LOCUS       NM_021498               1802 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus polymerase (DNA directed), epsilon 3 (p17 subunit)
            (Pole3), mRNA.
ACCESSION   NM_021498
VERSION     NM_021498.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1802)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1802)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1802)
  AUTHORS   Chen,D., He,F., Lu,T., Huang,J., Li,M., Cai,D., Huang,C., Chen,D.
            and Xiong,F.
  TITLE     VPS4B deficiency causes early embryonic lethality and induces
            signal transduction disorders of cell endocytosis
  JOURNAL   Genesis 59 (4), e23415 (2021)
   PUBMED   33682352
REFERENCE   4  (bases 1 to 1802)
  AUTHORS   Siamishi,I., Iwanami,N., Clapes,T., Trompouki,E., O'Meara,C.P. and
            Boehm,T.
  TITLE     Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit
            Pole3 Revealed by Neomorphic Alleles
  JOURNAL   Cell Rep 31 (11), 107756 (2020)
   PUBMED   32553171
REFERENCE   5  (bases 1 to 1802)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1802)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 1802)
  AUTHORS   Collins,N., Poot,R.A., Kukimoto,I., Garcia-Jimenez,C., Dellaire,G.
            and Varga-Weisz,P.D.
  TITLE     An ACF1-ISWI chromatin-remodeling complex is required for DNA
            replication through heterochromatin
  JOURNAL   Nat Genet 32 (4), 627-632 (2002)
   PUBMED   12434153
REFERENCE   8  (bases 1 to 1802)
  AUTHORS   Lemon,W.J., Bernert,H., Sun,H., Wang,Y. and You,M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
REFERENCE   9  (bases 1 to 1802)
  AUTHORS   Bolognese,F., Imbriano,C., Caretti,G. and Mantovani,R.
  TITLE     Cloning and characterization of the histone-fold proteins YBL1 and
            YCL1
  JOURNAL   Nucleic Acids Res 28 (19), 3830-3838 (2000)
   PUBMED   11000277
REFERENCE   10 (bases 1 to 1802)
  AUTHORS   Poot,R.A., Dellaire,G., Hulsmann,B.B., Grimaldi,M.A., Corona,D.F.,
            Becker,P.B., Bickmore,W.A. and Varga-Weisz,P.D.
  TITLE     HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1
            and two novel histone-fold proteins
  JOURNAL   EMBO J 19 (13), 3377-3387 (2000)
   PUBMED   10880450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732594.5.
            
            On Jul 12, 2022 this sequence version replaced NM_021498.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034004.1, SRR13422592.402334.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AL732594.5         117586-117723       c
            139-224             AL732594.5         117405-117490       c
            225-343             AL732594.5         116973-117091       c
            344-1802            AL732594.5         115307-116765       c
FEATURES             Location/Qualifiers
     source          1..1802
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.17 cM"
     gene            1..1802
                     /gene="Pole3"
                     /gene_synonym="1810034K18Rik; YBL1"
                     /note="polymerase (DNA directed), epsilon 3 (p17 subunit)"
                     /db_xref="GeneID:59001"
                     /db_xref="MGI:MGI:1933378"
     exon            1..138
                     /gene="Pole3"
                     /gene_synonym="1810034K18Rik; YBL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..510
                     /gene="Pole3"
                     /gene_synonym="1810034K18Rik; YBL1"
                     /EC_number="2.7.7.7"
                     /note="NF-YB-like protein; YB-like protein 1; DNA
                     polymerase II subunit 3; DNA polymerase epsilon subunit
                     p17"
                     /codon_start=1
                     /product="DNA polymerase epsilon subunit 3"
                     /protein_id="NP_067473.2"
                     /db_xref="CCDS:CCDS18244.1"
                     /db_xref="GeneID:59001"
                     /db_xref="MGI:MGI:1933378"
                     /translation="MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVF
                     VLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFITPLKEALEAYRREQKGKKEA
                     SEQKKKDKDKKDSEEQDKSREEEEEDEERLDEDDQNEEEEIDN"
     exon            139..224
                     /gene="Pole3"
                     /gene_synonym="1810034K18Rik; YBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..343
                     /gene="Pole3"
                     /gene_synonym="1810034K18Rik; YBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..1802
                     /gene="Pole3"
                     /gene_synonym="1810034K18Rik; YBL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      629..634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pole3"
                     /gene_synonym="1810034K18Rik; YBL1"
                     /note="hexamer: AATAAA"
     polyA_site      659
                     /gene="Pole3"
                     /gene_synonym="1810034K18Rik; YBL1"
                     /note="major polyA site"
     regulatory      1779..1784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pole3"
                     /gene_synonym="1810034K18Rik; YBL1"
                     /note="hexamer: AATAAA"
     polyA_site      1802
                     /gene="Pole3"
                     /gene_synonym="1810034K18Rik; YBL1"
                     /note="major polyA site"
ORIGIN      
        1 agcgacgcgg gaagtccaga caccagaact gtctggagac ctgagcagga gggtcgggcc
       61 ccagcggagg caatggcgga gaggcccgag gacctaaatc tgcccaacgc cgtcatcacc
      121 aggatcatca aggaggcgct cccggacggt gtcaacatct ccaaggaggc ccgaagcgcc
      181 atctcccgcg ccgccagtgt cttcgttttg tatgccacat cctgtgccaa taacttcgca
      241 atgaaaggaa agcgcaagac tctcaatgcc agtgacgtgc tgtcagccat ggaagagatg
      301 gaattccagc gattcataac accattgaaa gaagctctag aagcgtacag gcgggagcag
      361 aaaggcaaga aggaggcttc ggagcaaaag aagaaggaca aagacaaaaa ggattccgaa
      421 gagcaagaca aaagcagaga ggaggaggag gaggatgaag agagactgga cgaggacgac
      481 cagaacgaag aggaggaaat agacaactga atggagagag taggcagact gtggcgtggt
      541 ggaggggacc ctgagatcct gagacatgtc tgtgtgaagg ctttccctgc aaggcagagc
      601 catcttcggc actggtgcct gagatcaaaa taaaagctga ccagaaagat caaaaagaac
      661 tcttcccagg ctcagagcat ctgagttaca gaaaccggtc atgcgtcatc agtctgcagg
      721 ttaggatgtt tttgaataag cgattctgag tgactacata gtttggtatt gcttgtctac
      781 ttaaagtata tggctagcta gtttctgatc ccatttccct gcccctctga ataagtaata
      841 acatccatgt tgcctgcagt gttccaagtc acagaagcac taaaggctca gggggaaaca
      901 atggggcttt gagcctggtc acccagtttg actgtacagt agttgaccat aggaactcgt
      961 gcttagaatg gctgctctct aggagatgac taaggagctg tgagcgagcg aacgaggaaa
     1021 tgtcttcacc tgatggtagc attacttact tggtgtctgg ctttctagac ttacttagct
     1081 ttgtagtcct ctagtgactg tagatgctca gtcgtctggg gtggctgcac tcataggaca
     1141 cacactcttt aattctgagt gttgattaga atctgtcaaa aaaggtgcca attcttaaaa
     1201 gcaggggctt aatcttggag gtaactcagt gcctgccatg gtaggtccta gtgctacctc
     1261 ctggaaggta taaaatccca gatccatctc ccagacttat ggctgctgct tttcattccc
     1321 tgggctcata acaagttcca gagactttat ttcttccagg cacagcctgt tctgtctcca
     1381 tctctctggc ttctgcttcc cagcccggct ttctcctcct cttacttatt tcatcttcta
     1441 gtctagggac tctgataaca tatgtcatat tccaaagtgc aaggtcctca gattccttag
     1501 tcctaatctc ctgccttcta aagagagttg agaacacctc tgaaccttac ggtaagagga
     1561 atggtgctca ggaatgtagc accactgctg tggcttcgaa cgtgtctgtt ggcctttctt
     1621 tttccccatt gagtgctcca agcacttttt cctgtcttag ttgtgcactt gaggctgaca
     1681 ggtgatgtaa tatagttgga cactgtttac tagtaataca gggaagagtt tggtgagagt
     1741 gactggagac tgttgagaag attttaatgc tttctacaaa taaagaacat tcttgtttaa
     1801 aa
//
