LOCUS       NM_181730               1147 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus polymerase (RNA) I polypeptide D (Polr1d), transcript
            variant 2, mRNA.
ACCESSION   NM_181730
VERSION     NM_181730.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1147)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1147)
  AUTHORS   Yang,G., Xin,Q., Feng,I., Wu,D. and Dean,J.
  TITLE     Germ cell-specific eIF4E1b regulates maternal mRNA translation to
            ensure zygotic genome activation
  JOURNAL   Genes Dev 37 (9-10), 418-431 (2023)
   PUBMED   37257918
REFERENCE   3  (bases 1 to 1147)
  AUTHORS   Falcon,K.T., Watt,K.E.N., Dash,S., Zhao,R., Sakai,D., Moore,E.L.,
            Fitriasari,S., Childers,M., Sardiu,M.E., Swanson,S., Tsuchiya,D.,
            Unruh,J., Bugarinovic,G., Li,L., Shiang,R., Achilleos,A., Dixon,J.,
            Dixon,M.J. and Trainor,P.A.
  TITLE     Dynamic regulation and requirement for ribosomal RNA transcription
            during mammalian development
  JOURNAL   Proc Natl Acad Sci U S A 119 (31), e2116974119 (2022)
   PUBMED   35881792
REFERENCE   4  (bases 1 to 1147)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1147)
  AUTHORS   Miao,X., Sun,T., Golan,M., Mager,J. and Cui,W.
  TITLE     Loss of POLR1D results in embryonic lethality prior to blastocyst
            formation in mice
  JOURNAL   Mol Reprod Dev 87 (11), 1152-1158 (2020)
   PUBMED   33022126
  REMARK    GeneRIF: Loss of POLR1D results in embryonic lethality prior to
            blastocyst formation in mice.
REFERENCE   6  (bases 1 to 1147)
  AUTHORS   Yamamoto,K., Yamamoto,M., Hanada,K., Nogi,Y., Matsuyama,T. and
            Muramatsu,M.
  TITLE     Multiple protein-protein interactions by RNA polymerase
            I-associated factor PAF49 and role of PAF49 in rRNA transcription
  JOURNAL   Mol Cell Biol 24 (14), 6338-6349 (2004)
   PUBMED   15226435
REFERENCE   7  (bases 1 to 1147)
  AUTHORS   Yao,Y., Yamamoto,K., Nishi,Y., Nogi,Y. and Muramatsu,M.
  TITLE     Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa
            subunit is a homolog of yeast AC19 subunit of RNA polymerases I and
            III
  JOURNAL   J Biol Chem 271 (51), 32881-32885 (1996)
   PUBMED   8955128
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM948930.1, BC087884.1 and
            BF462386.1.
            
            On Feb 2, 2013 this sequence version replaced NM_181730.3.
            
            Summary: This gene encodes an RNA polymerase subunit that is a
            component of both the RNA polymerase I and RNA polymerase III
            complexes. RNA polymerase I is associated with transcription of
            pre-ribosomal RNAs, while RNA polymerase III is associated with
            transcription of small RNAs. Pseudogenes of this gene have been
            defined on chromosomes 4 and 6. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The encoded isoform (2)
            has a distinct and shorter C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI408083.1, BC087884.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               BM948930.1         298-498
            202-1136            BC087884.1         1-935
            1137-1147           BF462386.1         9-19                c
FEATURES             Location/Qualifiers
     source          1..1147
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 86.73 cM"
     gene            1..1147
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /note="polymerase (RNA) I polypeptide D"
                     /db_xref="GeneID:20018"
                     /db_xref="MGI:MGI:108403"
     exon            1..348
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..703
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /note="isoform 2 is encoded by transcript variant 2; RNA
                     polymerase 1-3; DNA-directed RNA polymerases I and III
                     subunit RPAC2; RNA polymerases I and III subunit AC2;
                     DNA-directed RNA polymerase I 16 kDa polypeptide"
                     /codon_start=1
                     /product="DNA-directed RNA polymerases I and III subunit
                     RPAC2 isoform 2"
                     /protein_id="NP_859419.1"
                     /db_xref="CCDS:CCDS39397.1"
                     /db_xref="GeneID:20018"
                     /db_xref="MGI:MGI:108403"
                     /translation="MEDDQELERKAIEELLKEAKRGKTRAETMGPMGWMKCPLAGTNK
                     RFLINTIKNTLPSHKEQDHEQKEGSKEPGKSQDQKEASGKKYRSHSYKRSLHSSRGSA
                     GCSPPRKRTSRTSRDKCDPRPSRR"
     exon            349..423
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /inference="alignment:Splign:2.1.0"
     exon            424..1137
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1116..1121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /note="hexamer: AATAAA"
     polyA_site      1136
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /note="major polyA site"
ORIGIN      
        1 gcgacaggtg agagcctatg ctcttcagtg gcacttgggg accggctggc tgtgcccggc
       61 agctggctta gcttccgcag ttccaggtga accgtcctgc ccgcgcctgg gcgtggtcgg
      121 gggcgggacc cggtttagcc ccgcccacag agggccctgc cgcgccgctg cggctccgcc
      181 cccctccttc cgtcatccgc ttcttccgtc ggtggtttct tccttcctgc cttgtcccgc
      241 acctttcgcg acatggggaa gagcttccat ttcgccagcg ccacctgagg atttcctgga
      301 gccgccaccc ccacctcccg cgatggaaga cgatcaggag ctggagagga aagccataga
      361 ggaattgcta aaggaggcaa agcgtgggaa aaccagagcg gagacaatgg ggccgatggg
      421 ctggatgaag tgtcctcttg ctggtacaaa taaaagattc ctaattaaca caattaagaa
      481 cacactgccc tcccataaag agcaagacca tgaacaaaaa gagggcagta aggagcctgg
      541 caaaagccaa gaccagaagg aagcaagtgg gaagaagtac cgaagtcact cgtacaagcg
      601 cagccttcac tcgtcccggg gctccgcagg ctgctctcct ccacggaagc ggacctcccg
      661 gacctcccgg gacaagtgcg acccacggcc cagcaggcga tgagacagcc gcagggctag
      721 cccagcccag cactgcacct gccactgagt gaagcaagga agacagggag gttggccggc
      781 tggcacctga gagtgacttt ctcagtgggt cctttgtttt aaggaggctg ttggtactgt
      841 gtggttgttc ttgttgctgt tgttgttgtt gttaacggga gaagaaaact ttactaaaac
      901 aaatcttaac taccttatcc tgaaggtgtc gcggtgagag caagctgact cggcatggcc
      961 cccgcatatc cgtggtgtct ttatcctacc ttacttggaa gttcgtttca aaacaggcag
     1021 ttttagaatt tgagattttg agattgttta aaaactccta gttttttgat gtactgctct
     1081 tttgtggtca tttcccagaa tttctcaaaa aaatcaataa aatacttaga aacgcggaaa
     1141 aaaaaaa
//
