LOCUS       NM_001368380            3010 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus polymerase (DNA-directed), delta 3, accessory subunit
            (Pold3), transcript variant 2, mRNA.
ACCESSION   NM_001368380 XM_006508149
VERSION     NM_001368380.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3010)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3010)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3010)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3010)
  AUTHORS   Zhou,Z., Wang,L., Ge,F., Gong,P., Wang,H., Wang,F., Chen,L. and
            Liu,L.
  TITLE     Pold3 is required for genomic stability and telomere integrity in
            embryonic stem cells and meiosis
  JOURNAL   Nucleic Acids Res 46 (7), 3468-3486 (2018)
   PUBMED   29447390
  REMARK    GeneRIF: These data suggest that Pold3 maintains telomere integrity
            and genomic stability of both Embryonic stem cells and meiosis by
            suppressing replicative stress.
REFERENCE   5  (bases 1 to 3010)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3010)
  AUTHORS   Ducoux,M., Urbach,S., Baldacci,G., Hubscher,U., Koundrioukoff,S.,
            Christensen,J. and Hughes,P.
  TITLE     Mediation of proliferating cell nuclear antigen (PCNA)-dependent
            DNA replication through a conserved p21(Cip1)-like PCNA-binding
            motif present in the third subunit of human DNA polymerase delta
  JOURNAL   J Biol Chem 276 (52), 49258-49266 (2001)
   PUBMED   11595739
REFERENCE   7  (bases 1 to 3010)
  AUTHORS   Hughes,P., Tratner,I., Ducoux,M., Piard,K. and Baldacci,G.
  TITLE     Isolation and identification of the third subunit of mammalian DNA
            polymerase delta by PCNA-affinity chromatography of mouse FM3A cell
            extracts
  JOURNAL   Nucleic Acids Res 27 (10), 2108-2114 (1999)
   PUBMED   10219083
REFERENCE   8  (bases 1 to 3010)
  AUTHORS   Mizuno,T., Ito,N., Yokoi,M., Kobayashi,A., Tamai,K., Miyazawa,H.
            and Hanaoka,F.
  TITLE     The second-largest subunit of the mouse DNA polymerase
            alpha-primase complex facilitates both production and nuclear
            translocation of the catalytic subunit of DNA polymerase alpha
  JOURNAL   Mol Cell Biol 18 (6), 3552-3562 (1998)
   PUBMED   9584195
REFERENCE   9  (bases 1 to 3010)
  AUTHORS   Longley,M.J., Pierce,A.J. and Modrich,P.
  TITLE     DNA polymerase delta is required for human mismatch repair in vitro
  JOURNAL   J Biol Chem 272 (16), 10917-10921 (1997)
   PUBMED   9099749
REFERENCE   10 (bases 1 to 3010)
  AUTHORS   Zeng,X.R., Jiang,Y., Zhang,S.J., Hao,H. and Lee,M.Y.
  TITLE     DNA polymerase delta is involved in the cellular response to UV
            damage in human cells
  JOURNAL   J Biol Chem 269 (19), 13748-13751 (1994)
   PUBMED   7910606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161205.3.
            
            On Feb 9, 2019 this sequence version replaced XM_006508149.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF294329.1, SRR17784645.1342666.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC161205.3         202432-202570       c
            140-195             AC161205.3         200742-200797       c
            196-298             AC161205.3         193338-193440       c
            299-338             AC161205.3         189580-189619       c
            339-471             AC161205.3         187631-187763       c
            472-733             AC161205.3         181488-181749       c
            734-806             AC161205.3         180532-180604       c
            807-969             AC161205.3         177441-177603       c
            970-1082            AC161205.3         174440-174552       c
            1083-1186           AC161205.3         170720-170823       c
            1187-1265           AC161205.3         169132-169210       c
            1266-3010           AC161205.3         163178-164922       c
FEATURES             Location/Qualifiers
     source          1..3010
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.32 cM"
     gene            1..3010
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /note="polymerase (DNA-directed), delta 3, accessory
                     subunit"
                     /db_xref="GeneID:67967"
                     /db_xref="MGI:MGI:1915217"
     exon            1..139
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1468
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /note="isoform 2 is encoded by transcript variant 2;
                     polymerase (DNA directed), delta 3; DNA polymerase delta
                     subunit 3; DNA polymerase delta subunit p66; GC12"
                     /codon_start=1
                     /product="DNA polymerase delta subunit 3 isoform 2"
                     /protein_id="NP_001355309.1"
                     /db_xref="GeneID:67967"
                     /db_xref="MGI:MGI:1915217"
                     /translation="MAEQLYLENIDEFVTDQNKIVTYKWLSYTLGVHVNQAKQMLYEY
                     VERKRKENSGAQLHVTYLVSGSLIQNGHSCHKVAVVREDKLEAVKSKLAVTASIHVYS
                     IQKAMLKDSGPLFNTDYDILKSNLQNCSKFSAIQCAAAVPRAPAESPSSRKYEQSNLQ
                     AASEAQASELTTNGHGPPASKQASQQPKGIMGMLISKAATKTQDTNKETKPEAREVTS
                     ASSAGGKAPGKGSVMSNFFGKAAMNKLKVNLDSEQAVKEEKTVEQPPVSVTEPKLAAP
                     PAQKKSSRKSEPGKVQQKEKSSRGKRVDLSDEEAKETEHLKKKRRRIKLPQSDSSEDE
                     VFEDSPEMYEADSPSPPPVSPPPDPMPKTEPPPVKRSSGETKRRRKRVLKSKTFVDEE
                     GCIVTEKVYESESCTDSEEELKMKPASAHKPPAAAVKREPREERKGPKKGAAALGKAN
                     RQVSITGFFQKK"
     exon            140..195
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            196..298
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            299..338
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            339..471
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            472..733
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            734..806
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            807..969
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1082
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1186
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1265
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..3010
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2987..2992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /note="hexamer: AATAAA"
     polyA_site      3009
                     /gene="Pold3"
                     /gene_synonym="2410142G14Rik; P66; P68"
                     /note="major polyA site"
ORIGIN      
        1 gagagtgagc gaagctgttt cccgccggcg ggagctacgg ctggggcggg ttgagcgcgg
       61 ggctcgaagc cgcaccacca tggcggaaca gctgtatcta gaaaacatag acgagttcgt
      121 cacggaccag aacaagatcg tgacttacaa gtggctaagc tatacactag gggttcatgt
      181 taaccaggcc aaacagatgc tctatgaata tgttgaaagg aaacggaaag aaaattcggg
      241 agctcagctg catgttacct acttggtgtc tggcagtctt atacagaacg gacattcttg
      301 ccacaaggtt gcagtagtga gagaagataa actggaagca gtgaagtcca agttagctgt
      361 gactgccagc atccatgtgt acagcatcca gaaagctatg ctaaaggaca gtgggcctct
      421 gttcaatacc gactatgaca tccttaaaag caatttgcag aactgcagca agtttagtgc
      481 catacagtgt gcagctgcag tccccagagc tcctgcagaa tccccatctt ccagaaagta
      541 tgaacagtca aatcttcagg cagcgagtga ggcacaagcc agtgagctga ctaccaatgg
      601 ccatggtcca cctgcctcca aacaggcttc ccagcagccc aaaggaatta tgggaatgtt
      661 aatctctaaa gctgctacta aaacccagga caccaacaag gaaaccaaac cagaggcccg
      721 agaagtaacc agtgcatctt ctgctggggg caaagcacca ggaaaaggga gtgtgatgag
      781 caactttttt ggaaaagctg caatgaataa acttaaagtc aatttggatt cagaacaagc
      841 agtaaaggaa gaaaaaacag tggagcaacc tccagtgtct gtcactgaac caaagctggc
      901 agctccccca gctcagaaga aatccagcag aaagtccgag cctgggaagg tgcagcagaa
      961 ggagaaaagc agcaggggca agcgagtaga cttgtcggat gaggaggcaa aggaaaccga
     1021 acacctgaag aaaaagagaa gaagaatcaa gcttcctcag tctgatagca gtgaagatga
     1081 agtcttcgaa gactcccctg agatgtatga agcagactca ccatctccac ctcctgtatc
     1141 tccacctcct gatcctatgc caaaaactga gccccctcct gtcaagcgtt caagtggaga
     1201 aaccaaaagg agacgaaagc gtgtactgaa atctaaaacc tttgtggatg aagaaggctg
     1261 catagtgact gagaaagtct atgagagtga gtcctgcaca gacagtgagg aggagcttaa
     1321 gatgaagccg gcctcagcac acaaaccccc tgctgccgct gtgaaaaggg agcccagaga
     1381 agaacggaag ggccccaaga aaggggctgc tgctctgggc aaagccaaca gacaagtgtc
     1441 cattactggc ttcttccaga aaaagtaaat gctacctctg aaaggactcg ggctggtcaa
     1501 gggagaagac caagaagtat agactgtcac ttactgtgta agtttgcctc gctccttgcc
     1561 tcgcctggat cagatgctgc tctgccatca cgggacacgt gtaccacttc tgttttcttc
     1621 acccaaaagg aagtcacctg gaaacggggc aaaagaacat tttaaaagct gttacattgt
     1681 aataagttta taaatataaa gcacaatctt tgccctgcct aggagaattc attcaagaat
     1741 gacctgctgg gccacacttg ccctgcgcat gtgcctctcc tggtctctgt gttctgtgag
     1801 cgggaggcag tgtttttatt tgatgagttc tactggatgt gttcaccgcg tctccacttt
     1861 cctctccaca ctaccatact tctgtccccc gaccccacaa tctgttttct gtaaatcttt
     1921 taagtcttag tcagatgaga agctaaaact aaaatcttct gtaattcccg atctccgttg
     1981 atgtagtgag tgactcagct ccaggctagg ccagtgtgca tcgtccagtc ctttcatctc
     2041 atccgctccc tctcacttcc ctcagactga gatgtgctga tgaatccagc ctcaccagaa
     2101 atgacttaaa gtcacatggt ggccaatgac agagctggca tgttgctagc acagggtatg
     2161 catatactca tgtgtggttt ctttcttcca gatttcctat acttattacc cagagagtgg
     2221 aacctgtaca gcgagatgaa agattaaaat aagaatgctt tctatgcacc agataactta
     2281 cctcaaggaa atacagagtc cagaaatgtc agtttcctgt cctgggaagg aagggagaac
     2341 ttagcacaca tttctacaca gatgttgctc ctctgttttg tcaagttctt catttgtcca
     2401 gcagcacagg ctccccagga ggggacaggg ggctgacttt tataactttc agtcaccttc
     2461 cattctggct gggcaggagg tgagccctgt ccgtgttgtg tggcagtggc tttgcacact
     2521 gagctgtagt gagggaaccc agactccact gctggtgtga acccagggga gatgagggat
     2581 gtctgctcca accctccgct gagggctggc ttgtgtcatg taatcagttg cctactgttg
     2641 gaggttgggg ttggggctga cttgggattt acacatctgc tttagcaacc aagcctgggc
     2701 tacctggaga ccagcagctt gggagatgag tcctggtctc ctgtcgagaa ctggagggca
     2761 gatgcttgtc catcaagctg agtaaaggtt ggtgtactcc aaaactgttt tttctaacgt
     2821 ggaaaagagt ggaatgcctg gacttaagct tacaggaaag ctctggagaa ttccctattt
     2881 tcagtggtta tttttgtcat tgcctctagt gatttttgta aatgggaatg gaaaagtaca
     2941 aggcaaccat ccagtcttta aaaaatttga ttatggtggg atttctaata aaaccaaatt
     3001 tgaattggag
//
