LOCUS       NM_145632                811 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus polymerase (RNA) II (DNA directed) polypeptide H
            (Polr2h), transcript variant 1, mRNA.
ACCESSION   NM_145632
VERSION     NM_145632.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 811)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 811)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 811)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 811)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010490.10.
            
            On Mar 1, 2023 this sequence version replaced NM_145632.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146429.1, BC092087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               CT010490.10        63042-63234
            194-277             CT010490.10        64064-64147
            278-371             CT010490.10        64231-64324
            372-455             CT010490.10        65759-65842
            456-811             CT010490.10        67150-67505
FEATURES             Location/Qualifiers
     source          1..811
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.5 cM"
     gene            1..811
                     /gene="Polr2h"
                     /note="polymerase (RNA) II (DNA directed) polypeptide H"
                     /db_xref="GeneID:245841"
                     /db_xref="MGI:MGI:2384309"
     exon            1..193
                     /gene="Polr2h"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..573
                     /gene="Polr2h"
                     /EC_number="2.7.7.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-directed RNA polymerases I, II, and III subunit
                     RPABC3; RPB17; DNA-directed RNA polymerase II subunit H;
                     RNA polymerases I, II, and III subunit ABC3; RPB8 homolog"
                     /codon_start=1
                     /product="DNA-directed RNA polymerases I, II, and III
                     subunit RPABC3 isoform 1"
                     /protein_id="NP_663607.1"
                     /db_xref="CCDS:CCDS28058.1"
                     /db_xref="GeneID:245841"
                     /db_xref="MGI:MGI:2384309"
                     /translation="MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVN
                     IQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGD
                     ETSTEAATRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKKLAF"
     exon            194..277
                     /gene="Polr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            278..371
                     /gene="Polr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            372..455
                     /gene="Polr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            456..811
                     /gene="Polr2h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      793..798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr2h"
                     /note="hexamer: ATTAAA"
     polyA_site      811
                     /gene="Polr2h"
                     /note="major polyA site"
ORIGIN      
        1 ctcgttgccg cttttggggc ggtactctgc cctgtcttac ttttctccac gtgagggggt
       61 gcgcgaatcc ccagtggtgg ccgcgcgctc acatcctctg cagctttcgt gcccttcgcg
      121 atggcgggca tcctgttcga ggatattttc gatgtgaaag acatcgaccc agaaggcaag
      181 aaatttgacc gagtatcccg gctgcactgt gagagtgaat ctttcaagat ggacctcatc
      241 ttagatgtaa acattcagat ttaccctgtg gacttaggtg acaagttccg gttggttata
      301 gctagtactt tgtatgaaga tggtaccttg gatgatggtg aatacaaccc cacagatgac
      361 aggccttcca gggctgacca gtttgagtat gtcatgtatg ggaaagtgta caggatcgaa
      421 ggggatgaga cctccactga agcagccaca cgcctctctg cgtacgtgtc ctatgggggc
      481 ctgctcatga ggcttcaggg tgatgccaac aacctgcatg gatttgaggt ggactccaga
      541 gtttatctgc tgatgaagaa gctggccttc tgaacttcgt gggaaaccag acttgctgct
      601 tagtcactca tgtcatggac actgttcaag gctgtgtaga agctgtcggt gttagcctgt
      661 aaaaggggcg gaactctgtc cactgtgggg acgtcttcag tttgtctgaa tgcagtggaa
      721 aaccgactct ccctctcgga aggccgagag ggagaactta gcatgaacct gaagttgtat
      781 atgatttttt ttattaaagt tttctttttc a
//
