LOCUS       NM_009085               1305 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus polymerase (RNA) I polypeptide C (Polr1c), mRNA.
ACCESSION   NM_009085
VERSION     NM_009085.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1305)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1305)
  AUTHORS   Falcon,K.T., Watt,K.E.N., Dash,S., Zhao,R., Sakai,D., Moore,E.L.,
            Fitriasari,S., Childers,M., Sardiu,M.E., Swanson,S., Tsuchiya,D.,
            Unruh,J., Bugarinovic,G., Li,L., Shiang,R., Achilleos,A., Dixon,J.,
            Dixon,M.J. and Trainor,P.A.
  TITLE     Dynamic regulation and requirement for ribosomal RNA transcription
            during mammalian development
  JOURNAL   Proc Natl Acad Sci U S A 119 (31), e2116974119 (2022)
   PUBMED   35881792
REFERENCE   3  (bases 1 to 1305)
  AUTHORS   Campbell,G.R., Baudhuin,A., Vranizan,K. and Ngai,J.
  TITLE     Transcription factors expressed in olfactory bulb local progenitor
            cells revealed by genome-wide transcriptome profiling
  JOURNAL   Mol Cell Neurosci 46 (2), 548-561 (2011)
   PUBMED   21194568
REFERENCE   4  (bases 1 to 1305)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 1305)
  AUTHORS   Nishi,Y., Yamamoto,K., Yao,Y., Yamamoto,M., Nogi,Y., Matsuo,H. and
            Muramatsu,M.
  TITLE     Isolation and characterization of cDNA encoding mouse RNA
            polymerase II subunit RPB14
  JOURNAL   Gene 187 (2), 165-170 (1997)
   PUBMED   9099876
REFERENCE   6  (bases 1 to 1305)
  AUTHORS   Seither,P. and Grummt,I.
  TITLE     Molecular cloning of RPA2, the gene encoding the second largest
            subunit of mouse RNA polymerase I
  JOURNAL   Genomics 37 (1), 135-139 (1996)
   PUBMED   8921381
REFERENCE   7  (bases 1 to 1305)
  AUTHORS   Song,C.Z., Hanada,K., Yano,K., Maeda,Y., Yamamoto,K. and
            Muramatsu,M.
  TITLE     High conservation of subunit composition of RNA polymerase I(A)
            between yeast and mouse and the molecular cloning of mouse RNA
            polymerase I 40-kDa subunit RPA40
  JOURNAL   J Biol Chem 269 (43), 26976-26981 (1994)
   PUBMED   7929437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY267923.1, AK132114.1 and CJ207889.1.
            
            On Dec 9, 2006 this sequence version replaced NM_009085.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146240.1, AK132114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               BY267923.1         1-168
            169-1244            AK132114.1         111-1186
            1245-1305           CJ207889.1         314-374
FEATURES             Location/Qualifiers
     source          1..1305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..1305
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /note="polymerase (RNA) I polypeptide C"
                     /db_xref="GeneID:20016"
                     /db_xref="MGI:MGI:103288"
     exon            1..151
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1123
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /note="AC40; RPC40; RNA polymerases I and III subunit AC1;
                     DNA-directed RNA polymerase I subunit C; DNA-directed RNA
                     polymerases I and III 40 kDa polypeptide; RNA polymerase
                     1-1 (40 kDa subunit)"
                     /codon_start=1
                     /product="DNA-directed RNA polymerases I and III subunit
                     RPAC1"
                     /protein_id="NP_033111.2"
                     /db_xref="CCDS:CCDS37632.1"
                     /db_xref="GeneID:20016"
                     /db_xref="MGI:MGI:103288"
                     /translation="MAAAQAVEEMRTRVVLGEFGVRNVHTTDFPGNYAGYDDAWDQNR
                     FEKNFRVDVVQMDEDTLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQ
                     DEILAHRLGLIPILADPRLFEYRNQGEEEGTEIDTLQFRLQVRCTRNPNAAKDSSDPN
                     ELYVNHKVYTRHMTWVPLGNQADVFPEGTIRPVHDDILIAQLRPGQEIDLMMHCVKGI
                     GKDHAKFSPVATASYRLLPAITLLEPVEGEAAEELSQCFSPGVIEVEEVQGKKVARVA
                     NARLDTFSREIFRHEKLKKAVRLARVRDHYIFSVESTGVLPPDVLVSEAIKILMGKCR
                     RFLDELDAVEMD"
     exon            152..223
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..331
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..464
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..584
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..737
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..887
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1004
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1305
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1276..1281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /note="hexamer: AATAAA"
     polyA_site      1298
                     /gene="Polr1c"
                     /gene_synonym="40kDa; Polr1e; RPA40; Rpo1-1"
                     /note="major polyA site"
ORIGIN      
        1 gacattcaag attgcgggag cccgagcgtt gctgcggaga cgcaggcgcg gactcgcctc
       61 cttttacagc gagtggcgga agatggcggc ggctcaggcg gtggaggaga tgcggactcg
      121 cgtggttctc ggagagtttg gggttcgcaa tgtccacacc acggactttc ccggtaacta
      181 cgccggttat gatgatgcct gggaccagaa ccgcttcgag aagaatttcc gtgtggacgt
      241 ggtgcaaatg gatgaagaca cgctggagtt cgacatggtg gggattgatg ctgccatcgc
      301 caatgctttc cggagaatcc tgttagctga ggtgccgaca atggccgtgg agaaggtctt
      361 ggtgtataac aacacgtcca tagtccagga tgagatcctt gctcaccgcc tggggctcat
      421 ccccatcctc gctgatcctc gtctctttga atatcggaac caaggagagg aggaaggaac
      481 agagatagac acgctgcagt tccggctgca ggtcaggtgt accaggaacc ccaatgctgc
      541 caaggattcc tcagacccca atgaactcta tgtcaaccat aaagtctaca ccaggcatat
      601 gacatgggtc cccttgggaa atcaggctga tgtcttccca gagggcacaa tccgtccagt
      661 gcacgacgac atcctcatcg ctcagcttcg gcctggccag gaaattgact tgatgatgca
      721 ttgcgtcaag ggcattggca aagaccatgc caagttctca ccagtggcca cagccagcta
      781 cagactgcta ccggccatca ctctgcttga gcctgtggaa ggagaagcgg ctgaggagct
      841 gagccagtgt ttctcccctg gcgtgattga ggtggaggaa gtacaaggta aaaaggtggc
      901 cagggtggcc aatgctcggc tggatacctt cagcagggaa atcttccggc atgagaaact
      961 caagaaggct gtgcggcttg cccgggttcg ggaccattat atcttttctg tggagtctac
     1021 tggagttttg ccaccagatg tgttggtgag tgaagccatc aagatcctga tggggaagtg
     1081 ccggcggttc ttggatgaac tggatgcagt tgagatggac tgaagcttac acacatacct
     1141 gggagggcgt ggctgctctt ggatcttttg cactgctgtg ctgttactag aggtcccttt
     1201 ccagtctcat ttccagtcaa tacattttat taaatgtgcc acagacacct ttgcctttgt
     1261 aaggccgttg ttgtaaataa attgctcttg gcaagttctt ttcag
//
