LOCUS       NM_011133               1695 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus polymerase (DNA directed), epsilon 2 (p59 subunit)
            (Pole2), mRNA.
ACCESSION   NM_011133
VERSION     NM_011133.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Bellelli,R., Borel,V., Logan,C., Svendsen,J., Cox,D.E., Nye,E.,
            Metcalfe,K., O'Connell,S.M., Stamp,G., Flynn,H.R., Snijders,A.P.,
            Lassailly,F., Jackson,A. and Boulton,S.J.
  TITLE     Polepsilon Instability Drives Replication Stress, Abnormal
            Development, and Tumorigenesis
  JOURNAL   Mol Cell 70 (4), 707-721 (2018)
   PUBMED   29754823
REFERENCE   4  (bases 1 to 1695)
  AUTHORS   Zhou,L., Dai,H., Wu,J., Zhou,M., Yuan,H., Du,J., Yang,L., Wu,X.,
            Xu,H., Hua,Y., Xu,J., Zheng,L. and Shen,B.
  TITLE     Role of FEN1 S187 phosphorylation in counteracting oxygen-induced
            stress and regulating postnatal heart development
  JOURNAL   FASEB J 31 (1), 132-147 (2017)
   PUBMED   27694478
REFERENCE   5  (bases 1 to 1695)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 1695)
  AUTHORS   Wada,M., Miyazawa,H., Wang,R.S., Mizuno,T., Sato,A., Asashima,M.
            and Hanaoka,F.
  TITLE     The second largest subunit of mouse DNA polymerase epsilon, DPE2,
            interacts with SAP18 and recruits the Sin3 co-repressor protein to
            DNA
  JOURNAL   J Biochem 131 (3), 307-311 (2002)
   PUBMED   11872158
  REMARK    GeneRIF: The second largest subunit of mouse DNA polymerase epsilon
            was found to interact with SAP18. The interaction induced
            repression of transcription.
REFERENCE   7  (bases 1 to 1695)
  AUTHORS   Jokela,M., Makiniemi,M., Lehtonen,S., Szpirer,C., Hellman,U. and
            Syvaoja,J.E.
  TITLE     The small subunits of human and mouse DNA polymerase epsilon are
            homologous to the second largest subunit of the yeast Saccharomyces
            cerevisiae DNA polymerase epsilon
  JOURNAL   Nucleic Acids Res 26 (3), 730-734 (1998)
   PUBMED   9443964
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK077592.1 and
            AF036898.1.
            
            On Apr 5, 2007 this sequence version replaced NM_011133.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077592.1, AK172024.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1695              AK077592.1         2-1696
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 28.73 cM"
     gene            1..1695
                     /gene="Pole2"
                     /note="polymerase (DNA directed), epsilon 2 (p59 subunit)"
                     /db_xref="GeneID:18974"
                     /db_xref="MGI:MGI:1197514"
     exon            1..94
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1610
                     /gene="Pole2"
                     /EC_number="2.7.7.7"
                     /note="DNA polymerase II subunit 2; DNA polymerase epsilon
                     subunit B; DNA polymerase epsilon small subunit"
                     /codon_start=1
                     /product="DNA polymerase epsilon subunit 2"
                     /protein_id="NP_035263.1"
                     /db_xref="CCDS:CCDS36463.1"
                     /db_xref="GeneID:18974"
                     /db_xref="MGI:MGI:1197514"
                     /translation="MAPERLRSRTVSAFKLRGLLLRSEATKYLTEALQSVTELELEEN
                     LGKIIDAVEKQPLSSNMIERSVVEAAVQECSQSMDETIEHVFNIIGAFDIPRFIYNSE
                     RKKFLPLSMTNHAAPTLFGTARDKAELYLERYTILHQRTHRHELFTPPVIGSHLEESG
                     SKFQLKTIETLLGSTSKVGDVIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLY
                     TEACFVLAEGWFEDQVFHANAFGFPPTEPSSTTRAYYGNINFFGGPSNASVKTYTKLR
                     QLEDENKDAMFVIVSDVWLDQVQVLEKFHVMFSGYSPAPPTCFILCGNFSSAPYGKNQ
                     VQALKDSLKSLADIICEYPSIHQSSRFVFVPGPEDPGFGSILPRPPLAESITQEFRQR
                     VPFSVFTTNPCRIQYCTQEIIIFREDLVNKMCRNCVRFPSSSLDIPTHFVKTILSQGH
                     LAPLPLYVCPVHWAYDYTLRVYPVPDLLVIADKYDPFTVTNTDCLCINPGSFPRSGFA
                     FKVFYPSSKTVEDSKLQGF"
     exon            95..195
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            196..271
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..349
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            350..443
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            444..518
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..602
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..659
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..708
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..781
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..954
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1044
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1099
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1159
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1237
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1346
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1523
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1591
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1695
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggcggtg gcgccaaatc gcgaacatgg cgccggagcg gctgcggagc cgcacggtct
       61 cagctttcaa gctgcggggc ttgctgctca ggagtgaagc caccaagtat ctgactgaag
      121 ctctccagtc tgtcactgaa ttggagctag aggagaacct aggaaagatc atcgatgcag
      181 ttgaaaagca gcccttgtcc tcgaacatga tcgaacgatc tgtcgtggag gcagctgtgc
      241 aagagtgcag tcagtctatg gatgagacta tagagcacgt tttcaatatc attggagctt
      301 ttgatattcc acgttttata tataattcag aaaggaaaaa atttcttcct ctatccatga
      361 ctaatcatgc tgcaccaacc ttatttggaa cagcaagaga caaagccgag ctgtatcttg
      421 aacgctatac cattttacac cagaggacac acagacatga attgttcact cctccggtga
      481 taggctcaca ccttgaagaa agtgggagca agttccagct taaaactata gaaaccttac
      541 tgggtagcac aagcaaagtt ggtgacgtga tcgtcctggg gatgataacc cagctgaaag
      601 aggggaagtt tttcctggaa gatcctactg gaacagtaca actggacctt agtaaagctc
      661 agttccacag tggcttatac accgaggcct gcttcgtcct ggcagaaggt tggtttgaag
      721 atcaagtgtt tcacgccaat gcctttggat ttcctcccac tgagccctcc agcaccacaa
      781 gggcgtacta tggaaatatt aatttttttg gagggccttc taatgcatca gtgaagacgt
      841 atacaaagct gagacagctg gaagatgaga acaaggacgc catgtttgtg attgtgtctg
      901 atgtttggtt ggaccaagtg caagtgttgg agaagtttca tgtaatgttt tctggttact
      961 cgccagcacc tccaacctgc tttattctgt gtggtaattt ttcatctgca ccatatggaa
     1021 aaaatcaagt ccaggctttg aaagattccc taaaatcttt ggcagacata atttgtgaat
     1081 atccaagtat ccaccaaagt agccgttttg tgtttgtgcc tggcccagag gatcctggat
     1141 ttggttccat tttaccaagg ccgccactcg ctgaaagcat cacacaggaa ttcagacaaa
     1201 gggttccgtt ttcagttttc acgactaatc cttgcagaat tcagtattgt acacaagaaa
     1261 taattatctt ccgtgaagac ttagtgaata aaatgtgtag aaactgtgtc cgttttccta
     1321 gcagcagttt ggatattcct actcacttcg taaagaccat cttatctcag ggacatctgg
     1381 ctcctctccc tctttacgta tgccccgtcc actgggcata tgattacacg ttgagagtgt
     1441 acccggtgcc cgacctgctg gtcattgcag acaagtacga cccgttcacc gtgaccaaca
     1501 ccgattgcct ctgcataaac cctggctcct ttccaagaag tggatttgca ttcaaagttt
     1561 tttacccttc cagtaaaaca gtagaagaca gcaaacttca gggcttttga gatcgatgag
     1621 aatatatgaa atgaattttc ttatttttat cttatgtatt ttgtatatta aattgtaata
     1681 aacttatgat aaacc
//
