LOCUS       NM_026389               1968 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus polymerase (DNA-directed), delta interacting protein 2
            (Poldip2), transcript variant 1, mRNA.
ACCESSION   NM_026389
VERSION     NM_026389.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Paredes,F., Williams,H.C., Suster,I., Tejos,M., Fuentealba,R.,
            Bogan,B., Holden,C.M. and San Martin,A.
  TITLE     Metabolic regulation of the proteasome under hypoxia by Poldip2
            controls fibrotic signaling in vascular smooth muscle cells
  JOURNAL   Free Radic Biol Med 195, 283-297 (2023)
   PUBMED   36596387
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Dolmatova,E.V., Forrester,S.J., Wang,K., Ou,Z., Williams,H.C.,
            Joseph,G., Kumar,S., Valdivia,A., Kowalczyk,A.P., Qu,H., Jo,H.,
            Lassegue,B., Hernandes,M.S. and Griendling,K.K.
  TITLE     Endothelial Poldip2 regulates sepsis-induced lung injury via Rho
            pathway activation
  JOURNAL   Cardiovasc Res 118 (11), 2506-2518 (2022)
   PUBMED   34528082
  REMARK    GeneRIF: Endothelial Poldip2 regulates sepsis-induced lung injury
            via Rho pathway activation.
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Ou,Z., Dolmatova,E., Mandavilli,R., Qu,H., Gafford,G., White,T.,
            Valdivia,A., Lassegue,B., Hernandes,M.S. and Griendling,K.K.
  TITLE     Myeloid Poldip2 Contributes to the Development of Pulmonary
            Inflammation by Regulating Neutrophil Adhesion in a Murine Model of
            Acute Respiratory Distress Syndrome
  JOURNAL   J Am Heart Assoc 11 (10), e025181 (2022)
   PUBMED   35535614
  REMARK    GeneRIF: Myeloid Poldip2 Contributes to the Development of
            Pulmonary Inflammation by Regulating Neutrophil Adhesion in a
            Murine Model of Acute Respiratory Distress Syndrome.
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   Lassegue,B., Kumar,S., Mandavilli,R., Wang,K., Tsai,M., Kang,D.W.,
            Demos,C., Hernandes,M.S., San Martin,A., Taylor,W.R., Jo,H. and
            Griendling,K.K.
  TITLE     Characterization of Poldip2 knockout mice: Avoiding incorrect gene
            targeting
  JOURNAL   PLoS One 16 (12), e0247261 (2021)
   PUBMED   34928942
  REMARK    GeneRIF: Characterization of Poldip2 knockout mice: Avoiding
            incorrect gene targeting.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Eidson,L.N., Gao,Q., Qu,H., Kikuchi,D.S., Campos,A.C.P.,
            Faidley,E.A., Sun,Y.Y., Kuan,C.Y., Pagano,R.L., Lassegue,B.,
            Tansey,M.G., Griendling,K.K. and Hernandes,M.S.
  TITLE     Poldip2 controls leukocyte infiltration into the ischemic brain by
            regulating focal adhesion kinase-mediated VCAM-1 induction
  JOURNAL   Sci Rep 11 (1), 5533 (2021)
   PUBMED   33692398
  REMARK    GeneRIF: Poldip2 controls leukocyte infiltration into the ischemic
            brain by regulating focal adhesion kinase-mediated VCAM-1
            induction.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1968)
  AUTHORS   Arakaki,N., Nishihama,T., Kohda,A., Owaki,H., Kuramoto,Y., Abe,R.,
            Kita,T., Suenaga,M., Himeda,T., Kuwajima,M., Shibata,H. and
            Higuti,T.
  TITLE     Regulation of mitochondrial morphology and cell survival by
            Mitogenin I and mitochondrial single-stranded DNA binding protein
  JOURNAL   Biochim Biophys Acta 1760 (9), 1364-1372 (2006)
   PUBMED   16860483
  REMARK    GeneRIF: overexpression of Mitogenin I or mitochondrial
            single-stranded DNA-binding protein increased elongated or
            fragmented mitochondria in mouse C2C12 myoblast cells,
            respectively.
REFERENCE   7  (bases 1 to 1968)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   8  (bases 1 to 1968)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1968)
  AUTHORS   Liu,L., Rodriguez-Belmonte,E.M., Mazloum,N., Xie,B. and Lee,M.Y.
  TITLE     Identification of a novel protein, PDIP38, that interacts with the
            p50 subunit of DNA polymerase delta and proliferating cell nuclear
            antigen
  JOURNAL   J Biol Chem 278 (12), 10041-10047 (2003)
   PUBMED   12522211
REFERENCE   10 (bases 1 to 1968)
  AUTHORS   Mink,M., Fogelgren,B., Olszewski,K., Maroy,P. and Csiszar,K.
  TITLE     A novel human gene (SARM) at chromosome 17q11 encodes a protein
            with a SAM motif and structural similarity to
            Armadillo/beta-catenin that is conserved in mouse, Drosophila, and
            Caenorhabditis elegans
  JOURNAL   Genomics 74 (2), 234-244 (2001)
   PUBMED   11386760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591177.14.
            
            On Mar 23, 2023 this sequence version replaced NM_026389.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012879.1, SRR17253012.150080.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AL591177.14        51412-51605
            195-276             AL591177.14        53053-53134
            277-374             AL591177.14        54221-54318
            375-471             AL591177.14        55952-56048
            472-547             AL591177.14        56686-56761
            548-655             AL591177.14        56958-57065
            656-792             AL591177.14        57206-57342
            793-819             AL591177.14        58086-58112
            820-945             AL591177.14        58313-58438
            946-1025            AL591177.14        60285-60364
            1026-1968           AL591177.14        60927-61869
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..1968
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /note="polymerase (DNA-directed), delta interacting
                     protein 2"
                     /db_xref="GeneID:67811"
                     /db_xref="MGI:MGI:1915061"
     exon            1..194
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /inference="alignment:Splign:2.1.0"
     exon            195..276
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /inference="alignment:Splign:2.1.0"
     exon            277..374
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /inference="alignment:Splign:2.1.0"
     exon            375..471
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /inference="alignment:Splign:2.1.0"
     exon            472..547
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /inference="alignment:Splign:2.1.0"
     exon            548..655
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /inference="alignment:Splign:2.1.0"
     exon            656..792
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /inference="alignment:Splign:2.1.0"
     exon            793..819
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /inference="alignment:Splign:2.1.0"
     exon            820..945
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1025
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1968
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /note="hexamer: ATTAAA"
     polyA_site      1968
                     /gene="Poldip2"
                     /gene_synonym="1300003F06Rik; Pdip38"
                     /note="major polyA site"
ORIGIN      
        1 gtgtcagcag ccgagcgggc gctcgggcgg gacatggctg gttgtgtggc ccgacgggcc
       61 ctagcagtgg gcagccgctg gtggtctcgg tcgctggcca cgacccgagg gtcgaggcca
      121 ctgtgtgcgg tcggtggagc agggggcctt ccgccggtgg ccacagcgac gacccgaagg
      181 catctgtcgt cccggaaccg tgcagagggc aaagtgctgg agacagttgg tgtgtttgag
      241 gtgccaaaac aaaatggaaa atatgagact gggcagctat tcctccatag tgtttttggc
      301 taccgagggg tcgtcctgtt tccctggcag gccagactgt atgaccggga tgtggcttct
      361 gcaactccag aaaaagcaga gaaccctgcc ggccatggct ctaaggaggt gaaaggcaaa
      421 actcacactt actaccaagt gctgattgat gcccgtgact gcccacatat atctcagaga
      481 tctcagacag aagctgtgac cttcttggct aaccatgatg acagccgggc gctctatgct
      541 atcccagggt tggactatgt cagccatgaa gacatcctcc cctacacctc cacggatcag
      601 gttcccattc aacacgagct ctttgaaaga tttcttctgt atgaccagac aaaagcacct
      661 ccttttgtgg ctcgagaaac gctgcgggcc tggcaagaga agaatcaccc gtggctagag
      721 ctctctgacg tgcacaggga gaccaccgag aacatccgcg tcacagtcat ccctttctac
      781 atgggcatga gggaagccca gaattcccac gtctactggt ggcgctattg tatacgcttg
      841 gaaaacttgg acagtgatgt ggtacagctc cgggagcggc actggcggat attcagtctc
      901 tcagggaccc tggaaacagt tcgaggacga ggggtggtgg gcagggaacc agtgttatcc
      961 aaggagcagc ctgcattcca gtatagcagc catgtctctc tgcaagcttc cagtgggcac
     1021 atgtggggca catttcgttt tgagagaccg gatggctccc actttgatgt ccggatccca
     1081 ccattctcct tggaaagcaa taaagatgag aagaccccac cctcaggcct tcactggtag
     1141 gccagctgag gcccaggttg gccctaagaa caacagctct caacccataa ttgctgcaga
     1201 actctaaacc tctccctact gtgaaattct ttttttggag ggagattgta acttttcttg
     1261 gaagacccac ataagactcc tccaaggttg gccttggccg ctgtccagga caccacgttc
     1321 cagcaaagct gtcagggaac tgttcagttg tcccatgttt tctggaatgt gaggtgtggt
     1381 caataaacca gtgctcactt ggccaccacg gccatttttg tctccagggt ctcaggcccc
     1441 cttgctggcc ctttaggaac tcttagttgc ttttcatgca aagtttcttc tagggagctg
     1501 ctggccctgc tagggtgcgc cttcctcaga ggctggacat cttggggcac tggtaacagt
     1561 gagcagcact ggactaagtt ccgggtctct ctaccctccg cccagtgtag aggaggccag
     1621 tgtagagttg gactgacctg actatagaca cggattaccc accagcactt ctggcttcac
     1681 taggcctgga gaagagtgag gcaaaaccag tcaggtttct gggaactgtg ggcttctgag
     1741 cattgagcaa agcctgtcaa gcatccagac cacaggggca ggaattcagc caagaagcag
     1801 cttaagttat ggtcagtgac caagtcaagc tgcttttgga gcttctttca ggccaacagg
     1861 agccagagaa ttggactgca ttttgcccca ggtcttagga ttccttcacc actatagtta
     1921 ctgttagagg tcctttcatt cttgcattat taaatctcag ttctagtc
//
