LOCUS       NM_009088               6145 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus polymerase (RNA) I polypeptide A (Polr1a), mRNA.
ACCESSION   NM_009088
VERSION     NM_009088.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6145)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6145)
  AUTHORS   Smallwood,K., Watt,K.E.N., Ide,S., Baltrunaite,K., Brunswick,C.,
            Inskeep,K., Capannari,C., Adam,M.P., Begtrup,A., Bertola,D.R.,
            Demmer,L., Demo,E., Devinsky,O., Gallagher,E.R., Guillen
            Sacoto,M.J., Jech,R., Keren,B., Kussmann,J., Ladda,R.,
            Lansdon,L.A., Lunke,S., Mardy,A., McWalters,K., Person,R.,
            Raiti,L., Saitoh,N., Saunders,C.J., Schnur,R., Skorvanek,M.,
            Sell,S.L., Slavotinek,A., Sullivan,B.R., Stark,Z., Symonds,J.D.,
            Wenger,T., Weber,S., Whalen,S., White,S.M., Winkelmann,J., Zech,M.,
            Zeidler,S., Maeshima,K., Stottmann,R.W., Trainor,P.A. and
            Weaver,K.N.
  TITLE     POLR1A variants underlie phenotypic heterogeneity in craniofacial,
            neural, and cardiac anomalies
  JOURNAL   Am J Hum Genet 110 (5), 809-825 (2023)
   PUBMED   37075751
REFERENCE   3  (bases 1 to 6145)
  AUTHORS   Falcon,K.T., Watt,K.E.N., Dash,S., Zhao,R., Sakai,D., Moore,E.L.,
            Fitriasari,S., Childers,M., Sardiu,M.E., Swanson,S., Tsuchiya,D.,
            Unruh,J., Bugarinovic,G., Li,L., Shiang,R., Achilleos,A., Dixon,J.,
            Dixon,M.J. and Trainor,P.A.
  TITLE     Dynamic regulation and requirement for ribosomal RNA transcription
            during mammalian development
  JOURNAL   Proc Natl Acad Sci U S A 119 (31), e2116974119 (2022)
   PUBMED   35881792
REFERENCE   4  (bases 1 to 6145)
  AUTHORS   Zhang,Q., Ji,S.Y., Busayavalasa,K. and Yu,C.
  TITLE     SPO16 binds SHOC1 to promote homologous recombination and
            crossing-over in meiotic prophase I
  JOURNAL   Sci Adv 5 (1), eaau9780 (2019)
   PUBMED   30746471
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6145)
  AUTHORS   Zhang,Q., Shao,J., Fan,H.Y. and Yu,C.
  TITLE     Evolutionarily-conserved MZIP2 is essential for crossover formation
            in mammalian meiosis
  JOURNAL   Commun Biol 1, 147 (2018)
   PUBMED   30272023
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6145)
  AUTHORS   Yamamoto,K., Yamamoto,M., Hanada,K., Nogi,Y., Matsuyama,T. and
            Muramatsu,M.
  TITLE     Multiple protein-protein interactions by RNA polymerase
            I-associated factor PAF49 and role of PAF49 in rRNA transcription
  JOURNAL   Mol Cell Biol 24 (14), 6338-6349 (2004)
   PUBMED   15226435
REFERENCE   7  (bases 1 to 6145)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 6145)
  AUTHORS   Dundr,M., Hoffmann-Rohrer,U., Hu,Q., Grummt,I., Rothblum,L.I.,
            Phair,R.D. and Misteli,T.
  TITLE     A kinetic framework for a mammalian RNA polymerase in vivo
  JOURNAL   Science 298 (5598), 1623-1626 (2002)
   PUBMED   12446911
  REMARK    GeneRIF: analyzed the kinetics of assembly and elongation of the
            RNA polymerase I complex on endogenous ribosomal genes in the
            nuclei of living cells with the use of in vivo microscopy [RPA43]
REFERENCE   9  (bases 1 to 6145)
  AUTHORS   Jansa,P. and Grummt,I.
  TITLE     Mechanism of transcription termination: PTRF interacts with the
            largest subunit of RNA polymerase I and dissociates paused
            transcription complexes from yeast and mouse
  JOURNAL   Mol Gen Genet 262 (3), 508-514 (1999)
   PUBMED   10589839
REFERENCE   10 (bases 1 to 6145)
  AUTHORS   Seither,P., Coy,J.F., Pouska,A. and Grummt,I.
  TITLE     Molecular cloning and characterization of the cDNA encoding the
            largest subunit of mouse RNA polymerase I
  JOURNAL   Mol Gen Genet 255 (2), 180-186 (1997)
   PUBMED   9236775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160970.1, AK147379.1 and CJ260853.1.
            
            On Sep 1, 2009 this sequence version replaced NM_009088.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053744.1, AK147379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4191              AK160970.1         2-4192
            4192-6076           AK147379.1         4185-6069
            6077-6145           CJ260853.1         390-458
FEATURES             Location/Qualifiers
     source          1..6145
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.21 cM"
     gene            1..6145
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /note="polymerase (RNA) I polypeptide A"
                     /db_xref="GeneID:20019"
                     /db_xref="MGI:MGI:1096397"
     exon            1..187
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            188..392
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            393..542
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..650
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            651..736
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            737..840
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            841..948
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1054
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1217
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1388
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1511
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1742
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1997
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2189
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2339
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2523
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2606
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2765
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2864
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3017
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3100
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3266
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3488
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3703
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..3871
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3872..4007
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4008..4165
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4292
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4293..4403
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4404..4679
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4680..4880
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4881..4998
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4999..5163
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            5164..6109
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6075..6080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /note="hexamer: AATAAA"
     polyA_site      6109
                     /gene="Polr1a"
                     /gene_synonym="194kDa; 2900087K15Rik; 3010014K16Rik;
                     mRPA1; RPA194; Rpo1-4"
                     /note="major polyA site"
ORIGIN      
        1 agcgcagtgg aaaaacacat ggtggctctg cgctacaaga ctcaagtggc gttctctgcg
       61 gctgactgga acttctctcg tagtgacgga cctcaaaact gactcggaag atgctggcct
      121 ccaagcacac accatggagg cggcttcagg gcatttcctt cggaatgtat tcggccgaag
      181 agctcaagaa gttaagtgtt aaatccatta caaatcctcg atacgtggac tacctgggaa
      241 acccttcagc aaatggcctg tatgatttgg ctttgggtcc tgcagattcc aaagaagtat
      301 gcgctacctg cgtgcaggac ttcaacaact gctctggaca cctgggccac attgatctcc
      361 cgctcacagt ctacaaccct ttcctctttg ataaactcta cctgctgctt cgaggctcct
      421 gtttgagttg ccacatgctg acttgtcctc gggctgcaat ttacctgttg atctcccagc
      481 tgagggtcct ggaagttgga gccctgcaag cagtctacga gcttgagcga attctcagca
      541 ggtttctgga agaaactgga gatccttccg ccttcgaaat tcaagaagag ttagaagaat
      601 acacaagcaa aattctgcag aacaacctct tggggtccca gggcacacat gtgaaaaatg
      661 tgtgcgagag cagaagcaaa cttgtcgctc agttctggaa gacacacatg gctgcgaagc
      721 agtgtccaca ctgcaagacg ggacggtcgg tggttcgaaa ggagcacaat agtaaactaa
      781 tcatcacata cccagccacg gtgcacaaga aatcagacca ggagggcaca gaactcccag
      841 aaggagtgcc ggaagctcca ggaattgaca aggctcagat ggggaaacga gggtacctga
      901 ccccaagcag cgcccaagaa caccttttcg ccatttggaa gaatgaagga ttctttctga
      961 attatctttt ttcgggattg gatgatattg gcccagagtc cagtttcaac cccagtatgt
     1021 tctttctaga cttcatagtc gtaccgccat ccaggtaccg tcccgtcaat cgcctgggtg
     1081 accagatgtt cactaatggc cagacagtaa acttgcaagc tgtcatgaag gatgcagttt
     1141 tgatccggaa acttctggcg ttgatggccc aagaacagaa actgccctgt gagatgacag
     1201 aactcaccat agacaaggaa aatgactcct cagtggctat cgaccgatcc ttcctgggtt
     1261 tgcttccagg cccgtctctc acagataaac tttacaacat ttggattcgc cttcagagcc
     1321 acgtcaatat tgtgtttgac agtgagatgg acaaattgat gttggaaaag taccctggca
     1381 taagacagat cctagagaag aaggaaggcc tgttccggaa gcacatgatg ggaaagcgag
     1441 ttgactacgc agcccgctcg gtcatctgcc cagacatgta catcaacacc aatgagatcg
     1501 gaatccccat ggtatttgcc acaaaactga cttaccctca gccagttacc ccctggaacg
     1561 tgcaggaact gagacaggca gtcatcaatg gacccaatgt gcacccagga gcctccatgg
     1621 tcatcaacga ggatggcagt cgcacagccc tgagctcagt ggatgctgcg cagcgggaag
     1681 ctgtggccaa acagctcctg acaccagcca caggggctcc gaagcctcag gggacaaaag
     1741 ttgtgtgccg gcatgtgaaa aatggggaca tcctcctcct gaaccgacag cctaccttgc
     1801 acagaccctc catccaggcc caccgtgccc gcattctgcc tgaagaaaaa gtcctacgcc
     1861 ttcactatgc caactgcaag gcctacaatg ctgactttga tggagatgag atgaacgccc
     1921 acttccccca gagtgagttg ggccgagctg aagcctatgt cctggcctgc actgatcagc
     1981 agtatcttgt tcccaaggat ggccagccat tggcaggact gatccaagat cacatggttt
     2041 caggtgcaaa catgaccatt cggggatgct ttttcacccg ggaacagtac atggaactgg
     2101 tgtaccgagg gctcacagac aaagtgggac gcgtgaagct ctttcctccc gccatcctga
     2161 agcccttccc actgtggaca ggaaaacagg ttgtgtcgac cctcctcata aacataattc
     2221 cagaggacta cgcccccctg aacttatctg gaaaggcaaa aattggcagc aaagcctggg
     2281 tgaaggaaaa gccacggcct atccctgact ttgacccgga ctccatgtgt gagtcccagg
     2341 tgatcatcag ggaaggagag ctgctctgcg gagtgctgga caaggcacac tatgggagct
     2401 ctgcctacgg cctggtccac tgctgctatg agatctatgg gggtgagacc agcggcaggg
     2461 ttctcacctg cctagcccgc ctcttcactg cctacctcca gctctataga ggtttcacct
     2521 tgggtgtaga agacattttg gttaagccaa atgcagatgt ggtgagacag cgtatcattg
     2581 aagaatctac ccagtgtgga ccccaggctg tcaaggctgc attgagcctg ccagaaactg
     2641 catcatgtga tgaaatccaa gggaaatggc aggatgccca tctgagcaaa gaccagaggg
     2701 attttaacat gattgatatg aagttcaagg aggaagtgaa ccattacagc aatgagatta
     2761 acaaggcatg tatgcctctt ggcttgcaca gacagttccc cgaaaacaac ctgcagatga
     2821 tggtgcagtc aggagccaaa gggtcaaccg tgaacacgat gcaaatctct tgcctgctgg
     2881 gccaaattga attggaaggt cggagacccc cactgatggc gtctggcaag tcactgccct
     2941 gctttgagcc ttacgagttc acccccaggg ctggtggctt tgtcactgga aggtttctta
     3001 ccggtatcag gcctcctgag ttcttcttcc actgcatggc aggacgagaa ggcctggtgg
     3061 acactgctgt caaaaccagc cgttctggct atctccaaag gtgtatcatc aagcacctgg
     3121 aggggctggt catccagtac gatctgacgg tccgtgacag cgatggcagc gtggtccagt
     3181 tcctgtatgg ggaggacggc ctggacatcc ccaagacaca gttcctacag cccaagcagt
     3241 tcccctttct ggccggcaat tatgaggtga taatgaaatc caagcatctt catgaagttt
     3301 tatccagagc agatccccag aaagtgctcg gccacatcaa agccattaaa aaatggcatc
     3361 acaagcattc cggtgccctg ctgaggaaag gcgccttcct cagtttttcc cagaagatcc
     3421 aggcagctgt gaaagctttg aacctaaagg gcagtatcca gaatggccgc agccccgaga
     3481 cccagcagat gttacagatg tggtatgact tggatgaaga gagccgatgg aaataccaga
     3541 agagggctgc cccttgtccc gaccctagcc tttctgtgtg gcgcccagac atctactttg
     3601 catctgtgtc tgaaacattt gaaaagaaga ttgatgactt cagtcaggaa tgggcagctc
     3661 aagcagagag gagttacaag aaatcagagc tttccctcga caggctgaga accttactgc
     3721 agctgaagtg gcagcgctca ctgtgtgacc caggcgaggc tgttggcctc ctggctgccc
     3781 agagcatcgg agagccctcc acacagatga cactgaacac cttccacttt gcaggcagag
     3841 gcgagatgaa cgtcaccctg ggcattccaa gattgaggga gattctcatg gtggccagtg
     3901 ccaacatcaa aacgcccatg atgagtgtgc ctgtgttcga caccaagaaa gcattgaaga
     3961 aagtgaagag tctaaagaag aggctcacca gagtgtgcct gggggaggta ttgcagaaag
     4021 ttgacatcca ggagtccttc tgtatgggag aaaaacggaa taagttccag gtgtatgagc
     4081 tccggtttca gttcctgcca catgcatatt accagcagga gaagtgcctg agacccgagg
     4141 acatcttgca cttcatggaa accagattct ttaagctact aatggaagct atcaaaaaga
     4201 agaaaaacaa agcatcagcc ttcagaaatg tgaattcgag gagagctaca cagaaggacc
     4261 tcaatgacac tgaggactcg gggaggagtc agagagagga ggaaagggat gaggaagagg
     4321 aggggaacat tgtggatgct gaagctgagg agggcgatgc agacgcttct gacaccaaac
     4381 gcaaggagaa gcaagaagaa gaggttgact atgagagtga ggaagaagga gaggaggaag
     4441 aggaggagga ggtacaagaa gaagggaaca tcaaaggcga cggtgtccac cagggccatg
     4501 agccagatga ggaagaacat ttaggcctcg aggaggagga gtcatcccag aagcctcccc
     4561 gccgccactc caggcctcag ggagctgagg ccataaaacg ccggatccag gctgtacggg
     4621 agtcctactc gttcatcgag gactaccagt atgacacaga ggagagcctg tggtgtcagg
     4681 tgactgtgaa gctcccactg atgaagatta attttgacat gagctccttg gttgtgtcct
     4741 tggcccacaa agccattgtc tatacgacca agggcatcac tcggtgcctc ctgaacgaaa
     4801 cgaccaacag taagaatgag aaggagcttg tactgaacac ggagggaatc aaccttcccg
     4861 agctgttcaa gtactccgag atactggacc tgcgccgcct ctactccaat gacatccacg
     4921 ccatggccaa tacttatggc atcgaggctg cgttgcgggt gatagagaag gagattaaag
     4981 atgtgtttgc tgtgtatggc attgcagttg atcctcgcca tctctccctg gtggctgatt
     5041 acatgtgttt tgagggggtt tataagccac tcaatcgctt tgggatccag tcaagctcct
     5101 cccctttgca gcagatgaca tttgaaacca gcttccagtt tctgaaacag gccaccatga
     5161 tgggatccca tgatgaactc aagtcacctt ccgcctgcct cgtggtggga aaggttgtca
     5221 aaggcgggac aggcctgttt gagctcaagc agcccctaag atagcagcat tgtctgccca
     5281 gcctggagga cctgggggtg ggcacagctg acagtacaga gtgacatagc aaagcagtag
     5341 ccttggggtc cggaaagcag atggcctgag ctgggccggc ttccctcaga aaaggctcct
     5401 cctacctagc ctttctcatc tcgggatcag gagcaaggct tcccaagccc tcagagatgg
     5461 ctgttgctcg acttttgctc ccagaggccc cagccaggat cctaacaaga cccaggacta
     5521 cacagtggga agatcaccgt gagccacatt tgctgttggg aatcccaggt gccaccgttg
     5581 ctgtgcgtat gctagtggct aaggaaacat tcccaggggt tcctgaagat ccagaaaggg
     5641 catgaaacct gctccatgtg cctgtccctc cctgctgcag ctaccaaagg agagtcctca
     5701 aagaggctcc actcagggct gctttcctgg gcctgagtca atggcacaag gcccccgcca
     5761 cactgccatt gctgtatggc tgcatacacc agaccagaac actcccacag ccaagacatc
     5821 tctctgggac cgcagcagct ccctacccca cagcctaaag tttcctactg gggctattca
     5881 gcaaggccac gtagcttgac cttcctgcct ctacactcag ctggatgtca gagcccctag
     5941 tcacccccag gccctgtact gttggggtct ttgagccatg cagtcaggtt ccctggctgg
     6001 acagaaaaga cagaggcttt atgaagccag accgtttcta tttttgtcca ctgttattcc
     6061 agcgtgggct gagtaataaa catggctgga actggctgtt agaagataaa aaaaaaaaaa
     6121 aaaaaaaaaa aaaaaaaaaa aaaaa
//
