LOCUS       NP_035261               1105 aa            linear   ROD 11-SEP-2024
DEFINITION  DNA polymerase delta catalytic subunit [Mus musculus].
ACCESSION   NP_035261
VERSION     NP_035261.3
DBSOURCE    REFSEQ: accession NM_011131.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1105)
  AUTHORS   Chen,T., Alcorn,H., Devbhandari,S., Remus,D., Lacy,E., Huangfu,D.
            and Anderson,K.V.
  TITLE     A hypomorphic mutation in Pold1 disrupts the coordination of embryo
            size expansion and morphogenesis during gastrulation
  JOURNAL   Biol Open 11 (8) (2022)
   PUBMED   35876795
REFERENCE   2  (residues 1 to 1105)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1105)
  AUTHORS   Bellelli,R., Borel,V., Logan,C., Svendsen,J., Cox,D.E., Nye,E.,
            Metcalfe,K., O'Connell,S.M., Stamp,G., Flynn,H.R., Snijders,A.P.,
            Lassailly,F., Jackson,A. and Boulton,S.J.
  TITLE     Polepsilon Instability Drives Replication Stress, Abnormal
            Development, and Tumorigenesis
  JOURNAL   Mol Cell 70 (4), 707-721 (2018)
   PUBMED   29754823
REFERENCE   4  (residues 1 to 1105)
  AUTHORS   Uchimura,A., Higuchi,M., Minakuchi,Y., Ohno,M., Toyoda,A.,
            Fujiyama,A., Miura,I., Wakana,S., Nishino,J. and Yagi,T.
  TITLE     Germline mutation rates and the long-term phenotypic effects of
            mutation accumulation in wild-type laboratory mice and mutator mice
  JOURNAL   Genome Res 25 (8), 1125-1134 (2015)
   PUBMED   26129709
REFERENCE   5  (residues 1 to 1105)
  AUTHORS   Vannier,J.B., Sandhu,S., Petalcorin,M.I., Wu,X., Nabi,Z., Ding,H.
            and Boulton,S.J.
  TITLE     RTEL1 is a replisome-associated helicase that promotes telomere and
            genome-wide replication
  JOURNAL   Science 342 (6155), 239-242 (2013)
   PUBMED   24115439
REFERENCE   6  (residues 1 to 1105)
  AUTHORS   Goldsby,R.E., Hays,L.E., Chen,X., Olmsted,E.A., Slayton,W.B.,
            Spangrude,G.J. and Preston,B.D.
  TITLE     High incidence of epithelial cancers in mice deficient for DNA
            polymerase delta proofreading
  JOURNAL   Proc Natl Acad Sci U S A 99 (24), 15560-15565 (2002)
   PUBMED   12429860
  REMARK    GeneRIF: A point mutation (D400A) in the proofreading domain of DNA
            polymerase delta, encoded by the Pold1 gene, inactivates the 3' -->
            5' exonuclease of poldelta and causes a mutator and epithelial
            cancer phenotype in a recessive manner.
REFERENCE   7  (residues 1 to 1105)
  AUTHORS   Ducoux,M., Urbach,S., Baldacci,G., Hubscher,U., Koundrioukoff,S.,
            Christensen,J. and Hughes,P.
  TITLE     Mediation of proliferating cell nuclear antigen (PCNA)-dependent
            DNA replication through a conserved p21(Cip1)-like PCNA-binding
            motif present in the third subunit of human DNA polymerase delta
  JOURNAL   J Biol Chem 276 (52), 49258-49266 (2001)
   PUBMED   11595739
REFERENCE   8  (residues 1 to 1105)
  AUTHORS   Goldsby,R.E., Lawrence,N.A., Hays,L.E., Olmsted,E.A., Chen,X.,
            Singh,M. and Preston,B.D.
  TITLE     Defective DNA polymerase-delta proofreading causes cancer
            susceptibility in mice
  JOURNAL   Nat Med 7 (6), 638-639 (2001)
   PUBMED   11385474
REFERENCE   9  (residues 1 to 1105)
  AUTHORS   Goldsby,R.E., Singh,M. and Preston,B.D.
  TITLE     Mouse DNA polymerase delta gene (Pold1) maps to chromosome 7
  JOURNAL   Mamm Genome 9 (1), 92-93 (1998)
   PUBMED   9434960
REFERENCE   10 (residues 1 to 1105)
  AUTHORS   Cullmann,G., Hindges,R., Berchtold,M.W. and Hubscher,U.
  TITLE     Cloning of a mouse cDNA encoding DNA polymerase delta: refinement
            of the homology boxes
  JOURNAL   Gene 134 (2), 191-200 (1993)
   PUBMED   8262377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ173955.1, AK167569.1 and BX634546.1.
            
            On Jul 23, 2009 this sequence version replaced NP_035261.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009128.1, AK146837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.83 cM"
     Protein         1..1105
                     /product="DNA polymerase delta catalytic subunit"
                     /EC_number="2.7.7.7"
                     /note="DNA polymerase delta 1, catalytic domain; 3'-5'
                     exodeoxyribonuclease"
                     /calculated_mol_wt=123660
     Region          1..31
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P52431.2)"
     Region          4..19
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P52431.2)"
     Site            19
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P28340; propagated from
                     UniProtKB/Swiss-Prot (P52431.2)"
     Region          78..1098
                     /region_name="PTZ00166"
                     /note="DNA polymerase delta catalytic subunit;
                     Provisional"
                     /db_xref="CDD:240301"
     Region          1056..1074
                     /region_name="CysB motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P52431.2)"
     CDS             1..1105
                     /gene="Pold1"
                     /gene_synonym="125kDa"
                     /coded_by="NM_011131.3:62..3379"
                     /db_xref="CCDS:CCDS21210.1"
                     /db_xref="GeneID:18971"
                     /db_xref="MGI:MGI:97741"
ORIGIN      
        1 mdckrrqgpg pgvppkrarg hlwdedepsp sqfeanlall eeieaenrlq eaeeelqlpp
       61 egtvggqfst adidprwrrp tlraldpste plifqqleid hyvgsapplp egplpsrnsv
      121 pilrafgvtd egfsvcchiq gfapyfytpa ppgfgaehls elqqelnaai srdqrggkel
      181 sgpavlaiel csresmfgyh ghgpspflri tlalprlmap arrlleqgvr vpglgtpsfa
      241 pyeanvdfei rfmvdadivg cnwlelpagk yvrraekkat lcqlevdvlw sdvishppeg
      301 qwqriaplrv lsfdiecagr kgifpeperd pviqicslgl rwgepepflr laltlrpcap
      361 ilgakvqsye reedllqawa dfilamdpdv itgyniqnfd lpylisraqa lkvdrfpflg
      421 rvtglrsnir dssfqsrqvg rrdskvismv grvqmdmlqv llrehklrsy tlnavsfhfl
      481 geqkedvqhs iitdlqngne qtrrrlavyc lkdaflplrl lerlmvlvnn vemarvtgvp
      541 lgylltrgqq vkvvsqllrq amrqgllmpv vktegsedyt gatvieplkg yydvpiatld
      601 fsslypsimm ahnlcyttll rpgaaqklgl kpdefiktpt gdefvkssvr kgllpqilen
      661 llsarkraka elaqetdplr rqvldgrqla lkvsansvyg ftgaqvgklp cleisqsvtg
      721 fgrqmiektk qlveskytve ngydanakvv ygdtdsvmcr fgvssvaeam slgreaanwv
      781 sshfpspirl efekvyfpyl liskkryagl lfssrsdahd kmdckgleav rrdncplvan
      841 lvtsslrril vdrdpdgava hakdvisdll cnridisqlv itkeltraaa dyagkqahve
      901 laermrkrdp gsapslgdrv pyviigaakg vaaymksedp lfvlehslpi dtqyyleqql
      961 akpllrifep ilgegraesv llrgdhtrck tvltskvggl laftkrrncc igcrsvidhq
     1021 gavckfcqpr eselyqkevs hlnaleerfs rlwtqcqrcq gslhedvict srdcpifymr
     1081 kkvrkdledq erllqrfgpp gpeaw
//
