LOCUS       NM_133692               3002 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus polymerase (DNA-directed), delta 3, accessory subunit
            (Pold3), transcript variant 1, mRNA.
ACCESSION   NM_133692
VERSION     NM_133692.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3002)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3002)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3002)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3002)
  AUTHORS   Zhou,Z., Wang,L., Ge,F., Gong,P., Wang,H., Wang,F., Chen,L. and
            Liu,L.
  TITLE     Pold3 is required for genomic stability and telomere integrity in
            embryonic stem cells and meiosis
  JOURNAL   Nucleic Acids Res 46 (7), 3468-3486 (2018)
   PUBMED   29447390
  REMARK    GeneRIF: These data suggest that Pold3 maintains telomere integrity
            and genomic stability of both Embryonic stem cells and meiosis by
            suppressing replicative stress.
REFERENCE   5  (bases 1 to 3002)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3002)
  AUTHORS   Ducoux,M., Urbach,S., Baldacci,G., Hubscher,U., Koundrioukoff,S.,
            Christensen,J. and Hughes,P.
  TITLE     Mediation of proliferating cell nuclear antigen (PCNA)-dependent
            DNA replication through a conserved p21(Cip1)-like PCNA-binding
            motif present in the third subunit of human DNA polymerase delta
  JOURNAL   J Biol Chem 276 (52), 49258-49266 (2001)
   PUBMED   11595739
REFERENCE   7  (bases 1 to 3002)
  AUTHORS   Hughes,P., Tratner,I., Ducoux,M., Piard,K. and Baldacci,G.
  TITLE     Isolation and identification of the third subunit of mammalian DNA
            polymerase delta by PCNA-affinity chromatography of mouse FM3A cell
            extracts
  JOURNAL   Nucleic Acids Res 27 (10), 2108-2114 (1999)
   PUBMED   10219083
REFERENCE   8  (bases 1 to 3002)
  AUTHORS   Mizuno,T., Ito,N., Yokoi,M., Kobayashi,A., Tamai,K., Miyazawa,H.
            and Hanaoka,F.
  TITLE     The second-largest subunit of the mouse DNA polymerase
            alpha-primase complex facilitates both production and nuclear
            translocation of the catalytic subunit of DNA polymerase alpha
  JOURNAL   Mol Cell Biol 18 (6), 3552-3562 (1998)
   PUBMED   9584195
REFERENCE   9  (bases 1 to 3002)
  AUTHORS   Longley,M.J., Pierce,A.J. and Modrich,P.
  TITLE     DNA polymerase delta is required for human mismatch repair in vitro
  JOURNAL   J Biol Chem 272 (16), 10917-10921 (1997)
   PUBMED   9099749
REFERENCE   10 (bases 1 to 3002)
  AUTHORS   Zeng,X.R., Jiang,Y., Zhang,S.J., Hao,H. and Lee,M.Y.
  TITLE     DNA polymerase delta is involved in the cellular response to UV
            damage in human cells
  JOURNAL   J Biol Chem 269 (19), 13748-13751 (1994)
   PUBMED   7910606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031778.1.
            
            On Apr 5, 2007 this sequence version replaced NM_133692.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031778.1, BC055325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3002              AK031778.1         3-3004
FEATURES             Location/Qualifiers
     source          1..3002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.32 cM"
     gene            1..3002
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /note="polymerase (DNA-directed), delta 3, accessory
                     subunit"
                     /db_xref="GeneID:67967"
                     /db_xref="MGI:MGI:1915217"
     exon            1..137
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1463
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     polymerase (DNA directed), delta 3; DNA polymerase delta
                     subunit 3; DNA polymerase delta subunit p66; GC12"
                     /codon_start=1
                     /product="DNA polymerase delta subunit 3 isoform 1"
                     /protein_id="NP_598453.1"
                     /db_xref="CCDS:CCDS21493.1"
                     /db_xref="GeneID:67967"
                     /db_xref="MGI:MGI:1915217"
                     /translation="MAEQLYLENIDEFVTDQNKIVTYKWLSYTLGVHVNQAKQMLYEY
                     VERKRKENSGAQLHVTYLVSGSLIQNGHSCHKVAVVREDKLEAVKSKLAVTASIHVYS
                     IQKAMLKDSGPLFNTDYDILKSNLQNCSKFSAIQCAAAVPRAPAESPSSRKYEQSNLQ
                     AASEAQASELTTNGHGPPASKQASQQPKGIMGMLISKAATKTQDTNKETKPEAREVTS
                     ASSAGGKAPGKGSVMSNFFGKAAMNKLKVNLDSEQAVKEEKTVEQPPVSVTEPKLAAP
                     PAQKKSSRKSEPGKVQQKEKSRGKRVDLSDEEAKETEHLKKKRRRIKLPQSDSSEDEV
                     FEDSPEMYEADSPSPPPVSPPPDPMPKTEPPPVKRSSGETKRRRKRVLKSKTFVDEEG
                     CIVTEKVYESESCTDSEEELKMKPASAHKPPAAAVKREPREERKGPKKGAAALGKANR
                     QVSITGFFQKK"
     exon            138..193
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            194..296
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            297..336
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            337..469
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            470..731
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            732..804
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            805..967
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1077
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1181
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1260
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..3002
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3002
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /note="putative"
ORIGIN      
        1 gagtgagcga agctgtttcc cgccggcggg agctacggct ggggcgggtt gagcgcgggg
       61 ctcgaagccg caccaccatg gcggaacagc tgtatctaga aaacatagac gagttcgtca
      121 cggaccagaa caagatcgtg acttacaagt ggctaagcta tacactaggg gttcatgtta
      181 accaggccaa acagatgctc tatgaatatg ttgaaaggaa acggaaagaa aattcgggag
      241 ctcagctgca tgttacctac ttggtgtctg gcagtcttat acagaacgga cattcttgcc
      301 acaaggttgc agtagtgaga gaagataaac tggaagcagt gaagtccaag ttagctgtga
      361 ctgccagcat ccatgtgtac agcatccaga aagctatgct aaaggacagt gggcctctgt
      421 tcaataccga ctatgacatc cttaaaagca atttgcagaa ctgcagcaag tttagtgcca
      481 tacagtgtgc agctgcagtc cccagagctc ctgcagaatc cccatcttcc agaaagtatg
      541 aacagtcaaa tcttcaggca gcgagtgagg cacaagccag tgagctgact accaatggcc
      601 atggtccacc tgcctccaaa caggcttccc agcagcccaa aggaattatg ggaatgttaa
      661 tctctaaagc tgctactaaa acccaggaca ccaacaagga aaccaaacca gaggcccgag
      721 aagtaaccag tgcatcttct gctgggggca aagcaccagg aaaagggagt gtgatgagca
      781 acttttttgg aaaagctgca atgaataaac ttaaagtcaa tttggattca gaacaagcag
      841 taaaggaaga aaaaacagtg gagcaacctc cagtgtctgt cactgaacca aagctggcag
      901 ctcccccagc tcagaagaaa tccagcagaa agtccgagcc tgggaaggtg cagcagaagg
      961 agaaaagcag gggcaagcga gtagacttgt cggatgagga ggcaaaggaa accgaacacc
     1021 tgaagaaaaa gagaagaaga atcaagcttc ctcagtctga tagcagtgaa gatgaagtct
     1081 tcgaagactc ccctgagatg tatgaagcag actcaccatc tccacctcct gtatctccac
     1141 ctcctgatcc tatgccaaaa actgagcccc ctcctgtcaa gcgttcaagt ggagaaacca
     1201 aaaggagacg aaagcgtgta ctgaaatcta aaacctttgt ggatgaagaa ggctgcatag
     1261 tgactgagaa agtctatgag agtgagtcct gcacagacag tgaggaggag cttaagatga
     1321 agccggcctc agcacacaaa ccccctgctg ccgctgtgaa aagggagccc agagaagaac
     1381 ggaagggccc caagaaaggg gctgctgctc tgggcaaagc caacagacaa gtgtccatta
     1441 ctggcttctt ccagaaaaag taaatgctac ctctgaaagg actcgggctg gtcaagggag
     1501 aagaccaaga agtatagact gtcacttact gtgtaagttt gcctcgctcc ttgcctcgcc
     1561 tggatcagat gctgctctgc catcacggga cacgtgtacc acttctgttt tcttcaccca
     1621 aaaggaagtc acctggaaac ggggcaaaag aacattttaa aagctgttac attgtaataa
     1681 gtttataaat ataaagcaca atctttgccc tgcctaggag aattcattca agaatgacct
     1741 gctgggccac acttgccctg cgcatgtgcc tctcctggtc tctgtgttct gtgagcggga
     1801 ggcagtgttt ttatttgatg agttctactg gatgtgttca ccgcgtctcc actttcctct
     1861 ccacactacc atacttctgt cccccgaccc cacaatctgt tttctgtaaa tcttttaagt
     1921 cttagtcaga tgagaagcta aaactaaaat cttctgtaat tcccgatctc cgttgatgta
     1981 gtgagtgact cagctccagg ctaggccagt gtgcatcgtc cagtcctttc atctcatccg
     2041 ctccctctca cttccctcag actgagatgt gctgatgaat ccagcctcac cagaaatgac
     2101 ttaaagtcac atggtggcca atgacagagc tggcatgttg ctagcacagg gtatgcatat
     2161 actcatgtgt ggtttctttc ttccagattt cctatactta ttacccagag agtggaacct
     2221 gtacagcgag atgaaagatt aaaataagaa tgctttctat gcaccagata acttacctca
     2281 aggaaataca gagtccagaa atgtcagttt cctgtcctgg gaaggaaggg agaacttagc
     2341 acacatttct acacagatgt tgctcctctg ttttgtcaag ttcttcattt gtccagcagc
     2401 acaggctccc caggagggga cagggggctg acttttataa ctttcagtca ccttccattc
     2461 tggctgggca ggaggtgagc cctgtccgtg ttgtgtggca gtggctttgc acactgagct
     2521 gtagtgaggg aacccagact ccactgctgg tgtgaaccca ggggagatga gggatgtctg
     2581 ctccaaccct ccgctgaggg ctggcttgtg tcatgtaatc agttgcctac tgttggaggt
     2641 tggggttggg gctgacttgg gatttacaca tctgctttag caaccaagcc tgggctacct
     2701 ggagaccagc agcttgggag atgagtcctg gtctcctgtc gagaactgga gggcagatgc
     2761 ttgtccatca agctgagtaa aggttggtgt actccaaaac tgttttttct aacgtggaaa
     2821 agagtggaat gcctggactt aagcttacag gaaagctctg gagaattccc tattttcagt
     2881 ggttattttt gtcattgcct ctagtgattt ttgtaaatgg gaatggaaaa gtacaaggca
     2941 accatccagt ctttaaaaaa tttgattatg gtgggatttc taataaaacc aaatttgaat
     3001 tg
//
