LOCUS       NM_025593               1671 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus polymerase (RNA) II (DNA directed) polypeptide L
            (Polr2l), mRNA.
ACCESSION   NM_025593 XM_888022 XM_916953
VERSION     NM_025593.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1671)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY124873.1 and AK149137.1.
            
            On or before Jan 22, 2009 this sequence version replaced
            XM_916953.3, XM_888022.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149137.1, BI330947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BY124873.1         3-23
            22-1671             AK149137.1         2-1651
FEATURES             Location/Qualifiers
     source          1..1671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.83 cM"
     gene            1..1671
                     /gene="Polr2l"
                     /gene_synonym="2510029B14Rik"
                     /note="polymerase (RNA) II (DNA directed) polypeptide L"
                     /db_xref="GeneID:66491"
                     /db_xref="MGI:MGI:1913741"
     exon            1..126
                     /gene="Polr2l"
                     /gene_synonym="2510029B14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..235
                     /gene="Polr2l"
                     /gene_synonym="2510029B14Rik"
                     /EC_number="2.7.7.6"
                     /note="DNA-directed RNA polymerase III subunit L; RNA
                     polymerases I, II, and III subunit ABC5; RPB10 homolog"
                     /codon_start=1
                     /product="DNA-directed RNA polymerases I, II, and III
                     subunit RPABC5"
                     /protein_id="NP_079869.1"
                     /db_xref="CCDS:CCDS52446.1"
                     /db_xref="GeneID:66491"
                     /db_xref="MGI:MGI:1913741"
                     /translation="MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYC
                     CRRMLLAHVDLIEKLLNYAPLEK"
     exon            127..1671
                     /gene="Polr2l"
                     /gene_synonym="2510029B14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      378..383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr2l"
                     /gene_synonym="2510029B14Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      419
                     /gene="Polr2l"
                     /gene_synonym="2510029B14Rik"
                     /note="major polyA site"
     regulatory      842..847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr2l"
                     /gene_synonym="2510029B14Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      860
                     /gene="Polr2l"
                     /gene_synonym="2510029B14Rik"
     regulatory      1430..1435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr2l"
                     /gene_synonym="2510029B14Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1469
                     /gene="Polr2l"
                     /gene_synonym="2510029B14Rik"
ORIGIN      
        1 actgccggca gcctgcacgc cagacgccgc catgatcatc ccggtgcgct gcttcacctg
       61 cgggaagatc gtcggcaaca aatgggaagc ctacctgggt ctgctgcagg ccgagtacac
      121 ggagggggat gccctggacg ctctgggcct aaagcgctac tgctgccgcc gcatgctgct
      181 agcacacgtg gacctgattg agaagctgct gaactatgca cccctagaga agtgaccgct
      241 ggagcctgcc ctcctctgtc tcctgctggc cacgggcagc ctgtcgtgct atgttcaaac
      301 tgagctattg gggatgttgg tgtattgcct ggctgtggcc ctgtggctaa gtcctgttac
      361 cctggaagga actgtttagt aaagatgttt gcagaaccac caacaggtct aacttccaag
      421 gtgctccatg tccatgtctg tgctgtctct gaggctacct ggcctgcctc cagtctttcc
      481 cctagggctg gtctccttcc ccttcatctg actgggagtc tcgtcctgtg gaggagtacc
      541 ctgcttccgt tccccggggc cttgaccact ttgatcaacg aggtagccct acagtagtct
      601 tgtaccacat tgctttaggg cctctccgct tcctgcctgt gttcaggatg ggcataatgg
      661 atgtgggcac cacaccatcc acaggtatgg atgggcccaa gcctggtgac aatattcctt
      721 tggaatgctg agcgtgcttg gaggtcccaa tccttgtgct agggttatta tgcatttggg
      781 tatttggtct gcttataagt ctttgtatca ctgtgtcccc acagaggcca gatcccctga
      841 gagtaaagtt atagaatgta taagctgcca tcaggtattg ggaatcaaac ccagatttat
      901 ttacctttca ttttccaaga cagggtttct ctgtttggcc ttgactatcc tggaattcaa
      961 ctctgcagac caggctggcc ttgaactaaa gagatcagtc tctgcctccc gagtgttgag
     1021 tttaaaggac ggcttgtgcc acccaaccaa acccagatac tgtaggagta cgcccaaggc
     1081 cacaggcctc acgaatttct tgggtcctaa agcccatcag ctgtgtgagc ctatctgctg
     1141 cccatgcctg aggatcttgt ttccagaatc ttcccaggcc cgacagctag gcagccctgc
     1201 cccttgaccc aatccccaca gcatgtagtc ctaagaagcc tactctaggc caaaggaggt
     1261 ggtgtagtgc tttagctcct aggcatctgc atcaagtacc ccgggttctt tctagcacat
     1321 tgatcccttt gagaattttg gtgggttttt ttgttttgtt ttttgagacc agctttggct
     1381 ggtttgaaac tcacaacagt cagcctgcct ttacctcttg gattctggga ttaaaggtgt
     1441 gtgtggcata gcatacccac cctaccccac ccctggtttt ttgttgtttt aaagaaaaag
     1501 gcgggctggt gagatggctc agtgggtaag agcacccaac tgctcttcca aaggtccaga
     1561 gttcaaatcc cagcaaccac atggtggctc acaaccatcc gcaacaagat cctcttctgg
     1621 agtgtctgaa gacagcaaca gtgtacttac atatattaat aaataaatct t
//
