LOCUS       NM_009090               1580 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus polymerase (RNA) II (DNA directed) polypeptide C
            (Polr2c), mRNA.
ACCESSION   NM_009090 XM_911681
VERSION     NM_009090.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1580)
  AUTHORS   Alldred,M.J., Lee,S.H., Petkova,E. and Ginsberg,S.D.
  TITLE     Expression profile analysis of vulnerable CA1 pyramidal neurons in
            young-Middle-Aged Ts65Dn mice
  JOURNAL   J Comp Neurol 523 (1), 61-74 (2015)
   PUBMED   25131634
REFERENCE   2  (bases 1 to 1580)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   3  (bases 1 to 1580)
  AUTHORS   Corbi,N., Bruno,T., De Angelis,R., Di Padova,M., Libri,V., Di
            Certo,M.G., Spinardi,L., Floridi,A., Fanciulli,M. and Passananti,C.
  TITLE     RNA polymerase II subunit 3 is retained in the cytoplasm by its
            interaction with HCR, the psoriasis vulgaris candidate gene product
  JOURNAL   J Cell Sci 118 (Pt 18), 4253-4260 (2005)
   PUBMED   16141233
REFERENCE   4  (bases 1 to 1580)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 1580)
  AUTHORS   Korobko,I.V., Yamamoto,K., Nogi,Y. and Muramatsu,M.
  TITLE     Protein interaction cloning in yeast of the mouse third largest RNA
            polymerase II subunit, mRPB31
  JOURNAL   Gene 185 (1), 1-4 (1997)
   PUBMED   9034305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129606.4.
            
            On Jul 11, 2009 this sequence version replaced NM_009090.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099548.1, AK160053.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC129606.4         110064-110255
            193-242             AC129606.4         110361-110410
            243-311             AC129606.4         112858-112926
            312-364             AC129606.4         113058-113110
            365-493             AC129606.4         114325-114453
            494-545             AC129606.4         114796-114847
            546-714             AC129606.4         115135-115303
            715-789             AC129606.4         115424-115498
            790-1580            AC129606.4         116066-116856
FEATURES             Location/Qualifiers
     source          1..1580
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.92 cM"
     gene            1..1580
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /note="polymerase (RNA) II (DNA directed) polypeptide C"
                     /db_xref="GeneID:20021"
                     /db_xref="MGI:MGI:109299"
     exon            1..192
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..934
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /EC_number="2.7.7.6"
                     /note="RPB31; RPB33; RNA polymerase II subunit 3; RNA
                     polymerase II subunit B3; DNA-directed RNA polymerase II
                     subunit C; DNA-directed RNA polymerase II 33 kDa
                     polypeptide"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase II subunit RPB3"
                     /protein_id="NP_033116.2"
                     /db_xref="CCDS:CCDS40442.1"
                     /db_xref="GeneID:20021"
                     /db_xref="MGI:MGI:109299"
                     /translation="MPYANQPTVRITELTEENVKFIIENTDLAVANSIRRVFIAEVPI
                     IAIDWVQIDANSSVLHDEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFT
                     LDVRCNEDQTRHVTSRDLISNSPRVIPVTSRNRDNDPNDYVEQDDILIVKLRKGQELR
                     LRAYAKKGFGKEHAKWNPTAGVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQA
                     PYDPNGKPERFYYNVESCGSLRPETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN"
     exon            193..242
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            243..311
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            312..364
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            365..493
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            494..545
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            546..714
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            715..789
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1580
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1227..1232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /note="hexamer: AATAAA"
     polyA_site      1250
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /note="major polyA site"
     regulatory      1490..1495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /note="hexamer: ATTAAA"
     polyA_site      1511
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
     regulatory      1559..1564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
                     /note="hexamer: AATAAA"
     polyA_site      1580
                     /gene="Polr2c"
                     /gene_synonym="33kDa; mRBP31; RPB3; Rpo2-3"
ORIGIN      
        1 gctgcgcccg cgactagccg gaagcgccga ttgccccgcc gacaaactgc tggtggccgc
       61 gcaggcgcgc tgtgcggctg gcgcgggagc ctggcggagg gtcgcgatgc cgtacgccaa
      121 ccagccaaca gtgcggatca cggaactcac cgaagagaac gtcaagttca ttatcgagaa
      181 cacggacctg gcggtggcca attccattcg gagggtcttc atcgcagagg tgcccataat
      241 agccatcgac tgggttcaga ttgacgccaa ctcctcggtc cttcatgatg aattcatcgc
      301 gcacaggctt ggtttaatcc ccctcactag tgatgacatt gtggacaagc tgcagtactc
      361 ccgggactgc acatgtgaag agttctgccc tgagtgttct gtggagttca ctctcgatgt
      421 gaggtgcaat gaagaccaga cgcgccatgt cacctcccga gatctcatct ccaacagccc
      481 ccgggttatt ccggtgacat ctcggaaccg ggataacgac cctaatgact atgtggagca
      541 ggatgacatc cttattgtca agctgaggaa ggggcaggag ctgagacttc gagcctatgc
      601 caagaagggc tttggcaagg aacatgccaa gtggaaccct actgcggggg tagcttttga
      661 atacgatcca gacaacgcac ttaggcatac agtgtatccc aagcctgagg aatggcccaa
      721 gagtgagtat tccgagctgg atgaggatga gtcgcaggct ccctacgacc ccaacggcaa
      781 gccagagagg ttttactaca atgtggagtc gtgtggctca ctgcgccctg aaaccattgt
      841 cctctcagcc ctgtcggggc taaagaagaa gctgagtgat ttacagactc agttaagcca
      901 tgagatccag agtgacgtgc tcaccataaa ctagccacgg ctcgcctgcc tccgaagact
      961 aggttcacgg tggctggact tcaggcctcg ggagcccttg tagtttctgg gctatgcact
     1021 gcacagtctg ccccctggaa ggccatcggg gagatggcca gggtcccact ggtgttagac
     1081 atggcgggtt ttattaagcg ttgagcatcc cgggccctac tgtagtggtt ttcaggcagc
     1141 atggggggaa acacacacca gcacggaaaa gaaggaatat ttattgatca acagtagttg
     1201 tctttttaaa agtttttatt tttggcaata aagagcacaa cataatctcc ttcatgcgtc
     1261 atcgtgccac taactgagcc agttttgcct ccctcccaaa gggttgggcc catttcttgt
     1321 acaaactagc tgacctctgg gtggtcattt cctgggtcac agagttgggc tggctgtgcc
     1381 acctccctgg ctctagggca ccccctggga ggggcccctt atcattctgc cacacatgtg
     1441 aacagtggtt atttacaagg tctgttccca caaatcagaa ccctaaagta ttaaaaaaca
     1501 gaaacacgca acaaaaggtt tgatgtgaat agaaagatag cccttctgca cggtagtcaa
     1561 taaataccag cactagaaaa
//
