LOCUS       NM_009087                907 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus polymerase (RNA) I polypeptide D (Polr1d), transcript
            variant 1, mRNA.
ACCESSION   NM_009087
VERSION     NM_009087.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 907)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 907)
  AUTHORS   Yang,G., Xin,Q., Feng,I., Wu,D. and Dean,J.
  TITLE     Germ cell-specific eIF4E1b regulates maternal mRNA translation to
            ensure zygotic genome activation
  JOURNAL   Genes Dev 37 (9-10), 418-431 (2023)
   PUBMED   37257918
REFERENCE   3  (bases 1 to 907)
  AUTHORS   Falcon,K.T., Watt,K.E.N., Dash,S., Zhao,R., Sakai,D., Moore,E.L.,
            Fitriasari,S., Childers,M., Sardiu,M.E., Swanson,S., Tsuchiya,D.,
            Unruh,J., Bugarinovic,G., Li,L., Shiang,R., Achilleos,A., Dixon,J.,
            Dixon,M.J. and Trainor,P.A.
  TITLE     Dynamic regulation and requirement for ribosomal RNA transcription
            during mammalian development
  JOURNAL   Proc Natl Acad Sci U S A 119 (31), e2116974119 (2022)
   PUBMED   35881792
REFERENCE   4  (bases 1 to 907)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 907)
  AUTHORS   Miao,X., Sun,T., Golan,M., Mager,J. and Cui,W.
  TITLE     Loss of POLR1D results in embryonic lethality prior to blastocyst
            formation in mice
  JOURNAL   Mol Reprod Dev 87 (11), 1152-1158 (2020)
   PUBMED   33022126
  REMARK    GeneRIF: Loss of POLR1D results in embryonic lethality prior to
            blastocyst formation in mice.
REFERENCE   6  (bases 1 to 907)
  AUTHORS   Yamamoto,K., Yamamoto,M., Hanada,K., Nogi,Y., Matsuyama,T. and
            Muramatsu,M.
  TITLE     Multiple protein-protein interactions by RNA polymerase
            I-associated factor PAF49 and role of PAF49 in rRNA transcription
  JOURNAL   Mol Cell Biol 24 (14), 6338-6349 (2004)
   PUBMED   15226435
REFERENCE   7  (bases 1 to 907)
  AUTHORS   Yao,Y., Yamamoto,K., Nishi,Y., Nogi,Y. and Muramatsu,M.
  TITLE     Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa
            subunit is a homolog of yeast AC19 subunit of RNA polymerases I and
            III
  JOURNAL   J Biol Chem 271 (51), 32881-32885 (1996)
   PUBMED   8955128
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM948930.1, AK002811.1 and
            AA023617.1.
            
            On Feb 2, 2013 this sequence version replaced NM_009087.1.
            
            Summary: This gene encodes an RNA polymerase subunit that is a
            component of both the RNA polymerase I and RNA polymerase III
            complexes. RNA polymerase I is associated with transcription of
            pre-ribosomal RNAs, while RNA polymerase III is associated with
            transcription of small RNAs. Pseudogenes of this gene have been
            defined on chromosomes 4 and 6. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO040276.1, CF618101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               BM948930.1         298-530
            234-894             AK002811.1         2-662
            895-907             AA023617.1         379-391
FEATURES             Location/Qualifiers
     source          1..907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 86.73 cM"
     gene            1..907
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /note="polymerase (RNA) I polypeptide D"
                     /db_xref="GeneID:20018"
                     /db_xref="MGI:MGI:108403"
     exon            1..348
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..724
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /note="isoform 1 is encoded by transcript variant 1; RNA
                     polymerase 1-3; DNA-directed RNA polymerases I and III
                     subunit RPAC2; RNA polymerases I and III subunit AC2;
                     DNA-directed RNA polymerase I 16 kDa polypeptide"
                     /codon_start=1
                     /product="DNA-directed RNA polymerases I and III subunit
                     RPAC2 isoform 1"
                     /protein_id="NP_033113.1"
                     /db_xref="CCDS:CCDS19876.1"
                     /db_xref="GeneID:20018"
                     /db_xref="MGI:MGI:108403"
                     /translation="MEDDQELERKISGLKTSMAEGERKTALEMVQAAGTDRQCVTFVL
                     HEEDHTLGNCLRYIIMKNPEVEFCGYTTTHPSESKINLRIQTRGALPAVEPFQKGLNE
                     LLNVCQHVLVKFEASIKDYKAKKASKKEPTF"
     exon            349..900
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      874..879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /note="hexamer: AATAAA"
     polyA_site      900
                     /gene="Polr1d"
                     /gene_synonym="1110003G10Rik; AC19; RPA16; Rpo1-3"
                     /note="major polyA site"
ORIGIN      
        1 gcgacaggtg agagcctatg ctcttcagtg gcacttgggg accggctggc tgtgcccggc
       61 agctggctta gcttccgcag ttccaggtga accgtcctgc ccgcgcctgg gcgtggtcgg
      121 gggcgggacc cggtttagcc ccgcccacag agggccctgc cgcgccgctg cggctccgcc
      181 cccctccttc cgtcatccgc ttcttccgtc ggtggtttct tccttcctgc cttgtcccgc
      241 acctttcgcg acatggggaa gagcttccat ttcgccagcg ccacctgagg atttcctgga
      301 gccgccaccc ccacctcccg cgatggaaga cgatcaggag ctggagagaa aaatatcagg
      361 attgaagacc tcaatggctg aaggcgagag gaagacagcc ctggaaatgg tccaggcagc
      421 tggaacagat agacagtgtg tgacatttgt cctgcacgag gaggaccata cactaggaaa
      481 ctgtctgcgg tacataatca tgaagaaccc ggaagtggaa ttttgtggtt acactacgac
      541 ccatccttca gagagcaaaa ttaatttgcg aattcagacc cggggtgccc ttccagctgt
      601 tgagccgttt cagaaaggcc tgaatgagct cttgaatgtc tgccagcatg tgcttgtcaa
      661 gtttgaggcc agcataaagg actataaagc taaaaaggca agcaaaaagg agcccacatt
      721 ctagtccctc gtgcagggta caagcaggac caccctcagg atggtgcaga acccagaatt
      781 gtgattgcag catgtactgt cctgtaggaa agaaaatgtg gctctagcta ttgacccata
      841 cagctgttgg aatctctgca agtatatttg cctaataaat tctctctttt gtttaaacta
      901 aaaaaaa
//
