa gagactttgg aggctggcta cacagtaaac agcagcccag ctgcccacat
      661 ccgagcccgg gcgccctcat ccgaagttaa ggagcatctc ccccagcact ctgtttcaag
      721 tcaagaggaa gagatctcca gcagcatcga cagtctcttc atcactaaat tgcaaaaaat
      781 cacaattgca gaccagagtg aaccctcaga agaaaacacc agcactgaga actttccaga
      841 actgcagagt gagactccta agaagcctca ttacatgaaa gtgctagaaa tgcgagccag
      901 aaacccagtg ccccctcctc ataagtttaa gaccaatgtg ttacccacac aacagagtga
      961 ctcaccaagt cattgtcaga ggggccagtc tcctgcttcc tcagaagagc agcgacgaag
     1021 ggctaggcag catcttgatg atatcacagc agcgcgcctc cttccgctcc accacctgcc
     1081 tgcacagctg ctttccatag aagagtcgct ggccctgcag agggagcaga agcagaatta
     1141 tgaggagatg caggcaaagc tcgcagcaca gaaactggcc gagagactga atattaaaat
     1201 gcagagctac aatccagaag gggagtcttc agggagatac cgagaagtga gggacgaagc
     1261 tgatgcccag tcctcggatg agtgctgaag acagggctgg gacaccccga gagctggctg
     1321 cagagctctc attggctcat cgaacttcct aacaagtatc aagaccagcg tcagaccttg
     1381 ttgagggaca gcaggttttt aagttacaca aaggtagcta caaagtaaga acccagtttg
     1441 tctttcagaa gacgctcttc acagcttgca cagtttaata tgtgaacctt gtatttggcc
     1501 gtattgtgtt acagttttgc agtatgttgt gcattggtct gatattttag tgtgagtaga
     1561 gcacacgttt tctttagctg cattttcctt atctgtactc ttatcagata gtgctgctta
     1621 caccctttct ggtgaaatac tttgttaccc caggcaccta aagtgaatta ggaaggcctg
     1681 gttccctcgc tcaagaaatg aagtgtaaag aatggtccac gtgcctgcat ggacatgttc
     1741 ctgagatgct ggatgtgaaa cactgtggaa gacactcaga aatgttacag caagtgcatt
     1801 ggctgatcct gtctctctgg ggtgactgct gtcttcctag gatgaggaca aggagcgctg
     1861 aagaggtgct gggcggggga gggtcttctg agctggtgtg gggagctgct cctggcctcc
     1921 cttggcttga actcattgct gtctcgatga taggtccctg tacagggcgt tcacgtttgg
     1981 taaggaaacc gatgtttttc taagagttac agttgacttg tgagtacatt gcttttttca
     2041 tttttaaacc caaagaggtg tttataggct gcagaaacct cagtcatgta tgtacacatt
     2101 tgtgttgttt aaaatgatta tatgatcgtt ttgagcaaag ataacagtat gttatcaaaa
     2161 gcctttgtct attacgtgga acttgtaaag aagaaataaa ataccaatca gagcagctcc
     2221 ccgagctcat ggcgatgtgt tcttggtaaa aaaaaaaaaa aaaaa
//
