LOCUS       NM_011131               3428 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus polymerase (DNA directed), delta 1, catalytic subunit
            (Pold1), mRNA.
ACCESSION   NM_011131
VERSION     NM_011131.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3428)
  AUTHORS   Chen,T., Alcorn,H., Devbhandari,S., Remus,D., Lacy,E., Huangfu,D.
            and Anderson,K.V.
  TITLE     A hypomorphic mutation in Pold1 disrupts the coordination of embryo
            size expansion and morphogenesis during gastrulation
  JOURNAL   Biol Open 11 (8) (2022)
   PUBMED   35876795
REFERENCE   2  (bases 1 to 3428)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3428)
  AUTHORS   Bellelli,R., Borel,V., Logan,C., Svendsen,J., Cox,D.E., Nye,E.,
            Metcalfe,K., O'Connell,S.M., Stamp,G., Flynn,H.R., Snijders,A.P.,
            Lassailly,F., Jackson,A. and Boulton,S.J.
  TITLE     Polepsilon Instability Drives Replication Stress, Abnormal
            Development, and Tumorigenesis
  JOURNAL   Mol Cell 70 (4), 707-721 (2018)
   PUBMED   29754823
REFERENCE   4  (bases 1 to 3428)
  AUTHORS   Uchimura,A., Higuchi,M., Minakuchi,Y., Ohno,M., Toyoda,A.,
            Fujiyama,A., Miura,I., Wakana,S., Nishino,J. and Yagi,T.
  TITLE     Germline mutation rates and the long-term phenotypic effects of
            mutation accumulation in wild-type laboratory mice and mutator mice
  JOURNAL   Genome Res 25 (8), 1125-1134 (2015)
   PUBMED   26129709
REFERENCE   5  (bases 1 to 3428)
  AUTHORS   Vannier,J.B., Sandhu,S., Petalcorin,M.I., Wu,X., Nabi,Z., Ding,H.
            and Boulton,S.J.
  TITLE     RTEL1 is a replisome-associated helicase that promotes telomere and
            genome-wide replication
  JOURNAL   Science 342 (6155), 239-242 (2013)
   PUBMED   24115439
REFERENCE   6  (bases 1 to 3428)
  AUTHORS   Goldsby,R.E., Hays,L.E., Chen,X., Olmsted,E.A., Slayton,W.B.,
            Spangrude,G.J. and Preston,B.D.
  TITLE     High incidence of epithelial cancers in mice deficient for DNA
            polymerase delta proofreading
  JOURNAL   Proc Natl Acad Sci U S A 99 (24), 15560-15565 (2002)
   PUBMED   12429860
  REMARK    GeneRIF: A point mutation (D400A) in the proofreading domain of DNA
            polymerase delta, encoded by the Pold1 gene, inactivates the 3' -->
            5' exonuclease of poldelta and causes a mutator and epithelial
            cancer phenotype in a recessive manner.
REFERENCE   7  (bases 1 to 3428)
  AUTHORS   Ducoux,M., Urbach,S., Baldacci,G., Hubscher,U., Koundrioukoff,S.,
            Christensen,J. and Hughes,P.
  TITLE     Mediation of proliferating cell nuclear antigen (PCNA)-dependent
            DNA replication through a conserved p21(Cip1)-like PCNA-binding
            motif present in the third subunit of human DNA polymerase delta
  JOURNAL   J Biol Chem 276 (52), 49258-49266 (2001)
   PUBMED   11595739
REFERENCE   8  (bases 1 to 3428)
  AUTHORS   Goldsby,R.E., Lawrence,N.A., Hays,L.E., Olmsted,E.A., Chen,X.,
            Singh,M. and Preston,B.D.
  TITLE     Defective DNA polymerase-delta proofreading causes cancer
            susceptibility in mice
  JOURNAL   Nat Med 7 (6), 638-639 (2001)
   PUBMED   11385474
REFERENCE   9  (bases 1 to 3428)
  AUTHORS   Goldsby,R.E., Singh,M. and Preston,B.D.
  TITLE     Mouse DNA polymerase delta gene (Pold1) maps to chromosome 7
  JOURNAL   Mamm Genome 9 (1), 92-93 (1998)
   PUBMED   9434960
REFERENCE   10 (bases 1 to 3428)
  AUTHORS   Cullmann,G., Hindges,R., Berchtold,M.W. and Hubscher,U.
  TITLE     Cloning of a mouse cDNA encoding DNA polymerase delta: refinement
            of the homology boxes
  JOURNAL   Gene 134 (2), 191-200 (1993)
   PUBMED   8262377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ173955.1, AK167569.1 and BX634546.1.
            
            On Jul 23, 2009 this sequence version replaced NM_011131.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009128.1, AK146837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                CJ173955.1         3-21
            20-3390             AK167569.1         3-3373
            3391-3428           BX634546.1         1-38                c
FEATURES             Location/Qualifiers
     source          1..3428
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.83 cM"
     gene            1..3428
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /note="polymerase (DNA directed), delta 1, catalytic
                     subunit"
                     /db_xref="GeneID:18971"
                     /db_xref="MGI:MGI:97741"
     exon            1..61
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            62..257
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            258..371
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            372..518
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            519..644
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            645..813
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            814..895
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1025
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1192
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1297
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1438
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1549
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1741
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1830
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1947
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2061
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2209
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2305
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2443
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2619
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2772
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2875
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3008
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3122
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3175
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3273
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3424
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3397..3402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /note="hexamer: AATAAA"
     polyA_site      3419
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /note="major polyA site"
ORIGIN      
        1 cgcgcagagg gttcaggggt cacggcggcg tatcttgtgg cgggaaaagc tgtttgaggc
       61 gatggattgt aagcggcgac aaggaccagg ccctggggtg cccccaaagc gggctcgagg
      121 gcacctctgg gatgaggacg agccttcgcc gtcgcagttt gaggcgaacc tggcactgct
      181 ggaggaaata gaggctgaga accggctgca ggaggcagag gaggagctgc agctgccccc
      241 agagggcacc gtgggtgggc agttttccac tgcagacatt gaccctcggt ggcggcggcc
      301 caccctacgt gccctggacc ccagcacgga gcccctcatc ttccagcagc tggagattga
      361 ccactatgtg ggctcagcac cacccctgcc agaagggccc ctgccatccc ggaactcagt
      421 gcccatactg agggcctttg gggtcaccga tgaaggcttc tccgtctgct gccacataca
      481 gggctttgcc ccctacttct acacccccgc gcctcctggt tttggggccg agcacctgag
      541 tgagctgcag caggagctga acgcagccat cagccgggac cagcgcggtg ggaaggagct
      601 ctcagggccg gcagtgctgg caatagagct atgctcccgt gagagcatgt ttgggtacca
      661 cggtcatggc ccttctccat ttctccgcat caccctggca ctaccccgcc ttatggcacc
      721 agcccgccgc cttctggaac agggtgtccg agtgccaggc ctgggcaccc cgagcttcgc
      781 accctacgaa gccaacgtgg actttgagat ccggttcatg gtggatgctg acattgtggg
      841 atgcaactgg ttggagctgc cagctggaaa gtacgttcgg agggcggaga agaaggccac
      901 cctgtgtcag ctggaggtgg acgtgctgtg gtcagatgtg atcagtcacc caccggaggg
      961 gcagtggcag cgcattgcac ccctgcgtgt gcttagcttc gacatcgagt gtgctggccg
     1021 aaaaggcatc ttccctgagc ctgagcgtga ccccgtgatc cagatctgtt ctctggggct
     1081 gcgctggggg gagccggagc cattcttgcg tctggcactc acgctgcggc cctgtgcccc
     1141 catcctgggt gccaaagtgc agagctatga gcgggaagaa gacctgctcc aggcctgggc
     1201 cgacttcatc cttgccatgg accctgacgt gatcaccggc tacaacattc agaactttga
     1261 cctcccatac ctcatctctc gggcacaggc cctaaaggtg gaccgcttcc ctttcctggg
     1321 ccgcgtgact ggtctccgct ccaacatccg tgactcctcc ttccaatcaa ggcaggtcgg
     1381 ccggcgggac agtaaggtga tcagcatggt gggtcgcgtt cagatggata tgctgcaggt
     1441 gctgcttcgg gaacacaagc tccgctccta cacgctcaac gctgtgagtt tccacttcct
     1501 gggcgagcag aaggaggacg ttcagcacag catcatcacc gacctgcaga atgggaacga
     1561 acagacgcgc cgccgcctgg ccgtgtactg cctgaaggac gcctttctgc cactccgact
     1621 actagagcgc cttatggtgc tggtgaataa tgtggagatg gcgcgtgtca cgggtgtacc
     1681 ccttgggtac ctgctcaccc ggggccagca ggtcaaggtc gtgtctcagc tgctgcgcca
     1741 ggccatgcgc caggggctgc tgatgcctgt ggtgaagacc gagggcagtg aggactacac
     1801 gggagccaca gtcattgagc ccctcaaagg gtactatgac gtccccattg ccaccctgga
     1861 cttctcctcc ttgtacccat ccatcatgat ggcccataat ctgtgctaca ccacgctgct
     1921 ccgacctggg gctgcccaga agctgggcct taaaccagat gagttcatca agacacccac
     1981 tggggatgag tttgtgaagt catctgtacg gaagggcctc ctgccccaga tcctggagaa
     2041 tctgctgagt gcccgcaaga gggccaaggc tgagctggct caggagacgg accccctgcg
     2101 gcgacaggtc ttggacggcc ggcaactggc actaaaagtg agtgccaact ccgtatatgg
     2161 cttcactggt gcccaggtgg gcaagctgcc atgtttggag atctcccaga gtgtcactgg
     2221 gttcgggcgg cagatgattg agaaaaccaa gcagcttgtg gagtccaagt acaccgtgga
     2281 aaatggctac gatgccaacg ccaaggtagt ctacggtgac acggactctg tgatgtgccg
     2341 gtttggcgtc tcctctgtgg ctgaagcaat gtctctgggg cgggaggctg caaactgggt
     2401 atccagtcac ttcccatcac ccatccggct ggagttcgag aaggtttact tcccatacct
     2461 gctcatcagc aagaagcgct atgctggcct gctcttctcc tcccgctctg atgcccatga
     2521 caaaatggac tgcaagggcc tggaggctgt gcgcagggac aactgtcccc tggtggccaa
     2581 cctcgttaca tcctctctgc gccggatcct cgtggaccgg gaccctgatg gggcagtagc
     2641 ccatgccaag gacgtcatct cggacctgct gtgcaaccgc atagacatct cccagctggt
     2701 catcaccaaa gagttgaccc gcgcagcagc agactatgct ggcaagcagg ctcacgtgga
     2761 gctggctgag aggatgagga agcgcgaccc cggcagtgcg cccagcctgg gtgaccgagt
     2821 cccctatgtg atcattggtg ctgctaaggg tgtggccgcc tacatgaagt cggaggaccc
     2881 cctgtttgtg ctggagcaca gcctgcccat cgacactcag tactacctgg agcagcagct
     2941 ggccaagccg ctcttgcgca tctttgagcc catcctgggt gagggccgtg cagagtctgt
     3001 gctgctgcgc ggtgaccaca cacgatgcaa gactgtgctc accagcaagg tgggcggcct
     3061 cttggccttc accaagcgcc gcaactgttg cattggctgc cgctccgtaa tcgaccatca
     3121 aggagccgtg tgtaagttct gtcagccacg ggagtcggag ctctatcaga aggaggtgtc
     3181 acacctgaat gccttggaag aacggttctc tcgcctctgg acacagtgtc aacgctgcca
     3241 gggcagcttg catgaggacg tcatctgtac cagccgtgac tgtcccatct tctacatgcg
     3301 caagaaggtg cgcaaggacc tggaagacca ggaacggctg ctgcagcgct ttggaccgcc
     3361 cggccctgag gcctggtgac ctgacacggg acaaggaata aagttcagat cttttgctac
     3421 tggcaaaa
//
