LOCUS       NM_027002               1074 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus polymerase (RNA) II (DNA directed) polypeptide D
            (Polr2d), transcript variant 1, mRNA.
ACCESSION   NM_027002 NM_027101
VERSION     NM_027002.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1074)
  AUTHORS   Meng,T.G., Guo,J.N., Zhu,L., Yin,Y., Wang,F., Han,Z.M., Lei,L.,
            Ma,X.S., Xue,Y., Yue,W., Nie,X.Q., Zhao,Z.H., Zhang,H.Y., Sun,S.M.,
            Ouyang,Y.C., Hou,Y., Schatten,H., Ju,Z., Ou,X.H., Wang,Z.B.,
            Wong,C.C.L., Li,Z. and Sun,Q.Y.
  TITLE     NLRP14 Safeguards Calcium Homeostasis via Regulating the K27
            Ubiquitination of Nclx in Oocyte-to-Embryo Transition
  JOURNAL   Adv Sci (Weinh) 10 (27), e2301940 (2023)
   PUBMED   37493331
REFERENCE   2  (bases 1 to 1074)
  AUTHORS   Yu,C., Ji,S.Y., Sha,Q.Q., Dang,Y., Zhou,J.J., Zhang,Y.L., Liu,Y.,
            Wang,Z.W., Hu,B., Sun,Q.Y., Sun,S.C., Tang,F. and Fan,H.Y.
  TITLE     BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition
            licensing factor in oocytes
  JOURNAL   Nat Struct Mol Biol 23 (5), 387-394 (2016)
   PUBMED   27065194
REFERENCE   3  (bases 1 to 1074)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 1074)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1074)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   6  (bases 1 to 1074)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1074)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161511.3, BU696372.1, AK011600.1 and BP770158.1.
            
            On or before Oct 28, 2017 this sequence version replaced
            NM_027101.2, NM_027002.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004810.1, BF122130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC161511.3         38879-38883         c
            6-34                BU696372.1         1-29
            35-763              AK011600.1         3-731
            764-1074            BP770158.1         1-311               c
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 17.85 cM"
     gene            1..1074
                     /gene="Polr2d"
                     /gene_synonym="2310002G05Rik; 2610028L19Rik; HSRBP4; RBP4"
                     /note="polymerase (RNA) II (DNA directed) polypeptide D"
                     /db_xref="GeneID:69241"
                     /db_xref="MGI:MGI:1916491"
     exon            1..120
                     /gene="Polr2d"
                     /gene_synonym="2310002G05Rik; 2610028L19Rik; HSRBP4; RBP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..476
                     /gene="Polr2d"
                     /gene_synonym="2310002G05Rik; 2610028L19Rik; HSRBP4; RBP4"
                     /EC_number="2.7.7.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-directed RNA polymerase II subunit RPB4; RNA
                     polymerase II subunit B4; DNA-directed RNA polymerase II
                     subunit D"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase II subunit RPB4
                     isoform 1"
                     /protein_id="NP_081278.1"
                     /db_xref="CCDS:CCDS29111.1"
                     /db_xref="GeneID:69241"
                     /db_xref="MGI:MGI:1916491"
                     /translation="MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHR
                     KQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLAN
                     LCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSFQY"
     exon            121..301
                     /gene="Polr2d"
                     /gene_synonym="2310002G05Rik; 2610028L19Rik; HSRBP4; RBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            302..397
                     /gene="Polr2d"
                     /gene_synonym="2310002G05Rik; 2610028L19Rik; HSRBP4; RBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            398..1057
                     /gene="Polr2d"
                     /gene_synonym="2310002G05Rik; 2610028L19Rik; HSRBP4; RBP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1025..1030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr2d"
                     /gene_synonym="2310002G05Rik; 2610028L19Rik; HSRBP4; RBP4"
                     /note="hexamer: AATAAA"
     polyA_site      1054
                     /gene="Polr2d"
                     /gene_synonym="2310002G05Rik; 2610028L19Rik; HSRBP4; RBP4"
                     /note="major polyA site"
ORIGIN      
        1 cgcggcttcc gtctccggcg gtggctgtgg cggcacgtcc taaagtaatg gcggcgggtg
       61 gaagcgatcc tcgggctggc gacgtagaag aagacgcttc ccagcttatc tttcccaaag
      121 agtttgagac agcggagact ctgctgaact cggaagtcca catgcttctg gagcatcgaa
      181 agcagcagaa cgagagcgcg gaggacgagc aggagctgtc ggaggtcttc atgaaaaccc
      241 tcaactacac ggcccgcttc agccggttca aaaacagaga gaccattgcc agtgtgcgca
      301 gcttgcttct ccagaaaaag ttacataagt ttgagttggc ctgtttagcc aatctttgcc
      361 cggagactgc tgaagagtcc aaagctctga ttccaagcct ggaagggcgt tttgaagatg
      421 aggagctgca gcagattctc gatgacatcc agacgaagcg cagcttccag tactgatccg
      481 cagacgtcac tctgctcctt gagttacagc accacggtct gaagcctggg gaggcctcat
      541 gcaggaacat tgcttcagaa gacgctggag cttctttcgt agtttttgct tcactgcgag
      601 agagtgtctc tccagttctc aaagtcataa cagtcctcct gcctcagcct cgcaggtgct
      661 gggattacag gtgtgagcca acactttcag cttggcttct ggagaggaaa gaaaggctgg
      721 ctattgatgc tgtaggtgct atcttcacag tgactgttag accataacta ccatctgcgc
      781 tccttgcagc cttttaaggc tgctgtggtc aggcaggctg ccatcctgaa ctgctgaggt
      841 agaatgatgt tcaaacattc gttgactact tcgtaccgtg gtttttttgg accccatgtt
      901 actatttttt tgttcttgac acttcagatt ttaatgtcaa ttattttgta gtttttgaag
      961 ctaaaatgat atataaaaaa cttgcatagg agaggagtgt tttcacttgg ttgtaaaggg
     1021 gagaaataaa ccagaacact gttttttttt aaaagaaaaa aaaaaaaaaa aaaa
//
